Lianne Parkin

Publications (2)29.48 Total impact

• Article: Smoking, Surgery, and Venous Thromboembolism Risk in Women: UK Cohort Study.

  Siân Sweetland, Lianne Parkin, Angela Balkwill, Jane Green, Gillian Reeves, Valerie Beral
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  ABSTRACT: BACKGROUND: Evidence about the effect of smoking on venous thromboembolism risk, generally and in the post-operative period, is limited and inconsistent. We examined the incidence of venous thromboembolism in relation to smoking habits, both in the absence of surgery and in the first 12 post-operative weeks in a large prospective study of UK women. METHODS AND RESULTS: During 6 years' follow-up of 1,162,718 women, mean age 56 years, 4630 were admitted to hospital for or died from venous thromboembolism. In the absence of surgery, current smokers had a significantly increased incidence of venous thromboembolism compared to never smokers (adjusted relative risk [RR]=1.38 [95% confidence interval 1.28-1.48]), with significantly greater risks in heavier than lighter smokers (RRs 1.47 [1.34-1.62] and 1.29 [1.17-1.42] for 15+ versus <15 cigarettes/day). Current smokers were also more likely to have surgery than never smokers (1.12 [1.12-1.13]). Among women who had surgery, the incidence of venous thromboembolism in the first 12 post-operative weeks was significantly greater in current than never smokers (1.16 [1.02-1.30]). CONCLUSIONS: Venous thromboembolism incidence was increased in current smokers, both in the absence of surgery and in the 12 weeks following surgery. Smoking is another factor to consider when assessing venous thromboembolism risk in patients undergoing surgery.
  Circulation 03/2013; · 14.74 Impact Factor
• Article: Body mass index, surgery, and risk of venous thromboembolism in middle-aged women: a cohort study.

  Lianne Parkin, Siân Sweetland, Angela Balkwill, Jane Green, Gillian Reeves, Valerie Beral
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  ABSTRACT: Obesity and surgery are known risk factors for venous thromboembolism (VTE), but there is limited information about the independent effects of obesity on the incidence of postoperative VTE. We linked questionnaire data from the Million Women Study with hospital admission and death records to examine the risk of VTE in relation to body mass index (BMI) both in the absence of surgery and in the first 12 weeks following an operation. Overall, 1 170 495 women (mean age, 56.1 years) recruited in 1996 to 2001 through the National Health Service Breast Screening Programme in England and Scotland were followed for an average of 6 years, during which time 6438 were admitted to hospital or died of VTE. The adjusted relative risks of VTE increased progressively with increasing BMI and women with a BMI ≥ 35 kg/m(2) were 3-4 times as likely to develop VTE as those with a BMI 22.5 to 24.9 (relative risk 3.45 [95% CI 3.09-3.86]). Overweight and obese women were more likely than lean women to be admitted for surgery and also to develop postoperative VTE. During a 12-week period without surgery, the incidence rates of VTE per 1000 women with a BMI < 25 and ≥ 25 were 0.10 (0.09-0.10) and 0.19 (0.18-0.20); the corresponding rates in the 12 weeks following day and inpatient surgery were, respectively, about 4 and 40 times higher. VTE risk increases with increasing BMI and the associated excess risk is much greater after surgery than without surgery.
  Circulation 03/2012; 125(15):1897-904. · 14.74 Impact Factor