Akuodor Godwin Christian

University of Calabar, Calabar, Cross River, Nigeria

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Publications (2)0.5 Total impact

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    ABSTRACT: Objective To investigate the in vivo antiplasmodial effect of methanol leaf extract of Maerua crassifolia in mice infected with chloroquine sensitive Plasmodium berghei berghei. Methods The extract was evaluated for activity against early infection, curative effect against established infection at dose levels of 100, 200 and 400 mg/kg p.o. Chloroquine at 10 mg/kg was used as standard drug. Results A dose dependent chemo-suppression of the parasites was obtained at different dose levels of the extract tested with a considerable mean survival time. Conclusions The results support continued investigation of components of traditional medicines as potential new antimalarial agents.
    Asian Pacific Journal of Tropical Disease. 01/2014; 4(1):35–39.
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    ABSTRACT: To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf. The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies. The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg). The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
    Asian Pacific Journal of Tropical Medicine 02/2012; 5(2):126-9. · 0.50 Impact Factor