Ji Hye Kim

Max Planck Institute for Coal Research, Mülheim-on-Ruhr, North Rhine-Westphalia, Germany

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Publications (295)610.85 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods according to the ISO-10993 cytotoxicity test for medical devices. The PACA/PLLA have similar or even better biocompatibility than those of commercially available cyanoacrylate (CA)-based TAs such as Dermabond® and Histoacryl®. The PACA/PLLA were not different from those exposed to Dermabond® and Histoacryl® in Raman spectra when biochemical changes of protein and DNA/RNA underlying during cell death were compared utilizing Raman spectroscopy. Histological analysis revealed that incised dermal tissues of rats treated with PACA/PLLA showed less inflammatory signs and enhanced collagen formation compared to those treated with Dermabond® or Histoacryl®. Of note, tissues treated with PACA/PLLA were stronger in the tensile strength compared to those treated with the commercially available TAs. Therefore, taking all the results into consideration, the PACA/PLLA we created might be a clinically useful TA for treating dermal wounds. Copyright © 2015 Elsevier B.V. All rights reserved.
    06/2015; 51. DOI:10.1016/j.msec.2015.02.042
  • Jin Ik Lim, Ji Hye Kim
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    ABSTRACT: Despite cyanoacrylate's numerous advantages such as good cosmetic results and fast application for first aid, drawbacks such as brittleness and local tissue toxicity have limited their applicability. In this study, to improve both the biocompatibility and mechanical properties of cyanoacrylate, allyl 2-cyanoacrylate (AC) was pre-polymerized and mixed with poly(l-lactide-co-ɛ-caprolactone) (PLCL, 50:50) as biodegradable elastomer. For various properties of pre-polymerized AC (PAC)/PLCL mixtures, bond strength, elasticity of flexure test as bending recovery, cell viability, and in vivo test using rat were conducted and enhanced mechanical properties and biocompatibility were confirmed. Especially, optimal condition for pre-polymerization of AC was determined to 150°C for 40min through cytotoxicity test. Bond strength of PAC/PLCL mixture was decreased (over 10 times) with increasing of PLCL. On the other hand, biocompatibility and flexibility were improved than commercial bio-glue. Optimal PAC/PLCL composition (4g/20mg) was determined through these tests. Furthermore, harmful side effects and infection were not observed by in vivo wound healing test. These results indicate that PAC/PLCL materials can be used widely as advanced bio-glues in various fields. Copyright © 2015. Published by Elsevier B.V.
    Colloids and surfaces B: Biointerfaces 05/2015; 133. DOI:10.1016/j.colsurfb.2015.05.004 · 4.29 Impact Factor
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    ABSTRACT: Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti-inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain, were employed. KF was shown to attenuate the expansion of inflammatory lesions seen in EtOH/HCl- and aspirin-induced gastritis, LPS/caerulein (CA)-triggered pancreatitis, and acetic acid-induced writhing This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Molecular Nutrition & Food Research 04/2015; DOI:10.1002/mnfr.201400820 · 4.91 Impact Factor
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    ABSTRACT: Bittern is made from marine water after extraction of salt, and its major components include magnesium chloride, magnesium sulfate, potassium chloride, sodium chloride and magnesium bromide. For a long time, it has been used as the main ingredient of tofu coagulant and chemical weapons. A 73-year-old woman arrived to the emergency department after a suicide attempt by drinking an unknown amount bittern. She complained of dizziness, general weakness, and altered mental state (Glasgow Coma Scale (GCS) 13/15). The brain computed tomography (CT) and magnetic resonance imaging (MRI) showed no abnormality. But blood chemistry showed hypermagnesemia ([Mg(2+)] 7.8 mEq/L) and hypernatremia ([Na(+)] 149 mEq/L). Electrocardiograph showed QT prolongation of 0.482 s. Electrolyte imbalances were corrected following adequate fluid therapy and injection of calcium gluconate. The patient recovered/was subsequently discharged without any complications. Electrolyte imbalances are a common presentation following bittern poisoning. Severe side effects like respiratory depression, hypotension, arrhythmia, bradycardia, and cardiac arrest can also occur. Patients will require immediate fluid therapy and correction of electrolyte imbalances. The symptoms vary depending on the electrolyte levels. It is mandatory to closely monitor the electrolyte levels and electrocardiograph in these patients.
    Journal of Emergencies Trauma and Shock 04/2015; 8(2):108-9. DOI:10.4103/0974-2700.145426
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    ABSTRACT: Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated the immunopharmacological activities of the methanolic extract of the aerial parts of this plant (Pa-ME) and validated its pharmacological targets. Lipopolysaccharide (LPS)-treated macrophages, an HCl/EtOH-induced gastritis model, and an acetic acid-injected capillary permeability mouse model were employed to evaluate the anti-inflammatory activity of Pa-ME. Potentially active anti-inflammatory components of this extract were identified by HPLC. The molecular mechanisms of the anti-inflammatory activity were studied by kinase assays, reporter gene assays, immunoprecipitation analysis, and overexpression of target enzymes. Pa-ME suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and prevented morphological changes in LPS-treated RAW264.7 cells. Moreover, both HCl/EtOH-induced gastric damage and acetic acid-triggered vascular permeability were restored by orally administered Pa-ME. Furthermore, this extract downregulated the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 and reduced the nuclear levels of NF-κB. Signalling events upstream of NF-κB translocation, such as phosphorylation of Src and Syk and formation of Src/Syk signalling complexes, were also inhibited by Pa-ME. The enzymatic activities of Src and Syk were also suppressed by Pa-ME. Moreover, Src-induced and Syk-induced luciferase activity and p85/Akt phosphorylation were also inhibited by Pa-ME. Of the identified flavonoids, kaempferol and quercetin were revealed as partially active anti-inflammatory components in Pa-ME. Pa-ME exerts anti-inflammatory activity in vitro and in vivo by suppressing Src, Syk, and their downstream transcription factor, NF-κB. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Journal of ethnopharmacology 03/2015; 168. DOI:10.1016/j.jep.2015.03.043 · 2.94 Impact Factor
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    The Korean Journal of Internal Medicine 03/2015; 30(2):256-8. DOI:10.3904/kjim.2015.30.2.256
  • 02/2015; 28(1):111-118. DOI:10.9799/ksfan.2015.28.1.111
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    ABSTRACT: Graphene, a two-dimensional carbon material, has attracted significant interest for applications in flexible electronics as an alternative transparent electrode to indium tin oxide. However, it still remains a challenge to develop a simple, reproducible, and controllable fabrication technique for producing homogeneous large-scale graphene films and creating uniform patterns with desired shapes at defined positions. Here, we present a simple route to scalable fabrication of flexible transparent graphene electrodes using an oxygen plasma etching technique in a capacitively coupled plasma (CCP) system. Ascorbic acid-assisted chemical reduction enables the large-scale production of graphene with solution-based processability. Oxygen plasma in the CCP system facilitates the reproducible patterning of graphene electrodes, which allows controllable feature sizes and shapes on flexible plastic substrates. The resulting graphene electrode exhibits a high conductivity of 80 S∙cm-1 and a transparency of 76%, and retains excellent flexibility upon hard bending at an angle of ±175° and after repeated bending cycles. A simple LED circuit integrated on the patterned graphene film demonstrates the feasibility of graphene electrodes for use in flexible transparent electrodes.
    Langmuir 02/2015; 31(9). DOI:10.1021/la504443a · 4.38 Impact Factor
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    ABSTRACT: Positron emission tomography (PET) images usually suffer from a noticeable amount of statistical noise. In order to reduce this noise, a post-filtering process is usually adopted. However, the performance of this approach is limited because the denoising process is mostly performed on the basis of the Gaussian random noise. It has been reported that in a PET image reconstructed by the expectation-maximization (EM), the noise variance of each voxel depends on its mean value, unlike in the case of Gaussian noise. In addition, we observe that the variance also varies with the spatial sensitivity distribution in a PET system, which reflects both the solid angle determined by a given scanner geometry and the attenuation information of a scanned object. Thus, if a post-filtering process based on the Gaussian random noise is applied to PET images without consideration of the noise characteristics along with the spatial sensitivity distribution, the spatially variant non-Gaussian noise cannot be reduced effectively. In the proposed framework, to effectively reduce the noise in PET images reconstructed by the 3-D ordinary Poisson ordered subset EM (3-D OP-OSEM), we first denormalize an image according to the sensitivity of each voxel so that the voxel mean value can represent its statistical properties reliably. Based on our observation that each noisy denormalized voxel has a linear relationship between the mean and variance, we try to convert this non-Gaussian noise image to a Gaussian noise image. We then apply a block matching 4-D algorithm that is optimized for noise reduction of the Gaussian noise image, and reconvert and renormalize the result to obtain a final denoised image. Using simulated phantom data and clinical patient data, we demonstrate that the proposed framework can effectively suppress the noise over the whole region of a PET image while minimizing degradation of the image resolution.
    IEEE Transactions on Nuclear Science 02/2015; 62(1):137-147. DOI:10.1109/TNS.2014.2360176 · 1.46 Impact Factor
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    ABSTRACT: A highly enantioselective kinetic resolution of diols via asymmetric acetalization has been achieved using a chiral confined imidodiphosphoric acid catalyst. The reaction is highly efficient for the resolution of tertiary alcohols, giving selectivity factors of up to >300. Remarkably, even in cases where the selectivity factors are only moderate, highly enantioenriched diols are obtained via a stereodivergent resolution to diastereomeric acetals.
    Journal of the American Chemical Society 01/2015; 137(5). DOI:10.1021/ja512481d · 11.44 Impact Factor
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    ABSTRACT: Carpal tunnel syndrome is the most common peripheral entrapment neuropathy. We report on the first Korean case of carpal tunnel syndrome induced by tophaceous deposition in flexor digitorum tendons of a patient with chronic gout. A 63-year-old male suffered from numbness, decreased sensation over both median nerve distribution, and weakness of thenar muscle for 3 years. Physical examinations revealed positive Tinel's sign and Phalen's test and thenar qjmuscle atrophy was found on both hands. In nerve conduction study, there was no action potential of the sensory and motor of the bilateral median nerve. Ultrasonography showed increased cross-sectional area of median nerve due to tophaceous deposition in flexor digitorum tendons in the carpal tunnel. Dual-energy computed tomography showed diffuse multifocal green color coding tophaceous deposition within the carpal tunnel. His neuropathic symptoms improved after injection of triamcinolone into the carpal tunnel and administration of oral medication including non-steroidal anti-inflammatory drugs and colchicine.
    01/2015; 22(1). DOI:10.4078/jrd.2015.22.1.29
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    ABSTRACT: The Cordyceps species have been widely used for treating various cancer diseases. Although the Cordyceps species have been widely known as an alternative anticancer remedy, which compounds are responsible for their anticancer activity is not fully understood. In this study, therefore, we examined the anticancer activity of 5 isolated compounds derived from the butanol fraction (Cb-BF) of Cordyceps bassiana. For this purpose, several cancer cell lines such as C6 glioma, MDA-MB-231, and A549 cells were employed and details of anticancer mechanism were further investigated. Of 5 compounds isolated by activity-guided fractionation from BF of Cb-EE, KTH-13, and 4-isopropyl-2,6-bis(1-phenylethyl)phenol, Cb-BF was found to be the most potent antiproliferative inhibitor of C6 glioma and MDA-MB-231 cell growth. KTH-13 treatment increased DNA laddering, upregulated the level of Annexin V positive cells, and altered morphological changes of C6 glioma and MDA-MB-231 cells. In addition, KTH-13 increased the levels of caspase 3, caspase 7, and caspase 9 cleaved forms as well as the protein level of Bax but not Bcl-2. It was also found that the phosphorylation of AKT and p85/PI3K was also clearly reduced by KTH-13 exposure. Therefore, our results suggest KTH-13 can act as a potent antiproliferative and apoptosis-inducing component from Cordyceps bassiana, contributing to the anticancer activity of this mushroom.
    Evidence-based Complementary and Alternative Medicine 01/2015; 2015:739874. DOI:10.1155/2015/739874 · 2.18 Impact Factor
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    ABSTRACT: Positron emission tomography (PET) images usually suffer from low spatial resolution mainly because of the finite dimension of crystals. To improve the spatial resolution based on wobble scanning, we previously proposed a sinogram-based super-resolution (SR) algorithm using a space-variant blur matrix. However, the algorithm may cause unwanted resolution loss owing to an inevitable interpolation process for preparing evenly spaced projections. In this article, we propose a novel one-step line of response (LOR)-based SR framework for 3D PET images. In the framework, we efficiently determine a large number of space-variant point spread functions (PSFs) in the image space by using the scanner symmetries and the proposed PSF interpolation scheme based on nonrigid registration. Furthermore, to minimize the resolution degradation in the evenly spaced parallel-beam rebinning and to reduce the computational time in the graphics processing unit (GPU) implementation, we introduce parallel-friendly LOR reconstruction based on cone-beam reordering. We then obtain a high resolution image via a one-step super-resolved 3D PET image reconstruction with the determined PSFs. The proposed framework provides noticeable improvement on the spatial resolution of PET images with a considerable reduction of computational time.
    IEEE Transactions on Nuclear Science 01/2015; 62(3):1-10. DOI:10.1109/TNS.2015.2421908 · 1.46 Impact Factor
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    ABSTRACT: The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.
    Tuberculosis and Respiratory Diseases 12/2014; 77(6):262-5. DOI:10.4046/trd.2014.77.6.262
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    ABSTRACT: Abstract We used the Job-demand-control model to answer our two research questions concerning the effects of working conditions on self-rated health, and gender differences in the association between these working conditions and health among Korean manual workers. Since the disproportionate representation of women in non-standard work positions is found in many countries including Korea, it is important to examine how working conditions explain gender inequality in health. We used data from the 2008-2009 Korean National Health and Nutrition Examination Survey and analyzed a total sample of 1,482 men and 1,350 women using logistic regression. We found that job control was positively related to self-rated health while both physical and mental job demands were negatively related to self-rated health. We also found significant interaction effects of job demands, control and gender on health. Particularly, female workers' health was more vulnerable to mentally demanding job conditions. Based on these findings, we discussed theoretical and practice implications for future studies.
    Health Care For Women International 11/2014; DOI:10.1080/07399332.2014.980889 · 0.63 Impact Factor
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    ABSTRACT: 21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3. In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses. ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production. Analysis of its molecular activity showed that this compound significantly suppressed the expression of inducible NO synthase (iNOS), nuclear translocation of nuclear factor- (NF-) κB subunits (p50 and p65), phosphorylation of inhibitor of κB kinase (IKK), and the enzyme activity of AKT1. Taken together, the novel triterpenoid saponin compound ATS-E3 contributes to the beneficial effects of tea plants by exerting anti-inflammatory and antioxidative activities in an AKT/IKK/NF-κB-dependent manner.
    Mediators of Inflammation 11/2014; 2014:658351. DOI:10.1155/2014/658351 · 2.42 Impact Factor
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    ABSTRACT: This study aimed to report the survival of a rare case of complete tracheal transection followed by blunt neck trauma. A 66-year-old man was presented in the emergency room after a motorcycle accident in which a rope was wrapped around his neck. Although alert, he was in respiratory distress. A computed tomographic scan showed transection of the cervical trachea. Emergency neck exploration revealed that the tracheal laceration had been cut from the tracheal anterior third ring to the posterior first ring and the anterior esophageal wall had ruptured. Laryngectomy, tracheostomy, and esophagopharyngeal anastomosis were performed. Prompt airway management and immediate neck exploration is important for survival in these cases.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 11/2014; 20(6):459-462. DOI:10.5505/tjtes.2014.32744 · 0.38 Impact Factor
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    ABSTRACT: Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P. ginseng. Recently, GF1 was reported to have beneficial effects on skin. However, there has not been fully understood its anti-melanogenic effect and underlying molecular mechanisms. In the present study, GF1 reduced -MSH-induced melanin secretion in B16F10 cell culture media by 60%. However, it did not suppress intracellular melanin levels, tyrosinase activity and expression. Immunofluorescence assay showed that GF1 had no effect on melanosome transport, but significantly induced dendrite retraction. Pull-down assay demonstrated that GF1 primarily modulate the Rho family GTPases resulting in dendrite retraction. Collectively, these data suggest that GF1 could act as a potent skin whitening agent.This article is protected by copyright. All rights reserved.
    Experimental Dermatology 11/2014; 24(2). DOI:10.1111/exd.12586 · 4.12 Impact Factor
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    ABSTRACT: Immunoassay of cardiac biomarkers using a photodiode array biochip, Sensors and Actuators B: Chemical (2014), http://dx.doi.org/10.1016/j.snb.2014.10.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    Sensors and Actuators B Chemical 10/2014; 207. DOI:10.1016/j.snb.2014.10.014 · 3.84 Impact Factor
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    ABSTRACT: The aim of the present study was to evaluate the comparative anti-Alzheimer's disease (AD) activities of different parts of Nelumbo nucifera (leaves, de-embryo seeds, embryos, rhizomes, and stamens) in order to determine the selectivity and efficient use of its individual components. Anti-AD activities of different parts of N. nucifera were evaluated via inhibitory activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) along with scavenging activity on peroxynitrite (ONOO(-)). Among the evaluated parts of N. nucifera, the embryo extract exhibited significant inhibitory potential against BACE1 and BChE as well as scavenging activity against ONOO(-). Thus, the embryo extract was selected for detailed investigation on anti-AD activity using BACE1- and ChEs-inhibitory assays. Among the different solvent-soluble fractions, the dichloromethane (CH2Cl2), ethyl acetate (EtOAc), and n-butanol (n-BuOH) fractions showed promising ChEs and BACE1 inhibitory activities. Repeated column chromatography of the CH2Cl2, EtOAc and n-BuOH fractions yielded compounds 1-5, which were neferine (1), liensinine (2), vitexin (3), quercetin 3-O-glucoside (4) and northalifoline (5). Compound 2 exhibited potent inhibitory activities on BACE1, AChE, and BChE with respective IC50 values of 6.37 ± 0.13, 0.34 ± 0.02, and 9.96 ± 0.47 µM. Likewise, compound 1 showed potent inhibitory activities on BACE1, AChE, and BChE with IC50 values of 28.51 ± 4.04, 14.19 ± 1.46, and 37.18 ± 0.59 µM, respectively; the IC50 values of 3 were 19.25 ± 3.03, 16.62 ± 1.43, and 11.53 ± 2.21 µM, respectively. In conclusion, we identified potent ChEs- and BACE1-inhibitory activities of N. nucifera as well as its isolated constituents, which may be further explored to develop therapeutic and preventive agents for AD and oxidative stress related diseases.
    Archives of Pharmacal Research 10/2014; 38(6). DOI:10.1007/s12272-014-0492-4 · 1.75 Impact Factor

Publication Stats

3k Citations
610.85 Total Impact Points


  • 2013–2015
    • Max Planck Institute for Coal Research
      Mülheim-on-Ruhr, North Rhine-Westphalia, Germany
    • Korea University of Science and Technology
      Sŏul, Seoul, South Korea
    • Dankook University Hospital
      Anjŏ, Gyeonggi Province, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2009–2015
    • Kyung Hee University
      • • Department of Biomedical Engineering
      • • Department of Applied Chemistry
      • • Institute of Oriental Medicine
      Sŏul, Seoul, South Korea
  • 2007–2015
    • Sungkyunkwan University
      • • Department of Genetic Engineering
      • • Samsung Medical Center
      • • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2006–2015
    • Inha University
      • • College of Medicine
      • • Department of Polymer Science and Engineering
      Chemulpo, Incheon, South Korea
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
  • 2005–2015
    • Korea Advanced Institute of Science and Technology
      • • Department of Electrical Engineering
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2014
    • Konkuk University Medical Center
      Changnyeong, Gyeongsangnam-do, South Korea
    • Jeju National University
      • Faculty of Biotechnology
      Tse-tsiu, Jeju-do, South Korea
  • 2013–2014
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 2012–2014
    • Myongji University
      • Department of Material Science and Engineering
      Sŏul, Seoul, South Korea
    • Pusan National University
      • Department of Internal Medicine
      Pusan, Busan, South Korea
    • Ajou University
      • Department of Surgery
      Seoul, Seoul, South Korea
    • The Chinese University of Hong Kong
      • Department of Sociology
      Hong Kong, Hong Kong
  • 2011–2014
    • CHA University
      • Department of Applied Bioscience
      Sŏul, Seoul, South Korea
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
  • 2010–2014
    • University of Texas MD Anderson Cancer Center
      • Department of Experimental Therapeutics
      Houston, Texas, United States
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
  • 2009–2014
    • Yonsei University
      • • Department of Oral Biology
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2008–2014
    • Chosun University
      Gwangju, Gwangju, South Korea
    • Sooam Biotech Research Foundation
      Sŏul, Seoul, South Korea
    • Kangwon National University
      • Department of Molecular Bioscience
      Gangneung, Gangwon, South Korea
  • 2006–2014
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 2002–2014
    • Hanyang University
      • Division of Chemical Engineering and Bioengineering
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
    • Kyungpook National University
      • • School of Food Science and Biotechnology
      • • School of Applied Biosciences
      Daikyū, Daegu, South Korea
    • Ewha Womans University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2010–2013
    • Gyeongsang National University
      • Institute of Agriculture and Life Science
      Shinshū, South Gyeongsang, South Korea
  • 2005–2013
    • Seoul National University
      • • Department of Orthopaedic Surgery
      • • College of Veterinary Medicine
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Korea University
      Sŏul, Seoul, South Korea
  • 2004–2012
    • Samsung Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2010–2011
    • The Ohio State University
      • College of Pharmacy
      Columbus, Ohio, United States
  • 2006–2011
    • Konkuk University
      • • Department of Chemical Engineering
      • • Department of Bioscience and Technology
      Seoul, Seoul, South Korea