Young Seok Kim

Sejong University, Sŏul, Seoul, South Korea

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Publications (264)536.51 Total impact

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    ABSTRACT: This study reports the emitting materials based on phenylanthracene-substituted naphthalene derivatives to achieve efficient electroluminescent properties for OLED applications. An OLED device using 4,4′-bis(10-phenylanthracen-9-yl)-1,1′-binaphthalene exhibited the blue emission with the CIE coordinates of (0.19, 0.16) and efficient electroluminescent properties with the luminance, power and external quantum efficiency of 1.70 cd/A, 0.79 lm/W and 1.26% at 20 mA/cm2, respectively. Also, the other device using 1,4-bis(10-phenylanthracene-9-yl)naphthalene exhibited white emission with the CIE coordinates of (0.34, 0.43) at 7 V, respectively. This device exhibits the luminance, power and external quantum efficiency of 2.22 cd/A, 1.13 lm/W and 0.86% at 20 mA/cm2, respectively.
    Journal of Luminescence 09/2015; 165:99-104. DOI:10.1016/j.jlumin.2015.04.029 · 2.37 Impact Factor
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    ABSTRACT: In this work, we used the Suzuki cross-coupling reaction to synthesize the following two emitting materials: 1,3-bis(10-phenylanthracen-9-yl)benzene (1) and 2,6-bis(10-phenylanthracen-9-yl)pyridine (2). To investigate the electroluminescent (EL) properties of these materials, multilayered organic light-emitting diodes (OLEDs) devices were fabricated in the following sequence: indium-tin-oxide (ITO) (180 nm)/4,4′-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (NPB) (50 nm)/emitting materials (1 and 2) (40 nm)/tris(8-hydroxyquinolinato)aluminium (Alq3) (15 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm). Of special significance, a device using 1 as an emitting material showed a white emission with maximum luminance, luminous, power, and external quantum efficiency values of 1727 cd/m2, 1.74 cd/A, 0.78 lm/W, and 0.67% at 20 mA/cm2, respectively, as well as CIE coordinates of (0.31, 0.44) at 7 V. Another device using 2 exhibited a sky-blue emission with maximum luminance, luminous, power, and external quantum efficiency values of 2279 cd/m2, 1.95 cd/A, 0.97 lm/W, and 0.93% at 20 mA/cm2, respectively as well as CIE coordinates of (0.24, 0.29) at 7 V.
    Journal of Photochemistry and Photobiology A Chemistry 09/2015; 310. DOI:10.1016/j.jphotochem.2015.05.027 · 2.50 Impact Factor
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    ABSTRACT: In this study, we have designed and synthesized blue emitters based on fluoranthene and triphenylene via Diels-Alder reaction. To investigate EL properties, multilayered OLEDs were fabricated by using these materials as emitting materials. The device structure was ITO / NPB / (50 nm) / Blue emitting materials (30 nm) / Bphen (30 nm) / Liq (2 nm) / Al. In particular, a device showed blue EL properties with luminous, power, and external quantum efficiencies of 2.34 cd/A, 1.18 lm/W, 1.36% at 20 mA/cm2, and the CIE coordinates of (0.17, 0.23) at 6 V, respectively. The balanced charge injection properties of devices as well as the nonplanar structures of the emitting materials have the profound effects on the EL efficiencies.
    Synthetic Metals 08/2015; 206:124-130. DOI:10.1016/j.synthmet.2015.05.020 · 2.22 Impact Factor
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    ABSTRACT: Under-recognition and under-treatment of chronic hepatitis C virus (HCV) infection is an important determinant of the disease outcome. The aim of this study was to investigate the treatment rate and factor of initiation of interferon-based antiviral treatment for chronic hepatitis C patients in a prospective, multicenter Korean HCV cohort. Treatment-naïve 759 patients with chronic HCV infection were prospectively followed from January 2007 to January 2013 at six university hospitals during a median (interquartile range) follow-up of 769 (76-1,427) days. The subjects consisted of patients with chronic hepatitis C (n = 553, 72.9%), liver cirrhosis (n = 127, 16.7%), and hepatocellular carcinoma (n = 79, 10.4%), and were treated usually using pegylated interferon alpha and ribavirin. Treatment initiation rate and its related factors were analysed. The initiation rate of antiviral treatment was 37.3% (n = 273), and the cumulative probability of treatment initiation over 5 years was 39.4%. Multivariate analysis showed that age < 58 years (hazard ratio [HR] = 1.588, 95% CI = 1.151-2.193), job employment (HR = 1.737, 95% CI = 1.279-2.363), absence of HCC (chronic hepatitis, HR = 2.534, 95% CI = 1.003-6.400; liver cirrhosis, HR = 2.873, 95% CI = 1.101-7.494), alanine transaminase (ALT) > 40 IU/L (HR = 1.682, 95% CI = 1.228-2.303), and genotype 2 (HR = 1.364, 95% CI = 1.034-1.798) were independent factors related to treatment initiation. Interferon-based antiviral treatment was initiated in more than one third of chronic HCV infected patients visiting university hospitals, who were young, employed, HCV genotype 2, and with abnormal ALT without HCC, in Korea. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Medical Virology 07/2015; DOI:10.1002/jmv.24335 · 2.22 Impact Factor
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    ABSTRACT: Reconstruction of oropharyngeal defects after resection of oropharyngeal cancer is a significant challenge. The purpose of this study is to introduce reconstruction using a combination of a buccinator myomucosal flap and a buccal fat pad flap after cancer excision and to discuss the associated anatomy, surgical procedure, and clinical applications. In our study, a combination of a buccinator myomucosal flap with a buccal fat pad flap was utilized for reconstruction after resection of oropharyngeal cancer, performed between 2013 and 2015. After oropharyngectomy, the defect with exposed vital structures was noted. A buccinator myomucosal flap was designed and elevated after an assessment of the flap pedicle. Without requiring an additional procedure, a buccal fat pad flap was easily harvested in the same field and gently pulled to obtain sufficient volume. The flaps were rotated and covered the defect. In addition, using cadaver dissections, we investigated the feasibility of transposing the flaps into the lateral oropharyngeal defect. The reconstruction was performed in patients with squamous cell carcinoma. The largest tumor size was 5 cm×2 cm (length×width). All donor sites were closed primarily. The flaps were completely epithelialized after four weeks, and the patients were followed up for at least six months. There were no flap failures or postoperative wound complications. All patients were without dietary restrictions, and no patient had problems related to mouth opening, swallowing, or speech. A buccinator myomucosal flap with a buccal fat pad flap is a reliable and valuable option in the reconstruction of oropharyngeal defects after cancer resection for maintaining functionality.
    Archives of Plastic Surgery 07/2015; 42(4):453-60. DOI:10.5999/aps.2015.42.4.453
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    ABSTRACT: . To investigate whether combined chemoradiotherapy (CTRT) confers a benefit for survival outcome over radiotherapy (RT) alone after primary surgery in patients with FIGO stage IIIC endometrial adenocarcinoma . . We conducted a multicenter retrospective study of patients with surgical stage IIIC endometrial cancer from 1990 to 2011. Adjuvant RT alone was performed in 85 patients (40.3%) and adjuvant CTRT in 126 patients (59.7%). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method and Cox proportional hazards model RESULTS: . Stage IIIC1 and stage IIIC2 accounted for 63% and 37%, respectively. FIGO IIIC2 had a higher recurrence rate than FIGO IIIC1 (38.5% vs. 29.3%, p=0.172). Five-year OS and DFS were lower in FIGO IIIC2 than FIGO IIIC1 (85.1% vs. 76.9%, p=0.417; 71.0% vs. 59.2%, p=0.108, respectively). Eighteen patients (13.5%) in stage IIIC1 developed PALN recurrence, whereas only one (3.3%) in stage IIIC2 had PALN recurrence (p=0.001). In multivariate analysis, predictors of DFS were parametrial invasion (HR, 3.49; 95%CI, 1.83-6.64; p<0.001), higher grade (HR, 2.78; 95%CI,1.31-5.89; p=0.008), and >3 positive pelvic nodes (HR, 1.84; 95%CI, 1.11-3.05; p=0.019). Combined CTRT did not affect DFS or OS in IIIC1 and IIIC2 compared with RT alone. Conclustion. CTRT showed comparable survival outcome to RT alone. Half of relapses (46%) in stage IIIC1 occurred in PALN region, whereas relapse in stage IIIC2 primarily occurred in distant metastasis (90%). Future randomized studies are needed to determine which subgroup may be most likely to benefit from CCRT. Copyright © 2015. Published by Elsevier Inc.
    Gynecologic Oncology 06/2015; DOI:10.1016/j.ygyno.2015.06.030 · 3.69 Impact Factor
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    ABSTRACT: The predictive role of contrast-enhanced ultrasonography (CEUS) before performing transarterial chemoembolization (TACE) has not been determined. We assessed the possible predictive factors of CEUS for the response to TACE. Seventeen patients with 18 hepatocellular carcinoma (HCC) underwent TACE. All of the tumors were studied with CEUS before TACE using a second-generation ultrasound contrast agent (SonoVue®, Bracco, Milan, Italy). The tumor response to TACE was classified with a score between 1 and 4 according to the remaining enhancing-tumor percentage based on modified response evaluation criteria in solid tumors (mRECIST): 1, enhancing tumor <25%; 2, 25%≤enhancing tumor<50%; 3, 50%≤enhancing tumor<75%; and 4, enhancing tumor≥75%). A score of 1 was defined as a "good response" to TACE. The predictive factors for the response to TACE were evaluated during CEUS based on the maximum tumor diameter, initial arterial enhancing time, arterial enhancing duration, intensity of arterial enhancement, presence of a hypoenhanced pattern, and the feeding artery to the tumor. The median tumor size was 3.1 cm. The distribution of tumor response scores after TACE in all tumors was as follows: 1, n=11; 2, n=4; 3, n=2; and 4, n=1. Fifteen tumors showed feeding arteries. The presence of a feeding artery and the tumor size (≤5 cm) were the predictive factors for a good response (P=0.043 and P=0.047, respectively). The presence of a feeding artery and a tumor size of less than 5 cm were the predictive factors for a good response of HCC to TACE on CEUS.
    Clinical and molecular hepatology 06/2015; 21(2):158-64. DOI:10.3350/cmh.2015.21.2.158
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    ABSTRACT: The functional inactivation of TP53 and Rb tumor suppressor proteins by the HPV-derived E6 and E7 oncoproteins is likely an important step in cervical carcinogenesis. We have previously shown siRNA technology to selectively silence both E6/E7 oncogenes and demonstrated that the synthetic siRNAs could specifically block its OPEN ACCESS Int. J. Mol. Sci. 2015, 16 12244 expression in HPV-positive cervical cancer cells. Herein, we investigated the potentiality of E6/E7 siRNA candidates as radiosensitizers of radiotherapy for the human cervical carcinomas. HeLa and SiHa cells were transfected with HPV E6/E7 siRNA; the combined cytotoxic effect of E6/E7 siRNA and radiation was assessed by using the cell viability assay, flow cytometric analysis and the senescence-associated β-galactosidase (SA-β-Gal) assay. In addition, we also investigated the effect of combined therapy with irradiation and E6/E7 siRNA intravenous injection in an in vivo xenograft model. Combination therapy with siRNA and irradiation efficiently retarded tumor growth in established tumors of human cervical cancer cell xenografted mice. In addition, the chemically-modified HPV16 and 18 E6/E7 pooled siRNA in combination with irradiation strongly inhibited the growth of cervical cancer cells. Our results indicated that simultaneous inhibition of HPV E6/E7 oncogene expression with radiotherapy can promote potent antitumor activity and radiosensitizing activity in human cervical carcinomas.
    International Journal of Molecular Sciences 05/2015; 16(6):12243-12260. DOI:10.3390/ijms160612243 · 2.86 Impact Factor
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    ABSTRACT: Mechanisms associated with the progression of non-alcoholic fatty liver disease (NAFLD) remain unclear. We attempted to identify the pattern of altered gene expression at different time points in a high fat diet (HFD)-induced NAFLD mouse model. The early up-regulated genes are mainly involved in the innate immune responses, while the late up-regulated genes represent the inflammation processes. Although recent studies have shown that microRNAs play important roles in hepatic metabolic functions, the pivotal role of microRNAs in the progression of NAFLD is not fully understood. We investigated the functions of miR-451, which was identified as a target gene in the inflammatory process in NAFLD. miR-451 expression was significantly decreased in the palmitate (PA)-exposed HepG2 cells and in liver tissues of HFD-induced non-alcoholic steatohepatitis (NASH) mice. Its decreased expressions were also observed in liver specimens of NASH patients. In vitro analysis of the effect of miR-451 on proinflammatory cytokine provided evidence for negative regulation of PA-induced interleukin (IL)-8 and tumor necrosis factor-alpha (TNF-α) production. Furthermore, miR-451 over-expression inhibited translocation of the PA-induced NF-κB p65 subunit into the nucleus. Our result showed that Cab39 is a direct target of miRNA-451 in steatotic cells. Further study showed that AMPK activated through Cab39 inhibits NF-κB transactivation induced in steatotic HepG2 cells. miR-451 over-expression in steatotic cells significantly suppressed PA-induced inflammatory cytokine. These results provide new insights into the negative regulation of miR-451 in fatty acid-induced inflammation via the AMPK/AKT pathway and demonstrate potential therapeutic applications for miR-451 in preventing the progression from simple steatosis to severely advanced liver disease. Copyright © 2015. Published by Elsevier Ltd.
    The international journal of biochemistry & cell biology 05/2015; 91. DOI:10.1016/j.biocel.2015.04.016 · 4.24 Impact Factor
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    ABSTRACT: (18)F-Fluorodeoxyglucose positron-emission tomography ((18)F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of (18)F-FDG PET for predicting tumor progression and survival in patients with intermediate Barcelona Clinic Liver Cancer (BCLC) intermediate-stage HCC treated by transarterial chemoembolization (TACE). From February 2006 to March 2013, 210 patients treated with TACE, including 77 patients with BCLC intermediate-stage HCC, underwent examination by (18)F-FDG PET. (18)F-FDG uptake was calculated based on the tumor maximum (Tmax) standardized uptake value (SUV), the liver mean (Lmean) SUV, and the ratio of the Tmax SUV to the Lmean SUV (Tmax/Lmean). The mean follow-up period for the 77 patients (52 males, 25 females; average age, 63.3 years) was 22.2 months. The median time to progression of HCC in patients with a low Tmax/Lmean (< 1.83) and high Tmax/Lmean (≥ 1.83) was 17 and 6 months, respectively (p < 0.001). The median overall survival time of patients with a low and high Tmax/Lmean was 44 and 14 months, respectively (p = 0.003). Multivariate analysis revealed that the Tmax/Lmean was an independent predictor of overall survival (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.210 to 3.156; p = 0.006) and tumor progression (HR, 2.05; 95% CI, 1.264 to 3.308; p = 0.004). (18)F-FDG uptake calculated by the Tmax/Lmean using PET predicted tumor progression and survival in patients with BCLC intermediate-stage HCC treated by TACE.
    The Korean Journal of Internal Medicine 05/2015; 30(3):308. DOI:10.3904/kjim.2015.30.3.308
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    ABSTRACT: Two phenylanthracene-substituted fluorene derivatives, 10-(9,9’-dimethyl-2-(10-phenylanthracen-9-yl)-9H-fluoren-7-yl)-phenylanthracene (1) and 2’,7’-di-(10-phenylanthracen-9-yl)-9,9’-spirobi[9H-fluorene] (2) have been designed, synthesized, and characterized. A device using compound 1 as an emitting material exhibited luminous efficiency, power efficiency, external quantum efficiency and CIE coordinates of 3.37 cd/A, 1.50 lm/W, 1.87% at 20 mA/cm2 and (0.18, 0.25) at 7V, respectively. Furthermore, by exploiting this efficient blue fluorescent material as a blue emitting material with the combination of red phosphorescent bis(2-phenylquinoline)acetylacetonate [(pq)2Ir(acac)], an efficient white OLED (WOLED) with a external quantum efficiency of 1.70%, luminous efficiency of 1.38 cd/A, power efficiency of 0.94 lm/W at 20 mA/cm2 and the color coordinates of (0.33, 0.36) at 14 V is demonstrated.
    Displays 05/2015; 39. DOI:10.1016/j.displa.2015.05.003 · 1.21 Impact Factor
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    DESCRIPTION: Microstructural investigations of a Fe81Nb9B10 ultrafine-eutectic composite reveal that spherical eutectic colonies are composed of the radial lamellar structure together with NbFeB pro-eutectic phases which are central area on radial structure. The spherical eutectic colonies are proposed to be effectual in high yield strength as well as large plasticity by a rotational motion of those along the colony boundary during deformation. Formation of the wavy and dense shear bands is related with strong interaction between specific microstructure and localized shear deformation. Accordingly, the control of microstructural and mechanical factors in hierarchical ultrafine composite is crucial for enhancement of macroscopic mechanical properties.
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    ABSTRACT: We synthesized a series of bis(10-phenylanthracen-9-yl) derivatives containing various heterocyclic moieties such as 9-ethylcarbazole, dibenzofuran and dibenzothiophene (1-3) by Suzuki cross-coupling reactions. To explore electroluminescent properties of these materials, multilayered devices were fabricated with configuration of indium-tin-oxide (ITO) (180 nm)/4,4′-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (NPB) (50 nm)/Emitters 1-3 (30 nm)/Tris(8-hydroxyquinolinato) aluminium (Alq3) (15 nm)/lithium quinolate (Liq) (2.0 nm)/Al (100 nm). In particular, a device using 2,8-bis(10-phenylanthracen-9-yl)dibenzo[b,d]furan (2), as an emitter, exhibited efficient blue emission with maximum luminance, luminous, power and external quantum efficiency of 620 cd/m2, 2.05 cd/A, 1.05 lm/W, 1.43% at 20 mA/cm2, and CIE coordinates of (x = 0.18, y = 0.17) at 8 V, respectively.
    Optical Materials 04/2015; 46. DOI:10.1016/j.optmat.2015.04.027 · 2.08 Impact Factor
  • Sang Yeob Kim · Jong-Sub Lee · Young Seok Kim · Yong-Hoon Byun
    03/2015; 25(1):93-102. DOI:10.9720/kseg.2015.1.93
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    ABSTRACT: In the present study, the microstructural evolution and improving the mechanical properties have been achieved in Fe–Nb binary eutectic alloy via controlling the amount of boron (B) content. The addition of B leads to evolution of a unique microstructure with different length-scale heterogeneities, i.e., formation of bimodal structure, spherical colonies containing length-scale heterogeneity and precipitation of primary NbFeB phase. Following the evolution of microstructure, the mechanical properties including yield strength and plastic strain were significantly enhanced from 1100 MPa to 1660 MPa and from ∼4% to ∼20%, respectively. To elucidate deformation mechanism fracture topography and lateral surface morphology analyses are performed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). From these observations two distinct plastic deformation mechanisms can be suggested by following ways: (1) deformation-induced rotation motion of dendrites/eutectic colonies and (2) deformation-induced interface migration of lamellar structure.
    Materials and Design 03/2015; 76. DOI:10.1016/j.matdes.2015.03.053 · 3.50 Impact Factor
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    ABSTRACT: Background & AimsThe outcomes of hepatitis C virus (HCV)-related liver cirrhosis was limitedly studied in a hepatitis B virus-endemic area. This multicenter, prospective cohort study was conducted to elucidate the incidence of hepatocellular carcinoma (HCC) and mortality in the Korean patients with HCV-related cirrhosis.Methods From Jan. 2007 through Jun. 2012, 196 patients with HCV-related cirrhosis were prospectively enrolled and regularly followed at six university hospitals to determine HCC occurrence and mortality. A multivariable analysis using Cox proportional hazards regression was performed to clarify the related factors to the outcomes.ResultsDuring a mean follow-up period of 39.2 months, 31 (15.8%) patients developed HCC, and 33 (16.8%) patients died or underwent liver transplantation. The estimated HCC incidence was 5.8 per 100 person-years, and the independent factors for HCC were absence of anti-HBs (hazard ratio [HR], 5.018; 95% confidence interval [CI], 1.710-14.726; p=0.003) and serum albumin < 3.8 g/dl (HR, 3.051; 95% CI, 1.318-7.067; p=0.009). The overall mortality rate was 5.1 per 100 person-years, and the related independent factors were the presence of ascites (HR, 2.448; 95% CI, 1.142-5.210; p=0.022), serum albumin < 3.8 g/dl (HR, 3.067; 95% CI, 1.254-8.139, p=0.014), and non-achievement of sustained virologic response (SVR) (HR, 0.066; 95% CI, 0.001-0.484, p=0.002).Conclusion The incidence of HCC in HCV-related cirrhosis seems to be high in Korea, and advanced liver disease and no achievement of SVR were associated with mortality. The absence of anti-HBs in hepatocarcinogenesis related to HCV warrants further study.
    Journal of Gastroenterology and Hepatology 03/2015; DOI:10.1111/jgh.12950 · 3.63 Impact Factor
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    ABSTRACT: Porous metallic glass compact (PMGC) using electro-discharge sintering (EDS) process of gas atomized Zr41.2Ti13.8Cu12.5Ni10Be22.5 metallic glass powder was developed. The formation of uniform PMGC can only be achieved when low electrical input energy was applied. Functional iron-oxides were formed on the surface of PMGCs by hydrothermal technique. This finding suggests that PMGC can be applied in the new area such as catalyst via hydrothermal technique and offer a promising guideline for using the metallic glasses as a potential functional application.
    Journal of Alloys and Compounds 02/2015; 635(635):233-237. DOI:10.1016/j.jallcom.2015.02.120 · 2.73 Impact Factor
  • Jangguen Lee · Young Seok Kim · Deokho Chae · Wanjei Cho
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    ABSTRACT: The seasonally frozen ground has been focused on as research topics such as the frost heaving under the asphalt road rather than the permafrost ground due to the latitudinal location of Korea. However, the recent construction of the second Korean Antarctic research station, the Jangbogo station and the participation on the development of the natural gas pipeline in Russia arouse the research interests on the behavior of the permafrost ground. At the design process of the geotechnical structures on the permafrost ground, the evaluation of the mechanical characteristics of frozen soil is very important. In the laboratory tests, it is crucial to understand the effects of testing conditions such as loading rate and temperature on the mechanical behavior of frozen soils. Therefore, unconfined compression tests are performed to evaluate the loading rate effects on the mechanical characteristics of frozen granular soils. Based on the experimental results, the loading rate affects both the strength and deformation characteristics of the frozen soils. The ASTM standards on the loading rate of the frozen sands are fast enough for the strength evaluations but not for the stiffness evaluations. Furthermore, the loading rate effects are evaluated on the bearing capacity and deformation of pile installed on the permafrost via numerical analyses with experimental results.
    KSCE Journal of Civil Engineering 02/2015; DOI:10.1007/s12205-015-1417-6 · 0.51 Impact Factor
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    ABSTRACT: This multicenter, randomized, open-labeled, clinical trial evaluated the efficacy and safety of cisplatin/5-fluorouracil (5-FU) hepatic arterial infusion chemotherapy (CF-HAIC) versus adriamycin adding to CF-HAIC (ACF-HAIC) in advanced HCC patients. Fifty-six patients with advanced HCC were randomized to two treatment groups: (1) CF-HAIC group [n = 29, 5-FU, 500 mg/m(2) on days 1-3, and cisplatin, 60 mg/m(2) on day 2] and (2) ACF-HAIC group [n = 27, adriamycin, 50 mg/m(2) on day 1, 5-FU, 500 mg/m(2) on days 1-3, and cisplatin, 60 mg/m(2) on day 2] every 4 weeks via an implantable port system. Primary efficacy endpoint was overall survival (OS). Treatment response and time to progression were secondary endpoints. Treatment response rates did not differ significantly between the two treatment groups. Time to progression (5.4 vs. 5.8 months, P = 0.863) and OS (11.1 vs. 8.8 months, P = 0.448) were not significantly different. When the factors affecting patient OS were analyzed, disease control rate [P < 0.001, HR 6.437 (95 % CI 2.580-16.064)] was independently associated with OS. Age (≥60 years) and serum AFP level (≥200 ng/dL) also were significant factors for OS [P = 0.007, HR 4.945 (95 % CI 1.543-15.850), P = 0.048, HR 2.677 (95 % CI 1.010-7.095), respectively]. Grade 4 treatment-related toxicity and mortality was not observed in both groups. Although both HAIC regimens are safe and effective in patients with advanced HCC, HAIC adding adriamycin did not show delayed tumor progression and survival benefit compared to CF-HAIC in advanced HCC.
    Cancer Chemotherapy and Pharmacology 02/2015; 75(4). DOI:10.1007/s00280-015-2692-0 · 2.57 Impact Factor
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    ABSTRACT: Background/aimsTransient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of liver stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB and CHC).Methods From April 2006 to June 2014, 916 patients (567 CHB and 349 CHC) who underwent LB and TE at 15 centers were analyzed. The Batts and Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)–to–platelet ratio indexes (APRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used.ResultsThe median age, LS value, and APRI score were 45 years, 8.8 kPa, and 0.61, respectively, in CHB patients versus 51 years, 6.8 kPa and 0.55, respectively in CHC patients. TE was significantly superior to APRI in CHB patients (AUROC 0.774 vs. 0.72 for ≥F2, 0.849 vs. 0.812 for ≥F3, and 0.902 vs. 0.707 for F4, respectively; all P<0.05). Furthermore, TE was significantly superior for predicting ≥ F3 stage (AUROC 0.865 vs. 0.840, P=0.009) whereas it was similar for predicting ≥ F2 and F4 stage (AUROC 0.822 vs. 0.796; 0.910 vs. 0.884; all P>0.05) in CHC patients. In CHB patients, optimal cutoff LS values were 7.8 kPa for ≥ F2, 8.2 kPa for ≥ F3, and 11.6 kPa for F4, versus 6.8 kPa, 8.6 kPa, and 14.5 kPa, respectively, in CHC patients.ConclusionsTE can accurately assess the degree of liver fibrosis in Korean patients with CVH. TE was superior to APRI for predicting each fibrosis stage.This article is protected by copyright. All rights reserved.
    Liver international: official journal of the International Association for the Study of the Liver 02/2015; DOI:10.1111/liv.12808 · 4.41 Impact Factor

Publication Stats

1k Citations
536.51 Total Impact Points

Institutions

  • 2015
    • Sejong University
      • Department of Electronic Engineering
      Sŏul, Seoul, South Korea
  • 2013–2015
    • Asan Medical Center
      • • Department of Radiation Oncology
      • • Department of Pathology
      Sŏul, Seoul, South Korea
    • Sungkyunkwan University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
    • Korea Electronics Technology Institute
      • Display Components and Materials Research Center
      Sŏngnam, Gyeonggi Province, South Korea
    • Hallym University
      Sŏul, Seoul, South Korea
    • Chungnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2012–2015
    • Korea Institute of Construction Technology
      Kōyō, Gyeonggi-do, South Korea
  • 2005–2015
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 2014
    • Wonju Severance Christian Hospital
      Genshū, Gangwon-do, South Korea
  • 2010–2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2008–2014
    • Yonsei University
      • Department of Plastic & Reconstructive Surgery
      Sŏul, Seoul, South Korea
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • University of California, Davis
      Davis, California, United States
    • Yuhan College
      South Korea
  • 2003–2014
    • University of Ulsan
      • • College of Medicine
      • • Department of Radiation Oncology
      Urusan, Ulsan, South Korea
  • 2012–2013
    • Seoul National University
      • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2004–2013
    • Soon Chun Hyang University Hospital
      • Department of Gastroenterology
      Sŏul, Seoul, South Korea
  • 2009–2010
    • University of Massachusetts Amherst
      • Department of Chemical Engineering
      Amherst Center, Massachusetts, United States
    • Korea Environmental Industry and Technology Institute
      Sŏul, Seoul, South Korea
    • Chung-Ang University
      • College of Medicine
      Sŏul, Seoul, South Korea
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
  • 2008–2010
    • Korea Institute of Industrial Technology
      Anzan, Gyeonggi Province, South Korea
  • 2006–2010
    • University of Florida
      • Department of Chemical Engineering
      Gainesville, FL, United States
    • Gachon University
      • Gil Medical Center
      Seongnam, Gyeonggi, South Korea
  • 2006–2007
    • Inha University
      • Department of Chemistry
      Seoul, Seoul, South Korea
  • 2003–2005
    • Korea University
      • Department of Chemical and Biological Engineering
      Sŏul, Seoul, South Korea
  • 1996
    • Rensselaer Polytechnic Institute
      Troy, New York, United States