Nader Pazyar

Ahvaz Jondishapour University of Medical Sciences, Nāşerī, Khūzestān, Iran

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Publications (31)22.1 Total impact

  • Jundishapur Journal of Microbiology 11/2015; 8(11). DOI:10.5812/jjm.25882 · 0.39 Impact Factor
  • Nader Pazyar · Sadigheh Tavakoli · Reza Yaghoobi ·
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    ABSTRACT: Castleman's disease (CD) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. Multicentric Castleman's disease (MCD) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. Human herpesvirus 8 (HHV-8) infection is present in nearly 100% MCD associated with HIV-1 infection, but in about 50% of cases of HIV negative. Herein, we report a 77-year-old man with systemic involvement and skin lesions on the anterior aspect of both legs in the previous site of saphenous vein angioplasty. Co-existence of MCD with Kaposi's sarcoma (KS) led us to present this rare case.
    Indian Journal of Dermatology 05/2015; 60(3):323. DOI:10.4103/0019-5154.156457
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    Jundishapur Journal of Microbiology 03/2015; 8(3):e19640. DOI:10.5812/jjm.19640 · 0.39 Impact Factor
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    Nader Pazyar · Reza Yaghoobi ·

    Jundishapur Journal of Natural Pharmaceutical Products 02/2015; 10(1):e20924. DOI:10.17795/jjnpp-20924

  • 09/2014; 22(3):218-220.
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    ABSTRACT: Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms. © 2014 S. Karger AG, Basel.
    Skin pharmacology and physiology 06/2014; 27(6):303-310. DOI:10.1159/000357477 · 2.37 Impact Factor
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    ABSTRACT: Improvement of uremic pruritus has been reported under shortterm administration of oral zinc sulfate. To confirm efficacy and safety of oral zinc sulfate in pruritus of hemodialytic patients METHOD: A pilot randomized, triple-blind study was conducted to evaluate the pruritus of hemodialytic patients. Forty eligible patients were screened and assigned to receive either zincsulfate (220mg/d) or matched placebo for a 4-week trial. Pruritus scale was evaluated at the initiation of the study and 1, 2, 3, and 4 weeks after the treatment . We used a modified score proposed by Duo assessing pruritus severity, distribution of pruritus, and frequency of pruritus-related sleep disturbance. Thirty-six patients completed the study. The mean pruritus score decreased in both groups during the first and the second weeks of trial; however, it was more prominent in zinc group than placebo one. In the zinc group, 4 (20%) patients showed pruritus discontinuation during treatment period whereas, in the placebo group, the number was only 1 (5%) patient. Nonetheless, T-test revealed no statistically significant difference between the zinc and placebo groups (P= 0.88 and P=0.56, respectively). Our findings demonstrated that oral zinc sulfate (220mg/d) during four weeks treatment might be safe and effective in discontinuation of uremic pruritus , but it was not significant. This could be because of the small number of patients; therefore, we suggest conducting more studies with larger sample size.
    Giornale Italiano di Dermatologia e Venereologia 05/2014; 150(4). · 0.68 Impact Factor
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    ABSTRACT: Phytomedicine has been successfully used in dermatology horizon for thousands of years. Jojoba (Simmondsia chinensis) is a long-lived, drought resistant, perennial plant with interesting economic value as it is processed for liquid wax production. The jojoba plant produces esters of long-chain alcohols and fatty acids (waxes) as a seed lipid energy reserve. The liquid wax is an important substrate for a variety of industrial applications and is used in skin treatment preparations. The oil from the jojoba plant is the main biological source of wax esters and has a multitude of potential applications. The review of literatures suggest that jojoba has anti-inflammatory effect and it can be used on a variety of skin conditions including skin infections, skin aging, as well as wound healing. Moreover, jojoba has been shown to play a role in cosmetics formulas such as sunscreens and moisturizers and also enhances the absorption of topical drugs. The intention of the review is to summarize the data regarding the uses of jojoba in dermatology for readers and researchers.
    Giornale Italiano di Dermatologia e Venereologia 12/2013; 148(6):687-691. · 0.68 Impact Factor
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    Nader Pazyar · Reza Yaghoobi ·

    São Paulo medical journal = Revista paulista de medicina 10/2013; 131(4):279-80. DOI:10.1590/1516-3180.2013.1314517 · 0.72 Impact Factor
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    ABSTRACT: Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis of pregnancy usually presents in the second or third trimester. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. Pathogenesis of PG is not fully established, however, most patients develop circulating autoantibodies targeting the bullous pemphigoid (BP) 180 antigen. The aim of this work is to draw a profile of the epidemiology, clinical aspects, treatment and evolution of the disease by studying hospital series. We retrospectively investigated the 13 patients who were diagnosed with PG based on hospital data at the Referral Center of Southwest Iran located in Ahvaz city between March 2002 and March 2011. The age of onset was 21 to 40 years (mean age: 27.5 years). The onset of the disease occurred in the second trimester of pregnancy in 6 patients and in the third trimester of pregnancy in 4 patients. One patient had a flare up of disease during the first trimester and two out of cases in puerperium period. In all cases, pruritus was the first symptom, followed by an erythematous vesiculobullous eruption. The diagnosis of PG was confirmed by skin biopsy. Ten out of the patients treated with oral corticosteroids (0.5-1 mg/kg/day), one of the patients underwent oral corticosteroids plus topical glucocorticoid and the last patient treated with topical glucocorticoid. PG remains a rare dermatosis of pregnancy. Our series had two particularities compared to other studies: high frequency in primigravida and the frequent involvement of the face. Additionally our study demonstrated that improvement could occur faster and provide acceptable management if the treatment of the patients would be implemented sooner.
    Acta medica Iranica 07/2013; 51(6):408-10.
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    Dataset: Anakinra
    Nader Pazyar · Reza Yaghoobi · Amir Feily ·

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    Reza Yaghoobi · Amir Feily · Nader Pazyar · Afshin Kazerouni ·

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    Amir Feily · Nader Pazyar ·

  • Nader Pazyar · Amir Feily · Reza Yaghoobi ·
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    ABSTRACT: Macrophage migration inhibitory factor (MIF) is a critical immunoregulatory pluripotent cytokine. It has been re-evaluated as a proinflammatory cytokine, pituitary hormone and glucocorticoid-induced immunoregulatory protein. MIF exists in human epidermis, especially in the basal layer and also is expressed constitutively by monocytes/macrophages, T cells, B cells, endocrine, and epithelial cells. In the field of dermatology, MIF is believed to be a detrimental factor in inflammatory dermatological diseases including atopic dermatitis (AD), psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid (BP), alopecia areata (AA) as well as other conditions such as photoaging, and photocarcinigenesis. The objective of this review is to gather and summarize MIF related disorders in dermatology and present valuable information for readers and researchers.
    Indian Journal of Dermatology 03/2013; 58(2):157. DOI:10.4103/0019-5154.108068
  • Nader Pazyar · Amir Feily · Afshin Kazerouni ·
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    ABSTRACT: The purpose of this brief review is to summarize all in vitro, in vivo, and controlled clinical trials on green tea preparations and their uses in dermatology. An extensive literature search was carried out to identify in vivo and in vitro studies as well as clinical trials. Twenty studies were assessed and the results suggest that oral administration of green tea can be effective in the scavenging of free radicals, cancer prevention, hair loss, and skin aging plus protection against the adverse effects associated with psoralen-UV-A therapy. Topical application of green tea extract should be potentially effective for atopic dermatitis, acne vulgaris, rosacea, androgenetic alopecia, hirsutism, keloids, genital warts, cutaneous leishmaniasis, and candidiosis. There are promising results with the use of green tea for several dermatologic conditions; however, the efficacy of oral and topical green tea has not always been confirmed.
    SKINmed 01/2013; 10(6):352-5.
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    ABSTRACT: To determine the efficacy of oral nicotinamide with placebo to ameliorate uremic pruritus (UP), we conducted a prospective, randomized, double-blind, 4-week study in 50 chronic kidney disease patients with refractory UP. The patients were randomly allocated to nicotinamide tablet 500 mg twice/day or placebo. All anti-pruritic agents were discontinued at least two weeks before the study. All the patients completed the period of the study and their severity of pruritus was evaluated before the start of the study and at the end of each week for four weeks by using a traditional Visual Analogue Scale and a modified questionnaire method (pruritus score). The average pruritus score before administration of oral nicotinamide in the study group and that in the placebo group was 2.96 ± 0.45 and 2.72 ± 0.37, respectively. In the nicotinamide group, the average score of pruritus gradually reduced to 1.29 ± 1.08 and in the placebo group it gradually decreased to 1.52 ± 1.61 at the end of the fourth week. There was no significant difference between the reductions of pruritus in both groups, but the interaction effect using a linear mixed model was significant between drug and time (P <0.026). We conclude that increasing the time of application of nicotinamide sodium to more than four weeks may be more effective than placebo in reducing itching in uremic patients.
    Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 01/2013; 24(5):995-9. DOI:10.4103/1319-2442.118070
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    ABSTRACT: Tea tree oil (TTO) is an essential oil, steam-distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen-4-ol and a maximum content of 1, 8-cineole. Terpinen-4-ol is a major TTO component which exhibits strong antimicrobial and anti-inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad-spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa. Several studies have suggested the uses of TTO for the treatment of acne vulgaris, seborrheic dermatitis, and chronic gingivitis. It also accelerates the wound healing process and exhibits anti-skin cancer activity. This review opens up new horizons for dermatologists in the use of this herbal agent.
    International journal of dermatology 09/2012; 52(7). DOI:10.1111/j.1365-4632.2012.05654.x · 1.31 Impact Factor
  • Nader Pazyar · Amir Feily · Reza Yaghoobi ·
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    ABSTRACT: Interleukin (IL)-1 is a pivotal proinflammatory cytokine consisting of two molecular species, IL-1α and IL-1β. Anakinra (Kineret), a recombinant human IL-1 receptor antagonist, is regarded as a biological agent which blocks the inflammatory effects of IL-1. The aim of this review was to search the literatures and summarizes in vivo, in vitro and human studies on anakinra uses in dermatological disorders. The results show that anakinra is currently used clinically for the treatment of a variety of skin conditions such as psoriasis, atopic dermatitis, photoagaing, melanoma, Schnitzler syndrome, pyoderma gangraenosum, PAPA syndrome, hidradenitis suppurativa, lamellar ichthyosis, Sweet's syndrome, panniculitis, Muckle-Wells syndrome, familial Mediterranean fever, SAPHO syndrome and other disorders. Notably, anakinra is expensive to produce and administer. Injection is the route of therapy and allergic reaction is most possible.
    07/2012; 7(4):271-5. DOI:10.2174/157488412803305821
  • Nader Pazyar · Noorodin Jamshydian ·

    Journal of alternative and complementary medicine (New York, N.Y.) 07/2012; 18(7):639-40. DOI:10.1089/acm.2012.0314 · 1.59 Impact Factor
  • Nader Pazyar · Reza Yaghoobi ·

    Journal of alternative and complementary medicine (New York, N.Y.) 04/2012; 18(4):316-7. DOI:10.1089/acm.2011.0892 · 1.59 Impact Factor

Publication Stats

88 Citations
22.10 Total Impact Points


  • 2009-2015
    • Ahvaz Jondishapour University of Medical Sciences
      • Department of Dermatology
      Nāşerī, Khūzestān, Iran
  • 2013
    • Tehran University of Medical Sciences
      • Skin and Stem Cell Research Center
      Teheran, Tehrān, Iran
    • Jahrom University of Medical Sciences
      Teheran, Tehrān, Iran
  • 2012
    • Iran University of Medical Science
      Teheran, Tehrān, Iran
    • Imam Khomeini International University
      Kazvin, Qazvīn, Iran