C. Liu

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (68)227.79 Total impact

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    ABSTRACT: We present an extraction of azimuthal correlations between two pairs of charged pions detected in opposite jets from electron-positron annihilation. These correlations may arise from the dependence of the di-pion fragmentation on the polarization of the parent quark in the process $e^+e^- \rightarrow q \bar{q}$. Due to the correlation of the quark polarizations, the cross-section of di-pion pair production, in which the pion pairs are detected in opposite jets in a dijet event, exhibits a modulation in the azimuthal angles of the planes containing the hadron pairs with respect to the production plane. The measurement of this modulation allows access to combinations of fragmentation functions that are sensitive to the quark's transverse polarization and helicity. Within our uncertainties we do not observe a significant signal from the previously unmeasured helicity dependent fragmentation function $G_1^\perp$. This measurement uses a dataset of 938~fb$^{-1}$ collected by the Belle experiment at or near $\sqrt{s}\approx10.58$ GeV.
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    ABSTRACT: Background: While area detector computed tomography (ADCT) is a useful tool for coronary artery disease (CAD) evaluation, myocardial perfusion imaging (MPI) with single photon emission computed tomography is a well-established method of predicting functional relevance of CAD. Purpose: We assess the usefulness for decision making using both ADCT and MPI and discussed from the standpoint of cost for diagnostic work-up and contrast agent. Method: Between January, 2013 to September, 2014, 78 patients underwent both ADCT and MPI within two months were analyzed their therapeutic strategy. From ADCT, severity of stenosis was divided non-significant(less than 50%), moderate (over or equal to 50% and less than 75%) and severe (over or equal to 75%). Summed difference score of MPI was judged as ischemia positive. Result: Table showed the result and executed treatment strategy. Patients with significant stenosis by ADCT were 40 patients (51.3%) and patients with ischemia positive were 25 patients (33.8%). Invasive revasculization was performed higher (82.3%, p<0.01) for the patients with significant stenosis and ischemia than moderate stenosis with ischemia (25%) or significant stenosis without ischemia (39.1%). Before taking invasive therapy, examination with ADCT and MPI saved 63700 yen and about 100ml of contrast agent in each case based study as it was compared with the case with ADCT and coronary angiography without MPI in spite of slightly higher radiation dose (4mSv). Conclusion: The combined use of ADCT and MPI could choose effectively treatment strategy of CAD with a reduction of cost and contrast agent.
    European heart journal cardiovascular Imaging; 05/2015
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    Z Cui · M Hui · Y Liu · C Song · X Li · Y Li · L Liu · G Shi · S Wang · F Li · X Zhang · C Liu · J Xiang · K H Chu
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    ABSTRACT: The sex determination system in crabs is believed to be XY-XX from karyotypy, but centromeres could not be identified in some chromosomes and their morphology is not completely clear. Using quantitative trait locus mapping of the gender phenotype, we revealed a ZW-ZZ sex determination system in Eriocheir sinensis and presented a high-density linkage map covering ~98.5% of the genome, with 73 linkage groups corresponding to the haploid chromosome number. All sex-linked markers in the family we used were located on a single linkage group, LG60, and sex linkage was confirmed by genome-wide association studies (GWAS). Forty-six markers detected by GWAS were heterozygous and segregated only in the female parent. The female LG60 was thus the putative W chromosome, with the homologous male LG60 as the Z chromosome. The putative Z and W sex chromosomes were identical in size and carried many homologous loci. Sex ratio (5:1) skewing towards females in induced triploids using unrelated animals also supported a ZW-ZZ system. Transcriptome data were used to search for candidate sex-determining loci, but only one LG60 gene was identified as an ankyrin-2 gene. Double sex- and mab3-related transcription factor 1 (Dmrt1), a Z-linked gene in birds, was located on a putative autosome. With complete genome sequencing and transcriptomic data, more genes on putative sex chromosomes will be characterised, thus leading towards a comprehensive understanding of the sex determination and differentiation mechanisms of E. sinensis, and decapod crustaceans in general.Heredity advance online publication, 15 April 2015; doi:10.1038/hdy.2015.26.
    Heredity 04/2015; DOI:10.1038/hdy.2015.26 · 3.80 Impact Factor
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    ABSTRACT: High-spin states of In-115 have been studied using the Cd-114 (Li-7, alpha 2n) reaction at a beam energy of 48 MeV. A total of 13 new transitions have been observed and added to the level scheme of In-115. Most of the states in In-115 can be interpreted in terms of the weak coupling of a g(9/2) proton hole to the core states of Sn-116 or a g(7/2) proton to the core states of Cd-114. A Delta I = 1 band with the pi(g(9/2))-1 circle times nu(h(11/2))(2) configuration was suggested as an oblate band built on the "stapler" mechanism with the aid of the tilted axis cranking model based on covariant density functional theory.
    Physical Review C 04/2015; 91(4). DOI:10.1103/PhysRevC.91.044303 · 3.88 Impact Factor
  • Y-F Xu · Y Lu · H Cheng · J Jiang · J Xu · J Long · L Liu · Q Ni · C Liu · X-J Yu
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    ABSTRACT: Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety of mechanisms are involved in PDAC biological behaviors, of which, the mechanisms of immune escape may be a pivotal hallmark. HLA-G is a tolerant molecule implicated in tumor escape and serves as a prognostic biomarker in tumors Our study evaluated the expression of HLA-G in PDAC and explored its clinical significance. In a cohort of 122 PDAC patients, 78 patents (63.9%) exhibited tumor tissues. Multivariate analysis suggested that HLA-G level for OS (HR = 3.894, 95% CI = 2.380-6.370, p <0.001). High level of HLA-G significantly correlated with PDAC aggressive features, such as more advanced stage (TNM Stage II) (p<0.001), extrapancreatic infiltration (T3 stage) (p<0.001), lymph node involvement (p=0.019) and poor differentiation (p=0.010). In western blot analysis, almost all of the tumor cell lines (5/6) expressed high level of HLA-G. In ELISA analysis, the level of plasma sHLA-G in PDAC patients were significantly increased than in healthy control (P=0.0037). Further analysis revealed the level of sHLA-G inversely related to numbers of peripheral activated T cells (CD8+CD28+ T cells), which may indicate that sHLA-G inactivates T cell responses resulting in tumor immune escape. In conclusion, tumor-derived HLA-G may indicate the mechanism of immune escape and impaired PDAC clinical outcome, especially in early-stage patients, which may also be a potential therapeutic target.
    Current Molecular Medicine 03/2015; 15(4). DOI:10.2174/1566524015666150401102218 · 3.61 Impact Factor
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    ABSTRACT: The measurement of cosmic ray energy spectra, in particular for individual species, is an essential approach in finding their origin. Locating the "knees" of the spectra is an important part of the approach and has yet to be achieved. Here we report a measurement of the mixed Hydrogen and Helium spectrum using the combination of the ARGO-YBJ experiment and of a prototype Cherenkov telescope for the LHAASO experiment. A knee feature at 640+/-87 TeV, with a clear steepening of the spectrum, is observed. This gives fundamental inputs to galactic cosmic ray acceleration models.
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    ABSTRACT: This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.
    European Physical Journal C 11/2014; DOI:10.1140/epjc/s10052-014-3026-9 · 5.44 Impact Factor
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    ABSTRACT: We report a measurement of the branching fraction of $B^+ \to \tau^+ \nu_\tau$ decays using a data sample of $772 \times 10^6 B \bar{B}$ pairs, collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. We reconstruct the accompanying $B$ meson in a semileptonic decay and detect the $B^+ \to \tau^+ \nu_\tau$ candidate in the recoiling event. We obtain a branching fraction of ${\cal B}(B^+ \to \tau^+ \nu_\tau) = [1.25 \pm 0.28 ({\rm stat.}) \pm 0.27({\rm syst.})] \times 10^{-4}$. This result is in good agreement with previous measurements and the expectation from calculations based on the Standard Model.
  • L N Liu · H X Xu · S G Zheng · L P Sun · L H Guo · Y F Zhang · J M Xu · C Liu · X H Xu
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    ABSTRACT: Purpose: To investigate the imaging features of intraductal papillary neoplasm in bile duct (IPNB) on baseline ultrasound and contrast-enhanced ultrasound (CEUS). Materials and Methods: The imaging features on baseline ultrasound and CEUS in 16 pathologically proven IPNB lesions in 15 patients were retrospectively analyzed. Real-time contrast specific modes and contrast agent of SonoVue were used for CEUS. Results: Bile duct dilation was present in all patients. The mean lengths for the intraductal papillary adenomas and adenocarcinomas were 2.5 ± 1.1 (range, 1.2 - 4.2 cm) and 5.6 ± 2.0 cm (range, 3.3 - 9.8 cm) (P = 0.004). Three imaging types of IPNB on ultrasound were depicted: bile duct dilation with intraductal mass (n = 8), bile duct dilation without intraductal mass (n = 3), and cystic-solid mixed type (n = 5). On CEUS, solid components of 13 lesions appeared hyper- (n = 12) or iso-enhancement (n = 1) in the arterial phase whereas all showed hypo-enhancement in the portal and late phases. For 3 lesions of bile duct dilation without intraductal mass, CEUS showed non-enhancement during all phases. Pre-surgical CEUS and conventional ultrasound made correct diagnoses in 12 (75.0 %) and 5(31.3 %) of 16 IPNBs respectively (P = 0.04). For CECT, correct diagnosis was also achieved in 12 (75.0 %) of 16 lesions (P = 1.00, in comparison with CEUS). Conclusions: IPNB should be taken into consideration when intraductal mass or cystic-solid mass with bile duct dilation, or remarkable bile duct dilation without intraductal mass, are found on US. Intraductal mass length > 3.0 cm is more commonly found in malignant IPNB. CEUS might facilitate the diagnosis of IPNB by easily excluding the possibility of commonly found sludge, nonshadowing stones, or blood clots.
    Ultraschall in der Medizin 09/2014; DOI:10.1055/s-0034-1366672 · 4.65 Impact Factor
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    ABSTRACT: We present the first model-independent measurement of the absolute branching fraction of the Λ_{c}^{+}→pK^{-}π^{+} decay using a data sample of 978 fb^{-1} collected with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The number of Λ_{c}^{+} baryons is determined by reconstructing the recoiling D^{(*)-}p[over ¯]π^{+} system in events of the type e^{+}e^{-}→D^{(*)-}p[over ¯]π^{+}Λ_{c}^{+}. The branching fraction is measured to be B(Λ_{c}^{+}→pK^{-}π^{+})=(6.84±0.24_{-0.27}^{+0.21})%, where the first and second uncertainties are statistical and systematic, respectively.
    Physical Review Letters 07/2014; 113(4):042002. · 7.51 Impact Factor
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    ABSTRACT: We present a search for the rare leptonic decays $B^+ \to e^+ \nu$ and $B^+ \to \mu^+ \nu$, using the full $\Upsilon(4S)$ data sample of $772\times 10^6$ $B\bar{B}$ pairs collected with the Belle detector at the $\rm {\small KEKB}$ asymmetric-energy $e^+ e^-$ collider. One of the $B$ mesons from the $\Upsilon(4S) \to B\bar{B}$ decay is fully reconstructed in a hadronic mode while the recoiling side is analyzed for the signal decay. We find no evidence of a signal in any of the decay modes. Upper limits of the corresponding branching fractions are determined as ${\cal B}(B^+ \to e^+ \nu)<3.4\times 10^{-6}$ and ${\cal B}(B^+ \to \mu^+ \nu)<2.7 \times 10^{-6}$ at 90$\%$ confidence level.
  • Y Lu · C Liu · H Cheng · Y Xu · J Jiang · J Xu · J Long · L Liu · X Yu
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    ABSTRACT: Stathmin (STMN) has been known as a p53-regulated protein and has been shown to play an oncogenic role in a range of human malignancies. Paradoxically, most recent studies demonstrated that stathmin has a dual function as both an oncogene and a metastasis suppressor. Stathmin is a member of microtubule dynamic destabilizing proteins and stathmin-regulated microtubule disruption could lead to a variety of cell dysfunctions such as enhanced chronic hypoxia in pancreatic cancer. In this study, we identified that stathmin promotes proliferation of pancreatic cancer cells by an underlying nuclear factor kappa B (Nf-κB) interacting mechanism. In human specimens, stathmin was significantly overexpressed in pancreatic cancer tissues and high expression of stathmin was correlated with vascular emboli (p=0.028), tumor size (p=0.019), and overall survival (p=0.031). Functional assays showed that knockdown of stathmin significantly reduced pancreatic cancer cell viability, colony formation, and arrested the cell cycle at the G2/M phase. Furthermore, silence of stathmin could reduce pancreatic tumor growth in nude mice. For the mechanism, Western blot analyses demonstrated that Nf-κB (p65) was significantly down-regulated when stathmin was silenced. In addition, co-immunoprecipitation (CoIP) assay suggested that stathmin was able to interact with Nf-κB (p65). Our findings indicate that stathmin might play its oncogenic role by an interaction with Nf-κB pathway, which may reveal a novel mechanism to uncover the role of microtubule-destabilizing stathmin in pancreatic cancer environment as well as provide a potential therapeutic strategy for pancreatic cancer.
    Current Molecular Medicine 02/2014; 14(3). DOI:10.2174/1566524014666140228120913 · 3.61 Impact Factor
  • S Shi · Y Lu · Y Qin · W Li · H Cheng · Y Xu · J Xu · J Long · L Liu · C Liu · X Yu
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    ABSTRACT: Accumulating evidence indicates that microRNAs (miRNAs) have great potential as tumor biomarkers and therapeutic agents owing to their functions in tumorigenesis and cancer progression. Aberrant expression of miR-1247 has been found in several cancers and is predicted to play an important role in the pathological processes of pancreatic cancer by miRNA-regulated network analysis. We investigated the expression profile of miR-1247 in pancreatic cancer tissue microarray by in situ hybridization and found that miR-1247 was significantly down-regulated in pancreatic cancer tissues compared to matched benign tissues. High levels of miR-1247 expression were positively correlated with higher overall and recurrence free survival in pancreatic cancer patients, while negatively correlated with tumor grade. Using in vitro and in vivo models, we demonstrated that increased expression of miR-1247 inhibited proliferation, tumorigenicity, colony formation and triggered G0/G1 cell cycle arrest in pancreatic cancer cells. Moreover, we confirmed that neuropilin1 (NRP1) and neuropilin2 (NRP2) are direct targets of miR-1247 by western blot and luciferase reporter assay. Further studies indicated that low dose all trans retinoic acid (ATRA) can induce redifferentiation and restoration of miR-1247 in pancreatic cancer cells. These findings suggest that miR-1247, a novel tumor suppressor, can act as a potential biomarker and therapeutic agent for pancreatic cancer.
    Current Molecular Medicine 02/2014; 14(3). DOI:10.2174/1566524014666140228120014 · 3.61 Impact Factor
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    L. Liu · S. Y. Wang · B. Qi · C. Liu
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    ABSTRACT: The interaction strength between chiral doublet bands is studied using the two-band mixing picture and the particle rotor model (PRM). The present calculations indicate that the interaction strength between chiral doublet bands is equal to zero for the ideal case of the pi h(11/2) circle times nu h(11/2)(-1) configuration with gamma = 30 degrees, and the interaction strength becomes larger as gamma deviates from 30 degrees. For gamma = 15 degrees or 45 degrees, the average interaction strength is approximately 180 keV in the chiral region.
    International Journal of Modern Physics E 09/2013; 22(08). DOI:10.1142/S0218301313500602 · 0.84 Impact Factor
  • X Zheng · K Zhang · X Zhou · C Liu · M Li · Y Li · R Wang · J Li · W Shi · X Xu
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    ABSTRACT: Although Streptococcus sanguinis has been reported to produce H2O2 to gain a competitive edge over Streptococcus mutans, the molecular mechanisms evolved by S. mutans to counter this "peer stress" are still to be identified. The current study was designed to investigate the ecological role of glutathione synthetase (gshAB) in the interspecies interaction between S. mutans and S. sanguinis. A gshAB in-frame deletion strain of S. mutans was constructed, and its phenotypic traits were characterized. The spatio-temporal interaction of the gshAB mutant with S. sanguinis was further investigated in a dual-species biofilm model by fluorescence in situ hybridization. We found that, although less tolerant for H2O2, the gshAB mutant produced more extracellular polysaccharides by up-regulating gtfs expression, so as to cluster as condensed microcolonies. In addition, the mutant was more susceptible to the conditioned medium of S. sanguinis, and its competitiveness was significantly compromised. Taken together, we believe that gshAB is essential for the competitiveness and prevalence of S. mutans through detoxifying the H2O2 produced by S. sanguinis. Given the ecological importance of bacterial equilibrium within the oral biofilm, gshAB may represent a promising target to modulate the S. mutans/S. sanguinis ratio under cariogenic conditions, thus contributing to the management of dental caries.
    Journal of dental research 07/2013; 92(9). DOI:10.1177/0022034513498598 · 4.14 Impact Factor
  • L Liu · H-X Xu · W-Q Wang · C-T Wu · T Chen · Y Qin · C Liu · J Xu · J Long · B Zhang · Y-F Xu · Q-X Ni · M Li · X-J Yu
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    ABSTRACT: Caveolin-1 exhibits a stage-dependent, functional fluctuation during pancreatic cancer development, but the underlying mechanisms remain unclear. Here, we report that cavin-1, a structural protein of caveolae, modulates the oncogenic function of caveolin-1 and cooperates with caveolin-1 to enhance pancreatic cancer aggressiveness. Cavin-1 expression is associated with caveolin-1 in pancreatic cancer tissue samples and cell lines, and predicts the metastatic potential of pancreatic cancer. Interactome analyses further revealed the physical interaction of cavin-1 and caveolin-1 and their colocalization in pancreatic cancer cells. Cavin-1 stabilizes caveolin-1 expression or activity by inhibiting its internalization and subsequent lysosomal degradation. More in-depth functional experiments showed that caveolin-1-enhanced aggressiveness of pancreatic cancer cells is dependent on the presence of cavin-1. In contrast, cavin-1 depletion inhibited the invasion and metastasis of pancreatic cancer cells, which could not be restored by caveolin-1-rescue construct. Tissue microarray analyses in two independent clinic cohorts also supported the augment of cavin-1 on the prognostic potency of caveolin-1, and showed that combination of cavin-1 with caveolin-1 predicted worse survival in pancreatic cancer patients. Of note, the phenotypes because of cavin-1 could not be achieved by other cavins such as cavin-2, and the tumor-promoting role of cavin-1 in pancreatic cancer was found to be largely dependent on caveolin-1 expression, which highlights the critical role of cavin-1/caveoin-1 in pancreatic cancer progression, and suggests that the interruption of cavin-1/caveolin-1 interaction is a promising therapeutic strategy for pancreatic cancer.Oncogene advance online publication, 17 June 2013; doi:10.1038/onc.2013.223.
    Oncogene 06/2013; DOI:10.1038/onc.2013.223 · 8.56 Impact Factor
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    ABSTRACT: The clinically appropriate duration of thromboprophylaxis in hospitalized patients with acute medical illnesses is unknown. In this multicenter, randomized, double-blind trial, we evaluated the efficacy and safety of oral rivaroxaban administered for an extended period, as compared with subcutaneous enoxaparin administered for a standard period, followed by placebo. We randomly assigned patients 40 years of age or older who were hospitalized for an acute medical illness to receive subcutaneous enoxaparin, 40 mg once daily, for 10±4 days and oral placebo for 35±4 days or to receive subcutaneous placebo for 10±4 days and oral rivaroxaban, 10 mg once daily, for 35±4 days. The primary efficacy outcomes were the composite of asymptomatic proximal or symptomatic venous thromboembolism up to day 10 (noninferiority test) and up to day 35 (superiority test). The principal safety outcome was the composite of major or clinically relevant nonmajor bleeding. A total of 8101 patients underwent randomization. A primary efficacy outcome event occurred in 78 of 2938 patients (2.7%) receiving rivaroxaban and 82 of 2993 patients (2.7%) receiving enoxaparin at day 10 (relative risk with rivaroxaban, 0.97; 95% confidence interval [CI], 0.71 to 1.31; P=0.003 for noninferiority) and in 131 of 2967 patients (4.4%) who received rivaroxaban and 175 of 3057 patients (5.7%) who received enoxaparin followed by placebo at day 35 (relative risk, 0.77; 95% CI, 0.62 to 0.96; P=0.02). A principal safety outcome event occurred in 111 of 3997 patients (2.8%) in the rivaroxaban group and 49 of 4001 patients (1.2%) in the enoxaparin group at day 10 (P<0.001) and in 164 patients (4.1%) and 67 patients (1.7%) in the respective groups at day 35 (P<0.001). In acutely ill medical patients, rivaroxaban was noninferior to enoxaparin for standard-duration thromboprophylaxis. Extended-duration rivaroxaban reduced the risk of venous thromboembolism. Rivaroxaban was associated with an increased risk of bleeding. (Funded by Bayer HealthCare Pharmaceuticals and Janssen Research and Development; MAGELLAN ClinicalTrials.gov number, NCT00571649.).
    New England Journal of Medicine 02/2013; 368(6):513-23. DOI:10.1056/NEJMoa1111096 · 54.42 Impact Factor
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    ABSTRACT: A search is presented for production of a heavy up-type quark ( t ′ ) together with its antiparticle, assuming a significant branching ratio for subsequent decay into a W boson and a b quark. The search is based on 4.7 fb−1 of pp collisions at s = 7 TeV recorded in 2011 with the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton + jets final state, characterized by a high-transverse-momentum isolated electron or muon, large missing transverse momentum and at least three jets. The analysis strategy relies on the substantial boost of the W bosons in the t ′ t ¯ ′ signal when m t ′ ≳ 400 GeV . No significant excess of events above the Standard Model expectation is observed and the result of the search is interpreted in the context of fourth-generation and vector-like quark models. Under the assumption of a branching ratio BR ( t ′ → W b ) = 1 , a fourth-generation t ′ quark with mass lower than 656 GeV is excluded at 95% confidence level. In addition, in light of the recent discovery of a new boson of mass ∼ 126 GeV at the LHC, upper limits are derived in the two-dimensional plane of BR ( t ′ → W b ) versus BR ( t ′ → H t ) , where H is the Standard Model Higgs boson, for vector-like quarks of various masses.
    Physics Letters B 01/2013; 718(4-5-4–5):1284 - 1302. DOI:10.1016/j.physletb.2012.11.071 · 6.02 Impact Factor
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Publication Stats

393 Citations
227.79 Total Impact Points

Institutions

  • 2015
    • Chinese Academy of Sciences
      Peping, Beijing, China
  • 2013–2015
    • Shandong University
      Chi-nan-shih, Shandong Sheng, China
    • Sichuan University
      • State Key Laboratory of Oral Diseases
      Hua-yang, Sichuan, China
  • 2014
    • University of Science and Technology of China
      Luchow, Anhui Sheng, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
  • 2012
    • University of Chicago
      Chicago, Illinois, United States
    • Tongji University
      Shanghai, Shanghai Shi, China
  • 1997
    • University of Toronto
      Toronto, Ontario, Canada