G. Taton

Publications (2)1.21 Total impact

• Article: Micro-PIXE studies on gallium incorporation in mineralized tissue

  E. Rokita, M. Korbas, P.H.A. Mutsaers, G. Taton, M.J.A. de Voigt
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  ABSTRACT: The influence of gallium ions on the development of the mineralization process in a cell culture model was investigated. To determine the elemental composition the proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and energy-dispersive X-ray fluorescence (XRF) were used. Micro-PIXE allows a precise quantification of elements combined with their accurate localization. In contrast, the XRF results may be used as a rough estimate of the mineralization process development. It was found that gallium influences the mineralization process in a dose-dependent manner. At low doses an increased while at high doses an impaired mineralization was observed. The amount of deposited gallium correlates with the concentration of the element in the cell culture medium.
  Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 181:529-532. · 1.21 Impact Factor
• Article: Microprobe studies of inorganic deposits in the aortic wall

  E. Rokita, P. Chevallier, P.H.A. Mutsaers, M. Stopa, G. Taton, M.J.A. de Voigt
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  ABSTRACT: The chemical composition and crystalline nature of inorganic deposits present in the human aortic wall were investigated. A proton microprobe in combination with proton induced X-ray emission and proton induced gamma-ray emission were used to determine quantitatively the elemental composition of the inorganic deposits while their structure was studied with the use of an X-ray microprobe in combination with X-ray diffraction and Fourier transform infrared microscopy.It was found that deposits in the aortic wall are composed of Ca–P compounds. Fluorine is accumulated in the inorganic phase. However, the mechanism of F deposition awaits further investigations. The only phase detected by the X-ray diffraction was a defective hydroxyapatite. The relative intensities of reflexes indicate that the c axis of the crystallites is parallel to the long axis of the vessel. IR microscopy revealed that the crystals were contaminated with carbonate groups. Moreover, the band characteristic for octacalcium phosphate was detected.
  Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms.