Fude Yang

Publications (3)8.5 Total impact

• Article: Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.

  Hongqiang Sun, Song Guo, Dafang Chen, Fude Yang, Yizhuang Zou, Xiaolan Di, Yanjun Cao, Thomas Kosten, Lin Lu, Xiang Yang Zhang
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  ABSTRACT: Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. We evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial among Chinese smokers. We conducted a double-blind, placebo-controlled, 8-week trial of SNT with a follow-up at week 12 among 250 Chinese smokers. Efficacy and safety were evaluated at day 4 and weeks 2, 4, 6, 8, and 12. Abstinence was biochemically verified by exhaled carbon monoxide (CO) and urine cotinine. The COMT Val108Met genotype was determined as a restriction fragment length polymorphism. Our results showed that the success rates for complete abstinence were greater for active versus placebo treatments at 8 weeks (48 vs. 17 %) and 12 weeks (52 vs. 19 %) (both p < 0.0001). Craving was significantly reduced from week 2 on active treatment compared to placebo. Adverse events were mild and tolerable. We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). We found that SNT significantly increased smoking abstinence, reduced craving and was well tolerated, and the COMT Val/Val genotype was associated with a greater improvement in smoking cessation.
  Acta Neurovegetativa 06/2012; · 2.73 Impact Factor
• Article: Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesiain Chinese Han patients with schizophrenia.

  Fan Wang, Hongzhen Fan, Hongqiang Sun, Fude Yang, Yixiao Luo, Haibo Liu, Thomas R Kosten, Lin Lu, Xiang Yang Zhang
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  ABSTRACT: Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α levels in the striatum significantly increased in haloperidol-induced TD in rats. The TNF-α gene -308A/G single nucleotide polymorphism (SNP) has been shown to directly influence TNF-α expression. The genetic association between the TNF-α gene -308A/G SNP and TD is unclear. The present study investigated whether this variation is associated with clinical phenotypes and TD in schizophrenia in a genetically homogeneous northern Chinese Han population. We genotyped the TNF-α gene -308A/G SNP in patients with schizophrenia with TD (n=350) and without TD (n=410). The Abnormal Involuntary Movement Scale (AIMS) and Positive and Negative Syndrome Scale (PANSS) were used to assess the severity of TD and psychopathology of schizophrenia, respectively. The allele and genotype frequencies did not significantly differ between patients with schizophrenia with and without TD (p>0.05). No significant difference was found in the total AIMS score between the genotypes (p>0.05). However, the PANSS negative symptom subscore was associated with risk for TD (p=0.004), and a significant difference was found in total AIMS score between the genotypes in TD patients (p=0.013). The TNF-α gene -308A/G polymorphism does not appear to play a major role in the susceptibility to TD in patients with schizophrenia in a northern Chinese Han population. However this polymorphism may play a role in the TD severity.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry 04/2012; 37(1):106-10. · 3.25 Impact Factor
• Article: Lower serum interleukin-2 levels in schizophrenic patients with tardive dyskinesia.

  Haibo Liu, Yimin Kang, Jun Liang, Cunbao Li, Meihong Xiu, Dachun Chen, Fude Yang, Fang Wang, Guiying Wu, Colin N Haile, Therese A Kosten, Thomas R Kosten, Xiang Yang Zhang
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  ABSTRACT: We determined serum IL-2 levels between schizophrenic patients with (n=45) and without tardive dyskinesia (TD; n=45) compared to normal controls (n=50). TD patients had lower serum IL-2 levels than non-TD, but higher IL-2 levels than normal controls. IL-2 was associated with the negative symptoms of schizophrenia, but not with TD severity. Immune disturbance may be involved in the pathophysiology of TD.
  Psychiatry Research 03/2012; · 2.52 Impact Factor