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ABSTRACT: Rats treated with marihuana extract to yield 1-Δ9THC doses of 0.25 and 0.50 mg/kg fought more than controls in a shock-induced aggression situation. A dose of 0.12 mg/kg was ineffective, while doses of 1.00 and 2.00 suppressed fighting. When animals were familiarized with the test situation, the drug, or both, increases in aggression were not produced by the drug.
Physiology & Behavior 05/1972; · 2.87 Impact Factor
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ABSTRACT: Rats were trained to run an alley for food reinforcement. Rats dosed with marihuana distillate before each session from the beginning of training showed a very slow improvement of performance during training. Rats that first received marijuana after reaching asymptotic performance showed a disruption of performance under the drug. These rats, however, rapidly developed a tolerance to the drug. It was concluded that increased prior training increases the rate of behavioral tolerance development.
Pharmacology Biochemistry and Behavior.
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ABSTRACT: Rats were trained to press a lever for food reinforcement in one study and water reinforcement in a second. Rats which received marihuana extract each day before behavioral testing showed an impairment of responding on the first day of drug application, but developed behavioral tolerance to the drug by the sixth day of drug application. Rats which received equal doses of marihuana after each session, rather than before, over the same period, showed little or no evidence of behavioral tolerance when the drug was administered before testing. This result was interpreted to indicate that the development of behavioral tolerance to marihuana involves a learning process.
Pharmacology Biochemistry and Behavior · 2.53 Impact Factor
