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ABSTRACT: Fecal mutagenicity, as a possible tool to evaluate risk for colon cancer, was measured in six healthy volunteers (24–33 yr) who consumed diets low in Se (19–24 μg/day) for 45 days followed by 24 days of a selenium repletion diet (203–224 μg/day). Samples were collected at the beginning of the dietary experiment, at the end of the Se-depletion period and at the end of the Se-repletion period. Mutagenic activity with S. typhimurium TA100 and TA98 did not vary significantly among samples taken after the two diet periods. Mutagenicity with TA98 was higher at the beginning of the dietary experiment than at the end of Se-depletion (p<0.01) and at the end of Se-repletion (p<0.1). This effect might be due to the change of the subjects from their habitual diet to the experimental liquid formula diet. Since fecal mutagenicity with both tester strains was the same after the Se-depletion and Se-repletion periods, Se does not appear to be a dominant factor for determining fecal mutagenicity under these experimental conditions.