Hiroshi Suzuki

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Publications (2)4.9 Total impact

  • Article: Genotoxicity evaluation for single-walled carbon nanotubes in a battery of in vitro and in vivo assays.
    Makoto Ema, Tadashi Imamura, Hiroshi Suzuki, Norihiro Kobayashi, Masato Naya, Junko Nakanishi
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    ABSTRACT: The genotoxicity of single-walled carbon nanotubes (SWCNTs) was determined using a battery of genotoxicity assays, comprising a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test and a mammalian erythrocytes micronucleus test. SWCNTs had no mutagenicity in S. typhimurium TA98, TA100, TA1535 or TA1537, or in E. coli WP2uvrA, in the absence or presence of metabolic activation. SWCNTs did not increase the number of structural or numerical chromosomal aberrations after short-term or continuous exposure. In the micronucleus test using CD-1 mice, SWCNTs did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes or the number of micronuclei in immature erythrocytes. SWCNTs appear not to pose a genotoxic risk. Copyright © 2012 John Wiley & Sons, Ltd.
    Journal of Applied Toxicology 07/2012; · 2.48 Impact Factor
  • Article: Evaluation of genotoxicity of multi-walled carbon nanotubes in a battery of in vitro and in vivo assays.
    Makoto Ema, Tadashi Imamura, Hiroshi Suzuki, Norihiro Kobayashi, Masato Naya, Junko Nakanishi
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    ABSTRACT: The genotoxic potential of two products of multi-walled carbon nanotubes (coded as N-MWCNTs, diameter of 44 nm/BET surface area of 69 m²/g and MWNT-7, diameter of 70 nm/BET surface area of 23 m²/g) was evaluated using a battery of genotoxicity assays, comprising a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test, and a mammalian erythrocytes micronucleus test. Neither type exerted mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, and TA1537, or in Escherichia coli WP2uvrA, in the absence or presence of metabolic activation. The products of MWCNTs did not increase the number of structural chromosomal aberrations either, regardless of metabolic activation, though they increased the number of numerical chromosomal aberrations, one slightly and the other distinctly, in the absence of metabolic activation. In ICR mice, the two products did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes, or the number of micronuclei in immature erythrocytes.
    Regulatory Toxicology and Pharmacology 04/2012; 63(2):188-95. · 2.43 Impact Factor
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