Zhuang Cui

Publications (2)5.61 Total impact

• Article: Prognostic relevance of circulating endothelial progenitor cells for severe traumatic brain injury.

  Dasen Gong, Mu Hao, Li Liu, Chunxiang Liu, Jingfei Dong, Zhuang Cui, Lin Sun, Shaobo Su, Jianning Zhang
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  ABSTRACT: Traumatic brain injury (TBI) promotes the recruitment of endothelial progenitor cells (EPCs) into the injured tissue where EPCs play an important role in repairing injured vasculature. However, the repair mechanism and prognostic significance of EPCs after TBI remain poorly understood. Blood samples were collected from 21 patients with severe TBI and 20 healthy subjects. EPCs were quantified by flow cytometry and serum VEGF and MMP-9 level measured by ELISA on days 1, 4, 7, 14 and 21 after TBI. EPCs in the patients decreased originally, then increased to the peak level at 7 days and was significantly correlated with GOS scores 6 months after TBI. VEGF and MMP-9 were significantly increased during the follow-up period after TBI. EPCs was also positively correlated with GCS score 1 day after TBI and with MMP-9 and VEGF 7 days and 14 days after TBI. The data demonstrate that TBI led to an increase of EPCs, VEGF and MMP-9, suggesting that increased VEGF and MMP-9 may mediate the recruitment of bone marrow-derived EPCs into the circulation. The association of EPCs with nerve functional recovery in patients provides evidence that EPCs may be a potential biomarker to monitor TBI angiogenesis and prognosis.
  Brain Injury 01/2012; 26(3):291-7. · 1.36 Impact Factor
• Article: Correlation of CD34+ cells with tissue angiogenesis after traumatic brain injury in a rat model.

  Xinbin Guo, Li Liu, Ming Zhang, Angela Bergeron, Zhuang Cui, Jing-Fei Dong, Jianning Zhang
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  ABSTRACT: Increasing evidence suggests that circulating endothelial progenitor cells, which are a subpopulation of hematopoietic progenitor CD34(+) cells, play a critical role in neovascularization and tissue repair. We have tested the hypothesis that traumatic brain injury (TBI) could mobilize CD34(+) cells to peripheral blood and brain tissue, a process critical for vascular repair, in a rat model of TBI. Male Wistar rats were subjected to controlled fluid percussion. Blood and brain tissue were collected before and after TBI to measure the levels of CD34(+) cells in peripheral blood and to detect their accumulation in the damaged cerebral tissue. Compared with surgery controls, CD34(+) cells significantly increased in the peripheral blood and accumulated in the brain tissue of TBI rats. Immunohistochemistry detected new vessels with incomplete CD34(+) endothelial-like cell lining and an increased number of microvessels in the injured and surrounding tissue. The results demonstrate a close correlation between an increase in circulating CD34(+) cells in response to traumatic injury and angiogenesis in TBI rat brain. They also suggest that transplantation of CD34(+) cells or augmentation of endogenous CD34(+) cells may be a novel therapeutic approach for patients with TBI.
  Journal of neurotrauma 03/2009; 26(8):1337-44. · 4.25 Impact Factor