Li Liu

Wuhan Textile University, Wu-han-shih, Hubei, China

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Publications (268)921.86 Total impact

  • [show abstract] [hide abstract]
    ABSTRACT: Drosophila larvae innately show light-avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involved in larval light-avoidance, compared with control w1118 larvae, larvae with γ-glutamyl transpeptidase 1 (Ggt-1) knockdown or Ggt-1 mutation were found to exhibit higher percentage of green-light avoidance which was mediated by Rh6 photoreceptors. However, their responses to blue light did not change significantly. By adjusting the expression level of Ggt-1 in different tissues, we found that Ggt-1 in malpighian tubules was both necessary and sufficient for green-light avoidance. Our results showed that glutamate levels were lower in Ggt-1 null mutants compared with controls. Feeding Ggt-1 null mutants glutamate can normalize green-light avoidance, indicating that high glutamate concentrations suppressed larval green-light avoidance. However, rather than directly, glutamate affected green-light avoidance indirectly through GABA, the level of which was also lower in Ggt-1 mutants compared with controls. Mutants in glutamate decarboxylase 1, which encodes GABA synthase, and knockdown lines of the GABAA receptor, both exhibit elevated levels of green-light avoidance. Thus, our results elucidate the neurobiological mechanisms mediating green-light avoidance, which was inhibited in wild-type larvae.This article is protected by copyright. All rights reserved.
    Journal of Neurochemistry 04/2014; · 3.97 Impact Factor
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    ABSTRACT: Gastric submucosal tumors (SMTs) originating from the muscularis propria layer are treated endoscopically. Successful closure of the wall defect is a critical step. This study evaluated the safety and feasibility of the endoscopic purse-string suture (EPSS) method using an endoloop and several metallic clips after endoscopic full-thickness resection (EFTR) or perforation due to endoscopic submucosal dissection (ESD). From December 2009 to April 2013, 30 patients with SMTs originating from the muscularis propria layer who received EFTR or ESD were retrospectively analyzed. After successful tumor resection, an endoloop was anchored onto the circumferential margin of the gastric defect with several metallic clips and tightened gently. Patient characteristics, tumor size, en bloc resection, and postoperative complications were evaluated. For all 30 patients, EPSS was successfully performed after EFTR or perforation due to ESD. The mean diameter of the resected specimen was 1.9 cm. No severe complications occurred during or after the procedure. The lesions were healed 1 month after the procedure, as confirmed endoscopically. The EPSS method using an endoloop and clips is an effective and safe technique for closing the gastric defect after EFTR or perforation due to ESD.
    Surgical Endoscopy 01/2014; · 3.43 Impact Factor
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    ABSTRACT: A quantitative structure–property relationship study was performed to correlate descriptors representing the molecular structures to fiber affinities for azo dyes. The complete set of 51 compounds was divided into a training set of 41 compounds and a test set of 10 compounds by using DUPLEX algorithm. Multiple linear regression analysis was used to select the best subset of descriptors and to build linear models; nonlinear models were developed by means of artificial neural network. The robustness of the obtained models was assessed by different approaches, including leave-many-out cross-validation, Y-randomization test, and external validation through test set. The obtained models with four descriptors show good predictive power: for the test set, a squared correlation coefficient (r2) of 0.916 was achieved by the linear model; while the nonlinear model with r2 of 0.935 for the test set performs better than the linear model. Furthermore, the applicability domain of the models was analyzed based on the Williams plot. The donor atom number for H-bonds, group polarizability and electronegativity of the dye molecules are found to play important roles for the dye-fiber affinity.
    Chemometrics and Intelligent Laboratory Systems 01/2014; · 2.29 Impact Factor
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    ABSTRACT: Long noncoding RNA(lncRNA) is the one particularly abundant but poorly understood class of ncRNAs. Although we presently know little about their function, lncRNAs' widely expressed in the nervous system suggested they're likely to play potential critical roles in neural functions. Here, we described one novel Drosophila lncRNA(lnc10) for its molecular characterizations, including fulllength sequence confirmation, protein-coding potential evaluation, conservation analysis, expression level analysis in three body parts, spatial-temporal expression tracing in nervous system, and regulation effects on its adjacent protein coding gene. We determined lnc10 as a long noncoding RNA. In this study, the lncRNA's spatial-temporal neural expression pattern and positive regulation on the neighbouring protein coding gene provided the possible molecular basis for the further investigation of the potential neural function of lnc10, besides, the underlying molecular mechanism and neural action location of lnc10 in the future analysis could also be determined by utilizing the Drosophila genetics, e.g. Gal4 and UAS system. This study will enrich the present biological significance of lncRNAs and may provide potential insights into neural dysfunction.
    Journal of Genetics and Genomics 01/2014; · 2.08 Impact Factor
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    ABSTRACT: Human telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting. A case-control study was conducted in a Han population in Wuhan, central China. The relative telomere length (RTL) was measured in peripheral blood leukocytes (PBLs) using quantitative real-time polymerase chain reaction (PCR) in 628 CRC cases and 1,256 age and sex frequency matched cancer-free controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression models to evaluate the association between RTL and CRC risk. Using median RTL in the controls as the cutoff, individuals with shorter RTL were associated with a significantly increased risk of CRC (adjusted OR = 1.27, 95%CI: 1.05-1.55). When participants were further categorized into 3 and 4 groups according to the tertile and quartile RTL values of controls, significant relationships were still observed between shorter RTL and increased CRC risk (OR per tertile = 1.13, 95%CI: 1.00-1.28, P trend = 0.045; OR per quartile = 1.12, 95%CI: 1.03-1.23, P trend = 0.012). In stratified analyses, significant association between shorter RTL and increased CRC risk was found in females, individuals younger than 60 years old, never smokers and never drinkers. This study suggested that short telomere length in PBLs was significantly associated with an increased risk of CRC in Chinese Han population. Further validation in large prospective studies and investigation of the biologic mechanisms are warranted.
    PLoS ONE 01/2014; 9(2):e88135. · 3.73 Impact Factor
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    ABSTRACT: The current dye-sensitized solar cell (DSSC) technology is mostly based on fluorine doped tin oxide (FTO) coated glass substrate. The main problem with the FTO glass substrate is its rigidity, heavyweight and high cost. DSSCs with a fabric as substrate not only offer the advantages of flexibility, stretchability and light mass, but also provide the opportunities for easy implantation to wearable electronics. Herein, a novel fabric counter electrode (CE) for DSSCs has been reported employing a daily-used cotton fabric as substrate and polypyrrole (PPy) as catalytic material. Nickel (Ni) is deposited on the cotton fabric as metal contact by a simple electroless plating method to replace the expensive FTO. PPy is synthesized by in situ polymerization of pyrrole monomer on the Ni-coated fabric. The fabric CE shows sufficient catalytic activity towards the reduction of I3−. The DSSC fabricated using the fabric CE exhibits power conversion efficiency of ∼3.30% under AM 1.5.
    Journal of Power Sources 01/2014; 257:230–236. · 4.68 Impact Factor
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    ABSTRACT: To explore the integrated application of sales of child-specific over-the-counter (OTC) cold related medications in retail pharmacies and healthcare visits of children for influenza-like illness (ILI) in surveillance and early warning of influenza among children. An integrated surveillance system (ISS) was implemented since 2012 in Qianjiang County, a rural area in Hubei Province of China. The daily information from August 1, 2012 to February 28, 2013 of health care visits of children for ILI reported by 80 health facilities and sales of 14 child-specific over-the-counter (OTC) cold related medications reported by 11 pharmacies were extracted from ISS database. Cumulative sums (CUSUM) model was conducted to analyze the degree of fitting and the early warning signal generated; the correlationship was then analyzed further. In 212 days, 983 visits of children for ILI and 12 819 sales by person of child-specific OTC were reported. Conducting CUSUM model, the fitting degree was in the acceptable range, 31 warning signals were generated from ILI data series with 3 peak periods and 14 from OTC data series with 2 peak periods. A similar time trend of two data series was observed with a correlation(r = 0.497, P < 0.05), but without any spatial clustering. And the optimal correlation(r = 0.505, P < 0.05) appeared at a time offset of 4 days preceded by OTC sales. The availability of integrated surveillance system for symptoms could be applied for surveillance of influenza among children; while it could explore the possibility of real epidemic in the very early stage.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 12/2013; 47(12):1095-1099.
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    ABSTRACT: Drosophila is a very favorable animal model for the studies of neuroscience. However, it remains a great challenge to employ electrophysiological approaches in Drosophila to study the neuronal assembly dynamics in vivo, partially due to the small size of the Drosophila brain. Small and sensitive microelectrodes for multi-unit recordings are greatly desired. We fabricated micro-scale stereotrodes for electrical recordings in Drosophila melanogaster. The stereotrodes were modified with iridium oxide (IrO2) under a highly controllable deposition procedure to improve their electrochemical properties. Electrical recordings were carried out using the IrO2 stereotrodes to detect spontaneous action potentials and LFPs in vivo. The IrO2 electrodes exhibited significantly higher capacitance and lower impedance at 1kHz. Electrical recording with the IrO2 stereotrodes in vivo demonstrated an average signal-to-noise ratio (SNR) of 7.3 and a significantly improved LFP sensitivity. 5 types of different neurons recorded were clearly separated. Electrophysiological responses to visual and odor stimulation were also detected, respectively. with Existing Method(s) The most widely used electrodes for electrical recording in Drosophila are glass microelectrode and sharpened tungsten microelectrode, which are typically used for single-unit recordings. Although tetrode technology has been used to record multi-neuronal activities from Drosophila, the fabricated IrO2 stereotrodes possess smaller geometry size but exhibited comparable recording signal-to noise ration and better sorting quality. The IrO2 stereotrodes are capable to meet the requirements of multi-unit recording and spike sorting, which will be a useful tool for the electrophysiology-based researches especially in Drosophila and other small animals.
    Journal of neuroscience methods 11/2013; · 2.30 Impact Factor
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    ABSTRACT: Multiple studies have indicated that selective cyclooxygenase-2 (COX-2) inhibitors possess clinically chemopreventive and preclinically anticancer activities. Their long-term use, however, may be limited by the cardiovascular toxicity. This study tried to investigate whether an apple oligogalactan (AOG) could enhance the growth inhibitory effect of celecoxib on colorectal cancer. Caco-2 and HT-29 cell lines were exposed to different concentrations of AOG (0-1 g/L), celecoxib (0-25 μmol/L), and their combination. COX-2 levels were assessed by reverse transcription PCR and Western blot. COX-2 activity was evaluated by measuring prostaglandin E2 concentration. A colitis-associated colorectal cancer (CACC) mouse model was used to determine the effect of the combination in vivo. AOG (0.1-0.5 g/L) could potentiate the inhibitory effect of physiologic doses of celecoxib (5 μmol/L) on cell growth and decrease COX-2 expressions both at RNA and protein levels. In vivo, the combination (2.5% AOG plus 0.04% celecoxib, w/w) prevented against CACC in mice effectively. Our data indicate that AOG could potentiate the growth inhibitory effect of celecoxib on colorectal cancer both in vitro and in vivo through influencing the expression and function of COX-2 and phosphorylation of MAPKs, which suggests a new possible combinatorial strategy in colorectal cancer therapy.
    Nutrition and Cancer 11/2013; · 2.70 Impact Factor
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    ABSTRACT: Plant sterols are thought to treat hypercholesterolemia via inhibiting intestinal cholesterol absorption. The aim of this study was to evaluate the contribution of impaired ATP-binding cassette transporter G5/8 (ABCG5/8) expression by diabetes to the increased β-sitosterol (BS) exposure and impact of increased BS on integrity of blood-brain barrier (BBB). Basal BS level in tissues of streptozotocin-inducted rats and ABCG5/8 protein levels in liver and intestine were investigated; pharmacokinetics of BS was studied following oral dose; and primarily cultured rat brain microvessel endothelial cells (rBMECs) were used to study BS transportation across BBB and effect of BS on BBB integrity. Diabetic rats showed greatly upgraded basal levels of BS in plasma, intestine, cerebral and hippocampus, accompanied by impairment of ABCG5/8 protein expression in liver and intestine. Pharmacokinetics studies demonstrated higher AUC0-48 and Cmax , and lower faecal recoveries of BS after oral administration, indicating enhancement of absorption or efflux impairment. In-vitro data showed increased ratio of BS/cholesterol in high levels BS-treated rBMECs was associated with increased BBB permeability of some biomarkers including BS itself. Impaired ABCG5/8 protein expression by diabetes led to increase in BS exposure, which may be harmful to BBB function.
    The Journal of pharmacy and pharmacology. 11/2013;
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    ABSTRACT: A rapid and sensitive liquid chromatography/tandem mass spectrometry method was developed and validated for the quantification of deoxypodophyllotoxin (DPT) concentration in rat plasma with diazepam as internal standard (IS). DPT and IS were extracted with ethyl acetate, and the chromatographic separation was accomplished by using a Waters Symmetry C18 analytical column (2.1mm×150mm, 5μm) with a mobile phase consisting of acetonitrile and deionized water (70:30, v:v) containing 0.1% formic acid at a flow rate of 0.2mL/min. Multiple Reaction Monitoring (MRM), using electrospray ionization in positive ion mode, was employed to quantitatively detect DPT and IS. The monitored transitions were set at m/z 399.05-231.00 and m/z 285.00-154.00 for DPT and IS, respectively. The calibration curve was linear over the concentration range of 7.8-1000ng/mL (R(2)≥0.9999). The intra- and inter-day precision values were less than 7%. Similarly, the mean intra- and inter-day accuracy were found to be within -2.8% to 1.9% of the interval, with all samples locating within general assay acceptability criteria for QC samples according to FDA guidelines. This method was further and successfully applied in the pharmacokinetics study of DPT in rat.
    Journal of pharmaceutical and biomedical analysis 10/2013; 88C:410-415. · 2.45 Impact Factor
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    ABSTRACT: This study was designed to explore the interactions of alcohol dehydrogenase 1B (ADH1B) rs1229984, aldehyde dehydrogenase 2 (ALDH2)(rs671) and cytochrome P4502E1(CYP2E1)rs1329149 with environmental factors and the interactions between genetic factors in the susceptibility of colorectal cancer (CRC). Roles of genetic factors in the development of colorectal cancer were also studied. With a case-only study design, 472 colorectal cancer cases were enrolled between 2007 and 2009 in this study. Data on demographic characteristics, histories of environmental exposure and clinico-pathological parameters were obtained from all the participants through written questionnaires. Genotypes were determined by Sequenom MassARRAY system. Unconditional logistic regression analysis was employed to explore the gene-environment interactions and gene-gene interactions. χ(2) test and unconditional logistic regression were used to evaluate the roles of polymorphisms on the risk of metastasis to CRC. Overweighted individuals that carrying at least one of the ADH1B rs1229984 G alleles presented significant increase on the risk to colorectal cancer(OR = 1.720, 95%CI:1.038-2.848,ORadj = 1.785, 95%CI:1.061-3.002). Modest interaction was seen between smoking and ADH1B(rs1229984) only before the adjustment of data, by sex, age and drinking status(OR = 0.597, 95% CI:0.387-0.921, ORadj = 0.922, 95%CI:0.509-1.669). Correlations between polymorphisms and the Dukes stage were not found. Overweight presented significant interaction with G allele of ADH1B rs1229984 in the susceptibility of CRC. None of the rs1229984, rs671 and rs1329149 exhibited significant influence on the development of CRC.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 10/2013; 34(10):1013-7.
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    ABSTRACT: Interleukin-23 (IL-23) and IL-23 receptor (IL23R) play an important role during the T-helper 17 (Th17) cell-mediated inflammatory process as well as pathogenesis of multiple cancers. Several IL-23R single nucleotide polymorphisms (SNPs), especially rs6682925, rs10889677 and rs1884444 polymorphisms, are considered to have significant impacts on susceptibility of multiple cancers. A number of case-control studies have explored the role these genetic polymorphisms in development of carcinogenesis, but the conclusions are inconsistent. Therefore, we conducted this meta-analysis to systematically investigate the associations between the three genetic variants and multiple cancer risk. A total of ten studies are eligible (12211 patients and 14650 controls). Pooled odds ratios (ORs) and the 95% confidence interval (95%CI) were appropriately calculated using either fixed-effect model or random-effect model. Significant associations between rs6682925 or rs10889677 polymorphism and cancer risk were found (OR=1.11, 95%CI=1.03-1.21, P=0.007; or 95% CI=0.71-0.92, P=0.001). However, there was no such association between rs1884444 genotypes and cancer susceptibility (P>0.05). These findings reveal that the IL-23R rs6682925 and rs10889677 genetic variants play a more important part in pathogenesis of multiple cancers.
    Gene 09/2013; · 2.20 Impact Factor
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    ABSTRACT: Neural networks in vertebrates exhibit endogenous oscillations that have been associated with functions ranging from sensory processing to locomotion. It remains unclear whether oscillations may play a similar role in the insect brain. We describe a novel "whole-brain" readout for Drosophila melanogaster, using a simple multichannel recording preparation to study electrical activity across the brain of flies exposed to different sensory stimuli. We recorded local field potential (LFP) activity from >2000 registered recording sites across the fly brain in >200 wild type and transgenic animals to uncover specific LFP frequency bands that correlate with: 1) brain region; 2) sensory modality (olfactory, visual, or mechanosensory); 3) activity in specific neural circuits. We found endogenous and stimulus-specific oscillations throughout the fly brain. Central (higher order) brain regions exhibited sensory modality-specific increases in power within narrow frequency bands. Conversely, in sensory brain regions such as the optic or antennal lobes, LFP coherence, rather than power, best defined sensory responses across modalities. By transiently activating specific circuits via expression of TrpA1, we found that several circuits in the fly brain modulate LFP power and coherence across brain regions and frequency domains. However, activation of a neuromodulatory octopaminergic circuit specifically increased neuronal coherence in the optic lobes during visual stimulation while decreasing coherence in central brain regions. Our multichannel recording and brain registration approach provides an effective way to track activity simultaneously across the fly brain in vivo, allowing investigation of functional roles for oscillations in processing sensory stimuli and modulating behavior.
    Journal of Neurophysiology 07/2013; · 3.30 Impact Factor
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    ABSTRACT: Clematichinenoside AR (C-AR), a pentacyclic triterpenoid saponin with anti-inflammatory and anti-rheumatoid activities, is the main active component of the traditional Chinese medicine Clematidis Radix et Rhizoma. However, its poor oral absorption indicated that not only the parent compound C-AR itself, but also its metabolites could be responsible for the pharmacological effects in rats. The present study aimed to investigate the metabolism of C-AR in rat intestinal microflora, where C-AR was extensively metabolized. C-AR was incubated with the content of the large intestine. The culture solution was collected at different time points and analyzed for the metabolites of C-AR. Eight metabolites were identified by liquid chromatography/quadrupole time-of-flight mass spectrometry. M1, M2 and M5 were the major metabolites. In addition, it was proposed that deglycosylation was the only pathway contributing to the biotransformation of C-AR in rat intestinal microflora. Copyright © 2013 John Wiley & Sons, Ltd.
    Biomedical Chromatography 07/2013; · 1.95 Impact Factor
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    ABSTRACT: Cytochrome P450 (CYP) 3A induction-mediated drug-drug interaction (DDI) is one of the major concerns in drug development and clinical practice. The aim of the present study was to develop a novel mechanistic physiologically based pharmacokinetic (PBPK)-enzyme turnover model involving both intestinal and hepatic CYP3A induction to quantitatively predict magnitude of CYP3A induction-mediated DDIs from in vitro data. The contribution of intestinal P-glycoprotein (P-gp) was also incorporated into the PBPK model. First, the pharmacokinetic profiles of three inducers and 14 CYP3A substrates were predicted successfully using the developed model, with the predicted area under the plasma concentration-time curve (AUC) [area under the plasma concentration-time curve] and the peak concentration (Cmax ) [the peak concentration] in accordance with reported values. The model was further applied to predict DDIs between the three inducers and 14 CYP3A substrates. Results showed that predicted AUC and Cmax ratios in the presence and absence of inducer were within twofold of observed values for 17 (74%) of the 23 DDI studies, and for 14 (82%) of the 17 DDI studies, respectively. All the results gave us a conclusion that the developed mechanistic PBPK-enzyme turnover model showed great advantages on quantitative prediction of CYP3A induction-mediated DDIs. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.
    Journal of Pharmaceutical Sciences 06/2013; · 3.13 Impact Factor
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    ABSTRACT: A new type of nonstoichiometric rutile titanium dioxide (TiO2) film with around 15 at% oxygen vacancies homogeneously distributed throughout the bulk was prepared. The resultant films, when used as a photoelectrode, showed a photoelectrochemical water splitting activity 1.7 times that of stoichiometric TiO2 at a bias of 0.9 V vs. Ag/AgCl. This is believed to result from the synergistic effect of the improved bulk transport and surface transfer of charge carriers compared to the stoichiometric rutile TiO2.
    Chemical Communications 06/2013; · 6.38 Impact Factor
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    ABSTRACT: Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms (SNPs) in E2F3P1 and hepatocellular carcinoma (HCC) risk in 1050 hepatitis B virus (HBV)-positive HCC cases and 1050 chronic HBV carriers. Logistic regression analysis was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC (adjusted OR = 0.66, 95% CIs = 0.51-0.86, P = 0.002) compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 (95% CIs = 1.07-1.86), and the A allele of rs9909601 was significantly associated with HCC risk compared to those with the G allele (adjusted OR = 1.17, 95% CIs = 1.03-1.33, P = 0.017). These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk.
    Journal of biomedical research. 05/2013; 27(3):215-219.
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    ABSTRACT: Highly ordered ZrO2 nanotube arrays have been fabricated by anodization at different voltages between 20–50 V. Photoluminescence of the as-prepared freestanding ZrO2 membrane were tested and photocatalytic activities of ZrO2 nanotube arrays were characterized by quantifying the degradation of methyl orange dye solution. It was found that the as-prepared samples exhibited two types of photoluminescence peaks, one is stable peaks and another is unstable peaks which shift with the excitation wavelength. In the samples annealed at 400 °C, only stable peaks are presented. The decolorization percentage decreases with a higher solution concentration, while increases with a larger diameter of ZrO2 nanotubes.
    Optical Materials 05/2013; 35(7):1461–1466. · 1.92 Impact Factor
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    ABSTRACT: An enantioselective tandem reaction of chromones-derived MBH carbonates () with benzylamines () catalyzed by a trifunctional organocatalyst, cinchonidine-amide-thiourea, has been developed in moderate to good yields (50-87%) and enantioselectivities (up to 89% ee).
    Chemical Communications 03/2013; · 6.38 Impact Factor

Publication Stats

1k Citations
921.86 Total Impact Points

Institutions

  • 2011–2014
    • Wuhan Textile University
      Wu-han-shih, Hubei, China
    • Hebei University
      Pao-ting-shih, Hebei, China
    • Tongji Medical University
      Wu-han-shih, Hubei, China
    • Tsinghua University
      • Department of Computer Science and Technology
      Peping, Beijing, China
    • Northwestern Polytechnical University
      Xi’an, Liaoning, China
  • 2005–2014
    • Chinese Academy of Sciences
      • • Institute of Biophysics
      • • Key Laboratory of Molecular Recognition and Function
      • • Institute of Chemistry
      Peping, Beijing, China
  • 2011–2013
    • Guangdong Pharmaceutical University
      Shengcheng, Guangdong, China
  • 2008–2013
    • Nanjing Medical University
      • • Key Laboratory of Modern Toxicology (MOE)
      • • Department of Epidemiology and Biostatistics
      • • Department of Clinical Pharmacology
      Nanjing, Jiangsu Sheng, China
  • 2007–2013
    • China Pharmaceutical University
      • • Key Laboratory of Drug Metabolism and Pharmacokinetics
      • • Jiangsu Center for Drug Screening
      • • Center of Drug Metabolism and Pharmacokinetics
      Nanjing, Jiangxi Sheng, China
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2005–2013
    • Fourth Military Medical University
      • • Department of Pharmacology
      • • Department of Cardiology
      Xi’an, Liaoning, China
  • 2004–2013
    • Northeast Institute of Geography and Agroecology
      • • Key Laboratory of Molecular Recognition and Function
      • • Institute of Biophysics
      • • Institute of Chemistry
      • • Molecular Biology and Cell Biology Laboratory
      Beijing, Beijing Shi, China
    • Beijing University of Chemical Technology
      • College of Materials Science and Engineering (SMSE)
      Peping, Beijing, China
  • 2010–2011
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • National Health Research Institutes
      • Institute of Population Health Sciences
      Miaoli, Taiwan, Taiwan
    • Jilin University
      • College of Physics
      Jilin, Jilin Sheng, China
  • 2008–2011
    • Huazhong University of Science and Technology
      • School of Public Health
      Wuhan, Hubei, China
  • 2009
    • Nankai University
      • Institute of New Energy Material Chemistry
      Tianjin, Tianjin Shi, China
  • 2004–2009
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2006
    • Government of the People's Republic of China
      Peping, Beijing, China