Suhasini Joshi

All India Institute of Medical Sciences, New Delhi, NCT, India

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Publications (2)2.86 Total impact

  • Suhasini Joshi, Ashish Tiwari
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    ABSTRACT: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
    Clinical Oncology 02/2011; · 2.86 Impact Factor
  • Suhasini Joshi, Ashish K. Tiwari
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    ABSTRACT: Tumour angiogenesis depends on the expression of specific mediators that initiate a cascade of events leading to the formation of new microvessels. Many growth factors have been discovered, and their critical and individual involvements in angiogenesis have been extensively investigated. The knowledge derived from the study of angiogenesis-related factors has been translated into designing several chemotherapeutic agents selectively targeting tumour microvasculature. Among many known classes of angiogenic factors, angiopoietin-1 and -2 (Ang1 and -2) have been implicated in many cancers. Their critical roles in angiogenesis and the prospects of developing Ang1- and Ang2-based chemotherapeutic regimens have fuelled extensive research on their mechanisms of actions in tumour cells and microenvironment. A more refined understanding of the angiopoietin signalling pathways controlling many aspects of vascular development as well as remodelling will help define new and more specific targets for future therapeutic interventions. Here we will discuss the recent advances in Ang1 and -2 biology, including their defined roles in cancer, plausible mechanisms of action and regulation, as well as novel approaches to inhibit them.
    Clinical Oncology - CLIN ONCOL-UK.

Publication Stats

2.86 Total Impact Points

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Institutions

  • 2011
    • All India Institute of Medical Sciences
      • Department of Biochemistry
      New Delhi, NCT, India