Ming-Hsiu Wu

Chi-Mei Medical Center, 臺南市, Taiwan, Taiwan

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Publications (8)17.01 Total impact

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    ABSTRACT: Obsessive-compulsive disorder (OCD) is a chronic debilitating anxiety disorder significant in intrusive thoughts and compensation repetitive behaviors. Few studies have reported on this condition Asia. This study estimated the prevalence, incidence and psychiatric comorbidities of OCD in Taiwan. We identified study subjects for 2000-2008 with a principal diagnosis of OCD according to the International Classification of Disease, 9th Revision, Clinical Modification (ICD-9-CM) diagnostic criteria by using National Health Research Institute database. These patients received either outpatient or inpatient care for their condition. Rates were directly age- and sex-adjusted to the 2004 Taiwan population distribution. The estimated mean annual incidence was 27.57 per 10(5) inhabitants and the one year prevalence was 65.05 per 10(5) inhabitants. Incidence and prevalence increased with age, peaking at age 18-24 years in males and at 35-44 years in females. About 53% of adults (≥18 years) and 48% of child and adolescent patients (6-17 years) had one or more comorbid psychiatric conditions. The most common comorbid diagnosis was depressive disorders for both adult and child-adolescent patients. We found a lower prevalence and incidence of clinically diagnosed OCD than that of community studies. Many Asian patients with OCD also had various psychiatric comorbidities, a clinically relevant finding.
    Psychiatry research. 08/2014;
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    ABSTRACT: Samaria-doped ceria (SDC)/La1−xSrxCo1−yFeyO3−δ (LSCF) and yttria-stabilized zirconia (YSZ)/Ni were prepared as the cathode and anode of a solid oxide fuel cell (SOFC), respectively, using glancing angle deposition (GLAD) in electron beam physical vapor deposition. Fuel cell current–voltage measurements and electrochemical impedance spectroscopy were performed at 600 °C. The investigations of the crystalline structures were examined using X-ray diffraction and transmission electron microscopy (TEM). A fluorite structure of SDC and the rhombohedral phase of the LSCF film were obtained. TEM images show that the diameter of each SDC single-crystalline column was approximately 50 nm. The results of scanning electron microscopy and electrochemical impedance spectroscopy indicate that high-density triple phase boundary (TPB) in the cathode enhances the performance of SOFC.
    Vacuum. 01/2014; 101:57–62.
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    ABSTRACT: To delineate the relationship between traumatic brain injury (TBI) and mood disorders from population-based data in Taiwan. This prospectively followed cohort study involved a subset of the National Health Insurance Research Database containing complete inpatient and outpatient data of 1 million randomly drawn beneficiaries. We included 10- to 24-year-old patients (n = 15 203) receiving the diagnosis of TBI in ambulatory visits or hospitalization from 2000-2004 and their age- and sex-matched comparison insureds using health service in the same year (n = 76 015). Diagnosis of mood disorders was recorded within 5 years after the traumatic event or index use of health service. Baseline demographics, clinical characteristics, and premorbid psychiatric conditions were compared using χ(2) analysis. Increased risk during the 5-year follow-up period was represented by crude and adjusted hazard ratios with 95% CI using a Cox proportional hazard regression. A total of 451/15 203 patients with TBI (2.97%) received a diagnosis of mood disorders in the 5-year follow-up period compared with 1153/97 445 individuals (1.52%) without antecedent TBI. After adjusting for select premorbid comorbidities, TBI remained a significant predisposing factor with a 1.96-fold (95% CI 1.74-2.22) increase in risk of mood disorders. Our findings show a higher likelihood of manifesting mood disorders in adolescents and young adults who sustained a prior TBI. Health professionals should carefully monitor both the physical and psychological impacts of head trauma.
    The Journal of pediatrics 10/2013; · 4.02 Impact Factor
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    ABSTRACT: The relationship between traumatic brain injury (TBI) and the risk of dementia remains controversial. This population based study was designed to estimate and compare the risk of dementia in TBI and non-TBI individuals during the 5 year period after TBI. This study was a retrospective cohort study. Data were obtained from the Longitudinal Health Insurance Database 2000. We included 44 925 patients receiving ambulatory or hospital care and 224 625 non-TBI patients; patients were matched for sex, age and year of index use of healthcare. Patients <15 years of age and those admitted to the intensive care unit were excluded. Each individual was studied for 5 years to identify the subsequent development of dementia. Data were analysed by Cox proportional hazard regression. During the 5 year follow-up period, 1196 TBI (2.66%) and 224 625 non-TBI patients (1.53%) patients developed dementia. During the 5 year follow-up period, TBI was independently associated with a 1.68 (range 1.57-1.80) times greater risk of dementia after adjusting for sociodemographic characteristics and selected comorbidities. The findings of this study suggest an increased risk of dementia among individuals with TBI. We suggest the need for more intensive medical monitoring and health education in individuals with TBI.
    Journal of neurology, neurosurgery, and psychiatry 07/2012; 83(11):1080-5. · 4.87 Impact Factor
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    ABSTRACT: Magnesium sulfate and nimesulide are commonly used drugs with reported neuroprotective effects. Their combination as stroke treatment has the potential benefits of decreasing individual drug dosage and fewer adverse effects. This study evaluated their synergistic effects and compared a low-dose combination with individual drug alone and placebo. Sprague-Dawley rats underwent 90 min of focal ischemia with intraluminal suture occlusion of the middle cerebral artery followed by reperfusion. The rats were randomly assigned to receive one of the following treatments: placebo, magnesium sulfate (MgSO₄; 45 mg/kg) intravenously immediately after the induction of middle cerebral artery occlusion, nimesulide (6 mg/kg) intraperitoneally before reperfusion, and combined therapy. Three days after the ischemia-reperfusion insult, therapeutic outcome was assessed by 2,3,5-triphenyltetrazolium chloride staining and a 28-point neurological severity scoring system. Cyclooxygenase-2, prostaglandin E₂, myeloperoxidase, and caspase-3 expression after treatment were evaluated using Western blot analyses and immunohistochemical staining, followed by immunoreactive cell analysis using tissue cytometry. Only the combination treatment group showed a significant decrease in infarction volume (10.93±6.54% versus 26.43±7.08%, p<0.01), and neurological severity score (p<0.05). Low-dose MgSO₄ or nimesulide showed no significant neuroprotection. There was also significant suppression of cyclooxygenase-2, prostaglandin E₂, myeloperoxidase, and caspase-3 expression in the combination treatment group, suggesting that the combination of the two drugs improved the neuroprotective effects of each individual drug. MgSO₄ and nimesulide have synergistic effects on ischemia-reperfusion insults. Their combination helps decrease drug dosage and adverse effects. Combined treatment strategies may help to combat stroke-induced brain damage in the future.
    Journal of neurotrauma 02/2012; 29(7):1518-29. · 4.25 Impact Factor
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    ABSTRACT: : Heatstroke has been defined as a form of hyperthermia associated with a systemic inflammatory response that leads to multiple organ dysfunction syndrome (MODS). It has also been documented that heat shock protein 70 (HSP70) preconditioning is able to induce thermotolerance. Here, the authors further investigated whether hypobaric hypoxia preconditioning (HHP) improved the MODS in heatstroke by up-regulation of HSP70. : Anesthetized rats were randomly assigned to (a) non-HHP + nonheated group, (b) non-HHP + heated group, (c) HHP + heated group and (d) HHP + HSP70 antibodies (Abs) + heated groups. All heated groups were exposed to heat stress (43°C, 70 minutes) to induce heatstroke. For HHP, animals were exposed to 0.66 atmosphere absolute (18.3% O2) for 5 hours daily for consecutive 5 days per week for 2 weeks before the start of heat exposure. : HHP significantly (i) attenuated hypotension, (ii) reduced plasma index of the toxic oxidizing radicals and the organ injury indicator, (iii) attenuated plasma systemic inflammatory response molecules, (iv) reduced an index of infiltration of polymorphonuclear neutrophils in the lung like myeloper-oxidase activity, (v) promoted plasma levels of an anti-inflammatory cytokine, interleukin-10, (vi) promoted the survival time to fourfold compared with non-HHP group and (vii) promoted the overexpression of HSP70 in different organs (eg, the lung) during heatstroke. The beneficial effects of HHP could be significantly attenuated by HSP70 Ab preconditioning. : Our results show that HHP protects rats from heat-induced MODS via up-regulating HSP70. Thus, HHP could be a novel strategy for the prevention of heatstroke animals or patients before heat exposure.
    The American Journal of the Medical Sciences 01/2012; 344(5):383-90. · 1.33 Impact Factor
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    ABSTRACT: Yttrium doped zirconia (YSZ) film was deposited on poly-crystalline 10at.% samaria doped ceria (SDC) and YSZ plate (doped with 8at.% yttria) by electron beam evaporation deposition. For electrolyte application in solid oxide fuel cells, YSZ can be used with SDC and act as an electron barrier. The conductivity of YSZ and SDC was measured after sintering at 1000°C. Results indicated that YSZ film became columnar structure, and a new layer formed between the YSZ film and SDC, due to the inter-diffusion between zirconium ions and cerium ions.
    Applied Surface Science 01/2011; 257(17):7871-7875. · 2.54 Impact Factor
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    ABSTRACT: Porous bilayer films of yttria-doped zirconia and strontia-doped lanthanum manganite are deposited by using electron beam evaporation. For practical use in solid oxide fuel cells, fully-stabilized zirconia is a candidate for the solid electrolyte due to its high oxygen diffusion rate. Longer triple phase boundary, which consists of catalyst, reacting gas and solid electrolyte in the cathode, is helpful for the exchange of oxygen gas and ions. By glancing angle deposition, higher density of triple phase boundary is achieved in the form of catalyst and electrolyte bilayer structure. This kind of triple phase boundary can be estimated from SEM images and it is rather easier than from conventional composite cathode which can only be analyzed with assistance of mathematic simulation. The resistance of this bilayer at 600°C is ten times lower than porous catalyst single layer.
    Surface & Coatings Technology - SURF COAT TECH. 01/2010; 205(1):30-34.

Publication Stats

8 Citations
17.01 Total Impact Points


  • 2014
    • Chi-Mei Medical Center
      臺南市, Taiwan, Taiwan
  • 2010–2014
    • National Cheng Kung University
      • • Department of Materials Science and Engineering
      • • Institute of Clinical Medicine
      臺南市, Taiwan, Taiwan
  • 2012
    • National Cheng Kung University Hospital
      臺南市, Taiwan, Taiwan