Hui Wang

Capital Medical University, Peping, Beijing, China

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Publications (5)13.5 Total impact

  • Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 09/2012; 20(9):705-6.
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    ABSTRACT: Purpose ‐ Embedding dimension determination in phase space reconstruction is difficult. The purpose of this paper is to present a new approach for embedding dimension determination based on empirical mode, showing that embedding dimensions for phase space reconstruction could be easily determined according to the number of intrinsic mode functions decomposed by empirical mode decomposition. Design/methodology/approach ‐ Through the relation analysis of intrinsic mode functions and embedding dimensions, the approach for embedding dimension determination by the number of intrinsic mode functions is presented. First, a time series is decomposed into several intrinsic mode functions. Second, correlation analysis between intrinsic mode functions and original signals is investigated, and then false intrinsic mode functions could be eliminated by the analysis of correlation coefficient thresholds, which makes the embedding dimension precise. Finally, the method presented is applied to the Lorenz system, Chen's system, and the Duffing equation. Simulation results prove this method is feasible. Findings ‐ A new approach for embedding dimension determination based on empirical mode decomposition is presented. Compared with G-P algorithms, this new method is effective and decreases computational complexity. Research limitations/implications ‐ This method provides an effective qualitative criterion to the selection of embedding dimensions in phase space reconstruction. Practical implications ‐ This method could be used to determine embedding dimensions of phase space reconstruction and degree-of-freedom of nonlinear dynamical systems. Originality/value ‐ The paper proposes a new method of embedding dimension determination in phase space reconstruction.
    Kybernetes 01/2012; 41(9). · 0.32 Impact Factor
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    ABSTRACT: N-methyl-4-isoleucine cyclosporine (NIM811), a new analogue of cyclosporine A, can inhibit collagen deposition in vitro and reduce liver necrosis in a bile-duct-ligation animal model. However, whether NIM811 effects on CCl(4) -induced rat liver fibrosis, and the related mechanism has not been determined. A liver fibrosis model was induced in Wistar rats using CCl(4) for 6 weeks. Meanwhile, two different doses of NIM811 (low-dose 10 mg/kg and high-dose 20 mg/kg) were given to the CCl(4) -treated rats. Liver fibrosis was then evaluated according to histopathological scoring and liver hydroxyproline content. Serum alanine aminotransferase, aspartate aminotransferase and albumin levels, expression of matrix metalloproteinase-13, tissue inhibitor of metalloproteinase-1, α-smooth muscle actin and cyclophilin B and D in liver tissue were determined. Cyclophilin B and D were also studied in an hepatic stellate cell line. Hydroxyproline content was decreased in both NIM811 groups compared with the model (P < 0.05). Liver necrosis and fibrosis were also attenuated in the NIM811 groups. NIM811 suppressed the expression of tissue inhibitor of metalloproteinase-1, transforming growth factor beta mRNA and α-smooth muscle actin protein in liver tissue. Expression of cyclophilin B in the fibrosis model was increased compared with the normal group (P < 0.05), and was decreased significantly in the low-dose NIM811 treatment group (P < 0.05), which indicated that cyclophilin B might have a profibrotic effect. In vitro studies revealed that cyclophilin B and/or D knockout were associated with collagen inhibition. NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D.
    Journal of Gastroenterology and Hepatology 03/2011; 26(3):558-67. · 3.33 Impact Factor
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    ABSTRACT: Although expandable hepatic progenitors provide renewable cell sources for treatment of hepatic disorders, long-term cultivation of hepatic progenitors may affect proliferation and differentiation abilities, and even initiate the formation of malignant cancer stem cells. This study aims to determine characteristics of primary cultured hepatic oval cells after prolonged cultivation in vitro. Hepatic oval cells isolated from rats fed with a choline-deficient, ethionine-supplemented diet were continuously propagated every 5-7 days, to 100 passages over two years. Hepatocytic differentiation was induced by sodium butyrate and characterized using western blot, periodic acid Schiff assays, albumin secretion and urea production. Proliferation capacity was evaluated using growth-curve and cell-cycle analysis; anchorage-independent growth and tumorigenicity were determined using soft agar and xenograft assay. After 2 years of serial passages, hepatic oval cells with typical epithelial morphology continuously expressed OV-6, BD-1, BD-2, and Dlk as markers for hepatic progenitors, cytokeratin 19 as a cholangiocyte marker, and alpha-fetoprotein and albumin as hepatocyte markers. Furthermore, sodium butyrate could induce these cells to become glycogen-storage cells with the functions of albumin secretion and ureagenesis from ammonia clearance, indicating hepatocytic differentiation. Although proliferation slightly accelerated after the 50th passage, hepatic oval cells stayed diploid cells with features of chromosomal stability, which did not acquire anchorage-independent growth capacity and caused no tumor in immunodeficient mice, suggesting no spontaneous malignant transformation. Hepatic oval cells retain the progenitor cell features without spontaneous malignant transformation after prolonged cultivation, and thus may serve as an expandable cell source for future exploitation of stem cell technology.
    Journal of Hepatology 11/2010; 53(5):863-71. · 9.86 Impact Factor
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    ABSTRACT: As for the limitation of traditional frequency, the concept of local frequency is proposed, which makes the physical meaning of frequency more clear. The wide adaptability of local frequency is also discussed. Moreover, a novel time-frequency analysis approach is presented based on local frequency and EMD. The time-frequency distributions of simulated signals are investigated by the new approach. Compared with the HHT time-frequency distribution, the results show that concept of local frequency is correct and the time-frequency analysis approach presented is effective.
    Audio, Language and Image Processing, 2008. ICALIP 2008. International Conference on; 08/2008