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Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis 04/2013; 24(3):352-3. · 1.25 Impact Factor
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European Journal of Internal Medicine 01/2013; 24(1):e2. · 2.00 Impact Factor
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ABSTRACT: We investigated the association of bone mineral density (BMD) by detected dual-energy X-ray absorptiometric (DXA) method and hemoglobin (Hb) levels in a large sample.
The current study enrolled 371 postmenopausal women (82 anemic patients), who were screened for osteopenia or osteoporosis by DXA. Patients with osteopenia or osteoporosis (T score<-1.0 SD) were grouped as having low bone mass (LBM).
Anemic patients were older and had significantly higher duration of menopause. When compared with subjects with normal Hb, anemic patients had significant lower femur t score, femur BMD, femur Z score, spinal t score, spinal BMD and spinal Z score (p<0.001). Additionally, the ratio of subjects with LBM in the femur and spine were significantly high in anemic patients (p<0.002, p<0.002, respectively). There were significant correlations between Hb values and femur t score, femur BMD, spine t score, and spine BMD values of the study population in bivariate correlation analysis (r=0.150, p=0.004, r=0.148, p=0.004, r=0.160, p=0.002, r=0.164, p=0.001, respectively). Furthermore, presence of anemia was found to be an independent predictor of LBM for spine [OR: 2.483 (95% CI: 1.309-4.712), p<0.005] in logistic regression analysis. Additionally, number of anemic patients was significantly high in low femur and spine BMD groups (56 vs. 26; p=0.01, 66 vs. 16; p=0.002, respectively).
We have found that the presence of anemia was as an independent predictor of LBM for spine after adjusting for body mass index and other confounders in postmenopausal Turkish women.
European Journal of Internal Medicine 03/2012; 23(2):154-8. · 2.00 Impact Factor
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ABSTRACT: In the present study, we investigated the effects of breast-feeding time on bone mineral density (BMD) later in life.
The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 years, who were screened for osteoporosis by dual energy X-ray absorptiometry (DXA).They were classified into 4 groups with respect to the duration of their breast-feeding as never (group 1), 1-24 months (group 2), 25-60 months (group 3), or > 60 months (group 4). Bone mineral density results for the femur neck and lumbar spine were classified into 3 groups according to WHO criteria as normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD), and osteoporosis (T score < -2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were considered as having low bone mass (LBM).
We found a correlation between duration of lactation and femur BMD or spine BMD in the study population (r = 0.116, p < 0.005; r = -0.151, p = 0.001, respectively). Significant differences were found between femur BMD and spine BMD of groups in one-way ANOVA analysis (p = 0.025, p = 0.005, respectively). Additionally, when compared with the other three groups, group 4 was older and had longer duration of menopause (p < 0.01). In logistic regression analysis, age and body mass index were found as independent risk factors of LBM [odds ratio: 1.084 (95% CI 1.031-1.141); odds ratio: 0.896 (95% CI 0.859-0.935)], while duration of lactation was not found as an independent predictor of LBM.
In this study, we have found that changes of bone metabolism during lactation had no effect on postmenopausal BMD measured by DXA. Consequently, it can be suggested that long breast-feeding duration is not a risk factor for low bone mass later in life.
Archives of medical science : AMS. 06/2011; 7(3):486-92.
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ABSTRACT: We investigated the association between bone mineral density (BMD) detected by dual-energy X-ray absorptiometric (DXA) method and blood pressure (BP) in a large sample of postmenopausal women.
The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 ±8.8 years, who were screened for osteopenia or osteoporosis by DXA. Patients with hypertension (HT, n= 306) were compared with normotensive (NT, n = 290) individuals. Bone mineral density results for the femur neck and spine were classified into 3 groups according to World Health Organization criteria: normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD) and osteoporosis (T score < -2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were grouped as having low bone mass (LBM).
There were no significant differences in femur T score, femur BMD, femur Z score, spinal T score, spinal BMD and spinal Z score between hypertensive and normotensive groups. The group of patients with low bone mass calculated from femur T scores had higher age, systolic BP, duration of hypertension and duration of menopause, but lower BMI. Similarly, patients with low spine BMD had higher age and duration of menopause, but lower BMI. Linear regression analysis showed a significant correlation between systolic BP and femur BMD and T score values. Furthermore, logistic regression analysis revealed that hypertension is an independent predictor of spinal osteopenia and osteoporosis.
The presence of hypertension is an independent predictor of spinal low bone density in Turkish women after menopause.
Archives of medical science : AMS. 04/2011; 7(2):264-70.
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ABSTRACT: Purpose: It is thought that arrhythmias are responsible for sudden deaths in patients with mitral valve prolapse (MVP). QT intervals may predict malignant arrhythmia potential in these patients. The aim of the present study is to assess QT variables in patients with MVP. Methods : We studied 46 patients with non-rheumatic, uncomplicated and isolated MVP and 25 healthy control subjects. All individuals underwent full M-mode; two -dimensional and color-Doppler examinations. MVP was defined as superior displacement of the mitral leaflets of more than 2 mm during systole and as a maximal leaflet thickness of at least 5 mm during diastole. Maximum (QTmax), minimum (QTmin) durations, corrected QT intervals and QT dispersion were measured in every case. The results of MVP patients were compared with the data gathered from the control cases. Results: Demographic and clinical variables were similar between the two groups. Anterior mitral leaflet thickness (AMLD), maximal leaflet displacement (DMR) and degree of mitral regurgitation (DMR) were found to be significantly higher in the patient group. QTc max, QT dispersion (QTd) and corrected QT dispersion (QTcD) were also significantly higher in MVP patients. A significant and fairly strong correlation was found between QTc max, QTcD and AMLT, MLD and DMR. Conclusion: QT durations were significantly increased in patients with isolated MVP, which may explain increased incidence of ventricular arrhythmias and sudden death in this population. Furthermore QT variables were related with the mitral l eaflet thickness and degree of mitral regurgitation; which means QT variables increases with the the severity of the disease.
