[Show abstract][Hide abstract] ABSTRACT: This cross-sectional study was carried out in some selected arsenic contaminated rural areas of Bangladesh to determine any clinical changes in oral cavity, among the arsenic exposed population through drinking water. Total 600 respondents (200 arsenicosis patients, 200 non-patients but having the history of taking arsenic contaminated water and another 200 arsenic non-exposed). 75.5% of arsenicosis patients had swelled vallate papillae whereas only 44.5% and 8.5% in case of arsenic exposure and non-exposure subjects respectively. The differences were found statistically significant (p < 0.001). This study suggests that there is a tendency of developing swelled vallate papillae among the arsenic exposed population.
Bangladesh Medical Research Council Bulletin 04/2010; 36(1):1-3.
[Show abstract][Hide abstract] ABSTRACT: The objective of this cross-sectional comparative study was to assess quality of life (QOL) of arsenicosis patients. A total of 104 arsenicosis patients, 104 arsenic-exposed individuals without arsenicosis (nonpatients), and 104 individuals not exposed to arsenic (controls) were interviewed based on a questionnaire constructed based on the WHOQOL-BREF instrument. The facets of life considered for assessing QOL were physical health domain, psychological domain, social relationships domain, and environment domain. All the domain-wise QOL scores of the arsenicosis patients were significantly smaller than those of the controls as well as of the nonpatients. The findings of the study assessing QOL of arsenicosis patients might be helpful to understand the condition and justify for the policy makers to adopt adequate measures to alleviate the sufferings through prevention, treatment, and rehabilitation.
Archives of Environmental and Occupational Health 01/2010; 65(2):70-6. · 1.19 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A cross-sectional survey was conducted in Matlab, Bangladesh, to determine the prevalence of skin lesions (a three-step procedure) associated with arsenic exposure and discuss validity and feasibility in relation to recommended screening algorithms. Cases with skin lesions were identified by screening above 4 years of age (n = 166,934). Trained field teams conducted a careful house-to-house screening and identified 1682 individuals with skin lesions, who were referred to physicians for confirmation. Physicians diagnosed 579 cases as probable and documented all these with digital photographs. Two experts inspected all photographs for consensus agreement that was reached for 504 cases. Using the experts' opinions as reference, the positive predictive value of the physicians' diagnosis was 87% (male = 82% vs. female = 94%; p < 0.01). The physicians had difficulties in separating arsenic-induced keratosis from differential diagnoses, while probability for correct diagnosis was high for arsenic-related pigmentation changes. Including information on current arsenic concentration in drinking water (which was masked at time of skin examination) or urine in the diagnostic algorithm should have increased the number of false negative cases. In the present transition of drinking water sources these markers of current exposure levels provide no information on past exposure. A 2-3 step procedure with house-to-house screening and clinic-based confirmation of arsenic-induced skin lesions is a feasible approach. Information on arsenic concentration in current water sources or in urine should not have improved the precision in the diagnosis. These results may have policy implications for community screening of arsenic-related skin lesions in Bangladesh and elsewhere.
International Journal of Environmental Health Research 05/2007; 17(2):141-9. · 1.20 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: This study was carried out among arsenic-exposed and non-exposed people of Bangladesh to assess and compare their cardiac status based on electrocardiographic (ECG) findings. For the purpose of the study, participants were included in three groups: arsenic-exposed persons with arsenicosis (arsenicosis group), arsenic-exposed persons without arsenicosis (non-arsenicosis group), and persons not exposed to arsenic (non-exposed group). Each group included 50 respondents. In this study, no significant difference in heart rate, rhythm, axis, and pulse rate interval was detected among the arsenicosis, non-arsenicosis and non-exposed groups. A significant difference in corrected QT interval between the arsenicosis and the non-exposed group (p<0.05) was observed. On the contrary, no statistically significant difference in corrected QT interval between the non-arsenicosis and the non-exposed group was found. Abnormal QRS complex was found among 14%, 8%, and 2% of the arsenicosis, non-arsenicosis, and non-exposed groups respectively. ECG findings, indicative of left ventricular hypertrophy, ischaemic heart disease, and right bundle branch block, were high among the arsenicosis group. Overall, abnormal ECG findings were high (58%) among the respondents of the arsenicosis group and were highly significant (p<0.001). The findings revealed that there was a significant association between ECG abnormalities and arsenic exposure.
Journal of Health Population and Nutrition 07/2006; 24(2):221-7. · 1.12 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: We studied a group of women of reproductive age (15-49 years) who were chronically exposed to arsenic through drinking water to identify the pregnancy outcomes in terms of live birth, stillbirth, spontaneous abortion, and preterm birth. We compared pregnancy outcomes of exposed respondents with pregnancy outcomes of women of reproductive age (15-49 years) who were not exposed to arsenic-contaminated water. In a cross-sectional study, we matched the women in both exposed and nonexposed groups for age, socioeconomic status, education, and age at marriage. The total sample size was 192, with 96 women in each group (i.e., exposed and nonexposed). Of the respondents in the exposed group, 98% had been drinking water containing [Greater and equal to] 0.10 mg/L arsenic and 43.8% had been drinking arsenic-contaminated water for 5-10 years. Skin manifestation due to chronic arsenic exposure was present in 22.9% of the respondents. Adverse pregnancy outcomes in terms of spontaneous abortion, stillbirth, and preterm birth rates were significantly higher in the exposed group than those in the nonexposed group (p = 0.008, p = 0.046, and p = 0.018, respectively).
Environmental Health Perspectives 07/2001; 109(6):629-31. · 7.26 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: This paper, firstly, shows the distribution of arsenic-contaminated groundwater in Samta village. This village, which is in Jessore district in Bangladesh, was chosen as a model village for investigating the mechanism of groundwater contamination. 90% of the tube wells in this village had arsenic concentrations above the Bangladesh standard of 0.05 mg/l. Tube wells with arsenic concentrations of over 0.50 mg/l were distributed in the southern part of the village with a belt-like shape from east to west. Secondly, groundwater distribution is discussed with respect to its flow and the high arsenic zone (As≥0.50 mg/l) agrees well with the drifting zone of the groundwater. Furthermore, arsenic-free water supply systems suitable for a small area in the village have been developed. A pond sand filter (PSF) system which purifies pond water is discussed in this paper. Prior to the construction of the PSF, the water quality in ponds was examined for arsenic levels. The inflow of drainage from the tube wells was found to be the major cause of arsenic contamination of pond water. The PSF installed in Samta is working very well and produces a good quality of treated water.
[Show abstract][Hide abstract] ABSTRACT: This study was conducted on the patients having chronic arsenicosis with a view to evaluate the effectiveness of management by vitamin A,E,C regimen. Prognosis of the patient was evaluated clinically in terms of change in severity of melanosis and keratosis. The patients perception of improvement was also evaluated. Of the 43 patients, 51.2 % used Arsenic Safe Water (up to 0.01mg/L) and took vitamins regularly, 20.9% took vitamin but used arsenic contaminated water, while the rest (27.90%) used the contaminated water and took the regimen irregularly. Improvement of melanosis and keratosis were observed in 90.9% and 86.4% of the patients respectively from amongst those who had used arsenic safe water and had taken regimen the regularly.
Indexing Words : Arsenic, Arsenicosis, melanosis, kelatosis, Vitamin A,E & C.