Gregory H Cohen

Publications (2)3.76 Total impact

• Article: Validation of the telephone-administered PHQ-9 against the in-person administered SCID-I major depression module.

  Thomas H Fine, Ateka A Contractor, Marijo Tamburrino, Jon D Elhai, Marta R Prescott, Gregory H Cohen, Edwin Shirley, Philip K Chan, Toyomi Goto, Renee Slembarski, Israel Liberzon, Sandro Galea, Joseph R Calabrese
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  ABSTRACT: BACKGROUND: We assessed item-to-item correspondence between the Patient Health Questionnaire-9 (PHQ-9) and the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) major depression episode portion of the major depressive module. METHOD: Four hundred and ninety-eight soldiers in the Ohio National Guard were administered the PHQ-9 and SCID-I. Data were analyzed using chi-square analyses, logistic regression, receiver operating characteristic (ROC) curve analyses and diagnostic efficiency statistics. RESULTS: To screen for depression effectively, results indicate use of the cardinal first two items, items representing fatigue, appetite and sleep changes with an item level cut-off point of two, and the item representing suicidal ideation with item level cut-off point of one. Further, total PHQ-9 scores significantly predicted SCID-I major depressive episode (MDE) and diagnosis (MDD) with moderate accuracy. Lastly, the cut-off total score of 10 had the optimal balance of sensitivity and specificity compared to other PHQ-9 scoring options. LIMITATIONS: Differences in timeline of administration of the measures, differences in "worst episode" reference between the measures, and use of a specific military population are some of the limitations. CONCLUSIONS: This validation study provides guidelines for the use of the telephone-administered PHQ-9 in assessing the lifetime prevalence of a major depressive episode and diagnosis in non-clinical populations, with implications for clinical use.
  Journal of affective disorders 06/2013; · 3.76 Impact Factor
• Article: The relationships of positive and negative symptoms with neuropsychological functioning and their ability to predict verbal memory in psychotic major depression.

  Andrea M Che, Rowena G Gomez, Jennifer Keller, Anna Lembke, Lakshika Tennakoon, Gregory H Cohen, Alan F Schatzberg
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  ABSTRACT: Neuropsychological functioning, in relation to positive and negative symptoms in psychotic major depression (PMD), has not been as thoroughly studied as it has been in schizophrenia. Thus, the current study investigated the associations between positive and negative symptoms with cognitive functioning, with an emphasis on verbal memory in PMD. Attention, working memory, and the executive functioning domains were analyzed among 49 PMD participants. Positive symptoms did not correlate significantly with any measures of verbal memory but did correlate with one measure of attention, working memory, and executive functioning. Negative symptoms correlated significantly with two California Verbal Learning Test-II (CVLT-II) measures of verbal memory and three measures of executive function. Hierarchical regressions were conducted to determine if negative symptoms could predict verbal memory performance after controlling for depression. Of the two verbal memory measures, negative symptoms significantly explained additional variance for CVLT Recognition, but not for CVLT Trials 1-5 total score. Our results provide some evidence that, consistent with the schizophrenia literature, negative symptoms contributed more to verbal memory deficits in PMD than positive symptoms, regardless of depression severity.
  Psychiatry research. 03/2012; 198(1):34-8.