N M Krotenko

Publications (2)0.12 Total impact

• Article: The state of the antioxidant system during therapy of patients with multiple sclerosis

  L. P. Smirnova, N. V. Krotenko, E. V. Grishko, N. M. Krotenko, V. M. Alifirova, S. A. Ivanova
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  ABSTRACT: Activity of erythrocyte glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GT), glucose-6-phosphate dehydrogenase (G6PDH), catalase and superoxide dismutase (SOD), the level of erythrocyte malonic dialdehyde (MDA) and also total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis (MS). Investigation of peripherical blood was carried out on the first day of admission to the hospital and after the standard therapy with copaxone. During the whole period of observation all MS patients had a high level of MDA and activity of erythrocyte GP compared with a control group. Other erythrocyte antioxidant enzymes and total antioxidant activity of blood serum exhibited weak positive dynamics in patients with relapsing-remitting multiple sclerosis (RRMS). The pathological decrease of antioxidant system activity in patients with secondary progressive multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with a more severe clinical course of this disease. Keywordsoxidative stress–antioxidant enzymes–multiple sclerosis
  Biochemistry (Moscow) Supplement Series B Biomedical Chemistry 04/2012; 5(1):76-80.
• Article: [Antibodies to native and denatured DNA in multiple sclerosis].

  V M Alifirova, N V Krotenko, N M Krotenko, S A Ivanova
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  ABSTRACT: An aim of the present paper was to study antibodies to native and denatured DNA in the serum of patients with multiple sclerosis (MS). Sixty-two patients and 27 healthy people (controls) have been studied. The significantly higher levels of antibodies to native (56% of patients) and denatured (67% of patients) DNA were observed compared to controls. The higher levels of antibodies were found in patients with remitting MS compared to primarily- and secondary progressive MS. The results obtained support the hypothesis that anti-DNA antibodies to DNA are the key component of the pathogenesis and their level depends on the immunoreactivity of the patient and MS course.
  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2011; 111(2 Pt 2):16-20. · 0.12 Impact Factor