Jong Wook Kim

Inje University, Kŭmhae, Gyeongsangnam-do, South Korea

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Publications (105)199.98 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to compare the clinical and microbiological characteristics between acute bacterial prostatitis and transrectal biopsy-related acute prostatitis. We retrospectively reviewed the records of 135 patients hospitalized for acute prostatitis in three urological centers between 2004 and 2013. Acute bacterial prostatitis was diagnosed according to typical symptoms, findings of physical examination, and laboratory test results. Clinical variables, laboratory test results, and anti-microbial susceptibility results were reviewed. Patients were classified into the spontaneous acute prostatitis group (S-ABP) or biopsy-related acute prostatitis (Bx-ABP) for comparison of their clinical, laboratory, and microbiological findings. The mean age of all patients was 61.7 ± 12.9 years. Compared with S-ABP patients, Bx-ABP patients were significantly older, had larger prostate volumes, higher PSA values, higher peak fever temperatures, and higher incidence of septicemia and antibiotic-resistant bacteria. Overall, of the 135 patients, 57.8% had positive bacterial urine and/or blood cultures. Bx-ABP patients had a higher incidence of bacterial (urine and/or blood) positive cultures compared to S-ABP patients (66.7% versus 55.6%). Escherichia coli was the predominant organism in both groups, but it was more common in Bx-ABP (88.9%) than in S-ABP (66.7%). Extended spectrum beta-lactamase -producing bacteria accounted for 64.7% of culture-positive patients in the Bx-ABP group compared to 13.3% in the S-ABP group. Bx-ABP patients showed a higher incidence of septicemia and antibiotic-resistant bacteria than S-ABP patients. These results have important implications for the management and antimicrobial treatment of Bx-ABP, which may well deserve to be considered a distinct prostatitis category. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
    Journal of Infection and Chemotherapy 02/2015; DOI:10.1016/j.jiac.2015.01.014 · 1.38 Impact Factor
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    ABSTRACT: Both testosterone therapy and chronic treatment with phosphodiesterase type 5 inhibitors (PDE5Is) have positive effects on the histology of penile corpora and erectile function. However, few clinical studies have evaluated the efficacy of combination therapy with both testosterone replacement and chronic PDE5Is. This study was designed to evaluate the efficacy and safety of combination treatment with long-acting injectable testosterone undecanoate (TU) and a once-daily tadalafil 5 mg for erectile dysfunction with testosterone deficiency syndrome. Sixty patients were consecutively enrolled and followed for 36 weeks. Thirty patients were randomly assigned to group I and received 1,000 mg of parenteral TU on day 1, followed by additional injections at weeks 6 and 18 with on-demand tadalafil 10-20 mg during the 30 weeks of treatment. The remaining 30 patients received the same dose and schedule of TU as group I, and were prescribed once-daily tadalafil 5 mg during 30 weeks. Serological tests were performed, and the International Index of Erectile Function (IIEF), Aging Males' Symptoms (AMS) questionnaires, and Global Assessment Question (GAQ) were administered to the patients. Total IIEF and AMS scores were significantly improved during the 30 weeks of treatment in both groups. When IIEF scores were compared between the two groups, group II showed better symptom scores than group I at weeks 6 and 30. A similar pattern was observed when comparing AMS scores between the groups. At week 36, changes in IIEF and AMS scores that indicated worsened symptoms compared with week 30 were observed in both groups; group II showed better symptom scores than group I. On the GAQ, the ratio of patients reporting improvement in erectile function was significantly higher in group II than group I. The combination of long-acting injectable TU and once-daily tadalafil 5 mg produced a significant improvement in erectile function. Moreover, the improvement in erectile function was well maintained, even after the cessation of treatment. Park MG, Yeo JK, Cho D-Y, Kim JW, Kim JW, Oh MM, Kim JJ, and Moon DG. The efficacy of combination treatment with injectable testosterone undecanoate and daily tadalafil for erectile dysfunction with testosterone deficiency syndrome. J Sex Med **;**:**-**. © 2015 International Society for Sexual Medicine.
    Journal of Sexual Medicine 02/2015; DOI:10.1111/jsm.12842 · 3.15 Impact Factor
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    ABSTRACT: Adequate screening colonoscopy in the general population decreases the mortality associated with colorectal cancer through detection and removal of adenomatous polyps. Prolonged colonoscopic withdrawal times (>6 min) are reportedly beneficial for adenoma detection rates (ADRs). However, the quality of the endoscopist compared with colonoscopic withdrawal times is not known. The aims of this study were to investigate the difference in ADRs between trainees and experienced examiners. A total of 967 consecutive patients who underwent screening colonoscopy in a single University hospital from June 2010 to November 2011 were enrolled in this prospective observational study. Colonoscopy was performed by four experienced staff and seven gastroenterology fellows. Seven gastroenterology fellows performed 633 colonoscopies and four experienced staff performed 334 colonoscopies. The overall detection rates of colorectal adenoma were 31.5% with ADRs of fellows and staff of 29.4% and 35.6%, respectively (p=0.047). Fellows also showed lower advanced ADRs (5.7% vs. 9.9%, p=0.016), and fellows had longer mean withdrawal times than staff (12.4±B1;4.9 min vs. 8.2±B1;4.1 min, p<0.001). Multivariate analysis showed significantly increased ADRs and advanced ADRs for staff compared with fellows (adjusted OR 2.41, 95% CI 1.70-3.43; adjusted OR 2.55, 95% CI 1.47-4.45, respectively). ADRs were significantly lower when colonoscopy was performed by trainees, although withdrawal times were longer than those of staff. Our results demonstrated that the quality of colonoscopy, as measured by ADRs, may be improved by experienced examiners. (Korean J Gastroenterol 2014;64:278-283).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 11/2014; 64(5):278-83. DOI:10.4166/kjg.2014.64.5.278
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    ABSTRACT: Background and Aims Although some ulcerative colitis (UC) patients are diagnosed when they do not have any UC-related symptoms, clinical features and prognosis of UC diagnosed in asymptomatic patients remain unclear. Methods Data for UC patients who were asymptomatic at diagnosis were retrospectively reviewed from the IBD database of the Asan Medical Center. The clinical characteristics and prognosis of those patients were analyzed and compared with matched (1:4) symptomatic UC patients. Results Only nineteen asymptomatic UC patients (1.1%) were identified from 1665 UC patients. The proportion of males was 78.9% (n = 15), and their median age at diagnosis was 48 years (range, 34–71 years). At diagnosis, proctitis was noted in 11 patients (57.9%), left-sided colitis in 4 (21.1%), extensive colitis in 0 (0%), and atypical distribution in 4 (21.1%). The 5-year cumulative probability of symptom development was 68.5% (95% confidence interval [CI], 62.8%–74.2%). After UC diagnosis, oral 5-aminisalicylic acid (ASA) and topical 5-ASA were used in 14 (73.7%) and 16 (84.2%) patients, respectively. During follow-up (3.7-year median for asymptomatic patients versus 3.7-year median for symptomatic patients; P = 0.961), the 5-year cumulative probability of corticosteroids (23.7% versus 57.1%; P = 0.022) and azathioprine (0% versus 24.7%; P = 0.003) use was higher in symptomatic patients than in asymptomatic patients. Conclusions The frequency of asymptomatic UC patients was 1.1% in our UC patient cohort. A majority of these patients became symptomatic during follow-up. Asymptomatic UC patients at diagnosis appear to have a better prognosis than symptomatic UC patients.
    Journal of Crohn s and Colitis 10/2014; 8(10). DOI:10.1016/j.crohns.2014.03.002 · 3.56 Impact Factor
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    ABSTRACT: The aim of this study was to compare the survival in elderly hepatocellular carcinoma (HCC) patients treated with curative modalities (radiofrequency ablation (RFA), percutaneous ethanol injection (PEIT) and surgery) to those treated with transcatheter arterial chemoembolization (TACE) and supportive care. Medical records of patients with HCC older than 75 years who had visited a single tertiary medical center from January 2000 to December 2011 were reviewed (n = 58). Multivariable-adjusted hazard ratios (HR) for mortality with 95% confidence intervals (CI) were estimated using Cox proportional hazard models. Twenty-nine patients were treated by TACE, 19 patients by supportive care, and 10 patients by curative treatment (four by PEIT, three by surgery and three by RFA).Variables associated with increased survival were better Child-Pugh class and lower TNM stage. Treatment with curative intent showed significant survival benefit compared to TACE (HR for mortality, 0.10; 95% CI, 0.01-0.95). In a subgroup analysis among patients with resectable HCC, supportive care showed significantly worse survival over TACE (HR for mortality, 6.47; 95% CI, 2.14-19.56) and curative intent (HR for mortality, 16.23; 95% CI, 1.92-136.83). Curative treatment seems to have a better survival benefit in comparison with other treatment modalities in elderly HCC patients.
    Hepato-gastroenterology 10/2014; 61(135):2001-8. DOI:10.5754/hge13659 · 0.91 Impact Factor
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    ABSTRACT: Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia. Clostridium difficile infection (CDI) is a common nosocomial diarrheal disease. Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI. The use of broad-spectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome. Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI. Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation.
  • 09/2014; 42(6). DOI:10.1007/s00240-014-0709-5
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    ABSTRACT: Objective To assess the risk factor that influences bladder stone formation in patients with benign prostatic hyperplasia (BPH). Materials and Methods We reviewed the data of 271 consecutive patients with BPH who underwent transurethral resection of the prostate between January 2008 and December 2012. Patients were classified into 2 groups based on the presence of a bladder stone: Group 1 had a bladder stone and group 2 did not. Univariate analysis was performed to determine the association between the presence of bladder stone and the patients' age, body mass index, International Prostate Symptom Score, total prostate volume (TPV), transitional zone volume, intravesical prostatic protrusion (IPP), uroflow parameters, and urodynamic parameters. Results The overall rate of bladder stone in patients with BPH was 9.9%. The patients' body mass index, International Prostate Symptom Score, and urodynamic parameters did not significantly differ between the 2 groups. The patients' age, TPV, transitional zone volume, and IPP were all significantly higher and the Qmax was significantly lower in group 1 than that in group 2. Multivariate analysis revealed that age (hazard ratio [HR] = 1.089; P = .020), IPP (HR = 1.145; P <.001), and Qmax (HR = 0.866; P = .019) significantly affected the presence of bladder stone in patients with BPH. A predictive model using logistic regression for bladder stone in BPH patients was defined as follows: probability = 1/[1 + exp (−8.499 + 0.085 (age) + 0.009 (TPV) + 0.136 (IPP) − 0.143 (Qmax))] with area under the curve of 0.850 obtained from the receiver operating characteristic curve analysis. Conclusion This study demonstrated that older age, longer IPP, and lower Qmax are independent factors that associated with the presence of bladder stone in patients with BPH.
    Urology 09/2014; 84(5). DOI:10.1016/j.urology.2014.06.038 · 2.13 Impact Factor
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    ABSTRACT: Large direct human impacts on the Yeongsan River resulting from the construction of two large weirs on the main stream, and dredging of almost all sections of the main river has occurred in the past 5 years. Subsequent to these human impacts, some problems related to the sediment budget, such as channel changes, have occurred. To evaluate the dominant source of suspended sediment in the Yeongsan River, three time-integrated suspended-sediment samplers were installed in the upper and middle Yeongsan River (YS-S1, -S2, and -S3), and we obtained suspended-sediment samples every month. Potential sources of the suspended sediment were sampled using a soil scraper on the forest floor and channel bank. Source fingerprinting was conducted using 137Cs, which exhibits distinguishable characteristics of surface and subsurface (bank) materials. Probability distribution functions fit to the detected values of 137Cs at the forest floor and channel bank were derived. The relative contributions of forest floor and bank materials to suspended sediment in the Yeongsan River were calculated using Monte Carlo simulation and a simple mixing model, and the results indicated that the dominant source of suspended sediment was bank materials. Dredging a riverbed and constructing river-crossing facilities can affect the channel in many ways, but it remains unclear from this study how much the human impacts influenced channel erosion due to the absence of pre-interference data. However, this study may contribute to planning prevention measures for sediment problems induced by human impacts in the Yeongsan River catchment. Additionally, to reduce the uncertainty and limitations of the 137Cs methodology, a multi-fingerprinting approach using geochemical analysis, various radionuclides, and so forth is needed for better spatial and temporal evaluation of the sediment sources.
    Quaternary International 09/2014; 344:64–74. DOI:10.1016/j.quaint.2014.05.033 · 2.13 Impact Factor
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    ABSTRACT: This study was performed to investigate the discomfort reported by patients taking phosphodiesterase type 5 inhibitors (PDE5Is) in clinical practice.
    08/2014; 32(2):69-75. DOI:10.5534/wjmh.2014.32.2.69
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    ABSTRACT: Previous reports have described several associations of PR, QRS, QT and heart rate with genomic variations by genome-wide association studies (GWASs). In the present study, we examined the association of ∼2.5 million SNPs from 2,994 Japanese healthy volunteers obtained from the JPDSC database with electrocardiographic parameters. We confirmed associations of PR interval, QRS duration, and QT interval in individuals of Japanese ancestry with 11 of the 45 SNPs (6 of 20 for QT, 5 of 19 for PR and 0 of 6 for QRS) observed among individuals of European, African, and Asian (Indian and Korean) ancestries. Those results indicate that many of the electrocardiographic associations with genes are shared by different ethnic groups including Japanese. Possible novel associations found in this study were validated by Korean data. As a result, we identified a novel association of SNP rs4952632[G] (maps near SLC8A1, sodium-calcium exchanger) (P=7.595 X 10(-6)) with PR interval in Japanese individuals, and replication testing among Koreans confirmed the association of the same SNP with prolonged PR interval. Meta-analysis of the Japanese and Korean datasets demonstrated highly significant associations of SNP rs4952632[G] with a 2.325-msec (95%CI, 1.693-2.957 msec) longer PR interval per minor allele copy (P=5.598 X 10(-13)). Cell-type specific SLC8A1 knockout mice have demonstrated a regulatory role of sodium-calcium exchanger in automaticity and conduction in sinoatrial node, atrium, and atrioventricular node. Our findings support a functional role of sodium-calcium exchanger in human atrial and atrioventricular nodal conduction as suggested by genetically-modified mouse models.
    Human Molecular Genetics 07/2014; DOI:10.1093/hmg/ddu375 · 6.68 Impact Factor
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    ABSTRACT: The electrocardiogram has several advantages in detecting cardiac arrhythmia - it is readily available, noninvasive, and cost-efficient. Recent genome-wide association studies have identified single nucleotide polymorphisms that are associated with electrocardiogram measures. We performed a genome-wide association study using Korea Association Resource data for the discovery phase (phase 1, n=6,805) and 2 consecutive replication studies in Japanese populations (phase 2, n=2,285; phase 3, n=5,010) for QRS duration and PR interval. Three novel loci were identified: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration, and rs17026156 (SLC8A1 locus) correlated with PR interval. PRDM16 was recently identified as a causative gene of left ventricular noncompaction and dilated cardiomyopathy in 1p36 deletion syndrome, which is characterized by heart failure, arrhythmia, and sudden cardiac death. Thus, our finding that a PRDM16 SNP is linked to QRS duration strongly implicates PRDM16 in cardiac function. In addition, C allele of rs17026156 increases PR interval (beta±se, 2.39±0.40 ms) and exist far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively).
    Human Molecular Genetics 07/2014; DOI:10.1093/hmg/ddu374 · 6.68 Impact Factor
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    ABSTRACT: Introduction: Fibrotic scar formation is a main cause of recurrent urethral stricture after initial management with direct vision internal urethrotomy (DVIU). In the present study, we devised a new technique of combined the transurethral resection of fibrotic scar tissue and temporary urethral stenting, using a thermo-expandable urethral stent (Memokath(TM) 044TW) in patients with anterior urethral stricture. Materials and Methods: As a first step, multiple incisions were made around stricture site with cold-utting knife and Collins knife electrode to release a stricture band. Fibrotic tissue was then resected with a 13Fr pediatric resectoscope before deployment of a MemokathTM 044TW stent (40 - 60mm) on a pre-mounted sheath using 0° cystoscopy. Stents were removed within12 months after initial placement.
    International braz j urol: official journal of the Brazilian Society of Urology 07/2014; 40(4):576-577. DOI:10.1590/S1677-5538.IBJU.2014.04.20
  • Gastroenterology 05/2014; 146(5):S-221. DOI:10.1016/S0016-5085(14)60783-6 · 13.93 Impact Factor
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    ABSTRACT: The optimal colon-cleansing method after failure of bowel preparation (BP) for colonoscopy has not been established. We aimed to compare BP rescue methods after failed initial BP and to identify risk factors for rescue BP failure. Eighty-five patients with BP failure after 4 L polyethylene glycol (PEG) ingestion were prospectively enrolled from March 2008 to March 2012. A second colonoscopy was performed either on the same day after ingestion of another 2 L PEG (group A) or 1 week later after ingestion of 4 L PEG plus 20 mg oral bisacodyl (group B). Differences between groups in terms of BP quality and risk factors for a poor BP on the second colonoscopy were investigated. Median patient age was 59 years, 45 were male (52.9 %), and 17 (20 %) had poor BP on the second colonoscopy. For group B, the multivariable-adjusted odds ratio (OR) for poor BP on the second colonoscopy relative to group A was 0.68 (95 % confidence interval [CI], 0.16-2.95). Adequately ingested PEG during the initial colonoscopy was associated with poor BP on the second colonoscopy (OR 4.05; 95 % CI 1.04-15.75). The two groups had similar patient discomfort rates during the second BP. The two groups did not differ in rescue BP failure rate. Initial BP failure after adequate consumption of 4 L PEG may be a risk factor for rescue BP failure. A stricter BP regimen should be considered for these patients.
    Digestive Diseases and Sciences 04/2014; 59(9). DOI:10.1007/s10620-014-3125-3 · 2.26 Impact Factor
  • 04/2014; 42(4). DOI:10.1007/s00240-014-0663-2
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    ABSTRACT: Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased. Conclusion Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.
    Urology 04/2014; 83(4):837–842. DOI:10.1016/j.urology.2013.12.060 · 2.13 Impact Factor
  • The Journal of Urology 04/2014; 191(4):e409-e410. DOI:10.1016/j.juro.2014.02.1275 · 3.75 Impact Factor
  • The American surgeon 04/2014; 80(4):114-115. · 0.92 Impact Factor
  • The Journal of Urology 04/2014; 191(4):e739. DOI:10.1016/j.juro.2014.02.2043 · 3.75 Impact Factor

Publication Stats

472 Citations
199.98 Total Impact Points


  • 2013–2014
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
    • Inje University Paik Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Korea University
      • • College of Medicine
      • • Department of Urology
      Sŏul, Seoul, South Korea
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
    • Catholic University of Korea
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
    • Kwandong University
      • College of Medicine
      Gangneung, Gangwon, South Korea
    • Korea Centers for Disease Control and Prevention
      Daiden, Daejeon, South Korea
  • 1999–2014
    • Seoul National University
      • • Department of Geography Education
      • • Department of Biosystems and Biomaterials Science and Engineering
      • • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Gangneung Asan Hospital
      Sŏul, Seoul, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2010–2012
    • Pusan National University
      • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2008–2012
    • Asan Medical Center
      • Department of Gastroenterology
      Sŏul, Seoul, South Korea
    • Cheongju University
      Sŏul, Seoul, South Korea
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2007–2011
    • Korea Institute of Energy Research
      • Energy R&D Strategy and Policy Research Division
      Sŏul, Seoul, South Korea
    • Arizona State University
      Phoenix, Arizona, United States
  • 2005–2010
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea
  • 2004–2007
    • Inha University
      • • Department of Biochemistry
      • • College of Medicine
      Seoul, Seoul, South Korea