M Watanabe

Shimane University, Matsu, Shimane Prefecture, Japan

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Publications (233)703.72 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A study of the effect of montirelin hydrate (NS-3), a new drug for the treatment of disturbance of consciousness, during the period of organogenesis was conducted in New Zealand white rabbits. Female rabbits were given the drug intravenously at dose levels of 0 (control), 0.01, 0.1 and 1 mg/kg from day 6 to day 18 of pregnancy. Female rabbits were sacrificed on day 29 of pregnancy for examination of their fetuses. In the 0.1 mg/kg group, food consumption decreased slightly. In the 1 mg/kg group, tachypnea, salivation and rhinorrhea were observed, and body weight and food consumption decreased and water consumption increased. The drug had no effect on the number of corpora lutea and implantations, or on fetal mortality, on fetal body weights, on placental weight, on sex ratio, or on external, visceral and skeletal development of the fetuses. These results show that the NOAEL of montirelin hydrate are 0.1 mg/kg for general toxicity in mother animals, and 1 mg/kg for pregnancy of mother animals and for development of fetuses.
    The Journal of Toxicological Sciences 01/1996; 20 Suppl 2:297-307. DOI:10.2131/jts.20.SupplementII_297 · 1.38 Impact Factor

Publication Stats

5k Citations
703.72 Total Impact Points

Institutions

  • 1987–2002
    • Shimane University
      • Department of Internal Medicine
      Matsu, Shimane Prefecture, Japan
  • 2001
    • Gifu University
      Gihu, Gifu, Japan
  • 1995–2001
    • Tokyo Gakugei University
      Koganei, Tōkyō, Japan
    • Sapporo Medical University
      • Division of Internal Medicine II
      Sapporo, Hokkaidō, Japan
  • 1991–2001
    • St. Marianna University School of Medicine
      • Department of Pharmacology
      Kawasaki, Kanagawa-ken, Japan
  • 2000
    • National Cancer Center, Japan
      • Endoscopy Division
      Edo, Tōkyō, Japan
  • 1997–2000
    • The University of Tokyo
      • • Institute of Molecular and Cellular Biosciences
      • • Division of Internal Medicine
      Tokyo, Tokyo-to, Japan
  • 1996–2000
    • Mie University
      • • Department of Pathophysiology
      • • Faculty of Medicine
      • • Department of Neurology
      • • School of Medicine
      Tu, Mie, Japan
  • 1994–2000
    • National Defense Medical College
      • • Division of Radiology
      • • Department of Surgery
      Tokorozawa, Saitama, Japan
  • 1999
    • Tohoku University
      • Graduate School of Dentistry
      Japan
  • 1998
    • Chiba University
      Tiba, Chiba, Japan
    • Keio University
      • Department of Surgery
      Tokyo, Tokyo-to, Japan
  • 1994–1996
    • National Institute of Health Sciences, Japan
      • Division of Division of Genetics and Mutagenesis
      Edo, Tōkyō, Japan
  • 1988–1996
    • Tottori University
      • Third Department of Internal Medicine
      TTJ, Tottori, Japan
  • 1993
    • Kyoto Pharmaceutical University
      Kioto, Kyōto, Japan
  • 1986–1993
    • The Graduate University for Advanced Studies
      Миура, Kanagawa, Japan
  • 1992
    • Teikyo University
      Edo, Tōkyō, Japan
  • 1982–1985
    • National Astronomical Observatory of Japan
      • Division of Optical and Infrared Astronomy
      Edo, Tōkyō, Japan