Sang Hyun Lee

Korea Polar Research Institute, Sŏul, Seoul, South Korea

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Publications (248)549.15 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Wood component-based composite hydrogels have potential applications in biomedical fields owing to their low cost, biodegradability, and biocompatibility. The controllable properties of wood mimetic composites containing three major wood components are useful for enzyme immobilization. Here, lipase from Candida rugosa was entrapped in wood mimetic beads containing cellulose, xylan, and lignin by dissolving wood components with lipase in [Emim][Ac], followed by reconstitution. Lipase entrapped in cellulose/xylan/lignin beads in a 5:3:2 ratio showed the highest activity; this ratio is very similar to that in natural wood. The lipase entrapped in various wood mimetic beads showed increased thermal and pH stability. The half-life times of lipase entrapped in cellulose/alkali lignin hydrogel were 31- and 82-times higher than those of free lipase during incubation under denaturing conditions of high temperature and low pH, respectively. Owing to their biocompatibility, biodegradability, and controllable properties, wood mimetic hydrogel beads can be used to immobilize various enzymes for applications in the biomedical, bioelectronic, and biocatalytic fields.
    Carbohydrate Polymers 01/2015; 115:223–229. · 3.92 Impact Factor
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    ABSTRACT: Although the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post-puncture headache, drug-induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7-year-old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature.
    Pediatrics International 12/2014; 56(6):921-924. · 0.88 Impact Factor
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    ABSTRACT: In this article, we report the results of electrochemical monitoring regarding a multicellular photosynthetic cyanobacterial species using a photoelectrochemical sensor. The sensor utilizes the photosynthesis-based reducing action of the cyanobacteria (Spirulina maxima) on an electrochemical mediator (2-hydroxyl-1,4-naphthoquinone) and reoxidation of the mediator at an electrode. When the amperometric signals from the cyanobacteria are compared with dry cell weight, chlorophyll a concentration, and pH, the amperometric signals from the system show a considerable relationship with the chlorophyll a concentration in the cyanobacteria during the cultivation over 54 days.
    Sensors and Actuators B Chemical 12/2014; 205:9–11. · 3.84 Impact Factor
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    ABSTRACT: We evaluated the impact of normal vs. high presenting blood pressure (BP) on clinical outcomes and cardiac function in patients with ST-elevation myocardial infarction (MI). In 11,292 patients, in-hospital mortality and major adverse clinical events (MACE; all-cause death, nonfatal MI, or any revascularization) during follow-up were compared between patients with normal (≥100mm Hg and ≤139mm Hg) and high (≥140mm Hg) systolic BP at presentation. Compared to patients with high BP, patients with normal BP had significantly higher in-hospital mortality (1.5% vs. 3.7%; P < 0.001), especially in those with prior hypertension, and higher rates of all-cause death (3.3% vs. 5.3%; P < 0.001) and MACE (9.8% vs. 11.8%; P = 0.04) during follow-up (median: 330 days). After multivariate adjustment, normal BP was associated with higher risk of in-hospital mortality (adjusted hazard ratio (HR) = 2.268; 95% confidence interval (CI) = 1.144-4.498; P = 0.019), but not all-cause death (adjusted HR = 0.956; 95% CI = 0.602-1.517) or MACE (adjusted HR = 0.935; 95% CI = 0.755-1.158). Left ventricular ejection fraction at baseline and follow-up was significantly lower in patients with normal BP (52% vs. 51%; P < 0.001 and 55% vs. 54%; P = 0.018, respectively). Our findings indicate that patients with normal presenting BP, especially those with prior hypertension, exhibit higher in-hospital mortality and poorer cardiac function compared to patients with high BP. Although outcomes during follow-up did not differ, cardiac function was persistently poorer in patients who presented with normal BP. © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email:
    American journal of hypertension. 11/2014;
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    ABSTRACT: We investigated the effects of commonly used contrast media (CM) on myocardial ischemia-reperfusion injury in isolated rat hearts. Isolated rat hearts were subjected to 30 minutes of regional ischemia and 2 hours of reperfusion. The following CM (1 mL/1 L Krebs-Henseleit buffer) were randomly perfused for 15 minutes beginning 5 minutes before reperfusion and ending 10 minutes after reperfusion: iohexol (n=8), iopromide (n=8), ioversol (n=8), iomeprol (n=8), iopamidol (n=7), ioxaglate (n=8), and iodixanol (n=7). The effects of a direct bolus injection of undiluted iohexol, iopromide, or ioxaglate (each n=6) via the aortic root immediately prior to reperfusion were also evaluated. The area of necrosis, expressed as the percentage of the area at risk (AN/AR), and cardiodynamic variables were measured. The AN/AR of the control and experimental groups in the order described in methods was 33.7±6.4%, 30.3±7.4%, 34.7±12.6%, 29.2±10.2%, 20.9±7.6%, 22.6±8.7%, 18.8±7.9%, and 19.9±11.4%, respectively. Groups that received iomeprol and ioxaglate exhibited significantly decreased AN/AR values compared to those of control hearts (p=0.042 and p=0.013). No significant differences in the AN/AR were observed between control hearts and the groups injected with a single bolus of CM. No significant hemodynamic changes were noted after reperfusion among the groups. The overall effects of the CM on coronary reperfusion were not deleterious, and better effects were noted in two CM groups. However, it is unclear whether this result was attributed to a specific physiochemical property of the CM.
    Korean Circulation Journal 11/2014; 44(6):423-428.
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    ABSTRACT: Zonate leaf spots and severe defoliation were observed on Manchurian apricot (Prunus mandshurica) growing in a humid location in Korea from 2011 through 2013. The main symptoms included greyish green to brownish grey and zonate leaf spots without border lines, which mostly led to premature defoliation. The morphological characteristics of the causal agent were consistent with Hinomyces pruni. Identification was supported by analysing the sequence of the internal transcribed spacer region of ribosomal DNA from an isolate. The pathogenicity of the isolate was confirmed by artificial inoculation. This is the first report of zonate leaf spot caused by H. pruni on Manchurian apricot globally as well as in Korea.
    Journal of Phytopathology 10/2014; · 1.00 Impact Factor
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    ABSTRACT: Topography of the 410- and 660-km seismic upper-mantle discontinuities beneath the Korean Peninsula and southwestern Japan were determined using teleseismic receiver functions. P-receiver functions were migrated from delayed times to corresponding piercing (conversion) points of P-to-S converted phases, using one-dimensional (1D) and three-dimensional (3D) models. Receiver functions were then stacked using Common Conversion Point (CCP) techniques, to enhance signal-to-noise ratios and thereby reduce uncertainty (noise). The 410- and 660-km discontinuities were clearly imaged, as positively valued amplitude peaks of CCP stacked receiver functions in the study area. Topographic variations were roughly consistent with the low temperature of the subducting Pacific Plate. However, the complex structure of the subducting Pacific Plate produced distinct changes of upper-mantle discontinuities, which cannot be explained by temperature variations alone. Depression of the 410-km discontinuity, observed in a wide region extending from the Korean Peninsula to Kyushu Island, may be related to trench-rollback history. Furthermore, the topography of the 660-km discontinuity varies significantly with latitude. At latitudes higher than 38°N, its depth remains unchanged, despite the presence of the stagnant slab, while significant depression has been observed at latitudes below 36°N. This may have been caused by differences in the angles of subduction of the Japan slab and the Izu-Bonin slab. However, heterogeneity of the water content of slabs may also have contributed to this topographical difference.
    Journal of Geophysical Research: Solid Earth 09/2014; · 3.44 Impact Factor
  • Peng Xu, David M Virshup, Sang Hyun Lee
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    ABSTRACT: Proper alignment of duplicated chromosomes at the metaphase plate involves both motor-driven chromosome movement, and the functional and physical end-on connection (K-fiber formation) between the kinetochore and the plus-end of microtubules. The B56 family of Protein Phosphatase 2A (PP2A) regulatory subunits, through their interaction with the mitotic checkpoint protein BUBR1, are required for proper chromosome alignment, but the underlying mechanism(s) has remained elusive. Here we show that B56-PP2A promotes chromosome alignment primarily by balancing chromosome movement towards the metaphase plate, rather than by directly establishing stable K-fibers. Notably, the poleward movement of chromosomes in cells depleted of the B56 family can be rescued by depletion of HSET/kinesin-14, a major minus end-directed motor protein. Strikingly, K-fiber formation can be restored if chromosome movement to the metaphase plate is rescued in B56-depleted cells. Furthermore, the B56:BUBR1 interaction is required for promoting motor-driven chromosome movement towards the metaphase plate. Thus, we propose that B56-PP2A functions in mitotic chromosome alignment by balancing chromosome movement towards the metaphase plate, which is essential for subsequent establishment of stable and functional kinetochore-microtubule attachment, and mitotic exit.
    Journal of cell science. 09/2014;
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    ABSTRACT: Neurogenic pulmonary edema (NPE) in brain dead organ donors occurring after an acute central nervous system insult threatens organ preservation of potential organ donors and the outcome of organ donation. Hence the active and immediate management of NPE is critical. In this case, a 50-year-old male was admitted to the intensive care unit (ICU) for organ donation. He was hypoxic due to NPE induced by spontaneous intracerebral hemorrhage and intraventricular hemorrhage. Protective ventilatory management, intermittent recruitment maneuvers, and supportive treatment were maintained in the ICU and the operating room (OR). Despite this management, the hypoxemia worsened after the OR admission. So inhaled nitric oxide (NO) therapy was performed during the operation, and the hypoxic phenomena showed remarkable improvement. The organ retrieval was successfully completed. Therefore, NO inhalation can be helpful in the improvement of hypoxemia caused by NPE in brain dead organ donors during anesthesia for the organ donation.
    Korean journal of anesthesiology 08/2014; 67(2):133-8.
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    ABSTRACT: We report an anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia (elevated free thyroxine, fT4 and normal 3, 5, 3'-L-triiodothyronine, T3) and suspected impairment of conversion from T4 to T3. Despite marked hyperthyroxinemia, this patient's perioperative hemodynamic profile was suspected to be the result of hypothyroidism, in reference to the presence of T4 to T3 conversion disorder. We suspected that pretreatment with antithyroid medication before surgery, surgical stress and anesthesia may have contributed to the decreased T3 level after surgery. She was treated with liothyronine sodium (T3) after surgery which restored her hemodynamic profile to normal. Anesthesiologists may be aware of potential risk and caveats of inducing hypothyroidism in patients with euthyroid hyperthyroxinemia and T4 to T3 conversion impairment.
    Korean journal of anesthesiology 08/2014; 67(2):144-7.
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    ABSTRACT: NAD-dependent formate dehydrogenase (FDH) from Candida boidinii (CbFDH) has been widely used in various CO<sub>2</sub>-reduction systems but its practical applications are often impeded due to low CO<sub>2</sub>-reducing activity. In this study, we demonstrated superior CO<sub>2</sub>-reducing properties of FDH from Thiobacillus sp. KNK65MA (TsFDH) for production of formate from CO<sub>2</sub> gas. To discover more efficient CO<sub>2</sub>-reducing FDHs than a reference enzyme, i.e. CbFDH, five FDHs were selected with biochemical properties and then, their CO<sub>2</sub>-reducing activities were evaluated. All FDHs including CbFDH showed better CO<sub>2</sub>-reducing activities at acidic pHs than at neutral pHs and four FDHs were more active than CbFDH in the CO<sub>2</sub> reduction reaction. In particular, the FDH from Thiobacillus sp. KNK65MA (TsFDH) exhibited the highest CO<sub>2</sub>-reducing activity and had a dramatic preference for the red
    PLoS ONE 07/2014; 9(7):e103111. · 3.53 Impact Factor
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    ABSTRACT: This study performed phytochemical and bioactive assessments of the mangrove Lumnitzera racemosa Willd. leaves. Bioassay-guided fractionation of the methanolic extracts led to the identification of thirty-six compounds (1-36), their structures were elucidated using detailed NMR spectroscopic and MS analysis. The extracts, fractions, and the isolated compounds were screened for potential antioxidant and cytotoxic activities. Antioxidant assays were performed using peroxyl radical-scavenging and reducing assays, whereas cytotoxicity was measured using MTT assays in HL-60 and Hel-299 cell lines. The methanolic extract, CH2Cl2 and n-BuOH fractions (10.0 μg/mL) exhibited potent antioxidant activity, with Trolox equivalent (TE) values of 24.94 ± 0.59, 28.34 ± 0.20, and 27.09 ± 0.37 (μM), respectively. In addition, the isolated compounds exerted cytotoxic effects in a dose-dependent manner; compounds 1 and 14 exhibited the most potent cytotoxicity in HL-60 cells, with IC50 values of 0.15 ± 0.29 and 0.60 ± 0.16 μM, respectively. To clarify the mechanism(s) behind these cytotoxic effects, we measured the time-dependent changes in apoptotic markers including the condensation and fragmentation of nuclear chromatin, and the downregulation of p-ERK1/2, p-AKT, and c-Myc levels.
    Archives of Pharmacal Research 07/2014; · 1.54 Impact Factor
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    ABSTRACT: Previous work has shown that prostate cancer in a Pten null murine model is dependent on the p110β isoform of PI3K, while breast cancer driven by either polyoma middle T antigen (MT) or HER2 is p110α dependent. Whether these differences in isoform dependence arise from tissue specificity, or from the nature of the oncogenic signal activating the PI3K pathway, is important given increasing interest in using isoform specific PI3K inhibitors in cancer therapy. To approach this question, we studied the PI3K isoform dependence of our recently constructed prostate cancer model driven by MT. Since MT activates a number of signaling pathways, we first confirmed that the MT prostate model was actually dependent on PI3K. A newly-generated transgenic prostate line expressing a MT allele (Y315F), known to be defective for PI3K binding, displayed a markedly reduced ability to drive tumor formation. We next selectively ablated expression of either p110α or p110β in mice expressing wild type MT in the prostate. We found that tumor formation driven by MT was significantly delayed by loss of p110α expression, while ablation of p110β had no effect. Since tumor formation by MT is p110α dependent in prostate as well as in mammary gland, our data suggest that PI3K isoform dependence is driven by the mode of PI3K pathway activation rather than by tissue type.
    Journal of virology. 07/2014;
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    ABSTRACT: Pulmonary thromboembolism (PTE) is a common clinical condition related to significant mortality. Furthermore, patients with PTE presenting with right heart thrombus show higher mortality due to rapid hemodynamic deterioration. But the optimal treatment of massive PTE is controversial although various methods have been developed and improved. Here, we presented a case of 56-yr-old woman with massive PTE showing hemodynamic collapse, who was successfully treated with extracorporeal membrane oxygenation (ECMO) adjunct to thrombolytic therapy even without thrombectomy. ECMO was useful for resuscitation and stabilization of the cardiopulmonary function. In conclusion, thrombolytic therapy complemented by ECMO may be an effective treatment option for acute massive PTE with hemodynamic instability.
    Journal of Korean medical science. 05/2014; 29(5):735-8.
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    ABSTRACT: The effect of lignin is a key issue in various cellulose processes. To study the effects of lignin state and content on cellulose electrospinning and fiber properties, two different types of cellulose solutions were prepared and electrospun under several different conditions. One was mixture of cellulose and lignin and the other one was hemp cellulose in which cellulose is naturally combined with lignin. In both the cases, the solutions were stably electrospun when the lignin concentration was lower than 5%. The lignin in the cellulose/lignin mixture resulted in film-like fiber and bimodal distribution of the fiber diameter, while the lignin in the hemp cellulose mainly increased the fiber diameter. It is originated from the different phase separation behaviors of the two solutions. The results can give the fundamental understandings for the roles and action of lignin in cellulose process. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40031.
    Journal of Applied Polymer Science 04/2014; 131(7). · 1.40 Impact Factor
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    ABSTRACT: Electroenzymatic conversion of environmentally detrimental CO2 into useful chemicals using a NADH-dependent formate dehydrogenase has been of great interest, but the system remained at a conceptual level because of its complexity. In this study, we found that CO2 was a direct substrate for formate formation with Candida boidinii formate dehydrogenase (CbsFDH), but HCO3− was not. Enzymatic formate formation with CbsFDH was inhibited at NADH concentrations higher than 0.35 mM. Electrochemical NADH regeneration was performed at a Cu electrode using the [Cp*Rh(bpy)Cl]+ complex, which catalyzed the conversion of NAD+ into the active NADH with almost 100% selectivity. The electroenzymatic reaction for HCO2H formation was conducted at 1.0 V, 0.25 mM NADH and 0.25 mM Rh complex during electrochemical NADH regeneration. CO2 was reduced into formate by enzymatic catalysis under the NADH regeneration condition, where protons and electrons was continuously supplied into a cathode cell through Nafion® membrane from water splitting at a Pt anode. The interactions of the Cu electrode, Rh mediator, NADH, and CbsFDH were analyzed for the first time. The Rh(III) mediator was hydrolyzed and reduced reversibly into a Rh(I) intermediate (Mred1) as well as irreversibly into a Rh(I) hydride intermediate (Mred2) at the Cu electrode. Interestingly, the Rh(I) species showed activity toward the direct reduction of CO2 as well as NADH regeneration, although the primary CO2 reduction occurred through CbsFDH at 1.0 V.
    Journal of Molecular Catalysis B Enzymatic 04/2014; · 2.82 Impact Factor
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    ABSTRACT: The chromosome passenger complex (CPC) must relocate from anaphase chromosomes to the cell equator for successful cytokinesis. Although this landmark event requires the mitotic kinesin MKlp2, the spatiotemporal mechanistic basis remains elusive. Here, we show that phosphoregulation of MKlp2 by the mitotic kinase Cdk1/cyclin B1 coordinates proper mitotic transition with CPC relocation. We identified multiple Cdk1/cyclin B1 phosphorylation sites within the stalk and C-terminal tail that inhibit microtubule binding and bundling, oligomerization/clustering, and chromosome targeting of MKlp2. Specifically, inhibition of these abilities by Cdk1/cyclin B1 phosphorylation is essential for proper early mitotic progression. Upon anaphase onset, however, reversal of Cdk1/cyclin B1 phosphorylation promotes MKlp2-CPC complex formation and relocates the CPC from anaphase chromosomes for successful cytokinesis. Thus, we propose that phosphoregulation of MKlp2 by Cdk1/cyclin B1 ensures that activation of MKlp2 kinesin and relocation of the CPC occur at the appropriate time and space for proper mitotic progression and genomic stability.
    Cell Reports 03/2014; · 7.21 Impact Factor
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    ABSTRACT: [1] In this study, we investigated spatial and temporal changes in precipitation over the COordinated Regional climate Downscaling EXperiment (CORDEX) East Asia domain, for present (1986–2005) and future (2031–2050) periods using the Regional Climate Model version 4 (RegCM4). Future meteorology produced by the Hadley Center Global Environmental Model version 2 coupled with the Atmosphere–Ocean (HadGEM2-AO) following global climate change scenarios (RCP 4.5 and 8.5) was used as meteorological boundary conditions for the RegCM4. Six sub-regions (South Korea, North China, South China, Japan, Mongolia, and India) in the CORDEX East Asia domain were considered for analysis. The RegCM4 simulated spatial distributions of precipitation over East Asia with a correlation coefficient of 0.7 against CRU data. The simulation skills of its temporal variability varied based on geographical regions and seasons, showing relatively poorer performance (under-estimation in rainfall amount) in summer than in winter, in general. The future climate simulations by the RegCM4 presented that the East Asian continental regions will be warmer and more humid, leading to increased precipitation amounts, especially in the summer. The summer precipitation amount was projected to increase by about 5%, on average, over the East Asian domain, 5 − 15% in most sub-regions, and even higher (44% and 24%) in the South Korean region for the RCP 4.5 and 8.5 scenarios, respectively. It was also expected that heavy rainfall (> 50 mm/day) events may occur more frequently in the future possibly owing to meteorological changes that are favorable to convective heavy precipitation.
    Journal of Geophysical Research: Atmospheres. 01/2014;
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    ABSTRACT: The synthesis of dye-doped (1,3,3-Trimethylindolinobenzopyrylospiran, TMLBPS and 2,3-Bis(2,4,5-trimethyl-3-thienyl)maleimide, BTMTMI) and free-standing mesoporous organosilica (PMO) films with cubic mesostructure (Im3m) was carried out using reactant mass ratio of 0.8 F108:0.1 2 M-HCl:10 EtOH:0.8H2 O:7.8 × 10−3–1.95 × 10−2 dye:1.77 BTSE ((C2H5O)3SiCH2CH2Si(OC2H5)3). Both samples of PMO-AS-TMLBPS and PMO-AS-BTMTMI have photochromic properties which show the decrease and increase of fluorescence intensity under visible and UV irradiation. The as-synthesized PMO-AS-TMLBPS film and PMO-AS-BTMTMI film contained template showed photochromic phenomena that are in agreement with the decrease and increase of fluorescence intensity over about 4 h. On the other hand, the dyes impregnation in mesopores of template-extracted PMO film showed photochromic phenomena that are in accordance with the decrease and increase of fluorescence intensity over 55 min. The thickness of dye-impregnated PMO films was also controlled from 1.3 μm to 38.1 μm.
    Science of Advanced Materials 01/2014; 6(7). · 2.51 Impact Factor
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    ABSTRACT: Amidoxime functionalized SBA-15 was prepared by post modification onto the mesoporous silica SBA-15 surface using chemically synthesized functional group 1,1′-dinitrilopropyltriethoxysilane (DNPTES), followed by further chemical conversion of nitrile part of the functional groups into amidoxime by post chemical transformation procedure using hydroxylamine hydrochloride reagent. The resulted materials have enriched amount of functional ligands onto the SBA-15 surfaces. The synthesized Amidoxime-SBA-15 materials were characterized by small-angle X-ray scattering (SAXS), Fourier-transform infrared (FT-IR) spectroscopy, N2 adsorption–desorption isotherms, 29Si MAS, 13C CP MAS NMR spectroscopic analyses and transmission electron microscopy (TEM) analysis and elemental analysis. The prepared Amidoxime-SBA-15 materials were tested for the selective adsorption of Li+ ions from the aqueous waste solution containing Li+, Cd2+, and Ni2+. Amidoxime-SBA-15 exhibited a high selectivity (∼90%) of Li+ ion with high amount of adsorption capacity (0.9 mmol g−1) under acidic medium (pH 5). Moreover, Amidoxime modified SBA-15 would be a desirable sorbent material for selective adsorption of Li+ ions in aqueous waste discharged from lithium battery and lithium ion fuel industries.
    Science of Advanced Materials 01/2014; 6(7). · 2.51 Impact Factor

Publication Stats

2k Citations
549.15 Total Impact Points


  • 2014
    • Korea Polar Research Institute
      Sŏul, Seoul, South Korea
    • Kongju National University
      • Department of Atmospheric Sciences
      Gongju, South Chungcheong, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2013–2014
    • Duke-NUS Graduate Medical School Singapore
      • PhD Program in Cancer and Stem Cell Biology
      Tumasik, Singapore
    • National Health Insurance Corporation Ilsan Hospital
      Sŏul, Seoul, South Korea
    • Dongguk University
      • Department of Chemical and Biochemical Engineering
      Seoul, Seoul, South Korea
  • 2010–2014
    • Dana-Farber Cancer Institute
      • Department of Cancer Biology
      Boston, Massachusetts, United States
    • National Cancer Center Korea
      Kōyō, Gyeonggi Province, South Korea
    • Yeungnam University
      • School of Chemical Engineering
      Onyang, South Chungcheong, South Korea
    • Kangwon National University
      Shunsen, Gangwon, South Korea
    • Centre for Cancer Biology
      Tarndarnya, South Australia, Australia
  • 2009–2014
    • Konkuk University
      Sŏul, Seoul, South Korea
    • Yonsei University
      • Department of Civil and Environmental Engineering
      Seoul, Seoul, South Korea
    • University of Hyogo
      • Graduate School of Material Science
      Kōbe-shi, Hyogo-ken, Japan
    • National Institute of Biological Resources
      Bucheon, Gyeonggi Province, South Korea
  • 2006–2014
    • Korea Forest Research Institute
      Sŏul, Seoul, South Korea
    • Massachusetts Institute of Technology
      • Department of Civil and Environmental Engineering
      Cambridge, Massachusetts, United States
    • University of Illinois, Urbana-Champaign
      • Department of Civil and Environmental Engineering
      Urbana, IL, United States
    • Chung-Ang University
      Sŏul, Seoul, South Korea
  • 2009–2013
    • University of Texas at Austin
      • Department of Electrical & Computer Engineering
      Austin, Texas, United States
  • 2002–2013
    • Pusan National University
      • • Department of Internal Medicine
      • • Department of Polymer Science and Engineering
      • • Department of Earth Science Education
      Pusan, Busan, South Korea
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea
    • Hanyang University
      • Division of Materials Science and Engineering (MSE)
      Seoul, Seoul, South Korea
  • 2012
    • Sangji University
      • Department of Pharmaceutical Engineering
      Wŏnju, Gangwon, South Korea
    • Sungkyunkwan University
      • Samsung Medical Center
      Seoul, Seoul, South Korea
    • Chungnam National University
      • College of Pharmacy
      Daiden, Daejeon, South Korea
    • University of South Australia
      Tarndarnya, South Australia, Australia
  • 2010–2012
    • Oak Ridge National Laboratory
      Oak Ridge, Florida, United States
  • 2006–2012
    • Korea Research Institute of Standards and Science
      • Division of Physical Metrology
      Sŏul, Seoul, South Korea
    • Tohoku University
      • • Graduate School of Environmental Studies
      • • Center for Interdisciplinary Research
      • • Institute for Materials Research
      Sendai, Kagoshima, Japan
  • 2011
    • Tufts University
      • Department of Biochemistry
      Georgia, United States
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea
    • Hannam University
      Daiden, Daejeon, South Korea
  • 2003–2010
    • Chonbuk National University
      • Department of Chemical Engineering
      Tsiuentcheou, North Jeolla, South Korea
  • 2006–2009
    • Inha University
      • Department of Biological Engineering
      Seoul, Seoul, South Korea
  • 2003–2009
    • Chonnam National University
      • • College of Agriculture and Life Sciences
      • • Department of Electrical, Electronic Communication and Computer Engineering
      • • Department of Cardiology
      Yeoju, Gyeonggi, South Korea
  • 2008
    • Rensselaer Polytechnic Institute
      • Department of Chemical and Biological Engineering
      New York City, NY, United States
    • Korea Research Institute of Chemical Technology
      • Division of Advanced Material
      Taiden, Daejeon, South Korea
  • 2005–2008
    • University of California, San Francisco
      San Francisco, California, United States
    • University of Ulsan
      • Department of Physics
      Ulsan, Ulsan, South Korea
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
    • Korea Advanced Institute of Science and Technology
      Sŏul, Seoul, South Korea
  • 2003–2008
    • Pohang University of Science and Technology
      • Department of Chemical Engineering
      Andong, North Gyeongsang, South Korea
  • 2007
    • Silla University
      Tsau-liang-hai, Busan, South Korea
  • 1976
    • Hope College
      Holland, Michigan, United States