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ABSTRACT: Mangiferin, a natural bioactive xanthone C-glycoside, is widely present in medicinal plants like the leaf of Mangifera indica L. (Anacardiaceae). It has been reported that mangiferin possesses a variety of biological activities, including antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, and anticarcinogenic.
The hypouricemic effect and xanthine oxidoreductase (XOR) inhibitory activity of mangiferin were investigated here for the first time.
The hypouricemic effect of mangiferin was investigated in normal and hyperuricemic mice induced by potassium oxonate. Mangiferin at a dose of 0.75-100.0 mg/kg was given intragastrically to mice. The serum urate levels were determined using the phosphotungstic acid method. The hepatic activities of xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) in hyperuricemic mice were assayed using commercially available kits.
The results showed that mangiferin at a dose of 1.5, 3.0, and 6.0 mg/kg significantly reduced the serum urate levels (148.7 ± 37.8, 142.2 ± 44.5, 121.7 ± 21.7 µmmol/L) in hyperuricemic mice, compared with untreated hyperuricemic mice (201.8 ± 71.2 µmmol/L). However, mangiferin did not decrease the serum urate levels in normal mice until mangiferin was up to 100 mg/kg. In addition, the hepatic activities of XDH in hyperuricemic mice were significantly decreased by mangiferin, while no changes of XOD were observed. Acute toxicity study in mice showed that mangiferin was very safe at a dose of up to 25 g/kg.
These findings demonstrate that mangiferin has the potential to be developed as a new therapeutic agent for the treatment of hyperuricemia and gout.
Pharmaceutical Biology 09/2012; 50(9):1177-82. · 0.88 Impact Factor
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R. Ischebeck,
M. Berry,
I. Blumenfeld,
F.-J. Decker,
M.J. Hogan,
R.H. Iverson,
N. Kirby,
R.H. Siemann,
D. Walz,
C.E. Clayton,
Chengkun Huang,
C. Joshi, Wei Lu,
K.A. Marsh,
T. Katsouleas,
P. Muggli,
E. Oz
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ABSTRACT: In the E-167 plasma wakefield acceleration experiment, electrons with an initial energy of 42 GeV are accelerated in a meter-scale lithium plasma. Particles are leaving plasma with a large energy spread. To determine the spectrum of the accelerated particles, a two-plane spectrometer has been set up.
Particle Accelerator Conference, 2007. PAC. IEEE; 07/2007
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R. Ischebeck,
F. Decker,
M. Hogan,
R.H. Iverson,
P. Krejcik,
R.H. Siemann,
D. Walz,
M. Lincoln,
C.E. Clayton,
Chengkun Huang, Wei Lu,
Suzhi Deng,
E. Oz
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ABSTRACT: In the plasma wakefield acceleration experiment E-167, optical transition radiation is used to measure the transverse profile of the electron bunches before and after the plasma acceleration. The distribution of the electric field from a single electron does not give a point-like distribution on the detector, but has a certain extension. Additionally, the resolution of the imaging system is affected by aberrations. The transverse profile of the bunch is thus convolved with a point spread function (PSF). Algorithms that deconvolve the image can help to improve the resolution. Imaged test patterns are used to determine the modulation transfer function of the lens. From this, the PSF can be reconstructed. The Lucy-Richardson algorithm is used to deconvolute this PSF from test images.
Particle Accelerator Conference, 2005. PAC 2005. Proceedings of the; 06/2005
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R. Ischebeck,
C. Barnes,
I. Blumenfeld,
F. Decker,
M. Hogan,
R.H. Iverson,
P. Krejcik,
R.H. Siemann,
D. Walz,
N. Kirby,
C. Clayton,
Chengkun Huang,
D.K. Johnson, Wei Lu,
K. Marsh,
Suzhi Deng,
E. Oz
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ABSTRACT: The accelerating field that can be obtained in a beam-driven plasma wakefield accelerator depends on the current of the electron beam that excites the wake. In the E-167 experiment, a peak current above 10 kA will be delivered at a particle energy of 28 GeV. The bunch has a length of a few ten micrometers and several methods are used to measure its longitudinal profile. Among these, autocorrelation of coherent transition radiation (CTR) is employed. The beam passes a thin metallic foil, where it emits transition radiation. For wavelengths greater than the bunch length, this transition radiation is emitted coherently. This amplifies the long-wavelength part of the spectrum. A scanning Michelson interferometer is used to autocorrelate the CTR. However, this method requires the contribution of many bunches to build an autocorrelation trace. The measurement is influenced by the transmission characteristics of the vacuum window and beam splitter. We present here an analysis of materials, as well as possible layouts for a single shot CTR autocorrelator.
Particle Accelerator Conference, 2005. PAC 2005. Proceedings of the; 06/2005
