Michael Zimmermann

Hospices Civils de Lyon, Lyons, Rhône-Alpes, France

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Publications (2)5.2 Total impact

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    ABSTRACT: Iodine deficiency (ID) remains common in Europe, and may be especially detrimental during pregnancy. The aim of our study was to assess iodine status and thyroid function in healthy pregnant women in the Lyon metropolitan area. In a cross-sectional study, healthy pregnant women (n=228) with no history of thyroid disease were consecutively recruited from an obstetric clinic during all trimesters. Thyrotropin (TSH), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO) antibodies, thyroglobulin (Tg), and urinary iodine concentration (UIC) (n=100) were measured. Thyroid functions were compared with those in a control group of nonpregnant adults. The median (range) UIC was 81 (8-832) μg/L, and 77% of pregnant women had a UIC <150 μg/L, indicating inadequate iodine intake. Overall, 11% of women had abnormal TSH or anti-TPO. The median FT4 (pmol/L) was 14.9, 12.6, and 11.5 in the first, second, and third trimesters, respectively. The median Tg in pregnant women was 16.2 μg/L, did not differ across trimesters, and was significantly higher than in the control group of nonpregnant adults (11.7 μg/L) (p=0.02). Controlling for maternal age and week of gestation, UIC was not a significant predictor of any of the thyroid function tests. Pregnant women in the Lyon area are iodine deficient and have increased serum Tg concentrations compared with nonpregnant controls, likely due to physiological thyroid hyperstimulation during gestation exacerbated by ID.
    Thyroid: official journal of the American Thyroid Association 04/2012; 22(5):522-8. · 2.60 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background Iodine deficiency (ID) remains common in Europe, and may be especially detrimental during pregnancy. Our study aim was to assess iodine status and thyroid function in healthy pregnant women in the Lyon metropolitan area. Method In a cross-sectional study, healthy pregnant women (n=228) with no history of thyroid disease were consecutively recruited from an obstetric clinic during all trimesters. Thyrotropin (TSH), free thyroxine (FT4), anti-thyroid peroxidase antibodies (anti-TPO), thyroglobulin and urinary iodine concentration (UIC) (n=100) were measured. Thyroid functions were compared to those in a control group of non-pregnant adults. Results The median (range) UIC was 81 (8-832) µg/L and 77% of pregnant women had a UIC <150 µg/L, indicating inadequate iodine intake. Overall, 11% of women had abnormal TSH or anti-TPO. The median FT4 (pmol/L) was 14.9, 12.6 and 11.5 in the first, second and third trimesters, respectively. The median thyroglobulin in pregnant women was 16.2 µg/L, did not differ across trimesters, and was significantly higher than in the control group of non-pregnant adults (11.7 µg/L) (p=0.02). Controlling for maternal age and week of gestation, UIC was not a significant predictor of any of the thyroid function tests. Conclusions Pregnant women in the Lyon area are iodine deficient and have increased serum thyroglobulin concentrations compared to non-pregnant controls, likely due to physiological thyroid hyperstimulation during gestation exacerbated by iodine deficiency.
    Thyroid: official journal of the American Thyroid Association 02/2012; · 2.60 Impact Factor