Cumali Gokce

Mustafa Kemal University, Myriandrus, Hatay, Turkey

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Publications (28)35.58 Total impact

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    ABSTRACT: Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA1c) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation. This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA1c levels: group 1, HbA1c levels ≤ 7%; group 2, HbA1c levels > 7%. Venous WBC, neutrophil and lymphocyte counts were determined. Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA1c. There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA1c in patients with type 2 diabetes mellitus.
    The Journal of international medical research 02/2014; · 0.96 Impact Factor
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    ABSTRACT: A 24-year-old woman was admitted with general weakness, umbilical swelling, developmental delay, speech disorder, constipation, gait problem. Her findings were umbilical hernia, xerosis, dry hair, and short stature. After thyroxine treatment, she also had headache, vomiting, and palpitation, lack of appetite, and sleep disturbance. Pituitary magnetic resonance imaging revealed a heterogeneous mass at the central part of the gland on coronal section and it was interpreted as pituitary apoplexy. In the current case, the patient with congenital hypothyroidism (CH) developed pituitary apoplexy (PA) after thyroxine therapy. Therefore, it is suggested that the complaints were related to PA rather than adrenal insufficiency. Here we describe a case report evaluating PA in a patient with thyrotrophic pituitary adenoma due to CH. To the best of our knowledge, this is the first case in terms of PA associated with CH after thyroxine therapy in the literature.
    Acta medica Indonesiana 10/2013; 45(4):306-11.
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    ABSTRACT: Obstructive sleep apnea syndrome (OSAS) is a common health problem, and associated with obesity, metabolic syndrome (MetS), and diabetes. Growing evidence shows that 25-hydroxyvitamin-D3 (25-OH-D) insufficiency and high parathyroid hormone (PTH) levels may be correlated to glucose intolerance, MetS, obesity, and cardiovascular abnormalities similar to OSAS. Bisphenol A (BPA) is an endocrine disruptor agent which exerts a wide variety of metabolic effects. It has estrogenic activity and its exposure may contribute to weight gain, obesity, impaired glucose metabolism, and the development of diabetes, also similar to OSAS. The aim of this study is to investigate the relationships between OSAS and serum BPA, 25-OH-D, and PTH levels. This study enrolled 128 subjects, with all of the OSAS patients having been diagnosed by polysomnography. The 128 subjects were divided into three groups: a control (n = 43), a moderate OSAS (n = 23) (AHI = 15-30), and a severe OSAS groups (n = 62) (AHI > 30). The serum BPA, 25-OH-D, and PTH levels for each subject were analyzed. 25-OH-D was lower in both OSAS groups, and PTH was higher in the OSAS groups than in the control subjects. The BPA levels were higher in the severe OSAS group than the moderate OSAS and control. There was a positive correlation between the BPA and body mass index, and a negative correlation between the 25-OH-D and BPA levels in all of the individuals. OSAS is related to high BPA and PTH levels, and low vitamin D levels. There is a positive association between BPA levels and OSAS, and the severity of OSAS. These results suggest that the BPA levels may have a role in the pathogenesis of OSAS.
    Endocrine 08/2013; · 1.42 Impact Factor
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    ABSTRACT: OBJECTIVE: To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. METHODS: Eighty-two male patients with LC were studied. The severity of liver disease was categorized by Child-Pugh score (Child-Pugh A, B, and C). Forty-two age-matched healthy subjects were used as a control group. The tPSA, fPSA, fPSA/tPSA ratio, total prostate volume (TPV), total testosterone (TT), and total protein (TP) were measured. The LC group was compared with the control group in terms of these parameters. In addition, intra-comparison and inter-comparison was made between all the Child-Pugh groups and normal subjects, in terms of these parameters. RESULTS: The tPSA and fPSA levels in LC cases, Child-Pugh A, Child-Pugh B, and Child-Pugh C groups were significantly decreased compared with the control group. The ratio of fPSA/tPSA in the LC subjects and Child-Pugh A groups significantly increased compared with the control group. TT, TP levels, and TPV in patients with LC were significantly lower compared with the control group and the results were significantly correlated with the Child-Pugh score. CONCLUSION: The present study reveals that tPSA and fPSA were decreased in patients with LC in comparison to healthy subjects in terms of 3 mechanisms. First, it might be due to shrunken prostatic volume. Second, it also resulted in decreased levels of testosterone because of the abnormality of hypothalamic-pituitary-testicular axis. Third, it might be the diminished serum protein level in the composition of the PSA.
    Urology 01/2013; · 2.42 Impact Factor
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    ABSTRACT: We are reporting an irreversible Horner Syndrome (HS) in a patient with benign thyroid gland nodule in which thyroidectomy was performed for treatment. A 37-year-old female was admitted to our clinic with a swelling in the left lobe of the thyroid gland and ptosis at the left eyelid. The clinical diagnosis of HS was confirmed pharmacologically by aproclonidine. Histopathologic examination of thyroidectomy specimen was reported as benign nodule. To the best of our knowledge, this is a very rare report in terms of thyroid benign nodule associated with irreversible HS due to cervical sympathetic chain compression.
    Pakistan Journal of Medical Sciences Online 01/2013; 29(1):224-6. · 0.10 Impact Factor
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    Journal of Dental Sciences. 12/2012; 7(4):401.
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    ABSTRACT: Background: Ectopic thyroid tissue is a rare embryological abnormality characterized by the occurrence of thyroid tissue in another site than its usual location. Thyroid hemiagenesis is also a very rare abnormality, in which one thyroid lobe could not develop embryologically. We report a case of left thyroid hemiagenesis and thyroiditis with an ectopic submandibular thyroid tissue, and this may be the first case. Patient: A 38 year-old female patient was admitted with the complaints of sweating and palpitation. There was no symptom regarding the compression. Thyroid ultrasonography and computed tomography revealed that there was no left lobe regarding the diagnosis of thyroid hemiagenesis, and there was no any ectopic thyroid tissue. The thyroid Tc-99m pertechnetate scan demonstrated two distinct areas of radiotracer uptake in the right submandibular region and lobe. Also, the case had no radiotracer uptake in the left thyroid bed. Conclusion: Even though, there are some cases of ectopic submandibular thyroid tissues in recent studies, we could not encounter any case about the togetherness of ectopic submandibular thyroid tissue and hemiagenesis. This report may be the first case.
    Thyroid: official journal of the American Thyroid Association 11/2012; · 2.60 Impact Factor
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    ABSTRACT: Isotretinoin is a retinoic acid derivative mostly used in the treatment of cystic acne vulgaris. The adverse effects of isotretinoin are well defined being the major limitation factor for its usage. The decrement of testosteron during isoretinoin treatment is defined in literature. We present a case with 20 years old man who developed gynecomastia after treatment with isotretinoin. To the best of our knowledge, this is the third report of the development of gynecomastia after isotretinoin treatment.
    Cutaneous and Ocular Toxicology 07/2012; · 1.04 Impact Factor
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    ABSTRACT: Background Our aim was to investigate the prevalence, size, locations, and shapes of torus palatinus (TP) in end-stage renal disease (ESRD) patients receiving peritoneal dialysis (PD) in order to analyze the relationship between the TP size and duration of PD.Materials and methodsDuring 2007, 91 ESRD patients receiving PD were studied using dental examinations at our outpatient clinic.ResultsThe prevalence of TP was 41.7% (n = 38). Most cases of TP were < 2 cm in size (81.6%) and spindle-shaped (78.9%). The duration of PD was statistically higher in patients with TP size > 2 cm (6.8 ± 3.6 years) than patients with TP size of < 2 cm (3.5 ± 2.6 years).Conclusions The higher prevalence of TP and different TP shape (spindle) in comparison with our previous study and the significant relationship between duration of PD and TP size might be due to an underlying disorder, such as renal osteodystrophy.
    Journal of Dental Sciences. 06/2012; 7(2):154–158.
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    Canadian Urological Association journal = Journal de l'Association des urologues du Canada 06/2012; 6(3):E129-30. · 1.66 Impact Factor
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    ABSTRACT: Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The aim of the present study was to investigate the seroprevalence of human parvovirus B19 (HPV B19) in the etiology of essential HT and the effect of HPV B19 on ET-1 and NO levels in this disorder. A total of 135 participants were enrolled in the study (90 patient and 45 controls). Antibodies to HPV B19 and ET-1 were measured by enzyme-linked immunosorbent assay method. Nitric oxide levels were calculated according to the Griess reaction. Of the total participants, 27 patients (30%) and 7 control subjects (15.6%) had IgM positive (P = .068), whereas 27 patients (30%) and 14 control subjects (31.1%) had IgG positive (P = .895). There was no statistical difference between patients and control subjects in terms of serum ET-1 and NO levels. The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations.
    Clinical and Experimental Hypertension 04/2012; 34(3):217-21. · 1.28 Impact Factor
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    ABSTRACT: The aims of this study were to evaluate the validity of preoperative basal serum cortisol levels measured in predicting preoperative adrenal insufficiency and also the validity of basal serum cortisol levels and early postoperative insulin tolerance test (ITT) in predicting postoperative adrenal insufficiency. The study was prospectively designed and included 64 patients who underwent pituitary surgery for conditions other than Cushing's disease. An ITT was performed preoperatively, on the 6th postoperative day and at the 1st postoperative month. Basal serum cortisol levels were measured on the 2nd, 3rd, 4th, 5th, and 6th postoperative days. Patients with a preoperative basal cortisol level of <165 nmol/l (6 microg/dl) showed insufficient cortisol response and those with levels higher than 500 nmol/l (18 microg/dl) had sufficient cortisol response to the preoperative ITT. The positive predictive value of the ITT performed on the 6th postoperative day was 69.7%, and the negative predictive value in predicting adrenal insufficiency at the 1st postoperative month was 58%. Patients were considered to have an insufficient cortisol response to ITT at the 1st postoperative month if their basal cortisol levels were <193 nmol/l (7 microg/dl) or 220 nmol/l (8 microg/dl) or 193 nmol/l (7 microg/dl) or 165 nmol/l (6 microg/dl) or 83 nmol/l (3 microg/dl) on the 2nd-6th postoperative days respectively. Serum basal cortisol levels may be used as the first-line test in the assessment of the hypothalamic-pituitary-adrenal axis both preoperatively and postoperatively. Dynamic testing should be limited to the patients with indeterminate basal cortisol levels.
    European Journal of Endocrinology 09/2010; 163(3):377-82. · 3.14 Impact Factor
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    ABSTRACT: A 21-year-old man was referred to our hospital for the evaluation and treatment of simple goiter. The patient's physical examination was normal except for a palpable left thyroid lobe (grade 1b). All the laboratory investigations and thyroid function tests were normal, except for a subnormal serum thyroid stimulating hormone level. The patient had no complaint of hyperthyroidism. Both the serum antibodies (antithyroglobulin and antithyroid peroxidase) were negative. Thyroid ultrasonography revealed the agenesis of the left lobe and isthmus of the thyroid. Thyroid scan with Tc-99 m pertechnate showed the absence of the left lobe and isthmus and diffusely enlarged right lobe hyperplasia. A follow-up of 6 months was carried out without any medication. Post follow-up, the thyroid function tests were still consistent with subclinical hyperthyroidism. In this report, we have described the case of a patient with thyroid hemiagenesis associated with subclinical hyperthyroidism and goiter.
    The Endocrinologist 06/2010; 20(4):155-156. · 0.12 Impact Factor
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    European journal of dentistry 05/2009; 3(2):155-7.
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    ABSTRACT: The aim of the current study was to determine the presence of styloid process elongation (SPE) detected on panoramic radiographs in patients with torus palatinus (TP). Between December 2005 and November 2007, a total of 149 patients with TP are investigated for routine dental examination in the outpatient clinic. Any patient who had disorders related to calcium and phosphorus metabolism was excluded. All medical data were obtained from the files. Twenty (15%) subjects demonstrated SPE at least one side. These patients consisted of 15 women (14.3% of all women) and five men (17.8% of all men). In our previous report performed in normal population at the same region, the prevalence had been found to be 7.7% in 698 dental patients. Although the number of the patients is different in both studies, there is a marked difference in terms of the SPE prevalence between the two reports. This prevalence difference might be related to concomitant disorder.
    Clinical Oral Investigations 11/2008; 13(3):269-72. · 2.20 Impact Factor
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    ABSTRACT: The objectives of this study were to determine the prevalence, size, shape and location of the torus palatinus (TP) in dental outpatients in Cappadocia region of Turkey and to investigate the relationship between the findings in relation to age and gender. The present study included 2660 patients, who attended the Department of Oral Diagnosis and Radiology in the Faculty of Dentistry at Erciyes University for their dental problems between December 2005 and May 2007. The presence or absence of TP was examined by clinical inspection and palpation. The prevalence of TP in our large sample was low (4.1%) in comparison to other Turkish population. It was found to be significantly higher (P<.001) in females (5.7%) than in males (1.8%). Most TP were found in flat shape (62.7%), smaller than 2 cm (75.4%) and located at premolar-molar region (66.4%). This study indicated that the prevalence of TP in Turkish population was low. Our results showed a significant relationship between the occurrence of TP and gender. According to the literature, it was firstly showed that flat TP was the most common type in our large population.
    European journal of dentistry 10/2008; 2(4):269-75.
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    ABSTRACT: The styloid process (SP) is a cylindrical, long cartilaginous bone located on the temporal bone. The normal SP length is approximately 20-30 mm. The styloid process elongation (SPE) can be assumed if either the SP or the adjacent stylohyoid ligament ossification shows an overall length in excess of 30 mm. Elongated SP is known as Eagle's syndrome when it causes clinical symptoms as neck and cervicofacial pain. It is supposed that this symptoms and signs are due to the compression of the SP on some neural and vascular structures. It may also cause stroke due to the compression of carotid arteries. This syndrome is diagnosed by both radiographical and physical examination. Instead of many hypotheses and studies, the exact etiology of elongated SP and the role of ectopic calcification are unknown. Ectopic calcification (EC) might have a role for the elongation of SP. Abnormal calcium (Ca), phosphorus (P) and vitamin D metabolism is very common in patients with end-stage renal disease (ESRD). Therefore, this calcification in nonosseous soft tissue due to abnormal serum Ca and P levels is commonly associated with this disorder. EC due to the abnormality in this metabolism which is related to the duration of dialysis is also very important for this calcification. Therefore, a study in patients with ESRD investigating the prevalence of SP and the correlation between dialysis period and the SP length may help us explaining the role of EC in the elongation of SP. Because, this disease might be a good model for the investigation of the EC in this elongation. However, further studies and large samples are also needed to clarify the etiology of this disorder.
    European journal of dentistry 08/2008; 2(3):224-8.
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    ABSTRACT: A 45-year-old woman with short stature and primary amenorrhoea was admitted during a health-screening programme. Physical examination revealed a shortness of proximal legs and arms, short stature and other clinical properties of achondroplasia. Secondary sexual characteristics assessment showed axillary hair stage 5, breast stage 4 and pubic hair stage 5 (Tanner staging). Chromosomal analysis showed a 46XX karyotype. Skeletal X-ray showed small iliac wings and narrow sciatic notches. On pelvic ultrasound examination, the uterus appeared infantile and the ovaries were not visualized. Physical examination and laboratory parameters revealed a diagnosis of hypergonadotrophic hypogonadism. To the authors' knowledge, this is the first case of achondroplasia with gonadal dysgenesis discussed in the literature.
    The Journal of international medical research 05/2008; 36(3):605-8. · 0.96 Impact Factor
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    ABSTRACT: The aim of this study is to determine the prevalence of styloid process elongation (SPE) detected on panoramic radiographs (PRs) in Cappadocia region population in Turkey and to investigate the SPE incidences in relation to the age subgroups. Between 2004 to 2007 years, a random sample of 750 PRs was collected from the data files and any questionable PR was excluded. Therefore, 698 PRs were included in the present study. The subjects were divided into six age subgroups: 10-19, 20-29, 30-39, 40-49, 50-59 and 60 years and older. Fifty-four (7.7%) patients demonstrated SPE at least one side. There were statistical differences between 10-19, 20-29 age subgroups and 30-39, 50-59 age subgroups in terms of the SPE prevalence, but not other subgroups. According to our knowledge, this is the highest prevalence in comparison to the other Turkish reports and the first study in terms of the SPE prevalence in Cappadocia region population. Also, the subgroup analyse suggested that the age may not have a role in the elongation of the SP.
    European journal of dentistry 02/2008; 2(1):18-22.
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    ABSTRACT: This study investigated the presence of carotid artery calcifications (CACs) on panoramic radiographs (PRs) in end-stage renal disease (ESRD) patients treated with peritoneal dialysis (PD), and analysed the relationship between CAC prevalence and PD duration. A random sample of 110 PRs were collected from ESRD patients (15 with questionable CACs were subsequently excluded). CACs were found in 26 (27.4%) patients; 10 males (23.3% of all males) and 16 females (30.8% of all females). The overall mean PD period was 4.0 +/- 3.2 years. There was a significant difference in PD period between patients with and without CACs (5.3 +/- 3.1 years versus 3.5 +/- 3.1 years, respectively). To our knowledge, this study has the highest CAC prevalence, is the first to be carried out in ESRD patients being treated with PD and has the largest sample of ESRD patients (n = 95). We believe dentists should carefully evaluate patients' PRs for evidence of CACs, enabling these incidental findings to provide life-saving information.
    The Journal of international medical research 01/2008; 36(1):47-53. · 0.96 Impact Factor