Hyo Jin Kwon

Publications (2)1.46 Total impact

• Article: Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea.

  Hyo Jin Kwon, Young Jun Rhie, Won Hee Seo, Gi-Young Jang, Byung Min Choi, Jung Hwa Lee, Chang-Kyu Lee, Yun Kyung Kim
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  ABSTRACT: BACKGROUND: The objective of our study was to understand the epidemiological and clinical features of respiratory adenoviral infections among children at a single institution over the course of several years. METHODS: From January 2005 to April 2009, 1,836 children (≤15 years old) who had been admitted to Korea University Ansan Hospital were tested for acute respiratory infection. The patients who were positive for an adenovirus infection were enrolled in this study, and their medical records were retrospectively reviewed. RESULTS: Adenoviruses were isolated from 310 patients. The male to female ratio was 1.6:1 and mean age was 32 ± 24 months. Children under 5 years of age had the highest prevalence. In 2007 adenovirus infections occurred endemically throughout the year. The clinical diagnoses were primarily upper respiratory tract infections (URTI) (45.4%), lower respiratory tract infections (LRTI) (48.1%), and neurologic disease (5.2%). Associated symptoms, signs and laboratory findings included fever (91.9%), cough (83.9%), pharyngeal injection (62.3%), rale (32.6%) and elevated C-reactive protein (93.9%). The most common radiologic findings were perihilar and peribronchial infiltrates (42.6%). Co-infections were observed in 29 cases. The mean durations of hospitalization and fever were 6.2 ± 6.5 and 4.8 ± 3.1 days, respectively. The lengths of hospitalization were similar for patients admitted for URTI with severe morbidity and those admitted for LRTI. No children died. CONCLUSION: Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.
  Pediatrics International 04/2013; · 0.63 Impact Factor
• Article: Severe osteomyelitis as a complication of Tokyo-172 BCG vaccination.

  Hyo Jin Kwon, Bo Hyun Chung, Byung Min Choi, Kyung Un Park, Yun Kyung Kim
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  ABSTRACT: The bacilli Calmette-Guérin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
  Journal of Korean medical science 02/2012; 27(2):221-4. · 0.84 Impact Factor