Li Wang

Institute of Chemistry and Materials, Lutetia Parisorum, Île-de-France, France

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Publications (648)1555.51 Total impact

  • BMC Microbiology 12/2015; 15(1). DOI:10.1186/s12866-015-0525-2 · 2.73 Impact Factor
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    ABSTRACT: The pharmacokinetics of parishin, gastrodin, Gastrodia elata extract and Rhizoma Gastrodiae capsule was investigated by intragastric and/or intravenous administration to rats. Parishin was metabolized into nine metabolites after intravenous administration, and the area under the curve (AUC0-∞) of parishin and its metabolites (except parishin G and parishin E) increased nonlinearly from 72.5 to 220 mg/kg. When combining regression equation with the AUC0-∞ and dose of gastrodin injection, the percent conversion of parishin to gastrodin was obtained as 50 %. Based on multi-active metabolites of parishin in vivo, integrated pharmacokinetic mode was established. It is notable that each metabolite from parishin shares the similar metabolic process at three dosages of parishin and the bioavailability of parishin was approximately 14 %. The integrated pharmacokinetic mode was successfully applied to evaluate the holistic pharmacokinetics of gastrodin injection, G. elata extract and Rhizoma Gastrodiae capsule. The results showed that the holistic pharmacokinetics of gastrodin injection and G. elata extract was closed to that of gastrodin, but for parishin and Rhizoma Gastrodiae capsule, integrated pharmacokinetic parameters were more suitable to evaluate its holistic pharmacokinetics. Graphical abstract Pharmacokinetic study of Gastrodia elata in rats.
    Analytical and Bioanalytical Chemistry 09/2015; DOI:10.1007/s00216-015-9054-y · 3.44 Impact Factor
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    ABSTRACT: This article described a novel method by coupling a universal DNA circuit with graphene sheets/polyaniline/AuNPs nanocomposites (GS/PANI/AuNPs) for highly sensitive and specific detection of BCR/ABL fusion gene (bcr/abl) in chronic myeloid leukemia (CML). DNA circuit known as catalyzed hairpin assembly (CHA) is enzyme-free and can be simply operated to achieve exponential amplification, which has been widely employed in biosensing. However, application of CHA has been hindered by the need of specially redesigned sequences for each single-stranded DNA input. Herein, a transducer hairpin (HP) was designed to obtain a universal DNA circuit with favorable signal-to-background ratio. To further improve signal amplification, GS/PANI/AuNPs with excellent conductivity and enlarged effective area were introduced into this DNA circuit. Consequently, by combining the advantages of CHA and GS/PANI/AuNPs, bcr/abl could be detected in a linear range from 10 pM to 20 nM with a detection limit of 1.05 pM. Moreover, this protocol showed excellent specificity, good stability and was successfully applied for the detection of real sample, which demonstrated its great potential in clinical application.
    Analytica chimica acta 09/2015; 889:90-97. DOI:10.1016/j.aca.2015.06.050 · 4.51 Impact Factor
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    ABSTRACT: The electromagnetic (EM) responses of a series of single layer and bilayer terahertz (THz) metamaterials (MMs) were systematically investigated. Bilayer split ring resonators (SRRs) consisting of different SRR units and/or surrounding dielectrics show an excellent capability to tailor and tune EM responses using the combined responses in the SRRs in different layers. By avoiding complex interactions between the layers, easy and quick design for complex multi-responses MMs can be carried out. This tailoring and tuning capability of bilayer MMs shows a great potential for many novel THz applications such as signature control, chem/bio detection, and multi-response sensors.
    Microelectronic Engineering 09/2015; 145. DOI:10.1016/j.mee.2015.03.015 · 1.20 Impact Factor
  • ACS Catalysis 09/2015; DOI:10.1021/acscatal.5b00747 · 9.31 Impact Factor
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    ABSTRACT: To determine the impact of partial reimbursement for antivirals on antiviral utilization and adherence for chronic hepatitis B patients. This was a retrospective cohort study. Two separate cohorts were enrolled, including 14163 and 16288 chronic hepatitis B outpatients, respectively. These patients were referred to Beijing You'an Hospital before and after the new partial reimbursement for antivirals, which was implemented on July 1, 2011. Demographic characteristics (including medical insurance status), routine biochemical, virological and serology laboratory test results, and antiviral agents' prescription information were collected from an electronic database. Patients were also defined as new and existing patients according to treatment history. Antiviral utilization, medication possession ratio and persistence rate were calculated and compared among the patients with different characteristics. A questionnaire survey was conducted among 212 randomly sampled outpatients from the same hospital to confirm the validity of the electronic database. Propensity score matching was used to adjust the distribution of patient's characteristics which may influence the antiviral utilization. χ(2) test or ANOVA was adopted and multivariate logistic regression was used to determine the factors associated with antiviral utilization and good adherence. A total of 13364 outpatients from each cohort were enrolled after the propensity score matching. The antiviral utilization rate for the insured patients increased from 57.4% to 75.9% (P < 0.0001) after the reimbursement, and the rate among those who paid out-of-pocket increased from 54.9% to 56.7% (P = 0.028). Approximately 71% of the patients had a medication possession ratio of more than 80% in each cohort before reimbursement. This increased to 79.2% and 73.1% for insured patients and those who paid out-of-pocket, respectively (P < 0.0001). Insured patients and those who paid out-of-pocket had the similar persistence rates before reimbursement. But after reimbursement, insured patients had higher persistence rates than those who paid out-of-pocket at 6 (86.5% vs 81.5%, P < 0.0001), 9 (79.7% vs 69.9%, P < 0.0001), 12 (73.4% vs 61.9%, P < 0.0001), and 15 mo (66.6% vs 53.1%, P < 0.0001). The reimbursement could significantly improve adherence for the insured patients than those who paid out-of-pocket even after adjusting other covariates, with an interaction odds ratio of 1.422 (95%CI: 1.220-1.657, P < 0.0001). The questionnaire survey supported the validity of the electronic database. The reimbursement policy shows a positive impact on antiviral utilization as well as adherence for insured chronic hepatitis B patients.
    08/2015; 21(32):9588-97. DOI:10.3748/wjg.v21.i32.9588
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    ABSTRACT: Citrate is commonly used as an anticoagulant in hemodialysis for chronic renal failure (CRF) and for the regulation of the immune dysfunction in CRF patients. The objective of this study was to investigate the effect of citrate on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in CRF. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly increased in the CRF model group compared to the control group, and were decreased in the citrate-treated groups. Citrate treatment inhibited the viability of Th17 cells while elevating the viability of Treg cells in CRF rats. Moreover, Th17-related cytokines significantly decreased while the Treg-related cytokines significantly increased with citrate treatment. Moreover, citrate had a negative influence on the deviation of Th17/Treg cells in CRF rats. Therefore, our study suggests that citrate had an anti-inflammatory effect on CRF through the modulation of the Th17/Treg balance.
    Inflammation 08/2015; DOI:10.1007/s10753-015-0225-y · 2.21 Impact Factor
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    ABSTRACT: Novel carbon nanotubes (CNTs) incorporated double-skinned thin film nanocomposite (TFN) membranes were fabricated by interfacial polymerization of polydopamine/CNTs and trimesoylchloride (TMC) on polysulfone (PSf) substrate. As controls, thin film composite (TFC) membrane without CNTs and FO membranes with single-skinned structures (top-skinned or bottom-skinned) was also fabricated. The prepared membranes were characterized and evaluated in terms of membrane morphology, structure, surface property, separation performance and antifouling capacity. The effect of membrane orientation, composition and concentration of draw solutions on FO performance was studied as well. It was found that CNTs had significant influence on the properties and the performances of the synthesized FO membranes. The double-skinned membranes owned excellent solute rejection without sacrificing water flux. By incorporation of CNTs, TFN membranes exhibited higher FO water flux than TFC membranes. The double-skinned TFN0.05 membrane, the optimal FO membrane, showed a 54% enhancement in water flux than double-skinned TFC membrane at TOP-FS orientation by using MgCl2 as draw solution and DI water as feed solution. Moreover, the double-skinned TFN0.05 membrane demonstrated remarkable antifouling capacity because of the prominent foulant resistance induced by CNT addition. This work paved a new way to fabricate high performance FO membrane by the utilization of double-skinned structure and incorporation of CNTs.
    Desalination 08/2015; 369. DOI:10.1016/j.desal.2015.04.020 · 3.76 Impact Factor
  • Applied Surface Science 08/2015; DOI:10.1016/j.apsusc.2015.08.077 · 2.71 Impact Factor
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    ABSTRACT: Atrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for <10% of heritability. Gene-gene interaction is assumed to account for a significant portion of missing heritability. Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. Thus, we analyzed the interaction among these three AF loci. We demonstrated significant interaction between rs2106261 and rs2200733 in three independent populations and combined population with 2,020 cases/5,315 controls. Compared to non-risk genotype GGCC, two-locus risk genotype AATT showed the highest odds ratio in three independent populations and the combined population (OR=5.36 (95% CI 3.87-7.43), P=8.00×10-24). The OR of 5.36 for AATT was significantly higher than the combined OR of 3.31 for both GGTT and AACC, suggesting a synergistic interaction between rs2106261 and rs2200733. Relative excess risk due to interaction (RERI) analysis also revealed significant interaction between rs2106261 and rs2200733 when exposed two copies of risk alleles (RERI=2.87, P<1.00×10-4) or exposed to one additional copy of risk allele (RERI=1.29, P<1.00×10-4). The INTERSNP program identified significant genotypic interaction between rs2106261 and rs2200733 under an additive by additive model (OR=0.85, 95% CI: 0.74-0.97, P=0.02). Mechanistically, PITX2c negatively regulates expression of miR-1, which negatively regulates expression of ZFHX3, resulting in a positive regulation of ZFHX3 by PITX2c; ZFHX3 positively regulates expression of PITX2C, resulting in a cyclic loop of cross-regulation between ZFHX3 and PITX2c. Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5. These results suggest that cyclic cross-regulation of gene expression is a molecular basis for gene-gene interactions involved in genetics of complex disease traits.
    PLoS Genetics 08/2015; 11(8):e1005393. DOI:10.1371/journal.pgen.1005393 · 7.53 Impact Factor
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    ABSTRACT: Vaccination of infants beginning at birth is recommended to prevent Hepatitis B virus (HBV) infection in China. Compared to 5μg/dose vaccine administered in other regions in China, a three-dose HB recombinant yeast vaccine at 10μg/dose has been administered for infants within 24h after birth, 1 month and 6 months of age in Beijing since 2006. In a community-based retrospective cohort study, factors influencing immunologic vaccine response were evaluated. A total of 3670 infants who completed a 3-dose 10μg recombinant HB vaccine regimen and who born to hepatitis B antigen negative mothers were included. The effect on anti-HBs titers of maternal nutrient status, infants' birth condition, growth factors, timeliness of vaccination, dosing interval and the interval until post-vaccination serologic testing (PVST) were evaluated. A total of 3666 infants with no markers of HBV infection were included in analysis. The mean anti-HB titers were 1767.17mIU/ml. Only 16.9% of the infants completed their PVST within 30-59 days after the final dose of vaccination. Multivariate linear regression analysis showed that delay in PVST (β=-0.097, p<0.0001) and maternal folic acid supplementation (β=0.067, p=0.002) were associated with log-transformed anti-HB titers. Also a trend toward significant association was observed between the calcium supplementation of infants and log-transformed anti-HBs titers (β=0.062, p=0.057). Longer interval between dose 2 and dose 3 was not observed to increase the anti-HB titers after cofactors adjustment. Our findings illustrate the importance of timing of PVST to avoid unnecessary revaccination. Multi-center large cohort studies should verify the effect and magnitude of folate and calcium supplementation on HB vaccine response. Copyright © 2015. Published by Elsevier Ltd.
    Vaccine 06/2015; DOI:10.1016/j.vaccine.2015.06.018 · 3.62 Impact Factor
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    ABSTRACT: Endogenous neural stem cells in central canal of adult mammalian spinal cord exhibit stem cell properties following injury. In the present study, the endogenous neural stem cells were labeled with Dil to track the differentiation of cells after mild spinal cord injury (SCI). Compared with 1 and 14 days post mild injury, the number of endogenous neural stem cells significantly increased at the injured site of spinal cord on 3 and 7 days post-injury. Dil-labeled βIII-tublin and GFAP expressing cells could be detected on 7 days post-injury, which indicated that the endogenous neural stem cells in central canal of spinal cord differentiated into different type of neural cells, but there were more differentiated astrocytes than the neurons after injury. Furthermore, after injury the expression of inhibitory Notch1 and Hes1 mRNA began to increase at 6 hours and was evident at 12 and 24 hours, which maintained high levels up to 7 days post-injury. These results indicated that a mild SCI in rat is sufficient to induce endogenous neural stem cells proliferation and differentiation. However, the ability to differentiate into neurons is limited, which may be, at least in part, due to high expression of inhibitory Notch1 and Hes1 genes after injury.
    International journal of clinical and experimental pathology 06/2015; 8(4):3835-3842. · 1.89 Impact Factor
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    Xi Lu · Li Wang · Caijia Yu · Daohai Yu · Gang Yu
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    ABSTRACT: It is becoming more evident that histone acetylation, as one of the epigenetic modifications or markers, plays a key role in the etiology of Alzheimer's disease (AD). Histone acetylases and histone deacetylases (HDACs) are the well-known covalent enzymes that modify the reversible acetylation of lysine residues in histone amino-terminal domains. In AD, however, the roles of these enzymes are controversial. Some recent studies indicate that HDAC inhibitors are neuroprotective by regulating memory and synaptic dysfunctions in cellular and animal models of AD; while on the other hand, increase of histone acetylation have been implicated in AD pathology. In this review, we focus on the recent advances on the roles of histone acetylation covalent enzymes in AD and discuss how targeting these enzymes can ultimately lead to therapeutic approaches for treating AD.
    Frontiers in Cellular Neuroscience 06/2015; 9:226. DOI:10.3389/fncel.2015.00226 · 4.29 Impact Factor
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    ABSTRACT: Amyloid beta (Aβ) is a key molecule in the neurodegenerative progression of Alzheimer's disease (AD). It is critical to develop a treatment that can arrest the Aβ-induced pathologic progression of AD. Erythropoietin (EPO) has various protective effects in the nervous system. However, the effect of EPO on Aβ-induced Alzheimer-like cognitive deficits and pathological changes remains unclear. In the present study, we observed that the treatment of mice with EPO (1000IU/kg) attenuated Aβ42-induced cognitive deficits and tau hyperphosphorylation at multiple AD-related sites through the regulation of glycogen synthase kinase-3β (GSK-3β). We also observed that EPO attenuated the Aβ42-induced mitochondrial dysfunction and apoptosis in brain. These results indicate a potential role for EPO in AD therapy. Copyright © 2015. Published by Elsevier B.V.
    Brain research 06/2015; 1618. DOI:10.1016/j.brainres.2015.05.031 · 2.84 Impact Factor
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    ABSTRACT: The unsupported Cu and Ag catalysts with different oxidation states were prepared, and their catalytic performances for propylene epoxidation were investigated. The metallic Cu catalyst exhibits much higher catalytic activity and propylene oxide (PO) selectivity than Cu2O and CuO catalysts. The Cu0 species are the main active sites for propylene epoxidation, but Cu2O and CuO species are in favor of CO2 and acrolein production. The PO selectivity of 54.2 % and propylene conversion of 2.6 % can be achieved over the metallic Cu catalyst at 160 °C in initial stage, but metallic Cu catalyst would be oxidized to Cu2O during propylene epoxidation, resulting in a sharp decrease in the PO selectivity and propylene conversion. Nanosize AgCu x bimetallic catalysts were prepared. It is found that adding Ag to the metallic Cu catalysts can prevent the oxidation of Cu and make AgCu x bimetallic catalysts more stable under the condition of propylene epoxidation. The Ag/Cu molar ratio can remarkably affect the catalytic performance of AgCu x catalyst and the selectivity to PO and acrolein. After AgCu x was supported on MO x -modified α-Al2O3, its catalytic performance can be improved and has a close relationship with the acid-base property of support.
    Rare Metals 05/2015; 34(7). DOI:10.1007/s12598-015-0500-y · 1.01 Impact Factor
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    ABSTRACT: Parishin, is a dominant active ingredient originating from Gastrodia elata Blume, has great neuroprotective effects against brain disorders. In the present study, metabolic profile of parishin by in vitro and in vivo experiments was investigated using ultra-high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC/Q-TOF MS) combined with an automated MS(E) technique. By comparison with reference compounds, accurate mass measurement, the characteristic fragmentation patterns of the parent drug parishin and gastrodin, and relevant bio-transformation knowledge, fourteen metabolites (seven hydrolyzates and seven derivatives of gastrodin) were detected and identified in rat plasma and urine after intragastric administration of parishin, including processes of hydrolyzation, oxidation, sulfation and glucuronidation. According to the proposed metabolic pathways of parishin, in vitro hydrolytic experiments and metabolic study of gastrodin in rat plasma, it can be inferred that parishin mainly functions as a prodrug and undergoes hydrolysis before being absorbed into the blood. The hydrolyzate, mainly gastrodin, was involved in further metabolism which was responsible for pharmacological activities of parishin. In conclusion, this work provided valuable information on parishin metabolism using the rapid and reliable UHPLC/Q-TOF MS method, which could be widely used for the metabolic investigation of natural product. This article is protected by copyright. All rights reserved.
    Biomedical Chromatography 05/2015; DOI:10.1002/bmc.3516 · 1.72 Impact Factor
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    ABSTRACT: To investigate the quality of life of rectal cancer patients after anterior resection and the role of 5-hydroxytryptamine(5-HT) in the pathogenesis of anterior resection syndrome (ARS). Between November 2012 and October 2014, 90 rectal cancer patients who underwent Dixon procedure in the Institute of Surgery Research, Daping Hospital, Third Military Medical University, and developed ARS postoperatively were enrolled in the study. By clinic interview and telephone follow-up, they were investigated according to the 4 questionnaires, including gastrointestinal quality of life index(GIQLI), Wexner constipation and incontinence score(WCS, WIS), and 36-item short form health survey(SF-36). Associated clinical data and above parameters were compared between postoperative 0-6 months and 7-24 months. Expression of 5-HT in rectal mucosa was determined by immunohistochemistry preoperatively and postoperatively. The GIQLI, WCS and WIS were significantly improved in 7-24 months group compared with those in 0-6 months group(all P<0.05). Furthermore, the SF-36 test result also showed significant improvement in the terms of physical function, physical role, vitality, social function, emotional role and health changes spheres in 7-24 months group(P<0.05). 5-HT expression in rectal mucosa(upper anastomosis 3402.95±1876.24, lower anastomosis 3045.35±1373.59 of ARS patients was significantly down-regulated compared with the preoperative expression(rectal margin mucosa 7176.60±3927.61)(P<0.05). Patients with ARS experience a significant trend toward recovery in their whole long-term quality of life. The down-regulation of 5-HT expression in rectal mucosa after surgery may be related with the pathogenesis of ARS.
    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 05/2015; 18(5):469-73.
  • The Breast Journal 05/2015; 21(4). DOI:10.1111/tbj.12427 · 1.41 Impact Factor
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    ABSTRACT: The New World is the last continent colonized by anatomically modern humans, Homo sapiens. The first migrants entered the New World from Asia through Beringia. It is suggested that there were three streams of Asian gene flow, one major and two additional minor gene flows. The first major migrants took a Pacific coastal route and began spreading to the American continent before the opening of the ice-free corridor. We investigated the diversity of full-length mitochondrial DNA genomes of the Zapotec population, residing in the Mesoamerican region, and reconstructed their demographic history using Bayesian Skyline Plots. We estimated the initial date of gene flow into the New World by Zapotec ancestors at around 17 000-19 000 years ago, which is highly concordant with previous studies. We also show a population decline after the initial expansion. This decline started 4000 years ago, long before European contact with Native Americans. This indicates that other factors including climate change should be considered to explain the observed demographic pattern.Journal of Human Genetics advance online publication, 21 May 2015; doi:10.1038/jhg.2015.55.
    Journal of Human Genetics 05/2015; DOI:10.1038/jhg.2015.55 · 2.46 Impact Factor
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    ABSTRACT: Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In the present study, we investigated the role of SNORD78 in the tumorigenesis of non-small cell lung cancer (NSCLC). We determined the expression level of SNORD78 in NSCLC tissues with quantitative real-time PCR and then studied its clinical significance. We explored the biological significance of SNORD78 with gain-and-loss-of-function analyses both in vitro and in vivo. A great upregulation of SNORD78 was observed in cancer tissues compared to their adjacent normal tissues. Meanwhile, patients with high SNORD78 expression have significantly poorer prognosis than those with low expression. Inhibition of SNORD78 suppressed the proliferation of NSCLC cells via inducing G0/G1 cell cycle arrest and apoptosis while SNORD78 overexpression promoted the cell proliferation. SNORD78 promoted invasion of NSCLC cells via inducing epithelial-mesenchymal-transition (EMT). SNORD78 was also obviously upregulated in cancer stem-like cells and is required for the self-renewal of NSCLC. The oncogenic activity of SNORD78 was also confirmed with in vivo data. Our study identified that SNORD78 may be a potential therapeutic target for NSCLC.
    Journal of Experimental & Clinical Cancer Research 05/2015; 34(1):49. DOI:10.1186/s13046-015-0170-5 · 4.43 Impact Factor

Publication Stats

5k Citations
1,555.51 Total Impact Points


  • 2015
    • Institute of Chemistry and Materials
      Lutetia Parisorum, Île-de-France, France
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
  • 2014–2015
    • Chongqing Cancer Hospital and Institute
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Tianjin Medical University Cancer Institute and Hospital
      T’ien-ching-shih, Tianjin Shi, China
    • Northwest Institute of Plateau Biology
      Hsi-ning-shih, Qinghai Sheng, China
    • Beijing University of Technology
      Peping, Beijing, China
  • 2013–2015
    • Huazhong (Central China) Normal University
      • • College of Chemistry
      • • Key Laboratory of Pesticide & Chemical Biology of Ministry of Education
      Wu-han-shih, Hubei, China
    • Hangzhou Normal University
      Hang-hsien, Zhejiang Sheng, China
    • Ocean University of China
      • College of Chemistry and Chemical Engineering
      Tsingtao, Shandong Sheng, China
    • Xuzhou Medical College
      Suchow, Jiangsu Sheng, China
    • Guilin University of Electronic Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
  • 2012–2015
    • Xi'an Jiaotong University
      • School of Medicine
      Ch’ang-an, Shaanxi, China
    • Natural History Museum, London
      • Department of Botany
      Londinium, England, United Kingdom
    • Beijing Normal University
      Peping, Beijing, China
    • Second Military Medical University, Shanghai
      • Department of Chemical-defence Medicine
      Shanghai, Shanghai Shi, China
    • Shandong University
      Chi-nan-shih, Shandong Sheng, China
    • Liaoning ShiHua University
      Fu-shan, Liaoning, China
    • South China Agricultural University
      • College of Food Science
      Shengcheng, Guangdong, China
  • 2011–2015
    • Peking University
      • • Institute of Molecular Medicine
      • • School of Basic Medical Science
      Peping, Beijing, China
    • Institute of Disaster Prevention
      Peping, Beijing, China
    • South China Institute Of Environmental Sciences
      Shengcheng, Guangdong, China
    • China Agricultural University
      • College of Biological Sciences
      Peping, Beijing, China
    • 宁德师范学院学报
      Chiao-ch’eng-chen, Guangdong, China
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Soochow University (PRC)
      Wu-hsien, Jiangsu Sheng, China
    • Huazhong Agricultural University
      Wu-han-shih, Hubei, China
  • 2010–2015
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Academy of Chinese Culture of Health Sciences
      Florida, United States
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
    • Institute of Genetics and Developmental Biology, CAS
      Peping, Beijing, China
    • Nanjing Agricultural University
      • College of Animal Science and Technology
      Nan-ching, Jiangsu Sheng, China
  • 2007–2015
    • East China University of Science and Technology
      • School of Materials Science and Engineering
      Shanghai, Shanghai Shi, China
    • Lanzhou Jiaotong University
      Kao-lan-hsien, Gansu Sheng, China
    • Yangtze University
      • School of Food Science and Technology
      Hu-pei-ts’un, Shanxi Sheng, China
    • Beijing Cancer Hospital
      Peping, Beijing, China
  • 2006–2015
    • Peking Union Medical College Hospital
      Peping, Beijing, China
    • Sichuan University
      • • State Key Laboratory of Biotherapy
      • • Department of Cardiology
      Hua-yang, Sichuan, China
  • 2004–2015
    • Third Military Medical University
      • • Department of Physiology
      • • Southwest Hospital
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Anhui Normal University
      Wu-hu-shih, Anhui Sheng, China
    • National Space Science
      Peping, Beijing, China
  • 2003–2015
    • Jilin University
      • • College of Chemistry
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      • • State Key Laboratory of Supramolecular Structure and Materials
      • • Department of Chemistry
      • • State Key Lab of Theoretical and Computational Chemistry
      • • Department of Molecular Biology
      Yung-chi, Jilin Sheng, China
  • 2001–2015
    • Chinese Academy of Sciences
      • • State Key Laboratory of Microbial Resources
      • • Institute of Psychology
      • • State Key Laboratory of Organic Geochemistry
      • • Laboratory of Analytical Chemistry for Life Science
      • • Institute of Biophysics
      • • Dalian Institute of Chemical Physics
      • • State Key Laboratory of Molecular Reaction Dynamics
      • • Institute of Genetics and Developmental Biology
      Peping, Beijing, China
    • Shandong University of Technology
      Chi-nan-shih, Shandong Sheng, China
  • 2013–2014
    • Wake Forest University
      Winston-Salem, North Carolina, United States
    • Wake Forest School of Medicine
      • Center for Cancer Genomics
      Winston-Salem, North Carolina, United States
    • Zhejiang Normal University
      Jinhua, Zhejiang Sheng, China
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
  • 2012–2014
    • Fourth Military Medical University
      • • Department of Pathology and Pathophysiology
      • • Department of Clinical Aerospace Medicine
      Xi’an, Liaoning, China
  • 2007–2014
    • Shanghai Jiao Tong University
      • • School of Agriculture and Biology
      • • Department of Cardiology (Renji)
      Shanghai, Shanghai Shi, China
  • 1998–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
  • 2009–2013
    • Yunnan Agricultural University
      Panlong, Shaanxi, China
    • Prince Henry's Institute
      Melbourne, Victoria, Australia
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
    • Harbin Institute of Technology
      • School of Municipal and Environmental Engineering
      Charbin, Heilongjiang Sheng, China
  • 2006–2013
    • Huazhong University of Science and Technology
      • • Department of Biliary-Pancreatic Surgery
      • • Department of Pathology and Pathophysiology
      • • School of Computer Science and Technology
      Wu-han-shih, Hubei, China
  • 2011–2012
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
  • 2009–2012
    • Tsinghua University
      • • School of Medicine
      • • Department of Electronic Engineering
      Peping, Beijing, China
  • 2010–2011
    • Jiangsu University
      • School of Pharmacy
      Chenkiang, Jiangsu Sheng, China
  • 2008–2011
    • University of Southampton
      • • Faculty of Physical and Applied Sciences
      • • Department of Electronics and Computer Science (ECS)
      Southampton, England, United Kingdom
    • South China University of Technology
      Shengcheng, Guangdong, China
  • 2007–2010
    • China Pharmaceutical University
      • Department of Pharmaceutical Analysis
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2005–2010
    • Dalian University of Technology
      • • State Key Laboratory of Fine Chemicals
      • • School of Chemical Engineering
      Lü-ta-shih, Liaoning, China
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • University of Connecticut
      Storrs, Connecticut, United States
    • Beijing Institute Of Technology
      Peping, Beijing, China
  • 2004–2010
    • Tongji University
      • Department of Physics
      Shanghai, Shanghai Shi, China
  • 2007–2009
    • Tianjin University
      • School of Electrical Engineering and Automation
      T’ien-ching-shih, Tianjin Shi, China
  • 2006–2008
    • Shanghai Institutes for Biological Sciences
      • Institute of Health Sciences
      Shanghai, Shanghai Shi, China
  • 2005–2008
    • Chinese Academy of Medical Sciences
      • Institute of Basic Medical Sciences (IBMS)
      Peping, Beijing, China
  • 2001–2006
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2004–2005
    • Beijing Jiaotong University
      • Institute of Optoelectronics Technology
      Beijing, Beijing Shi, China
  • 2002–2004
    • Keio University
      • Department of Applied Chemistry
      Edo, Tōkyō, Japan