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Publications (4)11.76 Total impact

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    ABSTRACT: BACKGROUND: In this study, the effect of processing conditions of acid degumming and enzymatic degumming on the removal of phospholipids from Silybum marianum seeds oil were investigated and the degumming efficiency was compared based on the phospholipids content. RESULTS: An orthogonal array experimental design was performed to optimize the process conditions of citric acid degumming. Based on the range analysis and analysis of variance (ANOVA), the optimum process condition was determined to be citric acid dosage of 3.0 g kg(-1) , temperature of 70°C, water amount of 40 g kg(-1) and degumming time of 30 min. After the acid degumming process, the phospholipid content of degummed S. marianum seeds oil was reduced from 273.0 mg kg(-1) to 128.1 mg kg(-1) . In the case of enzymatic degumming, the effect of reaction time and enzyme dosage on the degumming effect was investigated using the single factor experiment. The optimum processing conditions were found to be reaction time of 6 h and enzyme dosage of 100 mg kg(-1) of oil. At this optimum point, the phospholipid content of degummed S. marianum seeds oil was reduced to 17.95 mg kg(-1) . CONCLUSION: The results indicated that enzymatic degumming has better degumming effect compared with acid degumming.
    Journal of the Science of Food and Agriculture 02/2013; · 1.88 Impact Factor
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    ABSTRACT: As many traditional Chinese medicines have been founded to have protective effect on liver damage in recent years, they have also got involved in increasingly wide clinical application. Meanwhile, with the development of new hepatic protective formulations of traditional Chinese medicines, we have set increasingly higher requirements for quality control methods and measures. This essay summarizes the advance in studies on hepatic protective formulations of traditional Chinese medicine and their quality control methods in the combination of relevant domestic and foreign literatures, looking into the future of the development of new hepatic protective formulations of traditional Chinese medicines.
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 10/2012; 37(20):3007-11.
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    ABSTRACT: The purpose of this study was to develop porous silica nanoparticles (PSNs) as a carrier to improve oral bioavailability of poorly water-soluble drugs, using silymarin as a model. PSNs were synthesized by reverse microemulsion and ultrasonic corrosion methods. A 3-day release formulation consisting of a silymarin solid dispersion, a hydrophilic gel matrix and silymarin-loaded PSNs was prepared. In vitro release studies indicated that both the silymarin-loaded PSNs and the 3-day release formulation showed a typical sustained-release pattern over a long period, about 72 h. The in vivo studies revealed that the 3-day release formulation gave a significantly higher plasma concentration and larger area under the concentration-time curves than commercial tablets when orally administered to beagle dogs. This implies that the prepared 3-day release formulation significantly enhanced the oral bioavailability of silymarin, suggesting that PSNs can be used as promising drug carriers for oral sustained release systems. Thus providing a technically feasible approach for improving the oral bioavailability and long-term efficacy of poorly soluble drugs.
    Acta biomaterialia 02/2012; 8(6):2104-12. · 5.68 Impact Factor
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    ABSTRACT: The purpose of this study was to develop a sustained drug-release model for water-soluble drugs using silica nanoparticles. Hollow-type mesoporous silica nanoparticles (HMSNs) were prepared using Na(2)CO(3) solution as the dissolution medium for the first time. The water-soluble compound, silybin meglumine, was used as the model drug. The Wagner-Nelson method was used to calculate the in vivo absorption fraction. The results of transmission electron microscopy and nitrogen adsorption revealed that the empty HMSNs had uniformly distributed particles of size 50-100 nm, a spherical appearance, a large specific surface area (385.89 ± 1.12 m(2)/g), and ultralow mean pore size (2.74 nm). The highly porous structure allowed a large drug-loading rate (58.91% ± 0.39%). In 0.08 M Na(2)CO(3) solution, silybin meglumine-loaded HMSNs could achieve highly efficacious and long-term sustained release for 72 hours in vitro. The results of in vitro-in vivo correlation revealed that HMSNs in 0.08 M Na(2)CO(3) solution had a correlation coefficient R(2) value of 0.9931, while those of artificial gastric juice and artificial intestinal juice were only 0.9287 and 0.7689, respectively. The findings of in vitro-in vivo correlation indicate that HMSNs together with Na(2)CO(3) solution could achieve an excellent linear relationship between in vitro dissolution and in vivo absorption for 72 hours, leading to a promising model for sustained release of water-soluble drugs.
    International Journal of Nanomedicine 01/2012; 7:753-62. · 4.20 Impact Factor