Li Liu

Changzhou University, Wujin, Jiangsu Sheng, China

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Publications (281)947.84 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A mild, simple, and controllable metal-free photocatalytic system for the transformation of arylmethyl bromides to corresponding alcohols and aldehydes in high yields with visible-light irradiation has been achieved. Eosin Y was found to be an efficient promoter for this oxidative dehalogenation reaction under photo irradiation conditions.
    RSC Advances 09/2014; · 3.71 Impact Factor
  • Meixia Li, Li Liu
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    ABSTRACT: Long noncoding RNA (lncRNA) is an emerging category of transcript, and comprises the majority of the transcriptome of various complex organisms. The biological functions of only a handful of lncRNAs have been investigated in detail, showing involvement in a wide range of biological processes through different functional paradigms. However, most lncRNAs remain to be identified. Many lncRNAs are predicted to function, often preferentially, in the nervous system, potentially playing roles in mediating neural functions such as development, behavior, and cognition. To examine the biological significance and potential mechanisms of the remaining unknown neural lncRNAs, certain tractable model organisms, such as Drosophila, can provide advantages including the use of numerous genetic tools. Herein, we summarize recent progress on the in vivo or potential functions of Drosophila lncRNAs, in particular, behavior and development-related lncRNAs.
    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 09/2014;
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    ABSTRACT: Recently, more and more evidence are rapidly accumulating that long noncoding RNAs (lncRNAs) are involved in human tumorigenesis and misregulated in many cancers, including colon cancer. LncRNA could regulate essential pathways that contribute to tumor initiation and progression with their tissue specificity, which indicates that lncRNA would be valuable biomarkers and therapeutic targets. Colon cancer-associated transcript 1 (CCAT1) is a 2628 nucleotide-lncRNA and located in the vicinity of a well-known transcription factor c-Myc. CCAT1 has been found to be upregulated in many cancers, including gastric carcinoma and colonic adenoma-carcinoma. However, its roles in colon cancer are still not well documented and need to be investigated. In this study, we aim to investigate the prognostic value and biological function of CCAT1 and discover which factors may contribute to the deregulation of CCAT1 in colon cancer. Our results revealed that CCAT1 was significantly overexpressed in colon cancer tissues when compared with normal tissues, and its increased expression was correlated with patients' clinical stage, lymph nodes metastasis, and survival time after surgery. Moreover, c-Myc could promote CCAT1 transcription by directly binding to its promoter region, and upregulation of CCAT1 expression in colon cancer cells promoted cell proliferation and invasion. These data suggest that c-Myc-activated lncRNA CCAT1 expression contribute to colon cancer tumorigenesis and the metastatic process and could predict the clinical outcome of colon cancer and be a potential target for lncRNA direct therapy.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 09/2014;
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    ABSTRACT: Ammonia is considered to be the main neurotoxin responsible for hepatic encephalopathy resulting from liver failure. Liver failure has been reported to alter expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2) at the blood-brain barrier (BBB). The aim of this study was to investigate whether ammonia is involved in abnormalities of expression and activity of P-gp and Mrp2 at the BBB. Hyperammonemic rats were developed by an intraperitoneal injection of ammonium acetate (NH4Ac, 4.5mmol/kg). Results showed that Mrp2 function markedly increased in cortex and hippocampus of rats at 6 h following NH4Ac administration. Significant increase in function of P-gp was observed in hippocampus of rats. Meanwhile, such alterations were in line with the increase in mRNA and protein levels of P-gp and Mrp2. Significant increase in levels of nuclear amount of NF-κB p65 was also observed. Primarily cultured rat brain microvessel endothelial cells (rBMECs) were used for in vitro study. Data indicated that 24 h exposure to ammonia significantly increased function and expression of P-gp and Mrp2 in rBMECs, accompanied with activation of NF-κB. Furthermore, such alterations induced by ammonia were reversed by NF-κB inhibitor. In conclusion, the present study demonstrates that hyperammonemia increases the function and expression of P-gp and Mrp2 at the BBB via activating NF-κB pathway.This article is protected by copyright. All rights reserved.
    Journal of Neurochemistry 09/2014; · 3.97 Impact Factor
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    ABSTRACT: A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade trans-formation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, undergoes cyclization into the phenanthridines core.
    Organic & Biomolecular Chemistry 08/2014; · 3.57 Impact Factor
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    ABSTRACT: Aim:Simvastatin is frequently administered to diabetic patients with hypercholesterolemia. The aim of the study was to investigate the pharmacokinetics of simvastatin and its hydrolysate simvastatin acid in a rat model of type 2 diabetes.Methods:Diabetes was induced in 4-week-old rats by a treatment of high-fat diet combined with streptozotocin. After the rats received a single dose of simvastatin (20 mg/kg, po, or 2 mg/kg, iv), the plasma concentrations of simvastatin and simvastatin acid were determined. Simvastatin metabolism and cytochrome P4503A (Cyp3a) activity were assessed in hepatic microsomes, and its uptake was studied in freshly isolated hepatocytes. The expression of Cyp3a1, organic anion transporting polypeptide 2 (Oatp2), multidrug resistance-associated protein 2 (Mrp2) and breast cancer resistance protein (Bcrp) in livers was measured using qRT-PCR.Results:After oral or intravenous administration, the plasma concentrations and areas under concentrations of simvastatin and simvastatin acid were markedly decreased in diabetic rats. Both simvastatin metabolism and Cyp3a activity were markedly increased in hepatocytes of diabetic rats, accompanied by increased expression of hepatic Cyp3a1 mRNA. Furthermore, the uptake of simvastatin by hepatocytes of diabetic rats was markedly increased, which was associated with increased expression of the influx transporter Oatp2, and decreased expression of the efflux transporters Mrp2 and Bcrp.Conclusion:Diabetes enhances the metabolism of simvastatin and simvastatin acid in rats via up-regulating hepatic Cyp3a activity and expression and increasing hepatic uptake.
    Acta Pharmacologica Sinica 08/2014; · 2.35 Impact Factor
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    ABSTRACT: Two series of heterocyclic compounds, thiazolo[3,2-a]benzimidazoles and benzimidazo[2,1-b]-1,3-thiazines, were synthesized by the tunable base-controlled regioselective cascade reaction of 2-mercaptobenzimidazole with Morita–Baylis–Hillman acetates of nitroalkenes in good yields with high regioselectivities.
    Annalen der Chemie und Pharmacie 08/2014; · 3.10 Impact Factor
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    ABSTRACT: Aim:Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to elucidate the underlying mechanisms.Methods:Diabetes mellitus was induced in male SD rats by a high-fat diet combined with a low-dose streptozotocin injection. The rats were orally administered paroxetine (10 mg/kg) and pravastatin (10 mg/d) or both the drugs daily for 28 d. The pharmacokinetics of paroxetine and pravastatin were examined on d 1 and d 28. Biochemical parameters including serum insulin, glucose and lipids were monitored during the treatments. An insulin-secreting cell line (INS-1) was used for measuring insulin secretion.Results:In diabetic rats, co-administration of paroxetine and pravastatin markedly increased the concentrations of both the drugs compared with administration of each drug alone. Furthermore, co-administration severely impaired glucose homeostasis in diabetic rats, as demonstrated by significantly increased serum glucose level, decreased serum and pancreatic insulin levels, and decreased pancreatic Insulin-2 mRNA and tryptophan hydroxylase-1 (Tph-1) mRNA levels. Treatment of INS-1 cells with paroxetine (5 and 10 μmol/L) significantly inhibited insulin secretion, decreased the intracellular insulin, 5-HT, Insulin-2 mRNA and Tph-1 mRNA levels. Treatment of the cells with pravastatin (10 μmol/L) significantly stimulated insulin secretion, which was weakened by co-treatment with paroxetine.Conclusion:Paroxetine inhibits insulin secretion at least via decreasing intracellular 5-HT and insulin biosynthesis. The deregulation of glucose homeostasis by co-administration of paroxetine and pravastatin in diabetic rats can be attributed to enhanced paroxetine exposure.
    Acta pharmacologica Sinica. 06/2014; 35(6):792-805.
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    ABSTRACT: To investigate the effects of low-dose ketamine combined with propofol on the antidepressant efficacy in stressed rats undergoing electroconvulsive shock (ECS) and its impact on phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit glutamate receptor 1 (GluR1) and γ-aminobutyric acid receptor subunit A (GABAAR). Sprague-Dawley rats were stressed by chronic unpredictable mild stress. Fifty stressed rats were randomly divided into 5 groups (n = 10 per group): depression group (with no application, group D), ECS group (applied with ECS after intraperitoneal injection of isotonic sodium chloride solution, 8 mL/kg, group E), ketamine + ECS group (applied with ECS after intraperitoneal injection of ketamine, 10 mg/kg, group KE), propofol + ECS group (applied with ECS after intraperitoneal injection of propofol, 80 mg/kg, group PE), and ketamine + propofol + ECS group (applied with ECS after intraperitoneal injection of ketamine, 10 mg/kg, and propofol, 80 mg/kg, group KPE). All groups except group D underwent ECS once a day for 7 consecutive days. Sucrose preference test, open-field test, and Morris water maze were performed to assess the depressive behavior. Phosphorylation of GluR1 and GABAAR were evaluated by Western blot. Compared with group D, sucrose preference percentage and open-field scores were increased after ECS application in the 4 other groups; rats in group E reported prolonged escape latency and shortened space exploration time, whereas the escape latency were decreased and space exploration time were prolonged in group KPE; the ratio of p-GluR1/p-GABAAR in hippocampus were increased in the 4 other groups. When using group E as control, rats in group KPE exhibited higher sucrose preference percentage and open-field scores; the escape latency was shortened and space exploration time was prolonged in groups KE, PE, and KPE; the ratio of p-GluR1/p-GABAAR in the hippocampus was up-regulated in groups KE and KPE. When compared with groups KE and PE, the rats in group KPE exhibited higher sucrose preference percentage and open-field scores, the escape latency of group KPE was shortened and space exploration time was prolonged, the ratio of p-GluR1/p-GABAAR in the hippocampus of group KEP is between those of groups KE and PE. Low-dose ketamine combined with propofol may play a role in enhancing the antidepressant efficacy of ECS in stressed rats, ameliorating the cognitive impairment associated with ECS by balancing the expression of p-GluR1 and p-GABAAR in the hippocampus of stressed rats.
    The journal of ECT 05/2014; · 1.19 Impact Factor
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    ABSTRACT: Drosophila larvae innately show light-avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involved in larval light-avoidance, compared with control w1118 larvae, larvae with γ-glutamyl transpeptidase 1 (Ggt-1) knockdown or Ggt-1 mutation were found to exhibit higher percentage of green-light avoidance which was mediated by Rh6 photoreceptors. However, their responses to blue light did not change significantly. By adjusting the expression level of Ggt-1 in different tissues, we found that Ggt-1 in malpighian tubules was both necessary and sufficient for green-light avoidance. Our results showed that glutamate levels were lower in Ggt-1 null mutants compared with controls. Feeding Ggt-1 null mutants glutamate can normalize green-light avoidance, indicating that high glutamate concentrations suppressed larval green-light avoidance. However, rather than directly, glutamate affected green-light avoidance indirectly through GABA, the level of which was also lower in Ggt-1 mutants compared with controls. Mutants in glutamate decarboxylase 1, which encodes GABA synthase, and knockdown lines of the GABAA receptor, both exhibit elevated levels of green-light avoidance. Thus, our results elucidate the neurobiological mechanisms mediating green-light avoidance, which was inhibited in wild-type larvae.This article is protected by copyright. All rights reserved.
    Journal of Neurochemistry 04/2014; · 3.97 Impact Factor
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    ABSTRACT: Drosophila melanogaster feeds mainly on rotten fruits, which contain many kinds of sugar. Thus, the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior. Although several sugar receptors have been described, it remains poorly understood how the sensory input is transformed into an appetitive behavior. Here, we used a neural silencing approach to screen brain circuits, and identified neurons labeled by three Gal4 lines that modulate Drosophila feeding behavior. These three Gal4 lines labeled neurons mainly in the suboesophageal ganglia (SOG), which is considered to be the fly's primary taste center. When we blocked the activity of these neurons, flies decreased their sugar consumption significantly. In contrast, activation of these neurons resulted in enhanced feeding behavior and increased food consumption not only towards sugar, but to an array of food sources. Moreover, upon neuronal activation, the flies demonstrated feeding behavior even in the absence of food, which suggests that neuronal activation can replace food as a stimulus for feeding behavior. These findings indicate that these Gal4-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control.
    Science China. Life sciences 03/2014; · 2.02 Impact Factor
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    ABSTRACT: A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.
    Organic & Biomolecular Chemistry 03/2014; · 3.57 Impact Factor
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    ABSTRACT: Based on historical runs, one of the core experiments of the fifth phase of the Coupled Model Intercomparison Project (CMIP5), the snow depth (SD) and snow cover fraction (SCF) simulated by two versions of the Flexible Global Ocean-Atmosphere-Land System (FGOALS) model, Grid-point Version 2 (g2) and Spectral Version 2 (s2), were validated against observational data. The results revealed that the spatial pattern of SD and SCF over the Northern Hemisphere (NH) are simulated well by both models, except over the Tibetan Plateau, with the average spatial correlation coefficient over all months being around 0.7 and 0.8 for SD and SCF, respectively. Although the onset of snow accumulation is captured well by the two models in terms of the annual cycle of SD and SCF, g2 overestimates SD/SCF over most mid- and high-latitude areas of the NH. Analysis showed that g2 produces lower temperatures than s2 because it considers the indirect effects of aerosols in its atmospheric component, which is the primary driver for the SD/SCF difference between the two models. In addition, both models simulate the significant decreasing trend of SCF well over (30°-70°N) in winter during the period 1971–94. However, as g2 has a weak response to an increase in the concentration of CO2 and lower climate sensitivity, it presents weaker interannual variation compared to s2.
    Advances in Atmospheric Sciences 03/2014; 31(2). · 1.34 Impact Factor
  • ChemInform 02/2014; 45(5).
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    ABSTRACT: Gastric submucosal tumors (SMTs) originating from the muscularis propria layer are treated endoscopically. Successful closure of the wall defect is a critical step. This study evaluated the safety and feasibility of the endoscopic purse-string suture (EPSS) method using an endoloop and several metallic clips after endoscopic full-thickness resection (EFTR) or perforation due to endoscopic submucosal dissection (ESD). From December 2009 to April 2013, 30 patients with SMTs originating from the muscularis propria layer who received EFTR or ESD were retrospectively analyzed. After successful tumor resection, an endoloop was anchored onto the circumferential margin of the gastric defect with several metallic clips and tightened gently. Patient characteristics, tumor size, en bloc resection, and postoperative complications were evaluated. For all 30 patients, EPSS was successfully performed after EFTR or perforation due to ESD. The mean diameter of the resected specimen was 1.9 cm. No severe complications occurred during or after the procedure. The lesions were healed 1 month after the procedure, as confirmed endoscopically. The EPSS method using an endoloop and clips is an effective and safe technique for closing the gastric defect after EFTR or perforation due to ESD.
    Surgical Endoscopy 01/2014; · 3.43 Impact Factor
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    ABSTRACT: Accumulating evidences have shown that diabetes upregulated the function and expression of CYP3A4, but the mechanism remained unclear. In this study, HepG2 cells were incubated with serum from diabetic rats induced by streptozotocin, and the activity of CYP3A4 was measured by substrate metabolism. Results showed that incubation with diabetic serum significantly induced CYP3A4 activity in HepG2 cells. To identify the specific factors contributing to the regulation, the abnormally altered components in diabetic serum, including glucose, insulin, cholesterol, and free fatty acids were screened. It was found that only fatty acids concentration-dependently up-regulated CYP3A4 activity, and the induction by fatty acids was further confirmed in Fa2N-4 cells. Data from western blotting and QT-PCR showed that induction of CYP3A4 activity was associated with up-regulation of CYP3A4 protein and mRNA levels. In addition, effects of pharmacological inhibitors on fatty acid-induced CYP3A4 activity were studied. The results indicated that the induction of CYP3A4 activity by oleic acid may be partly via AMPK-, PKC-, and NF-κB-dependent pathways, whereas that by palmitic acid was possibly associated with the PKC-dependent pathway. In conclusion, the increased levels of fatty acids may be one of the reasons leading to the elevated function and expression of CYP3A4 under diabetic conditions.
    Journal of Pharmacological Sciences 01/2014; 124(4):433-44. · 2.15 Impact Factor
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    ABSTRACT: The variability of Atlantic Meridional Overturning Circulation (AMOC) in the pre-industrial control experiment of the Flexible Global Ocean-Atmosphere-Land System model, Grid-point Version 2 (FGOALS-g2) was investigated using the model outputs with the most stable state in a 512-yr time window from the total 1500-yr period of the experiment. The period of AMOC in FGOALS-g2 is double peaked at 20 and 32 years according to the power spectrum, and 22 years according to an auto-correlation analysis, which shows very obvious decadal variability. Like many other coupled climate models, the decadal variability of AMOC in FGOALS-g2 is closely related to the convection that occurs in the Labrador Sea region. Deep convection in the Labrador Sea in FGOALS-g2 leads the AMOC maximum by 3–4 years. The contributions of thermal and haline effects to the variability of the convection in three different regions [the Labrador, Irminger and Greenland-Iceland-Norwegian (GIN) Seas] were analyzed for FGOALS-g2. The variability of convection in the Labrador and Irminger Seas is thermally dominant, while that in the colder GIN Seas can be mainly attributed to salinity changes due to the lower thermal expansion. By comparing the simulation results from FGOALS-g2 and 11 other models, it was found that AMOC variability can be attributed to salinity changes for longer periods (longer than 35 years) and to temperature changes for shorter periods.
    Advances in Atmospheric Sciences 01/2014; 31(1). · 1.34 Impact Factor
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    ABSTRACT: Long noncoding RNA(lncRNA) is the one particularly abundant but poorly understood class of ncRNAs. Although we presently know little about their function, lncRNAs' widely expressed in the nervous system suggested they're likely to play potential critical roles in neural functions. Here, we described one novel Drosophila lncRNA(lnc10) for its molecular characterizations, including fulllength sequence confirmation, protein-coding potential evaluation, conservation analysis, expression level analysis in three body parts, spatial-temporal expression tracing in nervous system, and regulation effects on its adjacent protein coding gene. We determined lnc10 as a long noncoding RNA. In this study, the lncRNA's spatial-temporal neural expression pattern and positive regulation on the neighbouring protein coding gene provided the possible molecular basis for the further investigation of the potential neural function of lnc10, besides, the underlying molecular mechanism and neural action location of lnc10 in the future analysis could also be determined by utilizing the Drosophila genetics, e.g. Gal4 and UAS system. This study will enrich the present biological significance of lncRNAs and may provide potential insights into neural dysfunction.
    Journal of Genetics and Genomics 01/2014; · 2.08 Impact Factor
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    ABSTRACT: A quantitative structure–property relationship study was performed to correlate descriptors representing the molecular structures to fiber affinities for azo dyes. The complete set of 51 compounds was divided into a training set of 41 compounds and a test set of 10 compounds by using DUPLEX algorithm. Multiple linear regression analysis was used to select the best subset of descriptors and to build linear models; nonlinear models were developed by means of artificial neural network. The robustness of the obtained models was assessed by different approaches, including leave-many-out cross-validation, Y-randomization test, and external validation through test set. The obtained models with four descriptors show good predictive power: for the test set, a squared correlation coefficient (r2) of 0.916 was achieved by the linear model; while the nonlinear model with r2 of 0.935 for the test set performs better than the linear model. Furthermore, the applicability domain of the models was analyzed based on the Williams plot. The donor atom number for H-bonds, group polarizability and electronegativity of the dye molecules are found to play important roles for the dye-fiber affinity.
    Chemometrics and Intelligent Laboratory Systems 01/2014; · 2.29 Impact Factor

Publication Stats

2k Citations
947.84 Total Impact Points

Institutions

  • 2012–2014
    • Changzhou University
      Wujin, Jiangsu Sheng, China
    • Southwest University in Chongqing
      Pehpei, Chongqing Shi, China
  • 2011–2014
    • Wuhan Textile University
      Wu-han-shih, Hubei, China
    • Tsinghua University
      • • Center for Earth System Science
      • • Department of Computer Science and Technology
      Peping, Beijing, China
    • Hebei University
      Pao-ting-shih, Hebei, China
    • Tongji Medical University
      Wu-han-shih, Hubei, China
  • 2007–2014
    • China Pharmaceutical University
      • • Key Laboratory of Drug Metabolism and Pharmacokinetics
      • • Jiangsu Center for Drug Screening
      • • Center of Drug Metabolism and Pharmacokinetics
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2005–2014
    • Chinese Academy of Sciences
      • • Institute of Biophysics
      • • Key Laboratory of Molecular Recognition and Function
      • • Institute of Chemistry
      Peping, Beijing, China
  • 2013
    • Northeast Normal University
      • Department of Chemistry
      Hsin-ching, Jilin Sheng, China
  • 2011–2013
    • Guangdong Pharmaceutical University
      Shengcheng, Guangdong, China
  • 2008–2013
    • Nanjing Medical University
      • • Key Laboratory of Modern Toxicology (MOE)
      • • Department of Epidemiology and Biostatistics
      • • Department of Clinical Pharmacology
      Nanjing, Jiangsu Sheng, China
  • 2004–2013
    • Beijing University of Chemical Technology
      • College of Materials Science and Engineering (SMSE)
      Peping, Beijing, China
    • Northeast Institute of Geography and Agroecology
      • • Key Laboratory of Molecular Recognition and Function
      • • Institute of Biophysics
      • • Institute of Chemistry
      • • Molecular Biology and Cell Biology Laboratory
      Beijing, Beijing Shi, China
  • 2009–2012
    • Yantai University
      Chifu, Shandong Sheng, China
  • 2006–2012
    • Shanghai Jiao Tong University
      • School of Pharmacy
      Shanghai, Shanghai Shi, China
    • Government of the People's Republic of China
      Peping, Beijing, China
  • 2010–2011
    • Yangzhou University
      Chiang-tu, Jiangsu Sheng, China
    • National Health Research Institutes
      • Institute of Population Health Sciences
      Miaoli, Taiwan, Taiwan
    • Jilin University
      • College of Physics
      Jilin, Jilin Sheng, China
  • 2008–2011
    • Huazhong University of Science and Technology
      • School of Public Health
      Wuhan, Hubei, China
  • 2007–2011
    • Shanghai University
      • Department of Chemistry
      Shanghai, Shanghai Shi, China
  • 2004–2009
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2003–2007
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2004–2006
    • University of Science and Technology of China
      • Department of Polymer Science and Engineering
      Hefei, Anhui Sheng, China