Hye Jin Noh

Samsung Medical Center, Sŏul, Seoul, South Korea

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Publications (12)7.39 Total impact

  • Endoscopy 04/2012; 44 Suppl 2 UCTN:E25-6. DOI:10.1055/s-0031-1291504 · 5.20 Impact Factor
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    ABSTRACT: Endoscopic submucosal dissection (ESD) is accepted as a standard treatment of early gastric cancer (EGC) and gastric adenoma. Occasionally, tumorous lesion is not found and pathologic discrepancies can occur after ESD. The aim of this study was to analyze the factors affecting the negative pathologic results after ESD. We retrospectively reviewed the data from all patients with gastric neoplasm (276 EGC and 516 gastric adenomas) who were treated with ESD during past 3 years and enrolled the patients who had negative pathologic results. Out of 792 patients treated with ESD, 27 patients (3.4%) were eligible for inclusion. Among the 27 patients, factors affecting the negative pathologic results were, most commonly, the focal lesion (n=13, 48.2%) which was small enough to be removed completely during pre-ESD biopsy, followed by pathologic discrepancies (n=11, 40.7%) between pathologists and lastly the operator factor (n=3, 11.1%) dissecting incorrect lesions. Of the focal lesions, the initial pathologic diagnoses were adenocarcinoma in 11 cases (84.6%). In cases with pathologic discrepancies, all the pretreatment diagnoses were adenoma with low grade dysplasia. In cases caused by operator factors, intestinal metaplasia was accompanied by elevated adenoma in all cases. To decrease negative pathologic results after ESD, an endoscopist should perform ESD after sufficient communication with pathologists, especially for adenoma with low grade dysplasia, and choose correct lesion, especially located at the antrum and associated with intestinal metaplasia. The possibility of total removal of small lesions even by forcep biopsy should be considered.
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 03/2012; 59(3):211-7. DOI:10.4166/kjg.2012.59.3.211
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    ABSTRACT: Tuberculosis generally affects the respiratory tract. In developing nations, the pericardium is the most common location of extrapulmonary tuberculosis; however, tuberculous pericarditis rarely appears as a localized mass or tuberculoma. We present here a case of a 62-year-old woman with pericardial tuberculoma. She had a history of effusive tuberculous pericarditis and drainage. Because she had taken regular medication over a period of six months, the pericardial mass with an adjacent lung nodule newly detected on the chest radiogram was initially suspected of being invasive lung cancer. Prior to pathologic confirmation, precise information from imaging tests, including computed tomography, magnetic resonance imaging, and positron emission tomography-computed tomography are helpful when making decisions regarding which methods should be used for surgical approach and treatment. Through imaging, our case showed typical features of pericardial tuberculoma and a favorable clinical course after two months with a change in antituberculous therapy.
    Korean Circulation Journal 12/2011; 41(12):750-3. DOI:10.4070/kcj.2011.41.12.750
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    ABSTRACT: The reliability and usefulness of the right ventricular (RV) Tei index (RTX) remains controversial because it has not been possible to simultaneously measure RV inflow and outflow. However, dual pulsed-wave Doppler (DPD) enables flow velocities to be obtained at different sampling sites simultaneously. In this study we evaluated the feasibility and reliability of RTX values obtained by DPD (RTX(DPD)). Forty-one patients who underwent cardiac catheterization and echocardiography for RV volume or pressure overloading conditions were evaluated. Symptom-limited exercise treadmill testing with expired gas analysis was performed and maximal exercise capacity was measured. RTX by conventional flow Doppler (RTX(CFD), 0.262±0.164) was similar to RTX(DPD) (0.253±0.117, p=NS), whereas RTX by tissue Doppler echocardiography (RTX(TDE), 0.447±0.125) was significantly larger than RTX(DPD) (p<0.001). Based on multiple regression analysis, maximal exercise capacity was independently related to RTX(DPD) (β=-0.60, p<0.001), mid-RV dimension (β=-0.26, p=0.012), left ventricular ejection fraction (β=0.22, p=0.023), and early diastolic tricuspid annular velocity (β=0.21, p=0.048). It is feasible and reliable to evaluate RV function using RTX(DPD) values. However, to evaluate the clinical usefulness of RTX(DPD), additional studies are required with a large number of patients and long-term follow-up.
    Korean Circulation Journal 08/2010; 40(8):391-8. DOI:10.4070/kcj.2010.40.8.391
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    ABSTRACT: Although takotsubo cardiomyopathy (TTC) has been reported to have an excellent clinical recovery, there are few data regarding clinical, laboratory, and echocardiographic findings in TTC presenting as cardiogenic shock. We aimed to assess the differences in these parameters between TTC presenting with and without cardiogenic shock. Fifty patients were enrolled from the TTC registry database and divided according to the presence of cardiogenic shock. Sixteen patients presented with cardiogenic shock as initial presentation (S group), and 34 did not (NS group). The S group had a higher prevalence of dyspnea (81% vs 38%, P = .005), pulmonary edema (69% vs 29%, P = .009), and significant reversible mitral regurgitation (44% vs 15%, P = .025) than the NS group. In addition, the S group had significantly higher troponin-I (median, 8.2 vs 1.4 pg/mL; P = .043) and N-terminal prohormone brain natriuretic peptide levels (median, 8831 vs 2348 pg/mL; P = .046). During follow-up (median, 3.1 years), cardiac deaths associated with TTC itself and recurrences of TTC were not noted in both groups. The S group has a higher prevalence of heart failure symptoms, significant reversible mitral regurgitation, and troponin-I and N-terminal prohormone brain natriuretic peptide levels. However, with meticulous therapeutic strategies, prognosis of this syndrome may be excellent irrespective of hemodynamic instability.
    Journal of critical care 06/2010; 25(2):329-35. DOI:10.1016/j.jcrc.2009.12.016 · 2.19 Impact Factor
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    ABSTRACT: Flash pulmonary edema typically exhibits sudden onset and resolves rapidly. It generally is associated with bilateral renal artery stenosis or unilateral stenosis in conjunction with a single functional kidney. We describe a patient who presented with flash pulmonary edema treated by percutaneous therapy with stent implantation. Our case is unique in that the flash pulmonary edema occurred in the setting of unilateral renal artery stenosis with bilateral functioning kidneys.
    Korean Circulation Journal 01/2010; 40(1):42-5. DOI:10.4070/kcj.2010.40.1.42
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    ABSTRACT: Purpose: An accurate and reliable web-based repository for clinical study results of marketed drugs in a reader-friendly and standardized format serve timely communication and a great way to stay up-to-date on the latest outcomes in clinical research. The aim of this study was to translate the results of clinical trials carried out worldwide into Korean and develop a central and standardized electronic database that can serve as a repository for published clinical studies for Korean scientists. Methods: The clinical trials of antineoplastic, cardiovascular and nonsteroidal anti-inflammatory (NSAI) agents published within last 10 years in SCI journals were identified from relevant electronic databases, registries and clinical trial websites. Data were extracted from the included studies using a standard form and all the information or data elements of the clinical trials were translated into Korean by clinical researchers who were fluent both in English and Korean. The database was validated and confirmed by independent clinical trial experts. The database was developed to be searchable by medical condition, drug name or key words. Results: The clinical trial results database for antineoplastic, cardiovascular and NSAI agents included details on study characteristics, participant characteristics, study designs, method of selecting subjects, intervention and control, specific trial efficacy and safety endpoints, as well as adverse events reported. Conclusion: A scientific and evidence based standardized electronic database that can serve as a repository for published clinical studies for Korean scientists were developed. The database will be expanded to include the clinical trial results of antibiotics, CNS, and respiratory system agents in coming years.
    2009 American College of Clinical Pharmacy Annual Meeting; 10/2009
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    ABSTRACT: Purpose: This study was carried out to 1) determine the frequency of LOH (loss of heterozygosity) and CNV (copy number variation) in NK AML Korean patients, 2) identify the association between cytogenetic aberration and responses in NK AML patients treated with Ara-C and 3) identify the novel genes associated with the response of Ara-C. Methods: Patients diagnosed with NK AML in the tertiary hospital from 2003 to 2008 were included in the study and their clinical and lab data were collected. We obtained DNA samples from bone marrow aspirates or peripheral-blood samples at the time of diagnosis and then performed whole genome SNP chip analysis. Genes in LOH or CNV region were analyzed using the database from the NCBI and HapMap database. In addition, Ara-C resistant HEL cell lines in vitro (HEL-R) and ex vivo (HEL-BM1, HEL-BM2, HEL-Lymph) were established to investigate the association between the gene and Ara-C resistance. The MTT Assay and RT-PCR were performed to confirm the resistance and the variations in gene expressions, respectively. Paired t-test, chi-square test and ANOVA were used according to their analytical aim. Results: A total of 50 patients were grouped according to the response of chemotherapy (remission 33/50, persistence 17/50). 147 LOH were detected among 42 patients (remission 26/33, persistence 15/17). SLC 17 family and HIST1H family genes were frequently found in LOH regions. CNV gain was identified in 36 individuals (remission 24/33, persistence 12/17) and CNV loss in 27(18/33, 9/17). There were diverse genes in CNV regions in which the functions are not identified yet. Compared to the original HEL cell line, the expression level of SLC29A1, dCK and CDA was altered in resistance cell lines. Conclusion: This study found that SLC17 family and HIST1H family genes were frequently located in LOH region of NK AML patients treated with Ara-C.
    2009 American College of Clinical Pharmacy Annual Meeting; 10/2009
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    ABSTRACT: Intramural hematoma formation is not a well-studied complication of percutaneous coronary intervention. We describe a patient with stable angina who developed an intramural hematoma during elective percutaneous coronary intervention (PCI) in the right coronary artery (RCA). Total occlusion with dense dye staining developed a long way from the distal RCA, near the posterior descending artery bifurcation site. The true lumen was compressed by the enlarged, tense, false lumen. The patient was successfully treating with intravascular ultrasound-guided fenestration using a cutting balloon, and a stent was implanted in the distal RCA.
    Korean Circulation Journal 04/2009; 39(4):171-4. DOI:10.4070/kcj.2009.39.4.171
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    ABSTRACT: Recently, many Korean people travel abroad where malaria is prevalent. However, in Korea, relatively little is known about compliance of chemoprophylaxis against malaria. This study was performed to determine the factors influencing compliance of chemoprophylaxis against malaria in Korean travelers.
    Infection and Chemotherapy 01/2008; 40(5). DOI:10.3947/ic.2008.40.5.255
  • Hye Jin Noh, Nak Hyun Kwon, Shin Bae Joo
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    ABSTRACT: Metabolic syndrome and high sensitivity C-reactive protein (hs-CRP) are known to be strong predictors of coronary atherosclerosis. Even though there have been many observations and much research concerning the association of coronary atherosclerosis with CRP and metabolic syndrome, certain problems still need to be resolved in order to produce clear mechanistic illustrations. Therefore, the correlations of metabolic syndrome, hs-CRP and the severity of coronary atherosclerosis were evaluated herein.
    Korean Circulation Journal 01/2006; 36(12):802. DOI:10.4070/kcj.2006.36.12.802
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Publication Stats

27 Citations
7.39 Total Impact Points

Institutions

  • 2011
    • Samsung Medical Center
      • Cardiovascular Imaging Center
      Sŏul, Seoul, South Korea
  • 2009–2010
    • Sungkyunkwan University
      • • Samsung Medical Center
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Seoul National University
      • College of Pharmacy
      Sŏul, Seoul, South Korea