Hiroyuki Kobayashi

Publications (2)1.22 Total impact

• Article: Transient hepatofugal portal blood flow after hepatectomy in a patient with cirrhosis: Report of a case

  Masaki Kajikawa, Akio Harada, Hiroyuki Kobayashi, Yasushi Kasai, Toshiaki Nonami, Akimasa Nakao, Hiroshi Takagi
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  ABSTRACT: We report herein the case of a 60-year-old man who developed hepatic failure with simultaneous transient hepatofugal portal blood flow after undergoing hepatectomy for hepatocellular carcinoma accompanied by cirrhosis with a splenorenal shunt. The transient hepatofugal portal blood flow was detected by color Doppler ultrasonography. Following this case report, the possibility of a relationship between hepatofugal portal blood flow, portal-systemic shunts, and postoperative hepatic failure is discussed.
  Surgery Today 08/1996; 26(9):719-722. · 1.22 Impact Factor
• Article: The role of the spleen in endotoxin‐induced liver injury

  Eisaku Hiraoka MD, Toshiaki Nonami, Tsuyoshi Kurokawa, Hiroyuki Kobayashi, Hiroshi Takagi
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  ABSTRACT: In these experiments, the role of the spleen in endotoxin-induced liver injury was evaluated, using rats which underwent splenectomy or splenic vein ligation with antecedent spleno-systemic shunt. Male Wistar rats were divided into three groups: a sham-operated group, a splenectomy group, and a splenic vein ligation group. In each animal, 48 h after surgery, 5 mg/kg lipopolysaccharide (LPS) were injected intravenously. Six rats from each group were sacrificed 6 or 12 h after LPS administration. Bronchoalveolar lavage fluid (BALF) and arterial blood were also collected. Splenectomy reduced the liver injury as indicated by the serum lactate dehydrogenase level. A decrease in liver tissue adenosine triphosphate and increase in lipid peroxide were induced by LPS administration and inhibited by splenectomy. Splenectomy also reduced alveolar protein release as indicated by the protein level in BALF. Splenic vein ligation provided similar protective effects on the liver, but did not affect lung injury. From these results, it appears that the spleen plays a significant role in endotoxin-induced liver injury, and a mediator derived from the spleen is likely associated with development of liver injury. This mediator may be cleared or inactivated by not only splenectomy but also splenic vein ligation.
  Liver International 01/1995; 15(1):35 - 38.