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ABSTRACT: The bark of Alstonia scholaris when administered to diet of rats for 30 days caused a dose-dependent and significant lowering of serum glucose in rats. There were no significant changes in concentrations of triglycerides and HDL levels. However, cholesterol and LDL levels were significantly elevated compared to control when bark powder was administered at 0.1% w/w diet. The results indicate that regular monitoring of sugar and lipid profile in serum need to be maintained when the bark is taken for considerable lengths of time.