S N Novikov

Publications (16)0 Total impact

• Article: [Use of simultaneous double-tracer SPECT with 99m-Tc-technetril and 67-Ga-citrate for follow-up of patients with non-small cell lung cancer].

  S V Kanaev, S N Novikov, D S Beĭnusov, M M Girtovich, E V Levchenko, A S Barchuk, I I Semënov, L A Zhukova, D E Matsko
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  ABSTRACT: In 20 primary patients with focal abnormalities on conventional CT we evaluated diagnostic properties of simultaneous double-tracer SPECT. Scintigraphy was performed as a single examination with simultaneous registration of 67Ga and 99mTc-MIBI. Image acquisition was started 48-74 hours after IV injection of 130-175 MBq 67Ga-citrate and immediately after IV injection of 500-740 MBq of 99mTc-MIBI. All images for each agent were classified as positive and negative for primary tumor, N1 and N2 lymph-nodes (LN). According to histology 18 of 20 evaluated patients had non-small cell lung cancer (NSCLC), the other two patients had tuberculosis and nonspecific inflammation. SPECT with 99mTc-MIBI correctly visualized tumor in 18, 67Ga allowed correct visualization in 16 cases. Both tracers were truly negative in a patient with tuberculosis and false positive in a patient with nonspecific inflammation. Double-tracer SPECT was slightly more specific than CT in primary lesions. In 18 patients histological verification of LN status was obtained: NO was revealed in 9 cases, N1 in 4 and N2 in 5 cases. Both tracers correctly discriminated LN-positive and LN-negative cases with 94% specificity. On the contrary, CT was false-positive in 3 and false-negative in another 5 patients. Differentiation between N1 and N2 LN involvement is crucial for therapy planning. 99mTc MIBI and 67Ga revealed N1 in 2 cases and N2 in 4 cases, the diagnosis was later verified by postoperative morphology. In 2 patients SPECT overestimated extent of LN involvement and LN status was changed after surgery from N2 to N1. In 18 patients results of 99mTc-MIBI and 67Ga augmented each other. Accuracy of LN staging by SPECT with 99mTc-MIBI and 67Ga was 83%. CT accurately determined LN stage only in 7 patients, it was overestimated in 7 and underestimated in 4 cases. SPECT with 99mTc-MIBI and 67Ga demonstrated high overall accuracy in diagnostics of regional LN invasion for patients with NSCLC. Diagnostic value of conventional CT was significantly lower. Correct level of LN involvement was determined by SPECT in 83% of cases.
  Voprosy onkologii 01/2012; 58(3):346-51.
• Article: [Nuclear medicine in radiotherapy planning for patients with malignant neoplasms of different locations].

  S V Kanaev, S N Novikov, M M Girshovich, P V Krivorot'ko, D S Beĭnusov, P I Krzhivitskiĭ
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  ABSTRACT: The performance of nuclear medicine methods in radiation therapy tactics determination was analyzed in patients receiving therapy for Hodgkin lymphoma (HL, n=556), breast cancer (BC, n=230), treatment-naive patients with non-small cell lung cancer (NSCLC, n=86). In HL patients the nuclear medicine methods were used to determine the irradiation fields for spleen irradiation (67%) and abdominal lymph nodes (27%). The bone marrow scan data had significant influence on radiation therapy tactics in 10-27% of cases. The visualization of primary tumor lymphatic drainage lead to changing the irradiation field topography in 75% cases of external BC and 85% of internal BC localization. Tumorotropic isotope mammal scan data lead to the changes in planned irradiation volume in 16% of BC patietns. In NSLC patients the results of "positive" scintigraphy with lipophilic 99mTc-marked cations lead to the change in irradiation tactics in 16% of cases. Therefore, the results of diagnostic investigations suggest the important role of nuclear medicine diagnostic methods in patients with various tumors of different localizations.
  Voprosy onkologii 01/2012; 58(2):189-93.
• Article: [Lymphoscintigraphy of separate lymph nodes for radiotherapy planning in breast cancer].

  S V Kanaev, S N Novikov, L A Zhukova, O V Zotova, V F Semiglazov, P V Krivorot'ko
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  ABSTRACT: Determination of lymph flow from breast cancer can be used as effective tool for individualization of radiation portals for regional radiotherapy. We evaluated this technique in 86 patients with lymph nodes (LN) scintigraphy which was performed 20-240 min after intratumoural injection of 50-100 MBq of 99mTc-nanocolloids. After visualisation of lymph flow patterns standard radiation portals were modified in 75% of patients with external and 85%--with internal localisation of primary tumours, In addition we recognised that extent and wideness of radiation portals for internal mammary lymph LN must be arranged in accordance with individual lymph flow pattern. In particularly irradiation of LN on both sides of the sternum was performed only in 3 of 27 (11%) evaluated cases.
  Voprosy onkologii 01/2011; 57(5):616-21.
• Article: [Early diagnosis of breast cancer with scintimammography and ultrasound ].

  C V Kanaev, S N Novikov, V F Semiglazov, P V Krivorot'ko, L A Zhukova, P I Krzhivitskiĭ
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  ABSTRACT: The purpose of this study was to evaluate the role of scintimammography (SMG) and ultrasound (US) in early diagnosis of breast cancer. SMG was administered to 32 women with breast lesions of less than 1 cm in diameter. In addition, all patients underwent high frequency US imaging with digital wide field of view. The following US features were set as diagnostic: heterogeneous echo pattern, irregular morphology, hyperecho, poorly defined edges, posterior acoustic attenuation. SMG was performed in planar and tomography modes 15 min. after i/v injection of 740-860 MBq 99mTc-sestamibi. Images with focal and scattered patchy uptake were discarded. Data on all lesions were verified by biopsy and/or surgery. Thirty-six women revealed lesions of less than 1 cm: 12 out of 14 cases of breast cancer had them, while malignancy was not detected in 16 of 21 women with benign breast lesions. Sensitivity (Sen), Specificity (Sp) and Accuracy (Ac) of SMG in this group was as follows: 86%, 76% and 80%, respectively. US examinations in this group diagnosed benign lesions in 27 out of 35 women: 21--negative, 6--false negative. In the remaining 8 cases, US findings on breast cancer were positive: Sen was low (57%), Sp--high (100%) and Ac--moderate (82%). Taking into account that SMG represents functional status of breast lesions while US--anatomical one, we tested diagnostic value of their combination too (US+SMG). Cancer diagnosis was passed when either SMG or US revealed abnormalities. This diagnostic strategy featured outstanding Sen (100%), moderate Sp (76%) and Ac of 82%. It may be concluded that the combination procedure seems highly promising as far as early diagnosis of small (< 1 cm) breast cancers are concerned.
  Voprosy onkologii 01/2011; 57(5):622-6.
• Article: [Radionuclide visualization of lymphatic flow from primary breast cancer].

  S V Kanaev, S N Novikov, V F Semiglazov, O V Zotova, M M Girshtovich, P V Krivorot'ko, V G Ivanov, L A Zhukova
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  ABSTRACT: Our study was concerned with evaluation of patterns of lymph flow from primary breast cancer. Radionuclide scintigraphy (RS) of lymph nodes was performed in 92 patients. Scinitigraphic images were obtained 30-60 and 240-360 min after intratumoral injection of 75-150 MBq (0,5-1 vl) of 99mTc nanocolloids. The pool sites of the radiodrug collection were as follows: axillary (Ax), sub-supraclavicular (SSCL) and internal mammary (IM). Imaging proved effective in 86 cases. No drug transport was recorded in 5 cases; 4 of them revealed macroscopic metaststases to the lymph nodes. External involvement of the axillary lymph nodes was visualized in 51 patients out of 52 while in 26 it occurred on the axillary site only. In another 25 patients, images of lymph nodes were obtained on 2 or 3 sites: drainage Ax+SSCL (12;23.1%), Ax+IM (6;11.6%) and Ax+SSCL+IM (7;13.4%). In patients with tumors in internal quadrants (34), the lymph flow patterns were as follows: Ax (12;35.3%), IM (2;5.8%), Ax+SSCL (8;23.5%), Ax+IM+SSCL (5;14.7%). Hence, the efficacy of lymph node visualization after intratumoral injection of nanocolloids was 98%. Visualization on Ax sites was further confirmed by lymph flow to SSCL and IM (29.1%) and (35.9%), respectively. The likelihood of lymph flow to IM is significantly higher in patients with internal localization of breast cancer (37.1%) but it is not negligible (22.9%) in cases of external quadrants.
  Voprosy onkologii 01/2010; 56(4):417-23.
• Article: [Role of radionuclide imaging of bone marrow and spleen in choice of therapy and topometric preparation for radiotherapy of patients with Hodgkin disease].

  S V Kanaev, S N Novikov, M L Gershanovich, L A Zhukova, I A Korobova
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  ABSTRACT: Use of radionuclide methods of bone marrow (BM) and spleen visualization was assessed in 176 patients with primary Hodgkin's disease and 116 relapsing cases. The study was intended to help design treatment modality and carry out topometric measurements for exposure to radiation. Stage of tumor was revised in 19 primary patients as a result of BM scintigraphy, and this factor was responsible for major changes in the treatment modality in 11 patients (6.2%). This factor played a similar role in designing irradiation field boundaries in another 18 primary patients (10.2%). Similarly, the choice of treatment modality was revised in 33 relapsing patients (27.5%). The standard roentgenometric data on the anatomical reference points of the spleen and those of radionuclide-assisted visualization were compared in 37 patients. In 17 (45.9%), part of the spleen was shown by scintigraphy to be outside the irradiation boundaries delineated by the roentgenometric procedure. Roentgenometry located the spleen well inside the irradiation fields in 8 patients (21.6%). However, due to scintigraphy, their boundaries were altered to cut down the exposure of the left kidney (5) or the left lung (3). Complete agreement between roentgenometric and scintigraphic measurements were reported in 12 patients (32.4%) only.
  Voprosy onkologii 02/2002; 48(2):193-5.
• Article: [The role of indirect lower lymphoscintigraphy for radiotherapy planning in Hodgkin's lymphoma].

  S V Kanaev, S N Novikov, I I Semenov, L A Zhukova
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  ABSTRACT: The feasibility of application of indirect lower lymphoscintigraphy (ILLSG) was assessed in 202 patients with Hodgkin's disease. Its high diagnostic potential was demonstrated by comparison with direct X-ray contrast lymphography: ILLSG's sensitivity was 91.5%, specificity--76.1% and overall accuracy--88.4%. The procedure used for topometric preparation prior to exposure of paraaortal and ileaco-inguinal lymph nodes proved instrumental in designing individual irradiation fields: their boundaries were altered in 21.6% on the basis of ILLSG data.
  Voprosy onkologii 02/2002; 48(1):37-42.
• Article: [Clinical course and treatment of Hodgkin's disease with concomitant bone marrow lesions].

  M L Gershanovich, S V Kanaev, L V Filatova, S N Novikov, E E Leenman, K M Pozharisskiĭ
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  ABSTRACT: Fifty patients with confirmed local multiple lesions of bone marrow were selected by 99mTc scintigraphy, magnetic resonance imaging and morphologically-supported trepan biopsy from 155 cases of Hodgkin's disease stage II-IVAB. Bone marrow lesions were relatively more common in younger patients 1-11 months after primary tumor detection (an average of 6.5 months). They were detected within 12-156 months (an average of 48 months) among relapsing patients with nodal sclerosis and mixed-cell tumors stage III-IVAB, mostly concomitant with anemia and lymphopenia. Standard combination chemotherapeutical regimens for primary patients (MOPP, ABVD and LOPP) and relapsing ones (CCNU-OPP and ABVD) were effective in those with bone marrow lesions. Side-effects (myelodepression) did not exceed normal levels, provided human recombinant interleukin-1 beta (beta-leukin) was administered for protection and leukopoietic stimulation.
  Voprosy onkologii 02/2002; 48(1):29-36.
• Article: [The problem of restoring bone marrow, irradiated during radiotherapy of Hodgkin's disease patients].

  S V Kanaev, S N Novikov
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  ABSTRACT: The results of bone marrow (BM) visualisation of 663 irradiated regions were analysed. In all cases BM absorbed doses varied between 10-40 Gy. Active accumulation of 99mTc-colloids was observed in 48 out of 60 regions irradiated within 20 Gy. This pattern proved the possibility of effective and rapid hematopoietic regeneration after low-dose radiotherapy. On the contrary, during the first 6 months after BM irradiation with doses over 25 Gy we detected prominent depression of tracer uptake in 86.2% of all regions. It was shown that intensity of BM regeneration reached its peak during the second half-year after irradiation within 25-40 Gy. BM recovery during this period was dose dependent and was detected in 47.7% areas irradiated with 30 Gy and 24.7%--with 40 Gy. Regression analysis revealed significant correlation of postradiotherapy hematopoietic status with the value of BM absorbed dose and the time after the end of radiotherapy. Scintigraphic patterns of BM regeneration were registered in 69 of 89 (77.5%) regions irradiated within 25-30 Gy and only in 96 out of 231 (41.6%)--within 35-40 Gy.
  Voprosy onkologii 02/2001; 47(4):411-6.
• Article: [Post-radiation compensatory peripheral expansion of hemopoiesis in Hodgkin's disease patients].

  S V Kanaev, S N Novikov, L A Zhukova
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  ABSTRACT: Development of peripheral expansion (PE) of hematopoiesis provides a basic mechanism of compensation for radiation-related damage to the bone marrow (BM) in radiation-treated patients with Hodgkin's disease. Radio nuclide visualization of BM established a significant correlation between PE degree and extent of BM damage. Among other things, it was found that hematopoiesis PE does not increase significantly until 35% of BM is involved and not until 12-24 months after radiotherapy; after 25 months and later, PE starts to subside. In patients under the age of 15, PE was triggered on at an earlier stage than in adults (within the first 12 months) and there was no correlation between the volume of exposed.
  Voprosy onkologii 02/2001; 47(4):417-20.
• Article: [Comparative analysis of data from trepanobiopsy and radionuclide visualization of bone marrow].

  S V Kanaev, S N Novikov, E E Leenman, K M Pozharisskiĭ
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  ABSTRACT: Scintigraphy of the bone marrow was tested as a noninvasive procedure of hemopoiesis evaluation in 79 cancer patients. Scintigraphy and trepanobiopsy of the marrow of iliac bones were carried out in all patients. The results matched in 88.6% (70 out of 79) pointing to a significant correlation (p < 0.01). A similar correlation (p < 0.05) (80% matching) was observed in cases of irradiation of ilioinguinal nodes. Besides, the coefficient of correlation of the data of quantitative and semiquantitative analysis of marrow scintigraphs was 0.7725 (p < 0.01). To summarize, the significant correlation between the findings of scintigraphic and morphological examination pointed to the potential of the former as an noninvasive procedure for evaluation of hemopoiesis.
  Voprosy onkologii 01/2001; 47(5):566-70.
• Article: [Risk factors for bone marrow involvement in Hodgkin's disease].

  S V Kanaev, S N Novikov, L A Zhukova, K M Pozharisskiĭ, E E Leenman, M L Gershanovich
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  ABSTRACT: The significant factors of risk for bone marrow involvement in Hodgkin's disease included age over 40 yrs, such unfavorable histological features as lymphoid exhaustion and nodular sclerosing stage II, symptoms of intoxication, an ESR of more than 50 mm/h, increased fibrinogen (> 5.0 g/l), blood-plasma alkaline phosphatase (> 130 units), leukocyte concentration (> 10,000 per min) and decreased hemoglobulin (< 100 g/l). Despite the reliable correlation between bone marrow involvement and said factors, relevant data did not provide a similarly reliable basis for accurate prognosis of tumor dissemination. However, our findings pointed to two categories of Hodgkin's disease patients characterized by minimal risk of tumor dissemination--patients under 20, with stage I-II AB and IIIA tumors,--and patients with similar tumors and such favorable histological patterns of major pathology as high lymphocytic ratio and nodular sclerosing stage I.
  Voprosy onkologii 01/2001; 47(1):39-44.
• Article: [Role of bone marrow scintigraphy in defining the therapeutic approach for some malignant tumors in children] .

  S V Kanaev, S N Novikov, L A Zhukova, A P Malinin, B A Kolygin
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  ABSTRACT: The data on scintigraphic examinations of the bone marrow (BM) carried out in 76 patients, aged 2-16, are evaluated. Focal, multi-focal and diffuse lesions were identified. Metastases to BM were detected in 6 out of 28 (21%) patients with Hodgkin's disease. Scintigraphic evidence played a role in working out treatment modalities in 4 cases. Metastatic foci located outside primary tumor were detected in 3 out of 26 (11.5%) patients with Ewing's sarcoma and scintigraphic findings were considered in all 3 cases when scope of radiotherapy and chemotherapy intensity were elaborated. Also, lesions to BM were found in 9 out of 22 (41%) patients with neuroblastoma. Radiotherapy was ruled out in 4 cases of multi-focal and diffuse lesions while all 5 patients with focal ones received it.
  Voprosy onkologii 02/2000; 46(4):419-22.
• Article: [Comparison of diagnostic significance of bone and bone marrow scintigraphy in patients with Hodgkin disease].

  S V Kanaev, S N Novikov, L A Zhukova, K M Pozharisskiĭ, E E Leenman, M L Gershanovich, L A Tiutin, E N Shelkoplias
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  ABSTRACT: Diagnosis of skeletal tumors in patients with Hodgkin's disease is of paramount importance for precise staging of tumor process, prognosis and choice of optimal treatment. At present, according to the International Union Against Cancer (UICC), scintigraphy of bones and bone marrow is not regarded as a standard examination procedure for this pathology. We believe, however, that the sensitivity, specificity and overall accuracy of this procedure for bone marrow examination are 91.4; 94.8 and 92.9%, while those of osteoscintigraphy--49.1; 97 and 80.6%, respectively. According to our statistics (based on chi-square-test), the sensitivity and overall accuracy of osteoscintigraphy were significantly lower (p < 0.05) than those of bone marrow scintigraphy. The specificity (100%) of bone marrow trepanobiopsy is beyond doubt. However its sensitivity (36%) and overall accuracy (70.7%) were significantly lower (p < 0.05) than those of bone marrow scintigraphy (based on chi-square-test). Therefore, since the results of bone marrow scintigraphy are comparable to those of MRT which, like bone marrow trepanobiopsy, is a component of the diagnostic standard procedure approved by the UICC, bone marrow scintigraphy should be recommended for assaying the extent of involvement in Hodgkin's disease.
  Voprosy onkologii 02/2000; 46(6):676-81.
• Article: [Clinical experience of bone marrow scintigraphy in cancer patients].

  S V Kanaev, S N Novikov, ZhukovaLA
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  ABSTRACT: 129 patients with various malignant tumors and 10 persons from the control group were examined by BM scintigraphy with radio-colloids. The following scintigraphic signs were associated with neoplastic bone marrow pathology: 32 patients with BM metastasis had focal or multifocal defects on BM scans, 8-localized areas of increased tracer accumulation ("hot spots"), 5-diffusely diminished tracer uptake. There were no correlations between survival and grade of peripheral expansion of tracer uptake (scintigraphic sign of hematopoietic peripheral expansion) and the probability of bone marrow BM involvement by tumor cells.
  Voprosy onkologii 02/1997; 43(3):275-83.
• Article: [Experience with low-field magnetic resonance tomography for the diagnosis of bone marrow lesions].

  L A Tiutin, S V Kanaev, E N Shelkoplias, S N Novikov
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  ABSTRACT: Metastatic lesions of the bone marrow (BM) in cancer patients are instrumental in making prognosis and selecting optimal treatment modality. Recent evidence has pointed to insufficient sensitivity of morphological, X-ray and osteoscintigraphic diagnostic procedures to deal with focal alterations in BM. Vistas in application of low-field magnetic resonance tomography for detection and differential diagnosis of localized lesions in BM are discussed.
  Voprosy onkologii 02/1997; 43(2):221-4.