Publications (3)4.75 Total impact
Article: Prevalence of dementia and its correlates among participants in the National Early Dementia Detection Program during 2006-2009.[show abstract] [hide abstract]
ABSTRACT: To investigate the prevalence of dementia and its correlates among people with poor socioeconomic status, poor social support systems, and poor performance on the Korean version of the Mini-Mental Status Exam (MMSE-KC). We used 2006-2009 data of the National Early Dementia Detection Program (NEDDP) conducted on Jeju Island. This program included all residents >65 years old who were receiving financial assistance. We examined those who performed poorly (standard deviation from the norm of <-1.5) on the MMSE-KC administered as part of the NEDDP, using age-, gender-, and education-adjusted norms for Korean elders. A total of 1708 people were included in this category. The prevalence of dementia in this group was 20.5%. Multivariate logistic regression analysis revealed that the following factors were statistically significantly associated with dementia: age of 80 or older, no education, nursing home residence, and depression. The prevalence of dementia is very high among those with lower MMSE-KC scores, and significant correlates include older age, no education, living in a nursing home, and depression. Enhancing lifetime education to improve individuals' cognitive reserves by providing intellectually challenging activities, encouraging living at home rather than in a nursing home, and preventing and treating depression in its early phase could reduce the prevalence of dementia in this population.Psychiatry investigation 06/2012; 9(2):134-42. · 0.99 Impact Factor
Article: The influence of subcortical ischemic lesions on cognitive function and quality of life in late life depression.[show abstract] [hide abstract]
ABSTRACT: Subcortical ischemic lesions (SIL) are known to contribute to the pathogenesis of late life depression. The present study examined the influence of SIL on cognitive function and quality of life in elderly Koreans with major depressive disorder (MDD). MDD patients (n=86) underwent CT scans and were classified as having SIL if they had a score of 2 or above on age-related white matter changes (ARWMC) scale. Demographic data, psychiatric, medical history, neuropsychological test, quality of life, and depressive symptomatology were compared between MDD patients with and without SIL. SIL with grade 2 or above were found in deep white matter of 22 (25.6%) depressed patients and in basal ganglia of 9 (10.5%) depressed patients. Depressed patients with deep white matter lesions showed poor performance on MMSE-KC and decreased quality of life, particularly in physical function and physical role limitation, as compared to depressed patients without deep white matter lesions. These data support that SIL may cause general cognitive dysfunction and poor physical health. More attention should be paid to detection and management of SIL in late life depression in clinical setting.Journal of affective disorders 02/2012; 136(3):485-90. · 3.76 Impact Factor
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ABSTRACT: Tardive dyskinesia is characterized by choreiform movements, or rhythmic abnormal involuntary movements of the face, mouth, tongue, trunk, and limbs. It is frequently associated with the use of neuroleptic medications. The choreiform movements are irreversible in some patients, even after the drug is withdrawn. Although no reliable treatment for tardive dyskinesia exists, atypical antipsychotics are associated with a significantly lower incidence of tardive dyskinesia than typical antipsychotics. Moreover, recent reports suggest that atypical antipsychotics may have a beneficial effect on tardive dyskinesia remission. Until recently, evidence for the effectiveness of aripiprazole on tardive dyskinesia has been mixed. Aripiprazole has a unique mechanism of action and has various effects in tardive dyskinesia. The drug acts as a partial D(2) receptor agonist that can stabilize D(2) up-regulation, and as a partial 5-HT(1A) receptor agonist and a 5-HT(2A) receptor antagonist, and can increase the release of dopamine in the striatum.Clinical Psychopharmacology and Neuroscience 04/2011; 9(1):1-8.