Hee Sung Kim

Seonam University, Onyang, Chungcheongnam-do, South Korea

Are you Hee Sung Kim?

Claim your profile

Publications (5)12.66 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A series of ionic liquid-based zinc tetrahalide complexes were synthesized and their effects in the coupling reactions of ethylene oxide (EO) and carbon dioxide to produce ethylene carbonate (EC) were evaluated. The zinc tetrahalide complexes displayed high catalytic activities for the coupling reaction, but were found to cause a severe decomposition of EC during the vacuum-distillation of the product mixture. Among the various factors affecting the EC decomposition, the concentration of zinc tetrahalide species was most responsible for the decomposition: the lower the concentration, the lesser the decomposition. The addition of an imidazolium or ammonium halide was effective for enhancing the activity of the zinc tetrahalide complex while having only a minor effect on the decomposition rate. The optimum catalyst composition was discussed for producing EC feasibly with minimized product decomposition.
    Applied Catalysis A General 07/2005; 288(1-2):48-52. DOI:10.1016/j.apcata.2005.04.036 · 3.94 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the relationship between angiogenesis, apoptosis and cell proliferation in invasive ductal carcinoma of the breast and their relation to tumor behavior. Microvessels were immunohistochemically labeled with antibody to CD34 in sections from 82 cases of invasive ductal carcinoma. Computerized image analysis was used to evaluate microvessel density (MVD). The authors measured the apoptotic index (AI) using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling technique and proliferating cell nuclear antigen labeling index (PCNA LI) by PCNA immunohistochemistry on serial sections. Statistical analysis revealed a significant inverse correlation between MVD and AI (r = -.313, P = .004) and failed to find a significant correlation between MVD and PCNA LI. There was a significant positive correlation between AI and PCNA LI (r = .393, P = .000). Significant differences in AI between high MVD (> or = 59.9%) and low MVD (< 59.9%) were seen (P < .001), with no appreciable differences in PCNA LI between the two groups. Histologic grade and stage were the only independent prognostic factors in both disease-free and overall survival. Angiogenesis in breast cancer may be related to the ability of tumor cells to survive rather than to their proliferative activity. Apoptosis is related to cell proliferation in breast cancer.
    Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 05/2001; 23(2):161-8. · 0.49 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: beta-catenin serves not only as a structural component of the E-cadherin-mediated cell-cell adhesion system, but also as a signaling molecule of the Wnt/wingless pathway. Deregulated expression of beta-catenin and mutations of the gene have been identified in a number of human malignancies. To determine the role of beta-catenin defects in stomach cancer, we investigated beta-catenin exon 3 mutations and altered protein expression in 77 primary gastric carcinomas and 11 cell lines. In addition, the immunohistochemical expression pattern of beta-catenin in 303 consecutive gastric cancers was determined and their relationships with clinicopathologic features and patient outcome were investigated. This study revealed 5% (4 of 77) tumors and 27% (3 of 11) cell lines with beta-catenin gene alteration, 6 missense mutations, and 1 interstitial deletion. These genetic changes were shown to correlate closely with nuclear localization of the protein (p = 0.001). In an immunohistochemical analysis, abnormal expressions of beta-catenin, such as nuclear accumulation and loss of membranous distribution, were detected in 27% (81 of 303) of tumors overall. These altered beta-catenin expressions were more commonly observed in 37% (58 of 158) diffuse type gastric carcinomas (p < 0.001). Loss of membranous beta-catenin staining was associated with poor survival (p = 0.045). In conclusion, our results demonstrate that beta-catenin mutations are common in gastric cancer cell lines but occur infrequently in gastric carcinoma tissues. These mutations are one of the causes of the nuclear accumulation of beta-catenin. Frequent abnormalities of beta-catenin expression in gastric carcinoma support the idea that both structural and signaling functions of the protein play a critical role in gastric carcinogenesis.
    International Journal of Cancer 04/2001; 95(2):108-13. DOI:10.1002/1097-0215(20010320)95:2<108::AID-IJC1019>3.3.CO;2-R · 5.09 Impact Factor
  • H J Jang · Hyo Keun Lim · Hee Sung Kim · EY Cho · Soon Jin Lee · KA Kim · Dongil Choi
    [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this work was to describe the helical CT findings of intestinal metastasis from gastric adenocarcinoma. Twenty-three patients with intestinal metastasis from gastric adenocarcinoma found at helical CT were included. CT findings and clinical and pathologic data were reviewed. The most common characteristic finding was target-like concentric bowel wall thickening (thick inner high-outer low, n = 18) involving multiple long segments with progressive thickening of the enhancing inner layer. Fifteen cases (65%) involved multiple sites, and the ascending colon (n = 12) and rectum (n = 11) were the two most common sites. Peritoneal carcinomatosis (n = 15, 65%) and bowel obstruction (n = 14, 61%) were common associated findings. Regarding the primary lesion, the majority was linitis plastica (n = 16) and poorly differentiated adenocarcinoma with or without signet-ring cell differentiation (n = 14). Intestinal metastasis from gastric adenocarcinoma, especially of the linitis plastica type, most commonly showed target-like long segmental wall thickening with a characteristically thick inner enhancing layer on helical CT.
    Journal of Computer Assisted Tomography 01/2001; 25(1):61-7. DOI:10.1097/00004728-200101000-00011 · 1.41 Impact Factor
  • The Journal of Antibiotics 01/1997; 49(12):1275-7. DOI:10.7164/antibiotics.49.1275 · 1.73 Impact Factor