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Publications (2)4.43 Total impact

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    ABSTRACT: Methylene blue (MB) attenuates acute lung injury (ALI) induced by liver or pancreas ischemia-reperfusion. But the protective effects of MB on paraquat (PQ)-induced ALI have not been elucidated. In this study, we aimed to study the effects of MB on ALI caused by PQ in rats. Male Sprague-Dawley rats were challenged acutely by PQ (25mg/kg, i.p.) with or without MB posttreatment (2mg/kg, i.p.) 2h after PQ administration. Lung specimens and the bronchoalveolar lavage fluid were isolated for pathological examinations and biochemical analyses 24h after PQ exposure. We found that the administration of MB significantly increased the activity of superoxide dismutase and decreased lung wet dry radio, the content of malondialdehyde and lactate dehydrogenase, the total cell number and the level of myeloperoxidase in bronchoalveolar lavage fluid. Pathological examination also revealed that MB alleviated PQ-induced histological damage. These results provide evidence that MB may be a new therapy in the treatment of PQ-induced ALI.
    International immunopharmacology 07/2013; · 2.21 Impact Factor
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    ABSTRACT: Lactoferrin (LF) plays various anti-inflammatory roles in inflammation experimentally induced by lipopolysaccharides (LPS). But the protective effects of LF on LPS-induced acute lung injury (ALI) have not been elucidated. In this study, we aimed to study the effects of LF on ALI caused by LPS in mice. At 1h before or after LPS injection, an intraperitoneal injection of LF (5mg/body) was administered. Lung specimens and the bronchoalveolar lavage fluid (BALF) were isolated for histopathological examinations and biochemical analyses 12h after LPS exposure. We found that both prophylactic and therapeutic administration of LF significantly decreased the W/D ratio of the lung and protein concentration in the BALF. LF significantly reduced the pulmonary myeloperoxidase activity and the number of total cells in the BALF 12h after LPS challenge. LF treatment markedly attenuated lung edema, alveolar hemorrhage and inflammatory cells infiltration. Moreover, LF also decreased the production of TNF-α and increased interleukin-10 in the BALF. These results firstly indicate that LF may protect against LPS-induced ALI in mice.
    International immunopharmacology 02/2012; 12(2):460-4. · 2.21 Impact Factor