Nader Pazyar

Ahvaz Jondishapour University of Medical Sciences, Nāşerī, Khūzestān, Iran

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Publications (27)19.76 Total impact

  • Acta dermatovenerologica Croatica : ADC. 09/2014; 22(3):218-220.
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    ABSTRACT: Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms. © 2014 S. Karger AG, Basel.
    Skin pharmacology and physiology. 06/2014; 27(6):303-310.
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    ABSTRACT: Improvement of uremic pruritus has been reported under shortterm administration of oral zinc sulfate. To confirm efficacy and safety of oral zinc sulfate in pruritus of hemodialytic patients METHOD: A pilot randomized, triple-blind study was conducted to evaluate the pruritus of hemodialytic patients. Forty eligible patients were screened and assigned to receive either zincsulfate (220mg/d) or matched placebo for a 4-week trial. Pruritus scale was evaluated at the initiation of the study and 1, 2, 3, and 4 weeks after the treatment . We used a modified score proposed by Duo assessing pruritus severity, distribution of pruritus, and frequency of pruritus-related sleep disturbance. Thirty-six patients completed the study. The mean pruritus score decreased in both groups during the first and the second weeks of trial; however, it was more prominent in zinc group than placebo one. In the zinc group, 4 (20%) patients showed pruritus discontinuation during treatment period whereas, in the placebo group, the number was only 1 (5%) patient. Nonetheless, T-test revealed no statistically significant difference between the zinc and placebo groups (P= 0.88 and P=0.56, respectively). Our findings demonstrated that oral zinc sulfate (220mg/d) during four weeks treatment might be safe and effective in discontinuation of uremic pruritus , but it was not significant. This could be because of the small number of patients; therefore, we suggest conducting more studies with larger sample size.
    Giornale Italiano di Dermatologia e Venereologia 05/2014; · 0.68 Impact Factor
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    ABSTRACT: Phytomedicine has been successfully used in dermatology horizon for thousands of years. Jojoba (Simmondsia chinensis) is a long-lived, drought resistant, perennial plant with interesting economic value as it is processed for liquid wax production. The jojoba plant produces esters of long-chain alcohols and fatty acids (waxes) as a seed lipid energy reserve. The liquid wax is an important substrate for a variety of industrial applications and is used in skin treatment preparations. The oil from the jojoba plant is the main biological source of wax esters and has a multitude of potential applications. The review of literatures suggest that jojoba has anti-inflammatory effect and it can be used on a variety of skin conditions including skin infections, skin aging, as well as wound healing. Moreover, jojoba has been shown to play a role in cosmetics formulas such as sunscreens and moisturizers and also enhances the absorption of topical drugs. The intention of the review is to summarize the data regarding the uses of jojoba in dermatology for readers and researchers.
    Giornale Italiano di Dermatologia e Venereologia 12/2013; 148(6):687-691. · 0.68 Impact Factor
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    Amir Feily, Nader Pazyar
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    Dataset: Anakinra
    Nader Pazyar, Reza Yaghoobi, Amir Feily
  • Nader Pazyar, Amir Feily, Reza Yaghoobi
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    ABSTRACT: Macrophage migration inhibitory factor (MIF) is a critical immunoregulatory pluripotent cytokine. It has been re-evaluated as a proinflammatory cytokine, pituitary hormone and glucocorticoid-induced immunoregulatory protein. MIF exists in human epidermis, especially in the basal layer and also is expressed constitutively by monocytes/macrophages, T cells, B cells, endocrine, and epithelial cells. In the field of dermatology, MIF is believed to be a detrimental factor in inflammatory dermatological diseases including atopic dermatitis (AD), psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid (BP), alopecia areata (AA) as well as other conditions such as photoaging, and photocarcinigenesis. The objective of this review is to gather and summarize MIF related disorders in dermatology and present valuable information for readers and researchers.
    Indian Journal of Dermatology 01/2013; 58(2):157.
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    Nader Pazyar, Reza Yaghoobi
    São Paulo medical journal = Revista paulista de medicina 01/2013; 131(4):279-80. · 0.75 Impact Factor
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    ABSTRACT: Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis of pregnancy usually presents in the second or third trimester. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. Pathogenesis of PG is not fully established, however, most patients develop circulating autoantibodies targeting the bullous pemphigoid (BP) 180 antigen. The aim of this work is to draw a profile of the epidemiology, clinical aspects, treatment and evolution of the disease by studying hospital series. We retrospectively investigated the 13 patients who were diagnosed with PG based on hospital data at the Referral Center of Southwest Iran located in Ahvaz city between March 2002 and March 2011. The age of onset was 21 to 40 years (mean age: 27.5 years). The onset of the disease occurred in the second trimester of pregnancy in 6 patients and in the third trimester of pregnancy in 4 patients. One patient had a flare up of disease during the first trimester and two out of cases in puerperium period. In all cases, pruritus was the first symptom, followed by an erythematous vesiculobullous eruption. The diagnosis of PG was confirmed by skin biopsy. Ten out of the patients treated with oral corticosteroids (0.5-1 mg/kg/day), one of the patients underwent oral corticosteroids plus topical glucocorticoid and the last patient treated with topical glucocorticoid. PG remains a rare dermatosis of pregnancy. Our series had two particularities compared to other studies: high frequency in primigravida and the frequent involvement of the face. Additionally our study demonstrated that improvement could occur faster and provide acceptable management if the treatment of the patients would be implemented sooner.
    Acta medica Iranica 01/2013; 51(6):408-10.
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    ABSTRACT: To determine the efficacy of oral nicotinamide with placebo to ameliorate uremic pruritus (UP), we conducted a prospective, randomized, double-blind, 4-week study in 50 chronic kidney disease patients with refractory UP. The patients were randomly allocated to nicotinamide tablet 500 mg twice/day or placebo. All anti-pruritic agents were discontinued at least two weeks before the study. All the patients completed the period of the study and their severity of pruritus was evaluated before the start of the study and at the end of each week for four weeks by using a traditional Visual Analogue Scale and a modified questionnaire method (pruritus score). The average pruritus score before administration of oral nicotinamide in the study group and that in the placebo group was 2.96 ± 0.45 and 2.72 ± 0.37, respectively. In the nicotinamide group, the average score of pruritus gradually reduced to 1.29 ± 1.08 and in the placebo group it gradually decreased to 1.52 ± 1.61 at the end of the fourth week. There was no significant difference between the reductions of pruritus in both groups, but the interaction effect using a linear mixed model was significant between drug and time (P <0.026). We conclude that increasing the time of application of nicotinamide sodium to more than four weeks may be more effective than placebo in reducing itching in uremic patients.
    Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 01/2013; 24(5):995-9.
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    ABSTRACT: Tea tree oil (TTO) is an essential oil, steam-distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen-4-ol and a maximum content of 1, 8-cineole. Terpinen-4-ol is a major TTO component which exhibits strong antimicrobial and anti-inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad-spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa. Several studies have suggested the uses of TTO for the treatment of acne vulgaris, seborrheic dermatitis, and chronic gingivitis. It also accelerates the wound healing process and exhibits anti-skin cancer activity. This review opens up new horizons for dermatologists in the use of this herbal agent.
    International journal of dermatology 09/2012; · 1.18 Impact Factor
  • Nader Pazyar, Amir Feily, Reza Yaghoobi
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    ABSTRACT: Interleukin (IL)-1 is a pivotal proinflammatory cytokine consisting of two molecular species, IL-1α and IL-1β. Anakinra (Kineret), a recombinant human IL-1 receptor antagonist, is regarded as a biological agent which blocks the inflammatory effects of IL-1. The aim of this review was to search the literatures and summarizes in vivo, in vitro and human studies on anakinra uses in dermatological disorders. The results show that anakinra is currently used clinically for the treatment of a variety of skin conditions such as psoriasis, atopic dermatitis, photoagaing, melanoma, Schnitzler syndrome, pyoderma gangraenosum, PAPA syndrome, hidradenitis suppurativa, lamellar ichthyosis, Sweet's syndrome, panniculitis, Muckle-Wells syndrome, familial Mediterranean fever, SAPHO syndrome and other disorders. Notably, anakinra is expensive to produce and administer. Injection is the route of therapy and allergic reaction is most possible.
    Current clinical pharmacology. 07/2012; 7(4):271-5.
  • Nader Pazyar, Noorodin Jamshydian
    Journal of alternative and complementary medicine (New York, N.Y.) 07/2012; 18(7):639-40. · 1.69 Impact Factor
  • Nader Pazyar, Reza Yaghoobi
    Journal of alternative and complementary medicine (New York, N.Y.) 04/2012; 18(4):316-7. · 1.69 Impact Factor
  • Nader Pazyar, Reza Yaghoobi
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    ABSTRACT: Psoriasis is a clinical skin disease that is characterized by erythematous scaling plaques and involves the extensor site of the extremities, the scalp and other surfaces of the skin. Tea tree oil (TTO) is considered an essential oil, obtained by steam distillation of the leaves and terminal branchlets of Melaleuca alternifolia. Notably,terpinen-4-ol, the major TTO constituent, has been found to have potent anti-inflammatory properties. It is suggested that terpinen-4-ol may be a novel potential agent against psoriasis. This article draws attention to the antipsoriatic effect of TTO and provides a theoretical molecular approach.
    Skin pharmacology and physiology 04/2012; 25(3):162-3. · 2.89 Impact Factor
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    ABSTRACT: The purpose of this review is to gather and summarize in vitro, in vivo, and clinical trials on oatmeal preparations and their uses in dermatology. Literature searches have been carried out to collect in vivo and in vitro studies as well as clinical trials on this subject. The results suggest that oatmeal possesses antioxidant and anti-inflammatory properties and its administration is effective on a variety of dermatologic inflammatory diseases such as pruritus, atopic dermatitis, acneiform eruptions, and viral infections. Additionally, oatmeal plays a role in cosmetics preparations and skin protection against ultraviolet rays. Although some promising results citing the use of oatmeal to treat numerous dermatologic conditions have been found, the complete efficacy of oatmeal has not been sufficiently explored. This paper proposes accurate and useful information concerning the use of oatmeal in clinical practice to dermatologists.
    Indian journal of dermatology, venereology and leprology 03/2012; 78(2):142-5. · 0.98 Impact Factor
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    ABSTRACT: Keloid scars are large protruding claw-shaped lesions that develop beyond the confines of the wound and uniquely appears only in humans. For thousands of years ginseng has been used in the traditional medicine in oriental countries. It occupies a prominent position in the list of the best-selling medicinal herbs in the world. Panax ginseng often called Asian or Korean ginseng, is the most extensively used and the best grade of ginseng and the term of 'ginseng' generally refers to Panax ginseng. Previous studies have revealed that ginseng inhibits NF-kappa B, TGF-β, IL-6, ACE and MMP-2 and these factors play a pivotal role in keloid formation pathogenesis. Therefore it could be reasoned that ginseng could be effective for the treatment of the keloid scars. Clinical studies by topical applications of iPanax notoginseng (800 µg/ml) are warranted. Copyright © 2012 John Wiley & Sons, Ltd.
    Phytotherapy Research 02/2012; 26(10):1579-80. · 2.40 Impact Factor
  • Nader Pazyar, Reza Yaghoobi
    Journal of alternative and complementary medicine (New York, N.Y.) 02/2012; 18(3):210-1. · 1.69 Impact Factor
  • Amir Feily, Nader Pazyar
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    ABSTRACT: Vitiligo is an acquired clinical conundrum, characterized by white areas on the skin due to loss of functional melanocytes. Various studies demonstrated that vitiligo is associated with fewer risk of skin cancer but no exact molecular explanation for this interesting observation has been described. This article reviews the exist documents and provides a molecular mechanism for this negative association.
    Archives for Dermatological Research 08/2011; 303(9):623-4. · 2.71 Impact Factor

Publication Stats

27 Citations
19.76 Total Impact Points


  • 2011–2014
    • Ahvaz Jondishapour University of Medical Sciences
      • Department of Dermatology
      Nāşerī, Khūzestān, Iran
  • 2013
    • Tehran University of Medical Sciences
      • Skin and Stem Cell Research Center
      Teheran, Tehrān, Iran
  • 2012
    • Imam Khomeini International University
      Kazvin, Qazvīn, Iran
    • Jahrom University of Medical Sciences
      Teheran, Tehrān, Iran