J Vincent Price

University of Tennessee, Knoxville, TN, United States

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Publications (1)3.37 Total impact

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    ABSTRACT: Since its first application to antibody engineering 15 years ago, yeast display technology has been developed into a highly potent tool for both affinity maturing lead molecules and isolating novel antibodies and antibody-like species. Robust approaches to the creation of diversity, construction of yeast libraries, and library screening or selection have been elaborated, improving the quality of engineered molecules and certainty of success in an antibody engineering campaign and positioning yeast display as one of the premier antibody engineering technologies currently in use. Here, we summarize the history of antibody engineering by yeast surface display, approaches used in its application, and a number of examples highlighting the utility of this method for antibody engineering.
    Archives of Biochemistry and Biophysics 03/2012; 526(2):99-106. · 3.37 Impact Factor

Publication Stats

6 Citations
3.37 Total Impact Points

Institutions

  • 2012
    • University of Tennessee
      • Department of Chemical and Biomolecular Engineering
      Knoxville, TN, United States
    • The University of Tennessee Medical Center at Knoxville
      Knoxville, Tennessee, United States