Chong Ok Lee

Publications (2)2.41 Total impact

• Article: Synthesis and antitumor activity of cyclotriphosphazene-(diamine)platinum(II) conjugates

  Hyounggee Baek, Yangha Cho, Chong Ok Lee, Youn Soo Sohn
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  ABSTRACT: A new class of water-soluble cyclotriphosphazene-(diamine)platinum(II) conjugate drugs [NP(Am·Li2)(Am·PtA2)]3 (Am: dicarboxylic amino acid; A2: diamine) has been synthesized and characterized by means of elemental analysis, multinuclear (1H, 31P, 13C, 195Pt) NMR and IR spectroscopies. All the title compounds were subjected to both in vitro and in vivo assays against the murine leukemia L1210 cell line and selected human tumor cells. Most of the title compounds have shown higher in vivo antitumor activity than cisplatin and carboplatin, and, in particular, [NP(L-Glu·Li2)(L-Glu·Pt(dach)]3 (Glu=glutamate, dach=trans(±)-1,2-diaminocyclohexane) showed extraordinary high activity (ILS>500%) equally against both parent and cisplatin-resistant leukemia L1210 cell lines. Furthermore, this candidate compound (KI 60606) exhibited a wider spectrum of in vitro activity by showing higher cytotoxicity against all the selected human tumor cells than cisplatin and, therefore, was subjected to preclinical studies which are now near completion.
  Anti-Cancer Drugs 09/2000; 11(9):715-725. · 2.41 Impact Factor
• Article: Synthesis and antitumor activity of novel polyphosphazene-(diamine)platinum(II) conjugates

  Youn Soo Sohn, Hyonggee Baek, Yang Ha Cho, Young-A Lee, Ok-Sang Jung, Chong Ok Lee, Yun Soo Kim
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  ABSTRACT: A novel class of water-soluble polyphosphazene-(diamine)platinum(II) conjugate drugs [N=P(S)Am·PtA2)]n have been designed and synthesized by incorporating the antitumor (diamine)platinum(II) moiety (A2Pt2+) to a polyphosphazene back-bone along with a solubilizing groups (S) employing dicarboxylic amino acid (Am) as a spacer group. After characterization of these polymer conjugates by means of multinuclear (1H, 31P, 195Pt) NMR and IR spectroscopies, elemental analysis and GPC, their antitumor activity were evaluated both in vitro and in vivo against murine leukemia L1210 cell lines and in vitro against five human tumor cell lines. Most of the title polymer conjugates have shown higher in vivo antitumor activity than cisplatin, and in particular [N=P(OH)(Glu·Pt(DACH))]n (Glu=glutamate, DACH=trans(±)-1,2-diaminocyclohexane) exhibit extraordinary high activity (ILS(%)>500) without cross-resistance to cisplatin as well as good water solubility, and therefore, was subjected to preclinical studies for human clinical trials.
  International Journal of Pharmaceutics.