Jeong Won Hwang

Publications (2)4.11 Total impact

• Article: Lactobacillus caseiExtract Induces Apoptosis in Gastric Cancer by Inhibiting NF-κB and mTOR-Mediated Signaling.

  Jeong Won Hwang, Young-Mi Baek, Kyeong Eun Yang, Hwa-Seung Yoo, Chong-Kwan Cho, Yeon-Weol Lee, Junsoo Park, Chi-Yong Eom, Zee-Won Lee, Jong-Soon Choi, Ik-Soon Jang
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  ABSTRACT: Lactobacillus casei extract (LBX) has been reported to prevent gastric cancer, but the underlying mechanism remains unclear. The proliferation and cell death of gastric cancer KATO3 cells were examined after treatment with LBX for various times and at various doses. LBX inhibited the growth of gastric cancer cells and induced apoptosis by inactivating NF-κB promoter activity. Apoptosis induced by LBX, however, is not directly associated with the intrinsic mitochondrial pathway. Immunoblot analysis revealed that LBX decreased the expressions of NF-κB and IκB. The reduced NF-κB levels led to the decreased phosphorylation of mTOR signaling components, such as PI3K, Akt, and (p70)S6 kinase. These results showed for the first time that LBX induced apoptosis in gastric cancer cells by inhibiting NF-κB and mTOR-mediated signaling.
  Integrative Cancer Therapies 04/2012; · 2.14 Impact Factor
• Article: Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-κB.

  Jeong Won Hwang, Jung Han Oh, Hwa-Seung Yoo, Yeon-Weol Lee, Chong-Kwan Cho, Ki-Rok Kwon, Jung-Ho Yoon, Junsoo Park, Song Her, Zee-Won Lee, Ik-Soon Jang, Jong-Soon Choi
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  ABSTRACT: Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-κB. In addition, BX-MG activated p53 and p21, resulting in the attenuated proliferation of A549 cells. Reduced activity of the NF-κB promoter and increased activity of the p53 promoter indicate that BX-MG regulates apoptosis at the level of transcription in lung cancer cells. Furthermore, BX-MG blocked the nuclear translocation of RelA and the associated reduction in surviving. These results suggest that BX-MG inhibits lung cancer cell growth by activating tumor suppressors and inhibiting nuclear translocation of NF-κB.
  The American Journal of Chinese Medicine 01/2012; 40(1):187-202. · 1.98 Impact Factor