S Kumar

Asthagiri Herbal Research Foundation, Chennai, Tamil Nādu, India

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Publications (1)0.61 Total impact

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    ABSTRACT: Aloin (10-glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9(10H)-anthracenone), a bioactive compound in Aloe vera, although known to have an anticancer effect, has not been used in current drug research. Optimization of the lead structure could enhance the utility of this compound. Hence, aloin was modified using natural amino acids to produce Schiff's base, a potential pharmacophore, and its corresponding aglycones. The synthetic derivatives exhibited significant enhancement in their efficacy toward antioxidant (DPPH radical scavenging) and cytotoxic activities than those of the parent compound, aloin showing promise for application in cancer treatment.
    Journal of Asian natural products research 05/2010; 12(5):360-70. · 0.61 Impact Factor