Ji Hye Kim

Max Planck Institute for Coal Research, Mülheim-on-Ruhr, North Rhine-Westphalia, Germany

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Publications (281)571.53 Total impact

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    ABSTRACT: As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods according to the ISO-10993 cytotoxicity test for medical devices. The PACA/PLLA have similar or even better biocompatibility than those of commercially available cyanoacrylate (CA)-based TAs such as Dermabond® and Histoacryl®. The PACA/PLLA were not different from those exposed to Dermabond® and Histoacryl® in Raman spectra when biochemical changes of protein and DNA/RNA underlying during cell death were compared utilizing Raman spectroscopy. Histological analysis revealed that incised dermal tissues of rats treated with PACA/PLLA showed less inflammatory signs and enhanced collagen formation compared to those treated with Dermabond® or Histoacryl®. Of note, tissues treated with PACA/PLLA were stronger in the tensile strength compared to those treated with the commercially available TAs. Therefore, taking all the results into consideration, the PACA/PLLA we created might be a clinically useful TA for treating dermal wounds. Copyright © 2015 Elsevier B.V. All rights reserved.
    06/2015; 51. DOI:10.1016/j.msec.2015.02.042
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    ABSTRACT: Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated the immunopharmacological activities of the methanolic extract of the aerial parts of this plant (Pa-ME) and validated its pharmacological targets. Lipopolysaccharide (LPS)-treated macrophages, an HCl/EtOH-induced gastritis model, and an acetic acid-injected capillary permeability mouse model were employed to evaluate the anti-inflammatory activity of Pa-ME. Potentially active anti-inflammatory components of this extract were identified by HPLC. The molecular mechanisms of the anti-inflammatory activity were studied by kinase assays, reporter gene assays, immunoprecipitation analysis, and overexpression of target enzymes. Pa-ME suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and prevented morphological changes in LPS-treated RAW264.7 cells. Moreover, both HCl/EtOH-induced gastric damage and acetic acid-triggered vascular permeability were restored by orally administered Pa-ME. Furthermore, this extract downregulated the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 and reduced the nuclear levels of NF-κB. Signalling events upstream of NF-κB translocation, such as phosphorylation of Src and Syk and formation of Src/Syk signalling complexes, were also inhibited by Pa-ME. The enzymatic activities of Src and Syk were also suppressed by Pa-ME. Moreover, Src-induced and Syk-induced luciferase activity and p85/Akt phosphorylation were also inhibited by Pa-ME. Of the identified flavonoids, kaempferol and quercetin were revealed as partially active anti-inflammatory components in Pa-ME. Pa-ME exerts anti-inflammatory activity in vitro and in vivo by suppressing Src, Syk, and their downstream transcription factor, NF-κB. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Journal of ethnopharmacology 03/2015; DOI:10.1016/j.jep.2015.03.043 · 2.94 Impact Factor
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    The Korean Journal of Internal Medicine 03/2015; 30(2):256-8. DOI:10.3904/kjim.2015.30.2.256
  • 02/2015; 28(1):111-118. DOI:10.9799/ksfan.2015.28.1.111
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    ABSTRACT: Positron emission tomography (PET) images usually suffer from a noticeable amount of statistical noise. In order to reduce this noise, a post-filtering process is usually adopted. However, the performance of this approach is limited because the denoising process is mostly performed on the basis of the Gaussian random noise. It has been reported that in a PET image reconstructed by the expectation-maximization (EM), the noise variance of each voxel depends on its mean value, unlike in the case of Gaussian noise. In addition, we observe that the variance also varies with the spatial sensitivity distribution in a PET system, which reflects both the solid angle determined by a given scanner geometry and the attenuation information of a scanned object. Thus, if a post-filtering process based on the Gaussian random noise is applied to PET images without consideration of the noise characteristics along with the spatial sensitivity distribution, the spatially variant non-Gaussian noise cannot be reduced effectively. In the proposed framework, to effectively reduce the noise in PET images reconstructed by the 3-D ordinary Poisson ordered subset EM (3-D OP-OSEM), we first denormalize an image according to the sensitivity of each voxel so that the voxel mean value can represent its statistical properties reliably. Based on our observation that each noisy denormalized voxel has a linear relationship between the mean and variance, we try to convert this non-Gaussian noise image to a Gaussian noise image. We then apply a block matching 4-D algorithm that is optimized for noise reduction of the Gaussian noise image, and reconvert and renormalize the result to obtain a final denoised image. Using simulated phantom data and clinical patient data, we demonstrate that the proposed framework can effectively suppress the noise over the whole region of a PET image while minimizing degradation of the image resolution.
    IEEE Transactions on Nuclear Science 02/2015; 62(1):137-147. DOI:10.1109/TNS.2014.2360176 · 1.46 Impact Factor
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    ABSTRACT: A highly enantioselective kinetic resolution of diols via asymmetric acetalization has been achieved using a chiral confined imidodiphosphoric acid catalyst. The reaction is highly efficient for the resolution of tertiary alcohols, giving selectivity factors of up to >300. Remarkably, even in cases where the selectivity factors are only moderate, highly enantioenriched diols are obtained via a stereodivergent resolution to diastereomeric acetals.
    Journal of the American Chemical Society 01/2015; DOI:10.1021/ja512481d · 11.44 Impact Factor
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    ABSTRACT: The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.
    Tuberculosis and Respiratory Diseases 12/2014; 77(6):262-5. DOI:10.4046/trd.2014.77.6.262
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    ABSTRACT: Abstract We used the Job-demand-control model to answer our two research questions concerning the effects of working conditions on self-rated health, and gender differences in the association between these working conditions and health among Korean manual workers. Since the disproportionate representation of women in non-standard work positions is found in many countries including Korea, it is important to examine how working conditions explain gender inequality in health. We used data from the 2008-2009 Korean National Health and Nutrition Examination Survey and analyzed a total sample of 1,482 men and 1,350 women using logistic regression. We found that job control was positively related to self-rated health while both physical and mental job demands were negatively related to self-rated health. We also found significant interaction effects of job demands, control and gender on health. Particularly, female workers' health was more vulnerable to mentally demanding job conditions. Based on these findings, we discussed theoretical and practice implications for future studies.
    Health Care For Women International 11/2014; DOI:10.1080/07399332.2014.980889 · 0.63 Impact Factor
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    ABSTRACT: 21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3. In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses. ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production. Analysis of its molecular activity showed that this compound significantly suppressed the expression of inducible NO synthase (iNOS), nuclear translocation of nuclear factor- (NF-) κB subunits (p50 and p65), phosphorylation of inhibitor of κB kinase (IKK), and the enzyme activity of AKT1. Taken together, the novel triterpenoid saponin compound ATS-E3 contributes to the beneficial effects of tea plants by exerting anti-inflammatory and antioxidative activities in an AKT/IKK/NF-κB-dependent manner.
    Mediators of Inflammation 11/2014; 2014:658351. DOI:10.1155/2014/658351 · 2.42 Impact Factor
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    ABSTRACT: This study aimed to report the survival of a rare case of complete tracheal transection followed by blunt neck trauma. A 66-year-old man was presented in the emergency room after a motorcycle accident in which a rope was wrapped around his neck. Although alert, he was in respiratory distress. A computed tomographic scan showed transection of the cervical trachea. Emergency neck exploration revealed that the tracheal laceration had been cut from the tracheal anterior third ring to the posterior first ring and the anterior esophageal wall had ruptured. Laryngectomy, tracheostomy, and esophagopharyngeal anastomosis were performed. Prompt airway management and immediate neck exploration is important for survival in these cases.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 11/2014; 20(6):459-462. DOI:10.5505/tjtes.2014.32744 · 0.38 Impact Factor
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    ABSTRACT: Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P. ginseng. Recently, GF1 was reported to have beneficial effects on skin. However, there has not been fully understood its anti-melanogenic effect and underlying molecular mechanisms. In the present study, GF1 reduced -MSH-induced melanin secretion in B16F10 cell culture media by 60%. However, it did not suppress intracellular melanin levels, tyrosinase activity and expression. Immunofluorescence assay showed that GF1 had no effect on melanosome transport, but significantly induced dendrite retraction. Pull-down assay demonstrated that GF1 primarily modulate the Rho family GTPases resulting in dendrite retraction. Collectively, these data suggest that GF1 could act as a potent skin whitening agent.This article is protected by copyright. All rights reserved.
    Experimental Dermatology 11/2014; 24(2). DOI:10.1111/exd.12586 · 4.12 Impact Factor
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    ABSTRACT: The aim of the present study was to evaluate the comparative anti-Alzheimer's disease (AD) activities of different parts of Nelumbo nucifera (leaves, de-embryo seeds, embryos, rhizomes, and stamens) in order to determine the selectivity and efficient use of its individual components. Anti-AD activities of different parts of N. nucifera were evaluated via inhibitory activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) along with scavenging activity on peroxynitrite (ONOO(-)). Among the evaluated parts of N. nucifera, the embryo extract exhibited significant inhibitory potential against BACE1 and BChE as well as scavenging activity against ONOO(-). Thus, the embryo extract was selected for detailed investigation on anti-AD activity using BACE1- and ChEs-inhibitory assays. Among the different solvent-soluble fractions, the dichloromethane (CH2Cl2), ethyl acetate (EtOAc), and n-butanol (n-BuOH) fractions showed promising ChEs and BACE1 inhibitory activities. Repeated column chromatography of the CH2Cl2, EtOAc and n-BuOH fractions yielded compounds 1-5, which were neferine (1), liensinine (2), vitexin (3), quercetin 3-O-glucoside (4) and northalifoline (5). Compound 2 exhibited potent inhibitory activities on BACE1, AChE, and BChE with respective IC50 values of 6.37 ± 0.13, 0.34 ± 0.02, and 9.96 ± 0.47 µM. Likewise, compound 1 showed potent inhibitory activities on BACE1, AChE, and BChE with IC50 values of 28.51 ± 4.04, 14.19 ± 1.46, and 37.18 ± 0.59 µM, respectively; the IC50 values of 3 were 19.25 ± 3.03, 16.62 ± 1.43, and 11.53 ± 2.21 µM, respectively. In conclusion, we identified potent ChEs- and BACE1-inhibitory activities of N. nucifera as well as its isolated constituents, which may be further explored to develop therapeutic and preventive agents for AD and oxidative stress related diseases.
    Archives of Pharmacal Research 10/2014; DOI:10.1007/s12272-014-0492-4 · 1.75 Impact Factor
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    ABSTRACT: Selective killing of cancer cells is one of the major goals of cancer therapy. Although chemotherapeutic agents are being used for cancer treatment, they lack selectivity toward tumor cells. Among the six different death receptors (DRs) identified to date, DR4 and DR5 are selectively expressed on cancer cells. Therefore, unlike chemotherapeutic agents, these receptors can potentially mediate selective killing of tumor cells. In this review we outline various nutraceuticals derived from ‘Mother Nature’ that can upregulate DRs and thus potentiate apoptosis. These nutraceuticals increase tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of cancer cells through different mechanisms. First, nutraceuticals have been found to induce DRs through the upregulation of various signaling molecules. Second, nutraceuticals can downregulate tumor cell-survival pathways. Third, nutraceuticals alone have been found to activate cell-death pathways. Although both TRAIL and agonistic antibodies against DR4 and DR5 are in clinical trials, combination with nutraceuticals is likely to boost their anticancer potential.
    Trends in Pharmacological Sciences 10/2014; 35(10). DOI:10.1016/j.tips.2014.07.004 · 9.99 Impact Factor
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    ABSTRACT: Platelet-derived growth factor-D (PDGF-D) was recently identified, and acts as potent mitogen for mesenchymal cells. PDGF-D also induces cellular transformation and promotes tumor growth. However, the functional role of PDGF-D in adipose-derived stem cells (ASCs) has not been identified. Therefore, we primarily investigated the autocrine and paracrine roles of PDGF-D in the present study. Furthermore, we identified the signaling pathways and the molecular mechanisms involved in PDGF-D-induced stimulation of ASCs. It is of interest that PDGF-B is not expressed, but PDGF-D and PDGF receptor-β are expressed in ASCs. PDGF-D showed the strongest mitogenic effect on ASCs, and PDGF-D regulates the proliferation and migration of ASCs through the PI3K/Akt pathways. PDGF-D also increases the proliferation and migration of ASCs through generation of mitochondrial reactive oxygen species (mtROS) and mitochondrial fission. mtROS generation and fission were mediated by p66Shc phosphorylation, and BCL2A1 and SERPINE1 mediated the proliferation and migration of ASCs. In addition, PDGF-D up-regulated the mRNA expression of diverse growth factors such as VEGFA, FGF1, FGF5, LIF, INHBA, IL11 and HBEGF. Therefore, the preconditioning of PDGF-D enhanced the hair-regenerative potential of ASCs. PDGF-D-induced growth factor expression was attenuated by a pharmacological inhibitor of mitogen-activated protein kinase pathway. In summary, PDGF-D is highly expressed by ASCs, where it acts as a potent mitogenic factor. PDGF-D also up-regulates growth factor expression in ASCs. Therefore, PDGF-D can be considered a novel ASC stimulator, and used as a preconditioning agent before ASC transplantation. Stem Cells 2014
    Stem Cells 10/2014; 33(2). DOI:10.1002/stem.1865 · 7.70 Impact Factor
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    ABSTRACT: Metabolic disorders of the brain that manifest in the neonatal or early infantile period are usually associated with acute and severe illness and are thus referred to as devastating metabolic disorders. Most of these disorders may be classified as organic acid disorders, amino acid metabolism disorders, primary lactic acidosis, or fatty acid oxidation disorders. Each disorder has distinctive clinical, biochemical, and radiologic features. Early diagnosis is important both for prompt treatment to prevent death or serious sequelae and for genetic counseling. However, diagnosis is often challenging because many findings overlap and may mimic those of more common neonatal conditions, such as hypoxic-ischemic encephalopathy and infection. Ultrasonography (US) may be an initial screening method for the neonatal brain, and magnetic resonance (MR) imaging is the modality of choice for evaluating metabolic brain disorders. Although nonspecific imaging findings are common in early-onset metabolic disorders, characteristic patterns of brain involvement have been described for several disorders. In addition, diffusion-weighted images may be used to characterize edema during an acute episode of encephalopathy, and MR spectroscopy depicts changes in metabolites that may help diagnose metabolic disorders and assess response to treatment. Imaging findings, including those of advanced MR imaging techniques, must be closely reviewed. If one of these rare disorders is suspected, the appropriate biochemical test or analysis of the specific gene should be performed to confirm the diagnosis. ©RSNA, 2014.
    Radiographics 09/2014; 34(5):1257-1272. DOI:10.1148/rg.345130095 · 2.73 Impact Factor
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    The Korean Journal of Pathology 08/2014; 48(4):302-6. DOI:10.4132/KoreanJPathol.2014.48.4.302 · 0.17 Impact Factor
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    ABSTRACT: A unique synthesis method was developed, which is called solution combustion method (SCM). TiO2 nanoparticles were synthesized by this method. These SCM TiO2 nanoparticles (∼35 nm) were added to the dielectric layers of AC powder electroluminescence (EL) devices. The dielectric layers were made of commercial BaTiO3 particles (∼1.2 μm) and binding polymer. 0, 5, 10 and 15 wt% of SCM TiO2 nanoparticles were added to the dielectric layers during fabrication of AC powder EL devices respectively. Dielectric constants of these four kinds of dielectric layers were measured. The brightnesses and current densities of AC powder EL devices were also measured. When 10 wt% of SCM TiO2 nanoparticles was added, dielectric constant and brightness were increased by 30% and 60% respectively. Furthermore, the current density was decreased by 60%. This means that the addition of SCM TiO2 nanoparticles resulted in four fold higher luminous efficiency.
    Journal of Nanoscience and Nanotechnology 08/2014; 14(8):6120-6123. DOI:10.1166/jnn.2014.8314 · 1.34 Impact Factor
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    ABSTRACT: Objective: Adipose-derived stem cells (ASCs) isolated from subcutaneous adipose tissue have been tested in clinical trials. However, ASCs isolated by enzyme digestion and centrifugation are heterogeneous and exhibit wide variation in regenerative potential and clinical outcomes. Therefore, we developed a new method for isolating clonal ASCs (cASCs) that does not use enzyme digestion or centrifugation steps.Research design and methods: In addition to cell surface markers and differentiation potential, we compared the mitogenic, paracrine and hair growth-promoting effects of ASCs isolated by the gradient centrifugation method (GCM) or by the new subfractionation culturing method (SCM).Results: We selected three cASCs isolated by SCM that showed high rates of proliferation. The cell surface markers expressed by ASCs isolated by GCM or SCM were very similar, and SCM-isolated ASCs could potentially differentiate into different cell lineages. However, cASC lines exhibited better mitogenic and paracrine effects than ASCs isolated by GCM. The expression of Diras3, Myb, Cdca7, Mki67, Rrm2, Cdk1 and Ccna2, which may play a key role in cASC proliferation, was upregulated in cASCs. In addition, cASCs exhibited enhanced hair growth-promoting effects in dermal papilla cells and animal experiments.Conclusions: SCM generates a highly homogeneous population of ASCs via a simple and effective procedure that can be used in therapeutic settings.
    Expert Opinion on Biological Therapy 07/2014; 14(11). DOI:10.1517/14712598.2014.943661 · 3.65 Impact Factor
  • Ji Hye Kim, So Young Kim, Ji Hyun Park
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    ABSTRACT: We report a 20-year-old man with dilated cardiomyopathy and intracardiac thrombi associated with Cushing's disease. The patient presented with symptomatic heart failure. Follow-up echocardiography showed two thrombi in the apex of the left ventricle, which were resolved after intravenous heparin therapy. The patient was first treated symptomatically and then trans-sphenoidal adenomectomy was performed. Although cortisol excess alone may not be sufficient to produce severe cardiomyopathy, progressive improvement of cardiac function was observed within 3 years after surgery.
    The Canadian journal of cardiology 06/2014; 30(11). DOI:10.1016/j.cjca.2014.06.018 · 3.94 Impact Factor
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    ABSTRACT: Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50μM) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3K, p-Akt, p-IKK-α/β, p-IκB-α and nuclear p-NF-κBp65 protein expressions, and NF-κB transcriptional activity in LPS (0.1μg/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation.
    International Immunopharmacology 06/2014; DOI:10.1016/j.intimp.2014.06.009 · 2.71 Impact Factor

Publication Stats

3k Citations
571.53 Total Impact Points

Institutions

  • 2013–2015
    • Max Planck Institute for Coal Research
      Mülheim-on-Ruhr, North Rhine-Westphalia, Germany
    • Dankook University Hospital
      Anjŏ, Gyeonggi Province, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
    • Korea University of Science and Technology
      Sŏul, Seoul, South Korea
  • 2009–2015
    • Kyung Hee University
      • • Department of Biomedical Engineering
      • • Department of Applied Chemistry
      • • Institute of Oriental Medicine
      Sŏul, Seoul, South Korea
  • 2007–2015
    • Sungkyunkwan University
      • • Department of Genetic Engineering
      • • Samsung Medical Center
      • • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2005–2015
    • Korea Advanced Institute of Science and Technology
      • • Department of Electrical Engineering
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2014
    • Jeju National University
      • Faculty of Biotechnology
      Tse-tsiu, Jeju-do, South Korea
    • Konkuk University Medical Center
      Changnyeong, Gyeongsangnam-do, South Korea
  • 2013–2014
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 2012–2014
    • Myongji University
      • Department of Material Science and Engineering
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Surgery
      Seoul, Seoul, South Korea
    • The Chinese University of Hong Kong
      • Department of Sociology
      Hong Kong, Hong Kong
    • Pusan National University
      • Department of Internal Medicine
      Pusan, Busan, South Korea
  • 2011–2014
    • CHA University
      • Department of Applied Bioscience
      Sŏul, Seoul, South Korea
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
  • 2010–2014
    • University of Texas MD Anderson Cancer Center
      • Department of Experimental Therapeutics
      Houston, Texas, United States
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
  • 2009–2014
    • Yonsei University
      • • Department of Oral Biology
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2006–2014
    • Inha University
      • • College of Medicine
      • • Department of Polymer Science and Engineering
      Chemulpo, Incheon, South Korea
    • University of Seoul
      Sŏul, Seoul, South Korea
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
    • Ewha Womans University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Kyungpook National University
      • • School of Food Science and Biotechnology
      • • School of Applied Biosciences
      Daikyū, Daegu, South Korea
  • 2010–2013
    • Gyeongsang National University
      • Institute of Agriculture and Life Science
      Shinshū, South Gyeongsang, South Korea
  • 2005–2013
    • Seoul National University
      • • Department of Orthopaedic Surgery
      • • College of Veterinary Medicine
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Korea University
      Sŏul, Seoul, South Korea
  • 2004–2012
    • Samsung Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2010–2011
    • The Ohio State University
      • College of Pharmacy
      Columbus, Ohio, United States
  • 2006–2011
    • Konkuk University
      • • Department of Chemical Engineering
      • • Department of Bioscience and Technology
      Seoul, Seoul, South Korea
  • 2008
    • Sooam Biotech Research Foundation
      Sŏul, Seoul, South Korea
    • Kangwon National University
      • Department of Molecular Bioscience
      Gangneung, Gangwon, South Korea
    • Chosun University
      Gwangju, Gwangju, South Korea
  • 2002
    • Hanyang University
      • Division of Chemical Engineering and Bioengineering
      Ansan, Gyeonggi, South Korea