Jennifer J Brady

Publications (1)4.26 Total impact

• Source

  Available from: Michael Hutchinson

  Article: A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers.

  Aideen C Allen, Siobhan Kelly, Sharee A Basdeo, Katie Kinsella, Keith J Mulready, Kingston Hg Mills, Niall Tubridy, Cathal Walsh, Jennifer J Brady, Michael Hutchinson, Jean M Fletcher
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  ABSTRACT: Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.
  Multiple Sclerosis 03/2012; · 4.26 Impact Factor