Publications (1)3.79 Total impact
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Article: Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein.
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ABSTRACT: Because amyloidogenic proteins, such as prion protein, β-amyloid peptide and α-synuclein, are associated with a variety of diseases, methods for their detection are important. Recombinant prion protein (rPrP) can selectively induce aggregation of dihydrolipoic acid capped gold nanoparticles (DHLA-AuNPs), which reduces the absorbance of the DHLA-AuNPs and changes their color from red to blue. These changes were used for label-free qualitative and quantitative detection of amyloidogenic protein. The addition of NaCl improved the detection sensitivity considerably, and the detection limit was as low as 33 pmol/L.Talanta 01/2012; 89:401-6. · 3.79 Impact Factor
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Institutions
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2012
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Southwest University in Chongqing
Chongqing, Chongqing Shi, China
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