Tohru Sakai,
Emi Shuto,
Tomoyo Taki,
Honami Imamura,
Miku Kioka,
Akiko Nakamoto, Seiji Mizoguchi,
Shouko Amano,
Yukari Kawano,
Mariko Nakamoto,
Rie Tsutumi,
Toshio Hosaka
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ABSTRACT: NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)-immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
The Journal of Medical Investigation 02/2012; 59(1-2):95-101.
