Yu-Lin Feng

Publications (2)4.31 Total impact

• Article: Clinical applications of lung function tests: a revisit.

  Bin-Miao Liang, David C L Lam, Yu-Lin Feng
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  ABSTRACT: The development and clinical application of lung function tests have a long history, and the various components of lung function tests provide very important tools for the clinical evaluation of respiratory health and disease. Spirometry, measurement of the diffusion factor, bronchial provocation tests and forced oscillation techniques have found diverse clinical applications in the diagnosis and monitoring of respiratory diseases, such as chronic obstructive pulmonary disease, interstitial lung diseases and asthma. However, there are some practical issues to be resolved, including the establishment of reference values for individual test parameters and the roles of these tests in preoperative risk assessment and pulmonary rehabilitation. Novel measurements, including negative expiratory pressure, the fraction of exhaled nitric oxide and analysis of exhaled breath condensate, may provide new insights into physiological abnormalities or airway inflammation in respiratory diseases, but their clinical applications need to be further evaluated. The clinical application of lung function tests continues to face challenges, which may be overcome by further improvement of conventional techniques for lung function testing and further specification of new testing techniques.
  Respirology 02/2012; 17(4):611-9. · 2.42 Impact Factor
• Article: Association of gastroesophageal reflux disease symptoms with stable chronic obstructive pulmonary disease.

  Bin-Miao Liang, Yu-Lin Feng
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  ABSTRACT: Patients with various chronic respiratory diseases have a higher incidence of gastroesophageal reflux disease (GERD)-related symptoms, but the mechanisms of the relationship between GERD symptoms and chronic obstructive pulmonary disease (COPD) remain unclear. The aim of the present study was to explore the association of GERD symptoms with impaired pulmonary function and other factors in patients with COPD. Patients with clinically stable COPD were consecutively recruited, and a pulmonary function test, visual analogue scale (VAS), and Reflux Diagnostic Questionnaire (RDQ) were administered. The patients were categorized into GERD-positive and GERD-negative groups according to the RDQ. Univariate and multivariate analyses were performed to evaluate the factors associated with the incidence of GERD symptoms in COPD. A total of 1,486 patients with COPD were enrolled. There was no difference in age, gender proportion, body mass index, tobacco exposure, and the use of respiratory medications between the GERD-positive and GERD-negative groups. The respiratory pattern, the values of forced expiratory volume in 1 s, inspiratory capacity (IC), and residual volume, and VAS scores were significantly different between the groups (all P<0.05). Multivariate logistic regression analysis revealed that the decreased IC (odds ratio (OR) =1.56; 95% CI=1.32-2.27; P<0.001) and increased VAS scores (OR=1.38; 95% CI=1.19-1.68; P=0.011) were independent risk factors of GERD symptoms in patients with COPD. The severity of hyperinflation and dyspnea may be important associated risk factors for the incidence of GERD symptoms in patients with clinically stable COPD.
  Beiträge zur Klinik der Tuberkulose 01/2012; 190(3):277-82. · 1.90 Impact Factor