Suzana Assad Kahn

Publications (1)3.13 Total impact

• Article: Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.

  Gerardo Cebrián-Torrejón, Suzana Assad Kahn, Nathalie Lagarde, Flavia Castellano, Karine Leblanc, Jordi Rodrigo, Valérie Molinier-Frenkel, Antonieta Rojas de Arias, Maria Elena Ferreira, Cécile Thirant, Alain Fournet, Bruno Figadère, Hervé Chneiweiss, Erwan Poupon
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  ABSTRACT: Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.
  Journal of Natural Products 02/2012; 75(2):257-61. · 3.13 Impact Factor