Publications (2)2.5 Total impact
Article: Identification of a G8P Rotavirus Isolate Obtained from a Taiwanese Child: Evidence for a Relationship with Bovine Rotaviruses.Japanese journal of infectious diseases. 09/2012; 65(5):455-7.
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ABSTRACT: The molecular characterization of genotype P rotavirus strains collected from children admitted to hospital with acute dehydrating diarrhoea during a 6-year surveillance period in Taiwan is described in this study. In total, three G4P strains, one G5P and one G12P were characterized by sequencing and phylogenetic analysis of the VP4, VP7, VP6 and NSP4 genes. Whilst all four genes of the single Taiwanese G12P strain clustered with the respective genes of globally common human rotavirus strains, the G4 and G5 strains showed remarkable similarities to porcine rotavirus strains and putative porcine-origin human P strains reported previously from Taiwan. The overall proportion of porcine rotavirus-like strains in Taiwan remains around 1 % among hospitalized children; however, the circulation and sporadic transmission of these heterotypic strains from pigs to humans could pose a public-health concern. Therefore, continuation of strain monitoring is needed in the vaccine era to detect any possible vaccine breakthrough events associated with the introduction of such heterologous rotavirus strains.Journal of Medical Microbiology 03/2012; 61(Pt 7):990-7. · 2.50 Impact Factor