Publications (2)2.82 Total impact
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Article: [Restricting factors and countermeasures of Yunnan traditional Chinese medicine industry development].
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ABSTRACT: This paper summarizes the current situation and restricting factors of the Yunnan traditional Chinese medicine industry. With further analysis comparing, the research puts forward some suggestions and strategic countermeasures to promote the development of the Yunnan traditional Chinese medicine industry.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 05/2012; 37(10):1509-12. -
Article: Inhibition of advanced glycation end product formation by Pu-erh tea ameliorates progression of experimental diabetic nephropathy.
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ABSTRACT: Accumulation of advanced glycation end products (AGEs) has been implicated in the development of diabetic nephropathy. We investigated the effects of Pu-erh tea on AGE accumulation associated with diabetic nephropathy. Although it did not affect blood glucose levels and insulin sensitivy, Pu-erh tea treatment for 8 weeks attenuated the increases in urinary albumin, serum creatinine, and mesangial matrix in db/db mice. We found that Pu-erh tea prevented diabetes-induced accumulation of AGEs and led to a decreased level of receptor for AGE expression in glomeruli. Both production and clearance of carbonyl compounds, the main precursor of AGE formation, were probably attenuated by Pu-erh tea in vivo independent of glyoxalase I expression. In vitro, HPLC assay demonstrated Pu-erh tea could trap methylglyoxal in a dose-dependent manner. Our study raises the possibility that inhibition of AGE formation by carbonyl trapping is a promising approach to prevent or arrest the progression of diabetic complications.Journal of Agricultural and Food Chemistry 04/2012; 60(16):4102-10. · 2.82 Impact Factor
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2012
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Beijing Normal University
Beijing, Beijing Shi, China
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