Stefan Öberg

Skåne University Hospital, Malmö, Skåne, Sweden

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Publications (1)2.86 Total impact

  • Ester Lörinc, Stefan Öberg
    [Show abstract] [Hide abstract]
    ABSTRACT: A multipotential stem cell, possibly located in the submucosal gland ducts, has been suggested as the origin of metaplastic mucosa in the oesophagus. The topographic distribution of these glands and their excretory ducts (SMG) within the columnar lined oesophagus (CLO) is largely unknown. The aim of this study was to examine the distribution of SMG in relation to the type of overlying epithelium in patients with CLO. Seven oesophageal resection specimens were examined histologically in toto. The median frequency of SMG was similar in the metaplastic segments (0.12 SMG/mm) and the normal squamous segments (0.10 SMG/mm). Within the metaplastic segments, the median frequency of SMG beneath the squamous islands was significantly higher than that observed under the columnar lined parts (0.22 versus 0.08 SMG/mm, P = 0.046), There was a strong accumulation of SMG at the squamo-columnar transition zones (0.53 SMG/mm), which was significantly greater than that found in the columnar and squamous parts (P = 0.001 and 0.002, respectively). The relative accumulation of SMG beneath squamous islands and the squamo-columnar junctions within the metaplastic segment supports the hypothesis that both metaplastic columnar mucosa and neosquamous epithelium originate from a progenitor in the SMG.
    Histopathology 03/2012; 61(1):53-8. · 2.86 Impact Factor

Publication Stats

2.86 Total Impact Points

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Institutions

  • 2012
    • Skåne University Hospital
      Malmö, Skåne, Sweden
    • Lund University
      • Department of Laboratory Medicine
      Lund, Skane, Sweden