A.K. Saxena

Publications (2)5.38 Total impact

• Source

  Available from: arvind singh Negi

  Article: Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization

  A.P. Prakasham, A.K. Saxena, Suaib Luqman, Debabrata Chanda, Tandeep Kaur, Atul Gupta, D.K.Yadav, C.S. Chanotiya, Karuna Shanker, F. Khan, Arvind S. Negi
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  ABSTRACT: In an attempt to discover a potent and selective anticancer agent, gallic acid has been modified to ben- zylidene indanones as tubulin polymerization inhibitors. These compounds were evaluated against sev- eral human cancer cell lines and also evaluated for inhibition of tubulin polymerase in in vitro assays. Three of the analogues exhibited strong cytotoxicity against human cancer cell lines IC 50 = 10–880 nM and also showed tubulin polymerization inhibition (IC 50 = 0.62–2.04 lM). Compound 9j, the best candi- date of the series was found to be non-toxic in acute oral toxicity in Swiss-albino mice up to 1000 mg/kg dose.
  Bioorganic & Medicinal Chemistry Letters 04/2012; · 2.55 Impact Factor
• Source

  Available from: Prakasham A P

  Article: Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization.

  A P Prakasham, A K Saxena, Suaib Luqman, Debabrata Chanda, Tandeep Kaur, Atul Gupta, D K Yadav, C S Chanotiya, Karuna Shanker, F Khan, Arvind S Negi
  [show abstract] [hide abstract]
  ABSTRACT: In an attempt to discover a potent and selective anticancer agent, gallic acid has been modified to benzylidene indanones as tubulin polymerization inhibitors. These compounds were evaluated against several human cancer cell lines and also evaluated for inhibition of tubulin polymerase in in vitro assays. Three of the analogues exhibited strong cytotoxicity against human cancer cell lines IC(50)=10-880 nM and also showed tubulin polymerization inhibition (IC(50)=0.62-2.04 μM). Compound 9j, the best candidate of the series was found to be non-toxic in acute oral toxicity in Swiss-albino mice up to 1000 mg/kg dose.
  Bioorganic & medicinal chemistry 03/2012; 20(9):3049-57. · 2.82 Impact Factor