-
Tae-Hoon Oh, Jeong-Sik Byeon,
Seung-Jae Myung,
Suk-Kyun Yang,
Kwi-Sook Choi,
Jun-Won Chung,
Benjamin Kim,
Don Lee,
Jae Ho Byun,
Se Jin Jang,
Jin-Ho Kim
[show abstract]
[hide abstract]
ABSTRACT: Obesity as a risk factor for colorectal neoplasm (CRN) is controversial. In the present study, we evaluated visceral obesity as a risk factor for CRN.
We prospectively enrolled 200 consecutive, asymptomatic adults (male : female = 133:67, mean age, 50.9 +/- 8.5 years) undergoing both colonoscopy and abdominopelvic computed tomography (CT) scan for routine health evaluations. The presence or absence and the characteristics of CRN were determined during colonoscopy. The amount of visceral adipose tissue (VAT) and subcutaneous adipose tissue was measured by an abdominopelvic CT scan. Body mass index, waist circumference, and percentage of body fat were measured. Blood pressure and other blood markers for assessing the metabolic syndrome were also investigated.
Of the 200 patients, 53 (26.5%) had CRN. Old age, smoking, metabolic syndrome, and a high fasting plasma glucose level were associated with an increased risk of CRN. VAT (P < 0.01) and waist circumference (P = 0.01) were significantly higher in those with CRN. A multivariate analysis of the risks of CRN showed an odds ratio of 4.07 (95% confidence interval: 1.01-16.43, P = 0.03) for those with VAT over 136.61 cm(2) relative to those with VAT under 67.23 cm(2). Waist circumference, metabolic syndrome, and fasting plasma glucose levels were not independent risk factors for CRN in the multivariate analysis.
Increased VAT is an independent risk factor for CRN. Further large scale studies are needed to clarify the causal relationship between VAT and CRN.
Journal of Gastroenterology and Hepatology 03/2008; 23(3):411-7. · 2.87 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Although double balloon endoscopy (DBE) has demonstrated a high diagnostic yield in suspected small bowel bleeding, it is not known whether DBE is of equal value to all patients with suspected small bowel bleeding or of greater benefit in selected subgroups. We aimed to determine whether any clinical features predict an increased likelihood of finding a lesion in patients with suspected small bowel bleeding.
We retrospectively analyzed clinical features of 43 consecutive patients (M : F = 26:17, age 13-82 years) who underwent DBE because of suspected small bowel bleeding. Data associated with DBE procedure were collected prospectively. Predictive factors for the detection of a lesion were determined by comparison of clinical features between patients with positive DBE findings and those with negative findings.
Potential bleeding sources were discovered in 30 patients (69.8%) out of 43. Duration of bleeding was longer in patients with positive DBE findings than in those with negative findings (195 +/- 311 vs 18 +/- 17 days, P = 0.015). Number of bleeding episodes was higher in patients with positive DBE findings (2.2 +/- 1.2 vs 1.3 +/- 0.5, P = 0.011). The odds ratio for the detection of bleeding focus on DBE for patients with two or more bleeding episodes, relative to those with only one current bleeding episode was 5.67 (95% CI: 1.12-28.81, P = 0.036) in multivariate analysis.
DBE may be the most useful in patients with suspected small bowel bleeding if they have a history of frequent bleeding episodes over a long period.
Journal of Gastroenterology and Hepatology 01/2008; 23(7 Pt 1):1051-5. · 2.87 Impact Factor
-
Dong Hun Park,
Hyun Soo Kim,
Won Ho Kim,
Tae Il Kim,
Young Ho Kim,
Dong Il Park,
Hyo Jong Kim,
Suk-Kyun Yang, Jeong-Sik Byeon,
Moon Sung Lee,
Il Kwun Chung,
Sung Ae Jung,
Yoon Tae Jeen,
Jai Hyun Choi,
Hwang Choi,
Dong Soo Han
[show abstract]
[hide abstract]
ABSTRACT: Because of their potential for malignancy, flat colorectal neoplasias are a current topic of debate. This study was designed to investigate the clinicopathologic features of flat neoplasia and to compare them with those of polypoid neoplasia, as well as to identify the determinants of malignant transformation of both flat and polypoid colorectal neoplasia.
A prospective, cross-sectional study of 3,360 patients diagnosed with adenomas via total colonoscopy and polypectomy was performed at 11 tertiary medical centers between July 2003 and July 2004. In this study, potential risk factors for malignant transformation were analyzed. If multiple adenomas were identified, then only the adenoma with the most advanced degree of histology was recorded for the patient.
Of a total of 3,360 neoplasias identified, we found that the incidence of flat and polypoid neoplasias were 207 (6.2 percent) and 3,153 (93.8 percent), respectively. Patients with flat neoplasias tended to be older (59.6 vs. 57.1, P < 0.01), with the neoplasia located more frequently in the right colon than polypoid neoplasias (49.3 percent vs. 32 percent, P < 0.01). The incidence of high-grade dysplasia or cancer in flat neoplasias was similar to that of polypoid neoplasias (5.4 percent vs. 4.6 percent, P = 0.36). Multivariate analysis revealed that a size of > or =11 mm (odds ratio, 6.8; 95 percent confidence interval, 4.8-9.7) and location in the left colon (odds ratio, 1.6; 95 percent confidence interval, 1.1-2.4) were significant determinants for the malignancy potential of colonic neoplasias.
The clinicopathologic indices for the propensity of malignant transformation in colorectal neoplasias were a size > or =11 mm and location in the left colon rather than flat gross morphology.
Diseases of the Colon & Rectum 01/2008; 51(1):43-9; discussion 49. · 3.13 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Reflux symptom assessment had reliable accuracy in the diagnosis of gastroesophageal reflux disease (GERD). However, patients may recognize heartburn or regurgitation as dyspepsia because of inaccurate understanding or atypical presentation. The aim of the present study was to estimate endoscopic reflux esophagitis in patients with upper abdominal pain as a predominant symptom in the absence of heartburn or regurgitation.
Two hundred and sixty-three consecutive patients presenting dyspepsia without heartburn or regurgitation were enrolled. Patients with heartburn or regurgitation were excluded using the symptom interviewer method. Dyspepsia was categorized into pain-predominant or dysmotility-predominant groups according to the Rome II proposal. Endoscopic reflux esophagitis was graded using the Los Angeles classification.
One hundred and five patients were included in the pain-predominant group and 119 in the dysmotility-predominant group. Reflux esophagitis was found in 18.8% (42/224) of all dyspeptic patients. Grade A esophagitis was noted in 27.6% (29/105) of the pain-predominant group and in 7.6% (9/119) of the dysmotility-predominant group. Grade B was noted in two patients in each group. A total of 29.5% (31/105) and 9.3% (11/119) had reflux esophagitis, respectively (P < 0.001). Comparing patients with or without reflux esophagitis, there was no difference in body mass index, smoking habit, alcohol consumption, or Helicobacter pylori infection status.
A significant proportion of patients presenting dyspepsia, especially pain-predominant dyspepsia, have endoscopic reflux esophagitis. In view of GERD, pain-predominant dyspepsia should be investigated and managed differently from dysmotility-predominant dyspepsia.
Journal of Gastroenterology and Hepatology 12/2007; 22(12):2217-21. · 2.87 Impact Factor
-
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 11/2007; 50(4):213-5.
-
Jeong Sik Byeon
Gastrointestinal Endoscopy 10/2007; 66(3 Suppl):S69-71. · 4.88 Impact Factor
-
Gastrointestinal Endoscopy 10/2007; 66(3 Suppl):S96-8. · 4.88 Impact Factor
-
Hwang Choi,
Kyu-Yong Choi,
Chang-Soo Eun,
Hyun-Joo Jang,
Dong-Il Park,
Dong-Kyung Chang,
Jin-Oh Kim,
Bong-Min Ko,
Moon-Sung Lee,
Kyu-Chan Huh,
Dong-Soo Han, Jeong-Sik Byeon,
Suk-Kyun Yang,
Jin-Ho Kim
[show abstract]
[hide abstract]
ABSTRACT: Double balloon endoscopy (DBE) is a new diagnostic and therapeutic tool for the management of patients with small-bowel disease.
To evaluate the feasibility, clinical usefulness, and safety of DBE in Korean patients with suspected or known small-bowel disease.
Retrospective, multicenter study from April 2004 to March 2006.
University hospitals.
Two hundred twenty-five consecutive patients.
Subjects underwent 311 procedures with DBE via the oral and/or anal routes.
The indications, diagnostic yield, therapeutic use, and complications.
Overall diagnostic yield was 75% (169/225). Diagnostic yields for obscure GI bleeding (OGIB) (n = 137), chronic abdominal pain (n = 32), radiologic/capule endoscopic abnormality (n = 25), polyposis (n = 9), and chronic diarrhea (n = 9) were 73.7% (101/137), 75.0% (24/32), 64% (16/25), 100% (9/9), and 0% (0/9), respectively. In patients with OGIB, ulcerating lesions (n = 54) were more common than vascular lesions (n = 20) or tumors (n = 27). Some lesions detected in DBE were treated effectively with electrocoagulation or argon plasma coagulation, polypectomy, and dilation. Entrapped capsules were removed easily with polypectomy snare in 3 patients with small-bowel stricture. Some patients with strictures had transient abdominal discomfort during and/or after the procedure. With the exception of 1 mucosal tear, there were no technical problems or serious complications.
Descriptive, retrospective study.
DBE is safe and useful for diagnosis and treatment of a variety of small-bowel diseases. The most common indication of DBE was OGIB. Ulcerating small-bowel lesions are more common than vascular lesions in Korea.
Gastrointestinal Endoscopy 10/2007; 66(3 Suppl):S22-5. · 4.88 Impact Factor
-
Jeong-Sik Byeon,
Suk-Kyun Yang,
Tae Il Kim,
Won Ho Kim,
James Y W Lau,
Wai-Keung Leung,
Rikiya Fujita,
Govind K Makharia,
Murdan Abdullah,
Ida Hilmi,
Jose Sollano,
Khay-Guan Yeoh,
Deng-Chyang Wu,
Min Hu Chen,
Pradermchai Kongkam,
Joseph J Y Sung
[show abstract]
[hide abstract]
ABSTRACT: Colorectal neoplasm is rapidly increasing in Asia, but a guideline for screening is not available.
To evaluate the characteristics of colorectal neoplasm in asymptomatic Asian subjects.
Prospective cohort study.
Multinational multicenters, including both primary and referral centers in Asia.
A total of 860 consecutive asymptomatic adults undergoing screening colonoscopy in 11 Asian cities from July 2004 to December 2004. Patients under 16 years old; those patients with a colorectal resection history, colonoscopies, or barium enema within 5 years; symptoms suggestive of colorectal diseases; and those who had undergone surveillance colonoscopy were excluded.
The incidence and distribution of colorectal neoplasm and advanced neoplasm.
The mean age (+/-SD) was 54.4+/-11.6 years; 471 were men (54.8%). The prevalence of colorectal neoplasm and advanced neoplasm was 18.5% and 4.5%, respectively. Male sex, advancing age, and a family history of colorectal cancer were risk factors for advanced neoplasm. Of the 168 patients with colorectal neoplasm, 76 had distal neoplasm only (45.2%), 66 had proximal neoplasm only (39.3%), and 26 had both proximal and distal neoplasms (15.5%). Although the presence of distal advanced neoplasm was a significant risk factor for proximal advanced neoplasm, 14 of the 758 subjects without distal neoplasm had proximal advanced neoplasm (1.8%).
The small number of enrolled subjects, especially from certain ethnic groups.
The overall prevalence of advanced colorectal neoplasm in asymptomatic Asians is comparable with the West. Male sex, advancing age, and a family history of colorectal cancer were associated with a higher risk of advanced neoplasm.
Gastrointestinal Endoscopy 07/2007; 65(7):1015-22. · 4.88 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: To prospectively evaluate the reliability and accuracy of optical colonoscopy and computed tomographic (CT) colonography in polyp measurement, by using direct measurement as the reference standard, and to understand the basis for measurement discrepancy between both modalities.
Eighty-six simulated polyps that ranged from 3 to 15 mm were constructed by using pig colons obtained from an abattoir. Approval of the animal care and use committee for the study was not required. CT colonographic measurement was performed by two independent radiologists by using two-dimensional (2D) optimized multiplanar reformatted planes and three-dimensional (3D) endoluminal views. Optical colonoscopic measurement was performed by two independent gastroenterologists by using open biopsy forceps. Interobserver agreement, measurement error, measurement discrepancy defined as the result of subtracting the optical colonoscopic measurement from the CT colonographic measurement, and false-mismatch (ie, designation of matched polyps as mismatched between both modalities) rates according to different matching criteria were analyzed.
Intraclass correlation coefficients were 0.879 (95% confidence interval: 0.780, 0.930) for optical colonoscopy, 0.979 (95% confidence interval: 0.956, 0.989) for 2D CT colonography, and 0.985 (95% confidence interval: 0.976, 0.990) for 3D CT colonography. The mean standardized polyp size +/- standard deviation for each observer was 76.3% +/- 14.7 and 85.3% +/- 18.8 for optical colonoscopy, 104.6% +/- 11.6 and 101.6% +/- 10.1 for 2D CT colonography, and 114% +/- 12.4 and 113.4% +/- 13.2 for 3D CT colonography. These values indicated that there was a statistically significant difference among the methods (P<.001). Measurement discrepancy was not proportional to polyp size. A percentage-of-error criterion showed increasing false-mismatch rates with decreasing polyp size, whereas a fixed margin-of-error criterion resulted in more uniform false-mismatch rates across polyp size.
CT colonography is more reliable and accurate than optical colonoscopy for polyp measurement. A fixed margin-of-error criterion is better than a percentage-of-error criterion for polyp matching between CT colonography and optical colonoscopy with open biopsy forceps.
Radiology 07/2007; 244(1):157-64. · 5.73 Impact Factor
-
Jae Won Choe,
Hye-Sook Chang,
Suk-Kyun Yang,
Seung-Jae Myung, Jeong-Sik Byeon,
Don Lee,
Hye-Kyung Song,
Hyun Ju Lee,
Eun-Ju Chung,
Sun Young Kim,
Hwoon-Yong Jung,
Gin-Hyug Lee,
Weon-Seon Hong,
Jin-Ho Kim,
Young Il Min
[show abstract]
[hide abstract]
ABSTRACT: Although the incidence of colorectal cancer is rising in Asian countries, there are no guidelines for its screening in this region due in part to the lack of epidemiological data regarding colorectal neoplasms. This study aimed to evaluate the prevalence of colorectal neoplasms in average-risk Koreans and to assess the effectiveness of screening colonoscopy in Korea.
The prevalence of colorectal neoplasms was assessed by primary screening colonoscopy in 5,086 consecutive asymptomatic adults (males 70.5%; age 20-84 years) with no risk factors for colorectal cancer.
The overall prevalence of colorectal neoplasms in the 5,086 subjects was 21.9% and this increased linearly with age. Among the 2,435 subjects aged >or=50 years (males 66.7%; mean age 57.7 years), the prevalence of all colorectal neoplasms was 30.2% (males 35.9% vs females 18.7%; P < 0.001), while advanced neoplasms accounted for only 4.1% (males 5.1% vs females 2.0%; P < 0.001). The prevalence of advanced neoplasms in Korean men of a specific age group was similar to that of Korean women in the 10-years older age group. Also, Koreans in a specific age group showed a prevalence of advanced neoplasms similar to that of Westerners in the 10-years younger age group.
Colonoscopy is a useful modality for colorectal cancer screening in Korea, as established in Western countries. However, the screening colonoscopy may begin at an older age for Koreans than for Westerners. Similarly, the optimal starting age for screening in Korean women may be higher than that in men by 10 years.
Journal of Gastroenterology and Hepatology 07/2007; 22(7):1003-8. · 2.87 Impact Factor
-
Suck-Ho Lee,
Il-Kwun Chung,
Sun-Joo Kim,
Jin-Oh Kim,
Bong-Min Ko,
Won Ho Kim,
Hyun-Soo Kim,
Dong-Il Park,
Hyo-Jong Kim, Jeong-Sik Byeon,
Suk-Kyun Yang,
Byeong Ik Jang,
Sung-Ae Jung,
Yoon-Tae Jeen,
Jai-Hyun Choi,
Hwang Choi,
Dong-Soo Han,
Jae-Suk Song
[show abstract]
[hide abstract]
ABSTRACT: To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy.
A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) were randomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method, and early (< 12 h) and late bleeding complications (12 h-30 d) were observed.
A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall, bleeding complications occurred in 7.6% (37/486) of the patients, including 4.9% (12/244) in the epinephrine group, and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients, respectively, including 4.5% (11/244), 0.4% (1/244) in the epinephrine group, and 8.7% (21/242), 1.7% (4/242) in the saline group. No significant differences in the rates of overall, early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB.
The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB.
World Journal of Gastroenterology 06/2007; 13(21):2973-7. · 2.47 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Behçet's disease is a chronic, relapsing, systemic inflammatory disease characterized by recurrent oral and genital ulcers, skin lesions, and ocular lesions. Gastrointestinal tract is occasionally involved in Behçet's disease, and the typical gastrointestinal lesions are punched-out, discrete mucosal ulcerations. Corticosteroids, 5-aminosalicylic acid derivatives, thalidomide, and immunomodulators have been used to treat Behçet's disease. Some patients with gastrointestinal Behçet's disease undergo surgical management because of the refractoriness to these medical measures or complications, such as perforation and bleeding. Even after successful surgery, postoperative complications, such as poor healing of the anastomosis site and postoperative ulcer recurrence, are so common that repeated operations are frequently required. However, there have been few reports addressing the most effective way to reduce and treat postoperative complications and recurrences. We describe a patient with Behçet's disease involving the distal ileum, who was treated with infliximab as rescue therapy of an unhealed anastomosis site and early recurrent ulcers after a distal ileocecectomy because of persistent bleeding. Abdominal pain from recurrent ulcers improved by the fifth day after the infliximab infusion and almost disappeared by the second week. An ileocolonoscopy performed 15 days after the infliximab infusion showed near complete healing of the recurrent ulcers. This report suggests that infliximab may be an effective novel therapy for the management of early postoperative complications and recurrences in gastrointestinal Behçet's disease.
Diseases of the Colon & Rectum 06/2007; 50(5):672-6. · 3.13 Impact Factor
-
Tae Woo Yoo,
Dong Il Park,
Young-Ho Kim,
Hyun Soo Kim,
Won Ho Kim,
Tae Il Kim,
Hyo Jong Kim,
Suk-Kyun Yang, Jeong-Sik Byeon,
Moon Sung Lee,
Il Kwon Jung,
Moon Kwan Chung,
Sung-Ae Jung,
Yoon Tae Jeen,
Jai Hyun Choi,
Hwang Choi,
Dong Soo Han,
Jae Suk Song
[show abstract]
[hide abstract]
ABSTRACT: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer. However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality. We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
All colonoscopies were performed at 11 Korean tertiary medical centers, between July 2003 and March 2004. A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm). The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size. 'Cancer' here is defined as the invasion of malignant cells beyond the muscularis mucosa.
As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase. In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001). Interestingly enough, in Group 2, the prevalence of cancer was at least as high as in Group 4 (0.7% vs. 0.5%, p < 0.001).
In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm. Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
Hepato-gastroenterology 04/2007; 54(74):418-21. · 0.66 Impact Factor
-
Sang Hyoung Park,
Young Min Kim,
Suk-Kyun Yang,
Sai-Hui Kim, Jeong-Sik Byeon,
Seung-Jae Myung,
Yun Kyung Cho,
Chang-Sik Yu,
Kwi-Sook Choi,
Jun-Won Chung,
Benjamin Kim,
Kee Don Choi,
Jin-Ho Kim
[show abstract]
[hide abstract]
ABSTRACT: The clinical characteristics of ulcerative colitis (UC) in Asian populations have not been well characterized. We therefore investigated the clinical features and natural history of UC in Korea.
We retrospectively analyzed 304 Korean patients with UC first diagnosed at the Asan Medical Center between June 1989 and August 2005.
The male-to-female ratio of the patients was 0.94:1, and their median age at diagnosis was 40.0 years (range, 12-72 years). At diagnosis, proctitis was noted in 134 patients (44.1%), left-sided colitis in 69 patients (22.7%), and extensive colitis in 101 patients (33.2%). Disease activity at diagnosis was mild in 149 patients (49.0%), moderate in 125 patients (41.1%), and severe in 26 patients (8.6%). In addition, 4 asymptomatic patients (1.3%) were detected as a result of a screening colonoscopy. Clinical remission after the first attack was documented in 97.4% of patients. The cumulative relapse rate after 1, 5, and 10 years was 30.2%, 72.0%, and 88.4%, respectively. The cumulative risk of proximal extension in patients with proctitis or left-sided colitis was 33.0% after 5 years and 44.5% after 10 years. The cumulative probability of colectomy was 2.0% after 1 year, 2.8% after 3 years, and 3.3% after 5 to 15 years. The cumulative survival rate after 1, 5, and 10 years was 100%, 99.4%, and 97.4%, respectively.
The clinical features of Korean UC patients at diagnosis are similar to those of Westerners. However, UC in Koreans may have a milder course than in Westerners, as indicated by the lower rate of colectomy among Koreans.
Inflammatory Bowel Diseases 04/2007; 13(3):278-83. · 4.86 Impact Factor
-
Seong Soo Hong,
Hwoon-Yong Jung,
Kee Don Choi,
Ho June Song,
Gin Hyug Lee,
Tae Hoon Oh,
Ji-Yun Jo,
Kyu-Jong Kim, Jeong-Sik Byeon,
Seung-Jae Myung,
Suk-Kyun Yang,
Weon-Seon Hong,
Jin-Ho Kim,
Young Il Min
[show abstract]
[hide abstract]
ABSTRACT: Primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is known to be successfully treated with anti-Helicobacter pylori (H. pylori) therapy alone. However, there are few reports on long-term results after eradication therapy. The aims of this study were to analyze the rate and the interval to reach complete remission (CR), and to assess the rate and the factors affecting recurrence of MALT lymphoma.
Between 1996 and 2003, a total of 90 H. pylori-infected patients with low-grade MALT lymphoma were included in this study. For initial staging, endoscopic ultrasonography, chest-abdomen-pelvis CT scans, and bone marrow examination were taken. All patients were made to take anti-H. pylori therapy for 14 days. Tumoral response was assessed by endoscopy every 3 months till CR and every 6 months after achieving CR.
Among 90 treated patients, 85 (94.4%) reached CR. The median interval to CR was 3 months (range, 1-24). Seventy-nine (92.9%) patients were in CR at 12 months. Median follow-up period after CR was 45 months (range 15-109). Among 77 patients who were followed-up after CR, 8 (10.4%) patients were proved with recurrence of MALT lymphoma. Cumulative recurrence rate was 2.7, 11.5, and 12.2% at 1, 2, and 3 years. The presence of H. pylori was only a significant risk factor affecting recurrence.
The status of H. pylori is the most important risk factor affecting recurrence. Therefore, adequate eradication regimen and accurate regular evaluation for H. pylori status are needed during follow up of primary gastric low-grade B-cell MALT lymphoma.
Helicobacter 01/2007; 11(6):569-73. · 3.15 Impact Factor
-
Jong Beom Park,
Suk-Kyun Yang, Jeong-Sik Byeon,
Eui-Ryun Park,
Gyoo Moon,
Seung Jae Myung,
Won Kap Park,
Seo Gue Yoon,
Hyun Shig Kim,
Jong Gyun Lee,
Jin Ho Kim,
Young Il Min,
Kwang Yeon Kim
[show abstract]
[hide abstract]
ABSTRACT: Little information is available about the familial aggregation of inflammatory bowel disease (IBD) in Asian populations. We therefore determined the risk of familial aggregation of IBD among first-degree relatives of patients with ulcerative colitis (UC) or Crohn's disease (CD) in an ethnically distinct Korean population.
Familial aggregation of IBD was evaluated in terms of family history, prevalence, lifetime risk, and population relative risk in first-degree relatives of 1440 unrelated patients with UC (n = 1043) or CD (n = 397).
A positive first-degree family history of IBD was observed in 27 probands (1.88%): 21 of 1043 (2.01%) with UC and 6 of 397 (1.51%) with CD. The crude prevalence of IBD in first-degree relatives of probands with IBD was 0.31%. The lifetime risk of IBD was 0.54% in all first-degree relatives of IBD probands, 0.52% in UC probands, and 0.67% in CD probands, with overall lifetime relative risks of 0.12% in parents, 0.79% in siblings, and 1.43% in offspring. The age- and sex-adjusted population relative risk of IBD was 13.8 in first-degree relatives of probands with IBD.
Although a positive family history, prevalence, and lifetime risk of IBD among first-degree relatives of Korean IBD patients are much lower than among relatives of Western patients, the population relative risk in first-degree relatives is about equal in Koreans and Westerners. This finding indicates that a positive family history is an important risk factor for IBD in Koreans and in Westerners.
Inflammatory Bowel Diseases 01/2007; 12(12):1146-51. · 4.86 Impact Factor
-
Ji-Yun Jo, Jeong-Sik Byeon,
Kee Don Choi,
Hye Won Park,
Gin Hyug Lee,
Seung-Jae Myung,
Hwoon-Yong Jung,
Suk-Kyun Yang,
Weon-Seon Hong,
Jin-Ho Kim,
Hyun Kwon Ha
[show abstract]
[hide abstract]
ABSTRACT: The role of double balloon enteroscopy (DBE) is still evolving. The aim of this study was to compare the diagnostic yield of DBE with that of small bowel series (SBS).
We enrolled patients with suspected small bowel disease consecutively, and performed both DBE and SBS in all patients.
Eighteen patients (M:F=12:6, 14-82 years) were included. Indications for small bowel evaluation were obscure gastrointestinal bleeding (10), abdominal pain (5), diarrhea (2) and abnormal CT finding (1). Of 10 obscure gastrointestinal bleeding patients, 6 showed the same findings in both studies. However, 4 showed negative findings in SBS while DBE detected erosions or ulcerations. Of 5 abdominal pain patients, 3 showed the same results in both studies. However, 2 demonstrated different results. One was suspected of early Crohn's disease in SBS, but proved to be normal in DBE, and the other was suspected of malignancy in SBS but was suspected of benign ulcers in DBE. Of 2 chronic diarrhea patients, one was diagnosed as Crohn's disease in both studies. The other was suspected of tuberculosis in SBS but diagnosed as lymphangiectasia by DBE with biopsy. One patient with jejunal wall thickening in CT proved to be normal in both DBE and SBS. There were no serious complications associated with DBE and SBS.
DBE is better than SBS in terms of diagnostic accuracy. DBE may become an important method for the evaluation of small bowel diseases.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 08/2006; 48(1):25-31.
-
Seong Ho Park,
Hyun Kwon Ha,
Ah Young Kim,
Kyoung Won Kim,
Moon-Gyu Lee,
Pyo Nyun Kim,
Yong Moon Shin, Jeong-Sik Byeon,
Suk-Kyun Yang,
Jin Ho Kim,
Young Il Min
[show abstract]
[hide abstract]
ABSTRACT: OBJECTIVE: This study evaluates the ability of contrast-enhanced, 16-MDCT colonography to display flat colonic lesions when a very narrow slice thickness (1 mm) is used. CONCLUSION: Less than 50% of flat lesions in our population could be visualized by blinded and unblinded review. Before they could be visualized, flat lesions were 2 mm or greater in height and 7 mm or greater in diameter. Lesions with a height of 1 mm or less were not seen on CT colonography. Contrast enhancement, location on a haustral fold, and abnormal 2D and 3D morphology contributed to lesion conspicuity.
American Journal of Roentgenology 07/2006; 186(6):1611-7. · 2.78 Impact Factor
-
Gastrointestinal Endoscopy 06/2006; 63(6):886-8. · 4.88 Impact Factor
